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Anna L. Chien - One of the best experts on this subject based on the ideXlab platform.
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Characterization and Analysis of the Skin Microbiota in Rosacea: A Case–Control Study
American Journal of Clinical Dermatology, 2020Co-Authors: Barbara M. Rainer, Katherine G. Thompson, Liliana Florea, Alexander H. Fischer, H. Pasieka, Emmanuel F Mongodin, Corina Antonescu, Luis A Garza, Sewon Kang, Anna L. ChienAbstract:Background The efficacy of antibiotics in Rosacea treatment suggests a role for microorganisms in its pathophysiology. Growing concern over the adverse effects of antibiotic use presents a need for targeted antimicrobial treatment in Rosacea. Objective We performed a case–control study to investigate the skin microbiota in patients with Rosacea compared to controls matched by age, sex, and race. Methods Nineteen participants with Rosacea, erythematotelangiectatic, papulopustular, or both, were matched to 19 Rosacea-free controls. DNA was extracted from skin swabs of the nose and bilateral cheeks of participants. Sequencing of the V3V4 region of the bacterial 16S ribosomal RNA gene was performed using Illumina MiSeq and analyzed using QIIME/MetaStats 2.0 software. Results Compared with controls, skin microbiota in erythematotelangiectatic Rosacea was depleted in Roseomonas mucosa ( p = 0.004). Papulopustular Rosacea was enriched in Campylobacter ureolyticus ( p = 0.001), Corynebacterium kroppenstedtii ( p = 0.008), and the oral flora Prevotella intermedia ( p = 0.001). The highest relative abundance of C. kroppenstedtii was observed in patients with both erythematotelangiectatic and papulopustular Rosacea (19.2%), followed by papulopustular (5.06%) and erythematotelangiectatic (1.21%) Rosacea. C. kroppenstedtii was also associated with more extensive disease, with the highest relative abundance in Rosacea affecting both the cheeks and nose (2.82%), followed by Rosacea sparing the nose (1.93%), and controls (0.19%). Conclusions The skin microbiota in individuals with Rosacea displays changes from that of healthy skin, suggesting that further studies examining a potential role for the skin microbiota in the pathophysiology of Rosacea may be warranted.
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evidence based update on Rosacea comorbidities and their common physiologic pathways
Journal of The American Academy of Dermatology, 2018Co-Authors: Anna D Holmes, Anna L. Chien, Hilary E Baldwin, Julia Spoendlin, Anne Lynn S ChangAbstract:Rosacea is a common chronic inflammatory disease affecting the facial skin whose etiology and pathophysiology are the subject of much investigation. Risk factors include genetic and environmental elements that may predispose individuals to localized inflammation and abnormal neurovascular responses to stimuli. Recent studies have introduced an array of systemic Rosacea comorbidities, such as inflammatory bowel disease and neurologic conditions, that can be challenging to synthesize. We critically review the current data behind reported Rosacea comorbidities and identify and highlight underrecognized physiologic mediators shared among Rosacea and associated comorbidities. This information may be helpful in addressing patient questions about potential systemic implications of Rosacea and can serve as a candidate platform for future research to understand Rosacea and improve treatments.
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Rosacea is associated with chronic systemic diseases in a skin severity dependent manner results of a case control study
Journal of The American Academy of Dermatology, 2015Co-Authors: Barbara M. Rainer, Alexander H. Fischer, Sewon Kang, Dimitre Luz Felipe Da Silva, Anna L. ChienAbstract:Background Rosacea is a common chronic inflammatory dermatosis of unclear origin. It has been associated with systemic comorbidities, but methodical studies addressing this association are lacking. Objective We evaluated: (1) the association between Rosacea and systemic comorbidities; and (2) if the severity of Rosacea is impacted by comorbidities. Methods This was a case-control study: patients with Rosacea were matched (1:1) to Rosacea-free control subjects by age, sex, and race. Relative risk estimates were calculated using logistic regression as odds ratios with 95% confidence intervals. Results Among 130 participants (65 patients/65 control subjects), we observed a significant association between Rosacea and allergies (airborne, food), respiratory diseases, gastroesophageal reflux disease, other gastrointestinal diseases, hypertension, metabolic and urogenital diseases, and female hormone imbalance. Compared with mild Rosacea, moderate to severe Rosacea was significantly associated with hyperlipidemia, hypertension, metabolic diseases, cardiovascular diseases, and gastroesophageal reflux disease. Limitations This was a case-control study with moderate sample size. Associated medical conditions were self-reported and could not always be confirmed by medication use and medical records. Conclusions Rosacea is associated with numerous systemic comorbid diseases in a skin severity–dependent manner. Physicians should be aware of these associations to provide comprehensive care to patients with Rosacea, especially to those with more severe disease.
