The Experts below are selected from a list of 3999 Experts worldwide ranked by ideXlab platform
Andrew J Webb - One of the best experts on this subject based on the ideXlab platform.
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it is Rocket Science why dietary nitrate is hard to beet part ii further mechanisms and therapeutic potential of the nitrate nitrite no pathway
2017Co-Authors: Charlotte E Mills, Jibran Khatri, Perry Maskell, Chimed Odongerel, Andrew J WebbAbstract:Dietary nitrate (found in green leafy vegetables such as Rocket and in beetroot) is now recognized to be an important source of nitric oxide, via the nitrate‐nitrite‐NO pathway. Dietary nitrate confers several cardiovascular beneficial effects on blood pressure, platelets, endothelial function, mitochondrial efficiency and exercise. Having described key twists and turns in the elucidation of the pathway and the underlying mechanisms in Part I, we explore the more recent developments which have served to confirm mechanisms, extend our understanding, and discover new properties and potential therapeutic uses of the pathway in Part II. Even the established dependency on low oxygen states for bioactivation of nitrite has recently been challenged. Dietary nitrate appears to be an important component of ‘healthy diets’, such as the DASH diet to lower blood pressure and the Mediterranean diet, with its potential to lower cardiovascular risk, possibly through beneficial interactions with a range of other constituents. The World Cancer Research Foundation report strong evidence for vegetables including spinach and lettuce (high nitrate‐containing) decreasing cancer risk (mouth, pharynx, larynx, oesophagus and stomach), summarized in a ‘Nitrate‐Cancer Risk Veg‐Table’. The European Space Agency recommends that beetroot, lettuce, spinach and Rocket (high‐nitrate vegetables) are grown to provide food for long‐term space missions. Nitrate, an ancient component of Rocket fuel, could support sustainable crops for healthy humans.
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it is Rocket Science why dietary nitrate is hard to beet part i twists and turns in the realization of the nitrate nitrite no pathway
2017Co-Authors: Jibran Khatri, Charlotte E Mills, Perry Maskell, Chimed Odongerel, Andrew J WebbAbstract:Dietary nitrate (found in green leafy vegetables, such as Rocket, and in beetroot) is now recognized to be an important source of nitric oxide (NO), via the nitrate-nitrite-NO pathway. Dietary nitrate confers several cardiovascular beneficial effects on blood pressure, platelets, endothelial function, mitochondrial efficiency and exercise. While this pathway may now seem obvious, its realization followed a rather tortuous course over two decades. Early steps included the discovery that nitrite was a source of NO in the ischaemic heart but this appeared to have deleterious effects. In addition, nitrate-derived nitrite provided a gastric source of NO. However, residual nitrite was not thought to be absorbed systemically. Nitrite was also considered to be physiologically inert but potentially carcinogenic, through N-nitrosamine formation. In Part 1 of a two-part Review on the nitrate-nitrite-NO pathway we describe key twists and turns in the elucidation of the pathway and the underlying mechanisms. This provides the critical foundation for the more recent developments in the nitrate-nitrite-NO pathway which are covered in Part 2.
Jibran Khatri - One of the best experts on this subject based on the ideXlab platform.
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it is Rocket Science why dietary nitrate is hard to beet part ii further mechanisms and therapeutic potential of the nitrate nitrite no pathway
2017Co-Authors: Charlotte E Mills, Jibran Khatri, Perry Maskell, Chimed Odongerel, Andrew J WebbAbstract:Dietary nitrate (found in green leafy vegetables such as Rocket and in beetroot) is now recognized to be an important source of nitric oxide, via the nitrate‐nitrite‐NO pathway. Dietary nitrate confers several cardiovascular beneficial effects on blood pressure, platelets, endothelial function, mitochondrial efficiency and exercise. Having described key twists and turns in the elucidation of the pathway and the underlying mechanisms in Part I, we explore the more recent developments which have served to confirm mechanisms, extend our understanding, and discover new properties and potential therapeutic uses of the pathway in Part II. Even the established dependency on low oxygen states for bioactivation of nitrite has recently been challenged. Dietary nitrate appears to be an important component of ‘healthy diets’, such as the DASH diet to lower blood pressure and the Mediterranean diet, with its potential to lower cardiovascular risk, possibly through beneficial interactions with a range of other constituents. The World Cancer Research Foundation report strong evidence for vegetables including spinach and lettuce (high nitrate‐containing) decreasing cancer risk (mouth, pharynx, larynx, oesophagus and stomach), summarized in a ‘Nitrate‐Cancer Risk Veg‐Table’. The European Space Agency recommends that beetroot, lettuce, spinach and Rocket (high‐nitrate vegetables) are grown to provide food for long‐term space missions. Nitrate, an ancient component of Rocket fuel, could support sustainable crops for healthy humans.
