Rosa Damascena

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Serge Brand - One of the best experts on this subject based on the ideXlab platform.

  • Rosa Damascena oil improved sexual function and testosterone in male patients with opium use disorder under methadone maintenance therapy-results from a double-blind, randomized, placebo-controlled clinical trial.
    Drug and alcohol dependence, 2017
    Co-Authors: Vahid Farnia, Faeze Tatari, Mostafa Alikhani, Jalal Shakeri, Moshen Taghizadeh, Hassan Karbasizadeh, Dena Sadeghi Bahmani, Edith Holsboer-trachsler, Serge Brand
    Abstract:

    Abstract Background Some patients with opioid use disorder (OUD) are treated with methadone maintenance therapy (MMT). However, as with opioids, methadone has major side-effects; sexual dysfunction is a particularly distressing such effect. Rosa Damascena oil has been shown to reduce subjective sexual dysfunction in patients with major depressive disorders, but its influence on testosterone has not so far been tested. The aim of the present study was to investigate the influence of Rosa Damascena oil on sexual dysfunction and testosterone levels among male patients with OUD and undergoing MMT. Methods A total of 50 male patients (mean age: 40 years) diagnosed with OUD and receiving MMT were randomly assigned either to the Rosa Damascena oil (drops) or a placebo condition. At baseline, and four and eight weeks later, patients completed questionnaires covering sexual and erectile function. Blood samples to assess testosterone levels were taken at baseline and eight weeks later on completion of the study. Results Over time sexual dysfunction decreased, and testosterone increased in the Rosa Damascena oil, but not in the placebo condition. Sexual dysfunction scores and testosterone levels were not consistently related. Conclusions Results from this double-blind, randomized, and placebo-controlled clinical trial showed that Rosa Damascena oil improved sexual function and testosterone levels among males with OUD and undergoing MMT.

  • Adjuvant Rosa Damascena has a Small Effect on SSRI-induced Sexual Dysfunction in Female Patients Suffering from MDD.
    Pharmacopsychiatry, 2015
    Co-Authors: Vahid Farnia, Jalal Shakeri, Edith Holsboer-trachsler, S. Hojatitabar, Mansour Rezaei, Katayoun Yazdchi, Hafez Bajoghli, Serge Brand
    Abstract:

    Background: Treating major depressive disorders (MDD) with selective serotonin-reuptake inhibitors (SSRIs) may impact negatively on sexual function. On the other hand, a satisfying sexual life is associated with overall life satisfaction. Therefore, managing this negative side effect of SSRIs may have an important role in the treatment of MDD. In a former study, adjuvant Rosa Damascena oil improved sexual dysfunction in male patients suffering from both MDD and SSRI-induced sexual dysfunction (SSRI-I SD). The aim of the present study was to test whether the same pattern of results would be observed among female patients suffering from both SSRI-I SD and MDD. Method: In a double-blind, randomized and placebo-controlled clinical trial, a total of 50 female patients (mean age: 34 years) treated with an SSRI and suffering from MDD and SSRI-I SD were randomly assigned either to the verum (Rosa Damascena oil) or to the placebo condition. Patients completed self-ratings of depression and sexual function at baseline, 4 weeks later, and at the end of the study 8 weeks after its start. Results: Sexual desire, sexual orgasms, and sexual satisfaction increased over time. Patients in the verum group reported decreased pain. Overall sexual score increased in the verum as compared to the placebo condition. Conclusions: Whereas in male patients suffering from both MDD and SSRI-I SD adjuvant Rosa Damascena oil improved sexual function, data on female patients are less robust and suggest only modest effects on female sexual function.