Barbara M. Rainer - One of the best experts on this subject based on the ideXlab platform.
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Characterization and Analysis of the Skin Microbiota in Rosacea: A Case–Control Study
American Journal of Clinical Dermatology, 2020Co-Authors: Barbara M. Rainer, Katherine G. Thompson, Liliana Florea, Alexander H. Fischer, H. Pasieka, Emmanuel F Mongodin, Corina Antonescu, Luis A Garza, Sewon Kang, Anna L. ChienAbstract:Background The efficacy of antibiotics in Rosacea treatment suggests a role for microorganisms in its pathophysiology. Growing concern over the adverse effects of antibiotic use presents a need for targeted antimicrobial treatment in Rosacea. Objective We performed a case–control study to investigate the skin microbiota in patients with Rosacea compared to controls matched by age, sex, and race. Methods Nineteen participants with Rosacea, erythematotelangiectatic, papulopustular, or both, were matched to 19 Rosacea-free controls. DNA was extracted from skin swabs of the nose and bilateral cheeks of participants. Sequencing of the V3V4 region of the bacterial 16S ribosomal RNA gene was performed using Illumina MiSeq and analyzed using QIIME/MetaStats 2.0 software. Results Compared with controls, skin microbiota in erythematotelangiectatic Rosacea was depleted in Roseomonas mucosa ( p = 0.004). Papulopustular Rosacea was enriched in Campylobacter ureolyticus ( p = 0.001), Corynebacterium kroppenstedtii ( p = 0.008), and the oral flora Prevotella intermedia ( p = 0.001). The highest relative abundance of C. kroppenstedtii was observed in patients with both erythematotelangiectatic and papulopustular Rosacea (19.2%), followed by papulopustular (5.06%) and erythematotelangiectatic (1.21%) Rosacea. C. kroppenstedtii was also associated with more extensive disease, with the highest relative abundance in Rosacea affecting both the cheeks and nose (2.82%), followed by Rosacea sparing the nose (1.93%), and controls (0.19%). Conclusions The skin microbiota in individuals with Rosacea displays changes from that of healthy skin, suggesting that further studies examining a potential role for the skin microbiota in the pathophysiology of Rosacea may be warranted.
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Characterization and Analysis of the Skin Microbiota in Rosacea: A Case-Control Study.
American Journal of Clinical Dermatology, 2019Co-Authors: Barbara M. Rainer, Katherine G. Thompson, Liliana Florea, Alexander H. Fischer, H. Pasieka, Emmanuel F Mongodin, Corina Antonescu, Luis A Garza, Sewon KangAbstract:The efficacy of antibiotics in Rosacea treatment suggests a role for microorganisms in its pathophysiology. Growing concern over the adverse effects of antibiotic use presents a need for targeted antimicrobial treatment in Rosacea. We performed a case–control study to investigate the skin microbiota in patients with Rosacea compared to controls matched by age, sex, and race. Nineteen participants with Rosacea, erythematotelangiectatic, papulopustular, or both, were matched to 19 Rosacea-free controls. DNA was extracted from skin swabs of the nose and bilateral cheeks of participants. Sequencing of the V3V4 region of the bacterial 16S ribosomal RNA gene was performed using Illumina MiSeq and analyzed using QIIME/MetaStats 2.0 software. Compared with controls, skin microbiota in erythematotelangiectatic Rosacea was depleted in Roseomonas mucosa (p = 0.004). Papulopustular Rosacea was enriched in Campylobacter ureolyticus (p = 0.001), Corynebacterium kroppenstedtii (p = 0.008), and the oral flora Prevotella intermedia (p = 0.001). The highest relative abundance of C. kroppenstedtii was observed in patients with both erythematotelangiectatic and papulopustular Rosacea (19.2%), followed by papulopustular (5.06%) and erythematotelangiectatic (1.21%) Rosacea. C. kroppenstedtii was also associated with more extensive disease, with the highest relative abundance in Rosacea affecting both the cheeks and nose (2.82%), followed by Rosacea sparing the nose (1.93%), and controls (0.19%). The skin microbiota in individuals with Rosacea displays changes from that of healthy skin, suggesting that further studies examining a potential role for the skin microbiota in the pathophysiology of Rosacea may be warranted.