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it is Rocket Science why dietary nitrate is hard to beet part i twists and turns in the realization of the nitrate nitrite no pathway
2017Co-Authors: Jibran Khatri, Charlotte E Mills, Perry Maskell, Chimed Odongerel, Andrew J WebbAbstract:Dietary nitrate (found in green leafy vegetables, such as Rocket, and in beetroot) is now recognized to be an important source of nitric oxide (NO), via the nitrate-nitrite-NO pathway. Dietary nitrate confers several cardiovascular beneficial effects on blood pressure, platelets, endothelial function, mitochondrial efficiency and exercise. While this pathway may now seem obvious, its realization followed a rather tortuous course over two decades. Early steps included the discovery that nitrite was a source of NO in the ischaemic heart but this appeared to have deleterious effects. In addition, nitrate-derived nitrite provided a gastric source of NO. However, residual nitrite was not thought to be absorbed systemically. Nitrite was also considered to be physiologically inert but potentially carcinogenic, through N-nitrosamine formation. In Part 1 of a two-part Review on the nitrate-nitrite-NO pathway we describe key twists and turns in the elucidation of the pathway and the underlying mechanisms. This provides the critical foundation for the more recent developments in the nitrate-nitrite-NO pathway which are covered in Part 2.
Charlotte E Mills - One of the best experts on this subject based on the ideXlab platform.
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it is Rocket Science why dietary nitrate is hard to beet part ii further mechanisms and therapeutic potential of the nitrate nitrite no pathway
2017Co-Authors: Charlotte E Mills, Jibran Khatri, Perry Maskell, Chimed Odongerel, Andrew J WebbAbstract:Dietary nitrate (found in green leafy vegetables such as Rocket and in beetroot) is now recognized to be an important source of nitric oxide, via the nitrate‐nitrite‐NO pathway. Dietary nitrate confers several cardiovascular beneficial effects on blood pressure, platelets, endothelial function, mitochondrial efficiency and exercise. Having described key twists and turns in the elucidation of the pathway and the underlying mechanisms in Part I, we explore the more recent developments which have served to confirm mechanisms, extend our understanding, and discover new properties and potential therapeutic uses of the pathway in Part II. Even the established dependency on low oxygen states for bioactivation of nitrite has recently been challenged. Dietary nitrate appears to be an important component of ‘healthy diets’, such as the DASH diet to lower blood pressure and the Mediterranean diet, with its potential to lower cardiovascular risk, possibly through beneficial interactions with a range of other constituents. The World Cancer Research Foundation report strong evidence for vegetables including spinach and lettuce (high nitrate‐containing) decreasing cancer risk (mouth, pharynx, larynx, oesophagus and stomach), summarized in a ‘Nitrate‐Cancer Risk Veg‐Table’. The European Space Agency recommends that beetroot, lettuce, spinach and Rocket (high‐nitrate vegetables) are grown to provide food for long‐term space missions. Nitrate, an ancient component of Rocket fuel, could support sustainable crops for healthy humans.
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it is Rocket Science why dietary nitrate is hard to beet part i twists and turns in the realization of the nitrate nitrite no pathway
2017Co-Authors: Jibran Khatri, Charlotte E Mills, Perry Maskell, Chimed Odongerel, Andrew J WebbAbstract:Dietary nitrate (found in green leafy vegetables, such as Rocket, and in beetroot) is now recognized to be an important source of nitric oxide (NO), via the nitrate-nitrite-NO pathway. Dietary nitrate confers several cardiovascular beneficial effects on blood pressure, platelets, endothelial function, mitochondrial efficiency and exercise. While this pathway may now seem obvious, its realization followed a rather tortuous course over two decades. Early steps included the discovery that nitrite was a source of NO in the ischaemic heart but this appeared to have deleterious effects. In addition, nitrate-derived nitrite provided a gastric source of NO. However, residual nitrite was not thought to be absorbed systemically. Nitrite was also considered to be physiologically inert but potentially carcinogenic, through N-nitrosamine formation. In Part 1 of a two-part Review on the nitrate-nitrite-NO pathway we describe key twists and turns in the elucidation of the pathway and the underlying mechanisms. This provides the critical foundation for the more recent developments in the nitrate-nitrite-NO pathway which are covered in Part 2.
Chimed Odongerel - One of the best experts on this subject based on the ideXlab platform.
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it is Rocket Science why dietary nitrate is hard to beet part ii further mechanisms and therapeutic potential of the nitrate nitrite no pathway
2017Co-Authors: Charlotte E Mills, Jibran Khatri, Perry Maskell, Chimed Odongerel, Andrew J WebbAbstract:Dietary nitrate (found in green leafy vegetables such as Rocket and in beetroot) is now recognized to be an important source of nitric oxide, via the nitrate‐nitrite‐NO pathway. Dietary nitrate confers several cardiovascular beneficial effects on blood pressure, platelets, endothelial function, mitochondrial efficiency and exercise. Having described key twists and turns in the elucidation of the pathway and the underlying mechanisms in Part I, we explore the more recent developments which have served to confirm mechanisms, extend our understanding, and discover new properties and potential therapeutic uses of the pathway in Part II. Even the established dependency on low oxygen states for bioactivation of nitrite has recently been challenged. Dietary nitrate appears to be an important component of ‘healthy diets’, such as the DASH diet to lower blood pressure and the Mediterranean diet, with its potential to lower cardiovascular risk, possibly through beneficial interactions with a range of other constituents. The World Cancer Research Foundation report strong evidence for vegetables including spinach and lettuce (high nitrate‐containing) decreasing cancer risk (mouth, pharynx, larynx, oesophagus and stomach), summarized in a ‘Nitrate‐Cancer Risk Veg‐Table’. The European Space Agency recommends that beetroot, lettuce, spinach and Rocket (high‐nitrate vegetables) are grown to provide food for long‐term space missions. Nitrate, an ancient component of Rocket fuel, could support sustainable crops for healthy humans.