  • Adjuvant Rosa Damascena has a Small Effect on SSRI-induced Sexual Dysfunction in Female Patients Suffering from MDD.
    Pharmacopsychiatry, 2015
    Co-Authors: Vahid Farnia, Jalal Shakeri, Edith Holsboer-trachsler, S. Hojatitabar, Mansour Rezaei, Katayoun Yazdchi, Hafez Bajoghli, Serge Brand
    Abstract:

    Treating major depressive disorders (MDD) with selective serotonin-reuptake inhibitors (SSRIs) may impact negatively on sexual function. On the other hand, a satisfying sexual life is associated with overall life satisfaction. Therefore, managing this negative side effect of SSRIs may have an important role in the treatment of MDD. In a former study, adjuvant Rosa Damascena oil improved sexual dysfunction in male patients suffering from both MDD and SSRI-induced sexual dysfunction (SSRI-I SD). The aim of the present study was to test whether the same pattern of results would be observed among female patients suffering from both SSRI-I SD and MDD. In a double-blind, randomized and placebo-controlled clinical trial, a total of 50 female patients (mean age: 34 years) treated with an SSRI and suffering from MDD and SSRI-I SD were randomly assigned either to the verum (Rosa Damascena oil) or to the placebo condition. Patients completed self-ratings of depression and sexual function at baseline, 4 weeks later, and at the end of the study 8 weeks after its start. Sexual desire, sexual orgasms, and sexual satisfaction increased over time. Patients in the verum group reported decreased pain. Overall sexual score increased in the verum as compared to the placebo condition. Whereas in male patients suffering from both MDD and SSRI-I SD adjuvant Rosa Damascena oil improved sexual function, data on female patients are less robust and suggest only modest effects on female sexual function. © Georg Thieme Verlag KG Stuttgart · New York.

Vahid Farnia - One of the best experts on this subject based on the ideXlab platform.

  • Rosa Damascena oil improved sexual function and testosterone in male patients with opium use disorder under methadone maintenance therapy-results from a double-blind, randomized, placebo-controlled clinical trial.
    Drug and alcohol dependence, 2017
    Co-Authors: Vahid Farnia, Faeze Tatari, Mostafa Alikhani, Jalal Shakeri, Moshen Taghizadeh, Hassan Karbasizadeh, Dena Sadeghi Bahmani, Edith Holsboer-trachsler, Serge Brand
    Abstract:

    Abstract Background Some patients with opioid use disorder (OUD) are treated with methadone maintenance therapy (MMT). However, as with opioids, methadone has major side-effects; sexual dysfunction is a particularly distressing such effect. Rosa Damascena oil has been shown to reduce subjective sexual dysfunction in patients with major depressive disorders, but its influence on testosterone has not so far been tested. The aim of the present study was to investigate the influence of Rosa Damascena oil on sexual dysfunction and testosterone levels among male patients with OUD and undergoing MMT. Methods A total of 50 male patients (mean age: 40 years) diagnosed with OUD and receiving MMT were randomly assigned either to the Rosa Damascena oil (drops) or a placebo condition. At baseline, and four and eight weeks later, patients completed questionnaires covering sexual and erectile function. Blood samples to assess testosterone levels were taken at baseline and eight weeks later on completion of the study. Results Over time sexual dysfunction decreased, and testosterone increased in the Rosa Damascena oil, but not in the placebo condition. Sexual dysfunction scores and testosterone levels were not consistently related. Conclusions Results from this double-blind, randomized, and placebo-controlled clinical trial showed that Rosa Damascena oil improved sexual function and testosterone levels among males with OUD and undergoing MMT.

  • Adjuvant Rosa Damascena has a Small Effect on SSRI-induced Sexual Dysfunction in Female Patients Suffering from MDD.
    Pharmacopsychiatry, 2015
    Co-Authors: Vahid Farnia, Jalal Shakeri, Edith Holsboer-trachsler, S. Hojatitabar, Mansour Rezaei, Katayoun Yazdchi, Hafez Bajoghli, Serge Brand
    Abstract:

    Background: Treating major depressive disorders (MDD) with selective serotonin-reuptake inhibitors (SSRIs) may impact negatively on sexual function. On the other hand, a satisfying sexual life is associated with overall life satisfaction. Therefore, managing this negative side effect of SSRIs may have an important role in the treatment of MDD. In a former study, adjuvant Rosa Damascena oil improved sexual dysfunction in male patients suffering from both MDD and SSRI-induced sexual dysfunction (SSRI-I SD). The aim of the present study was to test whether the same pattern of results would be observed among female patients suffering from both SSRI-I SD and MDD. Method: In a double-blind, randomized and placebo-controlled clinical trial, a total of 50 female patients (mean age: 34 years) treated with an SSRI and suffering from MDD and SSRI-I SD were randomly assigned either to the verum (Rosa Damascena oil) or to the placebo condition. Patients completed self-ratings of depression and sexual function at baseline, 4 weeks later, and at the end of the study 8 weeks after its start. Results: Sexual desire, sexual orgasms, and sexual satisfaction increased over time. Patients in the verum group reported decreased pain. Overall sexual score increased in the verum as compared to the placebo condition. Conclusions: Whereas in male patients suffering from both MDD and SSRI-I SD adjuvant Rosa Damascena oil improved sexual function, data on female patients are less robust and suggest only modest effects on female sexual function.

  • Adjuvant Rosa Damascena has a Small Effect on SSRI-induced Sexual Dysfunction in Female Patients Suffering from MDD.
    Pharmacopsychiatry, 2015
    Co-Authors: Vahid Farnia, Jalal Shakeri, Edith Holsboer-trachsler, S. Hojatitabar, Mansour Rezaei, Katayoun Yazdchi, Hafez Bajoghli, Serge Brand
    Abstract:

    Treating major depressive disorders (MDD) with selective serotonin-reuptake inhibitors (SSRIs) may impact negatively on sexual function. On the other hand, a satisfying sexual life is associated with overall life satisfaction. Therefore, managing this negative side effect of SSRIs may have an important role in the treatment of MDD. In a former study, adjuvant Rosa Damascena oil improved sexual dysfunction in male patients suffering from both MDD and SSRI-induced sexual dysfunction (SSRI-I SD). The aim of the present study was to test whether the same pattern of results would be observed among female patients suffering from both SSRI-I SD and MDD. In a double-blind, randomized and placebo-controlled clinical trial, a total of 50 female patients (mean age: 34 years) treated with an SSRI and suffering from MDD and SSRI-I SD were randomly assigned either to the verum (Rosa Damascena oil) or to the placebo condition. Patients completed self-ratings of depression and sexual function at baseline, 4 weeks later, and at the end of the study 8 weeks after its start. Sexual desire, sexual orgasms, and sexual satisfaction increased over time. Patients in the verum group reported decreased pain. Overall sexual score increased in the verum as compared to the placebo condition. Whereas in male patients suffering from both MDD and SSRI-I SD adjuvant Rosa Damascena oil improved sexual function, data on female patients are less robust and suggest only modest effects on female sexual function. © Georg Thieme Verlag KG Stuttgart · New York.

Hassan Rakhshandah - One of the best experts on this subject based on the ideXlab platform.

  • relaxant effects of Rosa Damascena on guinea pig tracheal chains and its possible mechanism s
    Journal of Ethnopharmacology, 2006
    Co-Authors: Mohammad Hossain Boskabady, Sahar Kiani, Hassan Rakhshandah
    Abstract:

    Several therapeutic effects including hypnotic, antispasmodic, treatment of abdominal and chest pain and strengthening the heart have been described for the flowers of Rosa Damascena. Therefore in the present study, the relaxant effects of ethanolic extract and essential oils of Rosa Damascena on tracheal chains of guinea pigs were examined. The relaxant effects of four cumulative concentrations of ethanolic extract (0.25, 0.5, 0.75, and 1.0 g%) and essential oils (0.25, 0.5, 0.75, and 1.0 vol.%) in comparison with saline as negative control and four cumulative concentrations of theophylline (0.25, 0.5, 0.75, and 1.0 mM) were examined by their relaxant effects on precontracted tracheal chains of guinea pig by 60 mM KCl (group 1, n = 5) and 10 μM methacholine in two different conditions including: non-incubated tissues (group 2, n = 8) and incubated tissues with 1 μM propranolol and 1 μM chlorpheniramine (group 3, n = 5). In group 1 experiments two final concentrations of essential oil and theophylline and only final concentration of ethanolic extract showed relaxant effects compared to that of saline (p < 0.01–0.001). In group 2 three higher concentrations of ethanolic extract and theophylline and all concentrations of essential oil showed concentration dependent relaxant effects compared to that of saline (p < 0.05–0.001). In addition, the effect of 0.25 and 0.5 g% of essential oils in group 2 was significantly higher than those of theophylline and ethanolic extract (p < 0.01 for all cases). However, in group 3 experiments the extract and essential oil of Rosa Damascena did not show any significant relaxant effect. There were significant correlations between the relaxant effects and concentrations for ethanolic extract and essential oil and theophylline in groups 1 and 2. These results showed a potent relaxant effect of Rosa Damascena on tracheal chains of guinea pigs that was comparable to that of theophylline at concentrations used.