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Rosacea is associated with chronic systemic diseases in a skin severity dependent manner results of a case control study
Journal of The American Academy of Dermatology, 2015Co-Authors: Barbara M. Rainer, Alexander H. Fischer, Sewon Kang, Dimitre Luz Felipe Da Silva, Anna L. ChienAbstract:Background Rosacea is a common chronic inflammatory dermatosis of unclear origin. It has been associated with systemic comorbidities, but methodical studies addressing this association are lacking. Objective We evaluated: (1) the association between Rosacea and systemic comorbidities; and (2) if the severity of Rosacea is impacted by comorbidities. Methods This was a case-control study: patients with Rosacea were matched (1:1) to Rosacea-free control subjects by age, sex, and race. Relative risk estimates were calculated using logistic regression as odds ratios with 95% confidence intervals. Results Among 130 participants (65 patients/65 control subjects), we observed a significant association between Rosacea and allergies (airborne, food), respiratory diseases, gastroesophageal reflux disease, other gastrointestinal diseases, hypertension, metabolic and urogenital diseases, and female hormone imbalance. Compared with mild Rosacea, moderate to severe Rosacea was significantly associated with hyperlipidemia, hypertension, metabolic diseases, cardiovascular diseases, and gastroesophageal reflux disease. Limitations This was a case-control study with moderate sample size. Associated medical conditions were self-reported and could not always be confirmed by medication use and medical records. Conclusions Rosacea is associated with numerous systemic comorbid diseases in a skin severity–dependent manner. Physicians should be aware of these associations to provide comprehensive care to patients with Rosacea, especially to those with more severe disease.
Sewon Kang - One of the best experts on this subject based on the ideXlab platform.
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Characterization and Analysis of the Skin Microbiota in Rosacea: A Case–Control Study
American Journal of Clinical Dermatology, 2020Co-Authors: Barbara M. Rainer, Katherine G. Thompson, Liliana Florea, Alexander H. Fischer, H. Pasieka, Emmanuel F Mongodin, Corina Antonescu, Luis A Garza, Sewon Kang, Anna L. ChienAbstract:Background The efficacy of antibiotics in Rosacea treatment suggests a role for microorganisms in its pathophysiology. Growing concern over the adverse effects of antibiotic use presents a need for targeted antimicrobial treatment in Rosacea. Objective We performed a case–control study to investigate the skin microbiota in patients with Rosacea compared to controls matched by age, sex, and race. Methods Nineteen participants with Rosacea, erythematotelangiectatic, papulopustular, or both, were matched to 19 Rosacea-free controls. DNA was extracted from skin swabs of the nose and bilateral cheeks of participants. Sequencing of the V3V4 region of the bacterial 16S ribosomal RNA gene was performed using Illumina MiSeq and analyzed using QIIME/MetaStats 2.0 software. Results Compared with controls, skin microbiota in erythematotelangiectatic Rosacea was depleted in Roseomonas mucosa ( p = 0.004). Papulopustular Rosacea was enriched in Campylobacter ureolyticus ( p = 0.001), Corynebacterium kroppenstedtii ( p = 0.008), and the oral flora Prevotella intermedia ( p = 0.001). The highest relative abundance of C. kroppenstedtii was observed in patients with both erythematotelangiectatic and papulopustular Rosacea (19.2%), followed by papulopustular (5.06%) and erythematotelangiectatic (1.21%) Rosacea. C. kroppenstedtii was also associated with more extensive disease, with the highest relative abundance in Rosacea affecting both the cheeks and nose (2.82%), followed by Rosacea sparing the nose (1.93%), and controls (0.19%). Conclusions The skin microbiota in individuals with Rosacea displays changes from that of healthy skin, suggesting that further studies examining a potential role for the skin microbiota in the pathophysiology of Rosacea may be warranted.
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Characterization and Analysis of the Skin Microbiota in Rosacea: A Case-Control Study.