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it is Rocket Science why dietary nitrate is hard to beet part i twists and turns in the realization of the nitrate nitrite no pathway
2017Co-Authors: Jibran Khatri, Charlotte E Mills, Perry Maskell, Chimed Odongerel, Andrew J WebbAbstract:Dietary nitrate (found in green leafy vegetables, such as Rocket, and in beetroot) is now recognized to be an important source of nitric oxide (NO), via the nitrate-nitrite-NO pathway. Dietary nitrate confers several cardiovascular beneficial effects on blood pressure, platelets, endothelial function, mitochondrial efficiency and exercise. While this pathway may now seem obvious, its realization followed a rather tortuous course over two decades. Early steps included the discovery that nitrite was a source of NO in the ischaemic heart but this appeared to have deleterious effects. In addition, nitrate-derived nitrite provided a gastric source of NO. However, residual nitrite was not thought to be absorbed systemically. Nitrite was also considered to be physiologically inert but potentially carcinogenic, through N-nitrosamine formation. In Part 1 of a two-part Review on the nitrate-nitrite-NO pathway we describe key twists and turns in the elucidation of the pathway and the underlying mechanisms. This provides the critical foundation for the more recent developments in the nitrate-nitrite-NO pathway which are covered in Part 2.
Perry Maskell - One of the best experts on this subject based on the ideXlab platform.
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it is Rocket Science why dietary nitrate is hard to beet part ii further mechanisms and therapeutic potential of the nitrate nitrite no pathway
2017Co-Authors: Charlotte E Mills, Jibran Khatri, Perry Maskell, Chimed Odongerel, Andrew J WebbAbstract:Dietary nitrate (found in green leafy vegetables such as Rocket and in beetroot) is now recognized to be an important source of nitric oxide, via the nitrate‐nitrite‐NO pathway. Dietary nitrate confers several cardiovascular beneficial effects on blood pressure, platelets, endothelial function, mitochondrial efficiency and exercise. Having described key twists and turns in the elucidation of the pathway and the underlying mechanisms in Part I, we explore the more recent developments which have served to confirm mechanisms, extend our understanding, and discover new properties and potential therapeutic uses of the pathway in Part II. Even the established dependency on low oxygen states for bioactivation of nitrite has recently been challenged. Dietary nitrate appears to be an important component of ‘healthy diets’, such as the DASH diet to lower blood pressure and the Mediterranean diet, with its potential to lower cardiovascular risk, possibly through beneficial interactions with a range of other constituents. The World Cancer Research Foundation report strong evidence for vegetables including spinach and lettuce (high nitrate‐containing) decreasing cancer risk (mouth, pharynx, larynx, oesophagus and stomach), summarized in a ‘Nitrate‐Cancer Risk Veg‐Table’. The European Space Agency recommends that beetroot, lettuce, spinach and Rocket (high‐nitrate vegetables) are grown to provide food for long‐term space missions. Nitrate, an ancient component of Rocket fuel, could support sustainable crops for healthy humans.
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it is Rocket Science why dietary nitrate is hard to beet part i twists and turns in the realization of the nitrate nitrite no pathway
2017Co-Authors: Jibran Khatri, Charlotte E Mills, Perry Maskell, Chimed Odongerel, Andrew J WebbAbstract:Dietary nitrate (found in green leafy vegetables, such as Rocket, and in beetroot) is now recognized to be an important source of nitric oxide (NO), via the nitrate-nitrite-NO pathway. Dietary nitrate confers several cardiovascular beneficial effects on blood pressure, platelets, endothelial function, mitochondrial efficiency and exercise. While this pathway may now seem obvious, its realization followed a rather tortuous course over two decades. Early steps included the discovery that nitrite was a source of NO in the ischaemic heart but this appeared to have deleterious effects. In addition, nitrate-derived nitrite provided a gastric source of NO. However, residual nitrite was not thought to be absorbed systemically. Nitrite was also considered to be physiologically inert but potentially carcinogenic, through N-nitrosamine formation. In Part 1 of a two-part Review on the nitrate-nitrite-NO pathway we describe key twists and turns in the elucidation of the pathway and the underlying mechanisms. This provides the critical foundation for the more recent developments in the nitrate-nitrite-NO pathway which are covered in Part 2.