  • Relaxant effects of Rosa Damascena on guinea pig tracheal chains and its possible mechanism(s)
    Journal of ethnopharmacology, 2006
    Co-Authors: Mohammad Hossain Boskabady, Sahar Kiani, Hassan Rakhshandah
    Abstract:

    Several therapeutic effects including hypnotic, antispasmodic, treatment of abdominal and chest pain and strengthening the heart have been described for the flowers of Rosa Damascena. Therefore in the present study, the relaxant effects of ethanolic extract and essential oils of Rosa Damascena on tracheal chains of guinea pigs were examined. The relaxant effects of four cumulative concentrations of ethanolic extract (0.25, 0.5, 0.75, and 1.0 g%) and essential oils (0.25, 0.5, 0.75, and 1.0 vol.%) in comparison with saline as negative control and four cumulative concentrations of theophylline (0.25, 0.5, 0.75, and 1.0 mM) were examined by their relaxant effects on precontracted tracheal chains of guinea pig by 60 mM KCl (group 1, n = 5) and 10 μM methacholine in two different conditions including: non-incubated tissues (group 2, n = 8) and incubated tissues with 1 μM propranolol and 1 μM chlorpheniramine (group 3, n = 5). In group 1 experiments two final concentrations of essential oil and theophylline and only final concentration of ethanolic extract showed relaxant effects compared to that of saline (p 

  • Hypnotic Effect of Rosa Damascena in Mice
    Iranian Journal of Pharmaceutical Research, 2004
    Co-Authors: Hassan Rakhshandah, Mahmoud Hosseini, Karim Dolati
    Abstract:

    Rosa Damascena (Rosaceae) has been found to act on central nervous system including the brain. Several studies confirm that Rosa Damascena inhibits the reactivity of the hypothalamus and pituitary systems in rat and can suppress the reactivity of central nervous system. In traditional medicine the hypnotic effect of rose is also suggested. In the present study hypnotic effect of ethanolic, aqueous and chloroformic extracts of Rosa Damascena was investigated in mice. Hypnotic method was based on potentiation of pentobarbital induced sleeping time by extracts. Three doses of extracts (100, 500 and 1000 mg/kg) were injected intraperitoneally in comparison with diazepam (3 mg/kg) as the positive control and saline as the negative control. Thirty min after injection of extracts, pentobarbital (30 mg/kg) was injected and any increase in the sleeping time due to the extracts was recorded. Results showed that the ethanolic and aqueous extracts in doses of 500 and 1000 mg/kg significantly increased the pentobarbital induced sleeping time (P

  • hypnotic effect of Rosa Damascena in mice
    Iranian Journal of Pharmaceutical Research, 2004
    Co-Authors: Hassan Rakhshandah, Mahmoud Hosseini, Karim Dolati
    Abstract:

    Rosa Damascena (Rosaceae) has been found to act on central nervous system including the brain. Several studies confirm that Rosa Damascena inhibits the reactivity of the hypothalamus and pituitary systems in rat and can suppress the reactivity of central nervous system. In traditional medicine the hypnotic effect of rose is also suggested. In the present study hypnotic effect of ethanolic, aqueous and chloroformic extracts of Rosa Damascena was investigated in mice. Hypnotic method was based on potentiation of pentobarbital induced sleeping time by extracts. Three doses of extracts (100, 500 and 1000 mg/kg) were injected intraperitoneally in comparison with diazepam (3 mg/kg) as the positive control and saline as the negative control. Thirty min after injection of extracts, pentobarbital (30 mg/kg) was injected and any increase in the sleeping time due to the extracts was recorded. Results showed that the ethanolic and aqueous extracts in doses of 500 and 1000 mg/kg significantly increased the pentobarbital induced sleeping time (P<0.001, compared to the negative control), which was comparable to diazepam. The chloroformic extract showed no hypnotic effect.