American Journal of Clinical Dermatology, 2019Co-Authors: Barbara M. Rainer, Katherine G. Thompson, Liliana Florea, Alexander H. Fischer, H. Pasieka, Emmanuel F Mongodin, Corina Antonescu, Luis A Garza, Sewon KangAbstract:The efficacy of antibiotics in Rosacea treatment suggests a role for microorganisms in its pathophysiology. Growing concern over the adverse effects of antibiotic use presents a need for targeted antimicrobial treatment in Rosacea. We performed a case–control study to investigate the skin microbiota in patients with Rosacea compared to controls matched by age, sex, and race. Nineteen participants with Rosacea, erythematotelangiectatic, papulopustular, or both, were matched to 19 Rosacea-free controls. DNA was extracted from skin swabs of the nose and bilateral cheeks of participants. Sequencing of the V3V4 region of the bacterial 16S ribosomal RNA gene was performed using Illumina MiSeq and analyzed using QIIME/MetaStats 2.0 software. Compared with controls, skin microbiota in erythematotelangiectatic Rosacea was depleted in Roseomonas mucosa (p = 0.004). Papulopustular Rosacea was enriched in Campylobacter ureolyticus (p = 0.001), Corynebacterium kroppenstedtii (p = 0.008), and the oral flora Prevotella intermedia (p = 0.001). The highest relative abundance of C. kroppenstedtii was observed in patients with both erythematotelangiectatic and papulopustular Rosacea (19.2%), followed by papulopustular (5.06%) and erythematotelangiectatic (1.21%) Rosacea. C. kroppenstedtii was also associated with more extensive disease, with the highest relative abundance in Rosacea affecting both the cheeks and nose (2.82%), followed by Rosacea sparing the nose (1.93%), and controls (0.19%). The skin microbiota in individuals with Rosacea displays changes from that of healthy skin, suggesting that further studies examining a potential role for the skin microbiota in the pathophysiology of Rosacea may be warranted.
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Rosacea is associated with chronic systemic diseases in a skin severity dependent manner results of a case control study
Journal of The American Academy of Dermatology, 2015Co-Authors: Barbara M. Rainer, Alexander H. Fischer, Sewon Kang, Dimitre Luz Felipe Da Silva, Anna L. ChienAbstract:Background Rosacea is a common chronic inflammatory dermatosis of unclear origin. It has been associated with systemic comorbidities, but methodical studies addressing this association are lacking. Objective We evaluated: (1) the association between Rosacea and systemic comorbidities; and (2) if the severity of Rosacea is impacted by comorbidities. Methods This was a case-control study: patients with Rosacea were matched (1:1) to Rosacea-free control subjects by age, sex, and race. Relative risk estimates were calculated using logistic regression as odds ratios with 95% confidence intervals. Results Among 130 participants (65 patients/65 control subjects), we observed a significant association between Rosacea and allergies (airborne, food), respiratory diseases, gastroesophageal reflux disease, other gastrointestinal diseases, hypertension, metabolic and urogenital diseases, and female hormone imbalance. Compared with mild Rosacea, moderate to severe Rosacea was significantly associated with hyperlipidemia, hypertension, metabolic diseases, cardiovascular diseases, and gastroesophageal reflux disease. Limitations This was a case-control study with moderate sample size. Associated medical conditions were self-reported and could not always be confirmed by medication use and medical records. Conclusions Rosacea is associated with numerous systemic comorbid diseases in a skin severity–dependent manner. Physicians should be aware of these associations to provide comprehensive care to patients with Rosacea, especially to those with more severe disease.
Ilia L Ferrusi - One of the best experts on this subject based on the ideXlab platform.
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Quality of Life in Individuals with Erythematotelangiectatic and Papulopustular Rosacea: Findings From a Web-based Survey.