  • antitussive effect of Rosa Damascena in guinea pigs
    Iranian Journal of Pharmaceutical Research, 2003
    Co-Authors: Mohammad Nasser Shafei, Hassan Rakhshandah, Mohammad Hossain Boskabady
    Abstract:

    Several therapeutic effects including hypnotic, antispasmodic, treatment of abdominal and chest pain and strengthening the heart have been described for the flowers of Rosa Damascena. North American Indian tribes use a decoction of the roots obtained from the Rosa Damascena plant as a cough remedy and to treat eye problem. Therefore, in the present study the antitussive effect of this plant in guinea pigs was evaluated. The antitussive effect of aerosols of two different concentrations of ethanolic extract (5 and10% w/v), aqueous extract (10 and 20% w/v), codeine, and saline were tested counting the number of cough produced due to aerosol of citric acid 10 min after exposing animal to aerosols of different solutions (n=6 for each solution). The results showed a significant reduction in the number of coughs obtained in the presence of both concentrations of ethanolic extract, higher concentrations of aqueous extract and codeine (P<0.001 for all cases). The number of coughs obtained in the presence of higher concentrations of extract was less than that of lower concentrations. However, this difference was only statistically significant for the aqueous extract. In addition the numbers of coughs obtained in the presence of both concentrations of ethanolic extract and higher concentrations of aqueous extract were not significantly different from that of codeine. These results indicated the antitussive effect of Rosa Damascena, which was comparable to codeine at concentrations used.

Jalal Shakeri - One of the best experts on this subject based on the ideXlab platform.

  • Rosa Damascena oil improved sexual function and testosterone in male patients with opium use disorder under methadone maintenance therapy-results from a double-blind, randomized, placebo-controlled clinical trial.
    Drug and alcohol dependence, 2017
    Co-Authors: Vahid Farnia, Faeze Tatari, Mostafa Alikhani, Jalal Shakeri, Moshen Taghizadeh, Hassan Karbasizadeh, Dena Sadeghi Bahmani, Edith Holsboer-trachsler, Serge Brand
    Abstract:

    Abstract Background Some patients with opioid use disorder (OUD) are treated with methadone maintenance therapy (MMT). However, as with opioids, methadone has major side-effects; sexual dysfunction is a particularly distressing such effect. Rosa Damascena oil has been shown to reduce subjective sexual dysfunction in patients with major depressive disorders, but its influence on testosterone has not so far been tested. The aim of the present study was to investigate the influence of Rosa Damascena oil on sexual dysfunction and testosterone levels among male patients with OUD and undergoing MMT. Methods A total of 50 male patients (mean age: 40 years) diagnosed with OUD and receiving MMT were randomly assigned either to the Rosa Damascena oil (drops) or a placebo condition. At baseline, and four and eight weeks later, patients completed questionnaires covering sexual and erectile function. Blood samples to assess testosterone levels were taken at baseline and eight weeks later on completion of the study. Results Over time sexual dysfunction decreased, and testosterone increased in the Rosa Damascena oil, but not in the placebo condition. Sexual dysfunction scores and testosterone levels were not consistently related. Conclusions Results from this double-blind, randomized, and placebo-controlled clinical trial showed that Rosa Damascena oil improved sexual function and testosterone levels among males with OUD and undergoing MMT.

  • Adjuvant Rosa Damascena has a Small Effect on SSRI-induced Sexual Dysfunction in Female Patients Suffering from MDD.
    Pharmacopsychiatry, 2015
    Co-Authors: Vahid Farnia, Jalal Shakeri, Edith Holsboer-trachsler, S. Hojatitabar, Mansour Rezaei, Katayoun Yazdchi, Hafez Bajoghli, Serge Brand
    Abstract:

    Background: Treating major depressive disorders (MDD) with selective serotonin-reuptake inhibitors (SSRIs) may impact negatively on sexual function. On the other hand, a satisfying sexual life is associated with overall life satisfaction. Therefore, managing this negative side effect of SSRIs may have an important role in the treatment of MDD. In a former study, adjuvant Rosa Damascena oil improved sexual dysfunction in male patients suffering from both MDD and SSRI-induced sexual dysfunction (SSRI-I SD). The aim of the present study was to test whether the same pattern of results would be observed among female patients suffering from both SSRI-I SD and MDD. Method: In a double-blind, randomized and placebo-controlled clinical trial, a total of 50 female patients (mean age: 34 years) treated with an SSRI and suffering from MDD and SSRI-I SD were randomly assigned either to the verum (Rosa Damascena oil) or to the placebo condition. Patients completed self-ratings of depression and sexual function at baseline, 4 weeks later, and at the end of the study 8 weeks after its start. Results: Sexual desire, sexual orgasms, and sexual satisfaction increased over time. Patients in the verum group reported decreased pain. Overall sexual score increased in the verum as compared to the placebo condition. Conclusions: Whereas in male patients suffering from both MDD and SSRI-I SD adjuvant Rosa Damascena oil improved sexual function, data on female patients are less robust and suggest only modest effects on female sexual function.

  • Adjuvant Rosa Damascena has a Small Effect on SSRI-induced Sexual Dysfunction in Female Patients Suffering from MDD.
    Pharmacopsychiatry, 2015
    Co-Authors: Vahid Farnia, Jalal Shakeri, Edith Holsboer-trachsler, S. Hojatitabar, Mansour Rezaei, Katayoun Yazdchi, Hafez Bajoghli, Serge Brand
    Abstract:

    Treating major depressive disorders (MDD) with selective serotonin-reuptake inhibitors (SSRIs) may impact negatively on sexual function. On the other hand, a satisfying sexual life is associated with overall life satisfaction. Therefore, managing this negative side effect of SSRIs may have an important role in the treatment of MDD. In a former study, adjuvant Rosa Damascena oil improved sexual dysfunction in male patients suffering from both MDD and SSRI-induced sexual dysfunction (SSRI-I SD). The aim of the present study was to test whether the same pattern of results would be observed among female patients suffering from both SSRI-I SD and MDD. In a double-blind, randomized and placebo-controlled clinical trial, a total of 50 female patients (mean age: 34 years) treated with an SSRI and suffering from MDD and SSRI-I SD were randomly assigned either to the verum (Rosa Damascena oil) or to the placebo condition. Patients completed self-ratings of depression and sexual function at baseline, 4 weeks later, and at the end of the study 8 weeks after its start. Sexual desire, sexual orgasms, and sexual satisfaction increased over time. Patients in the verum group reported decreased pain. Overall sexual score increased in the verum as compared to the placebo condition. Whereas in male patients suffering from both MDD and SSRI-I SD adjuvant Rosa Damascena oil improved sexual function, data on female patients are less robust and suggest only modest effects on female sexual function. © Georg Thieme Verlag KG Stuttgart · New York.

Edith Holsboer-trachsler - One of the best experts on this subject based on the ideXlab platform.

  • Rosa Damascena oil improved sexual function and testosterone in male patients with opium use disorder under methadone maintenance therapy-results from a double-blind, randomized, placebo-controlled clinical trial.
    Drug and alcohol dependence, 2017
    Co-Authors: Vahid Farnia, Faeze Tatari, Mostafa Alikhani, Jalal Shakeri, Moshen Taghizadeh, Hassan Karbasizadeh, Dena Sadeghi Bahmani, Edith Holsboer-trachsler, Serge Brand
    Abstract:

    Abstract Background Some patients with opioid use disorder (OUD) are treated with methadone maintenance therapy (MMT). However, as with opioids, methadone has major side-effects; sexual dysfunction is a particularly distressing such effect. Rosa Damascena oil has been shown to reduce subjective sexual dysfunction in patients with major depressive disorders, but its influence on testosterone has not so far been tested. The aim of the present study was to investigate the influence of Rosa Damascena oil on sexual dysfunction and testosterone levels among male patients with OUD and undergoing MMT. Methods A total of 50 male patients (mean age: 40 years) diagnosed with OUD and receiving MMT were randomly assigned either to the Rosa Damascena oil (drops) or a placebo condition. At baseline, and four and eight weeks later, patients completed questionnaires covering sexual and erectile function. Blood samples to assess testosterone levels were taken at baseline and eight weeks later on completion of the study. Results Over time sexual dysfunction decreased, and testosterone increased in the Rosa Damascena oil, but not in the placebo condition. Sexual dysfunction scores and testosterone levels were not consistently related. Conclusions Results from this double-blind, randomized, and placebo-controlled clinical trial showed that Rosa Damascena oil improved sexual function and testosterone levels among males with OUD and undergoing MMT.