The Journal of clinical and aesthetic dermatology, 2018Co-Authors: Joshua A. Zeichner, Lawrence F. Eichenfield, J Scott Kasteler, Ilia L FerrusiAbstract:OBJECTIVE: The objective of the study was to evaluate the impact of Rosacea on self-perception, emotional, social, and overall well-being and quality of life in individuals with erythematotelangiectatic Rosacea (ETR) and papulopustular Rosacea (PPR). DESIGN: We distributed a cross-sectional email invitation for participants in the United States to fill out a web-based survey. PARTICIPANTS: We included adults who reported having previously received a diagnosis of erythematotelangiectatic Rosacea or papulopustular Rosacea. MEASUREMENTS: Questionnaires measured the psychosocial aspects of Rosacea, including the Satisfaction With Appearance Scale and modified Satisfaction With Appearance Scale questionnaires, Impact Assessment for Rosacea Facial Redness, Rosacea-Specific Quality-of-Life questionnaire, and RAND 36-Item Short Form Health Survey. The Impact Assessment for Rosacea Facial Bumps or Pimples was administered to the papulopustular Rosacea cohort. RESULTS: Six hundred participants enrolled and completed the survey, with most rating their Rosacea as mild or moderate (ETR: 95.6%; PPR: 93.7%). In the erythematotelangiectatic Rosacea and papulopustular Rosacea cohorts, respectively, 45 and 53 percent disagreed/strongly disagreed that they were satisfied with their appearance due to Rosacea; 42 and 27 percent agreed/strongly agreed that they "worry how people will react when they see my Rosacea"; and 43 and 59 percent agreed/strongly agreed that they feel their Rosacea is unattractive to others. Rosacea-Specific Quality-of-Life total and domain scores indicated negative impact of Rosacea for both cohorts. Both cohorts reported worse 36-item Short Form Health Survey overall and domain scores than population norms in the United States. CONCLUSION: Rosacea had wide-ranging, negative effects on self-perceptions and emotional, social, and overall well-being as well as Rosacea-specific quality of life. Overall, both erythematotelangiectatic Rosacea and papulopustular Rosacea cohorts reported a substantial negative impact of Rosacea on quality of life on a range of instruments.
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The Burden of Illness of Erythematotelangiectatic Rosacea and Papulopustular Rosacea: Findings From a Web-based Survey.
The Journal of clinical and aesthetic dermatology, 2017Co-Authors: James Q. Del Rosso, Hilary E Baldwin, Emil Tanghetti, David Rodriguez, Ilia L FerrusiAbstract:Objective: Evaluate patients' perceptions of Rosacea symptoms and treatments. Design: Cross-sectional, web-based survey conducted from May 8 to July 1,2015. Setting: E-mail invitation. Participants: Male and female adults in the United States who self-reported having a physician's diagnosis of Rosacea. Measurements: Sociodemographic and clinical characteristics were collected for eligible respondents using the Self-Assessment of Rosacea Facial Redness scale and the Symptom Assessment for Rosacea Facial Bumps and Pimples questionnaire. Respondents were instructed how to differentiate erythematotelangiectatic Rosacea and papulopustular Rosacea. Use of different treatments and satisfaction with treatment were assessed, as were coping mechanisms. Results: More than 4,000 individuals responded and 600 completed the survey. The participants' mean age was 51.7 years and more than 90 percent rated their Rosacea severity as mild or moderate. Most practiced stress and/or anxiety management, used makeup to cover Rosacea, used sun protection, and changed their exercise regimens to cope with Rosacea flare-ups. Participants reported avoiding sun exposure, hot baths and saunas, and specific skin care products to circumvent potential Rosacea flare-ups. More than half (55.7%) had used a prescribed topical agent for Rosacea in the preceding month, and 26.3 percent had used a prescribed oral antibiotic. Fewer than half were satisfied with treatment outcomes. Conclusion: Despite the chronic nature of Rosacea, participants commonly used prescription agents only to treat flare-ups and relied on sun protection and other avoidance mechanisms to reduce their frequency. Education is needed to communicate the long-term nature of Rosacea and the need for continued treatment to maintain long-term control.
Jean S Mcgee - One of the best experts on this subject based on the ideXlab platform.
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Rosacea not just skin deep understanding the systemic disease burden
Clinics in Dermatology, 2020Co-Authors: Peyton Morsswalton, Jean S McgeeAbstract:Abstract Rosacea is a common inflammatory skin condition with four main clinical subtypes: erythematotelangiectatic, papulopustular, rhinophymatous, and ocular. While several genetic and environmental factors have been linked with triggering Rosacea, the pathogenesis still remains poorly understood. There is an increasing evidence in the literature to support that Rosacea is a harbinger of several systemic comorbidities and may represent a chronic, systemic, inflammatory state. We have provided the most up-to-date evidence on the association between Rosacea and several systemic diseases, discussing that Rosacea is not just a skin disorder but a systemic disease process.