  • Adjuvant Rosa Damascena has a Small Effect on SSRI-induced Sexual Dysfunction in Female Patients Suffering from MDD.
    Pharmacopsychiatry, 2015
    Co-Authors: Vahid Farnia, Jalal Shakeri, Edith Holsboer-trachsler, S. Hojatitabar, Mansour Rezaei, Katayoun Yazdchi, Hafez Bajoghli, Serge Brand
    Abstract:

    Background: Treating major depressive disorders (MDD) with selective serotonin-reuptake inhibitors (SSRIs) may impact negatively on sexual function. On the other hand, a satisfying sexual life is associated with overall life satisfaction. Therefore, managing this negative side effect of SSRIs may have an important role in the treatment of MDD. In a former study, adjuvant Rosa Damascena oil improved sexual dysfunction in male patients suffering from both MDD and SSRI-induced sexual dysfunction (SSRI-I SD). The aim of the present study was to test whether the same pattern of results would be observed among female patients suffering from both SSRI-I SD and MDD. Method: In a double-blind, randomized and placebo-controlled clinical trial, a total of 50 female patients (mean age: 34 years) treated with an SSRI and suffering from MDD and SSRI-I SD were randomly assigned either to the verum (Rosa Damascena oil) or to the placebo condition. Patients completed self-ratings of depression and sexual function at baseline, 4 weeks later, and at the end of the study 8 weeks after its start. Results: Sexual desire, sexual orgasms, and sexual satisfaction increased over time. Patients in the verum group reported decreased pain. Overall sexual score increased in the verum as compared to the placebo condition. Conclusions: Whereas in male patients suffering from both MDD and SSRI-I SD adjuvant Rosa Damascena oil improved sexual function, data on female patients are less robust and suggest only modest effects on female sexual function.

  • Adjuvant Rosa Damascena has a Small Effect on SSRI-induced Sexual Dysfunction in Female Patients Suffering from MDD.
    Pharmacopsychiatry, 2015
    Co-Authors: Vahid Farnia, Jalal Shakeri, Edith Holsboer-trachsler, S. Hojatitabar, Mansour Rezaei, Katayoun Yazdchi, Hafez Bajoghli, Serge Brand
    Abstract:

    Treating major depressive disorders (MDD) with selective serotonin-reuptake inhibitors (SSRIs) may impact negatively on sexual function. On the other hand, a satisfying sexual life is associated with overall life satisfaction. Therefore, managing this negative side effect of SSRIs may have an important role in the treatment of MDD. In a former study, adjuvant Rosa Damascena oil improved sexual dysfunction in male patients suffering from both MDD and SSRI-induced sexual dysfunction (SSRI-I SD). The aim of the present study was to test whether the same pattern of results would be observed among female patients suffering from both SSRI-I SD and MDD. In a double-blind, randomized and placebo-controlled clinical trial, a total of 50 female patients (mean age: 34 years) treated with an SSRI and suffering from MDD and SSRI-I SD were randomly assigned either to the verum (Rosa Damascena oil) or to the placebo condition. Patients completed self-ratings of depression and sexual function at baseline, 4 weeks later, and at the end of the study 8 weeks after its start. Sexual desire, sexual orgasms, and sexual satisfaction increased over time. Patients in the verum group reported decreased pain. Overall sexual score increased in the verum as compared to the placebo condition. Whereas in male patients suffering from both MDD and SSRI-I SD adjuvant Rosa Damascena oil improved sexual function, data on female patients are less robust and suggest only modest effects on female sexual function. © Georg Thieme Verlag KG Stuttgart · New York.

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