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Susel, Ravello Alayo - One of the best experts on this subject based on the ideXlab platform.
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Efecto sinérgico antifúngico in vitro del aceite esencial de Rosmarinus officinalis y clotrimazol sobre Trichophyton rubrum
'Universidad Cesar Vallejo', 2019Co-Authors: Susel, Ravello AlayoAbstract:En este trabajo el objetivo fue evaluar el efecto antifúngico del aceite esencial de Rosmarinus officinalis “romero”, el clotrimazol y la sinergia de ambos, sobre Trichophyton rubrum. Se diseñó un estudio experimental in vitro. Se obtuvo el aceite esencial por el método de arrastre con vapor de agua y se evaluó mediante el método de difusión con pozos en agar; formando 4 grupos: aceite esencial de romero + clotrimazol; aceite esencial de romero; clotrimazol y DMSO, realizándose 10 repeticiones por cada grupo. Se observó que la asociación de Rosmarinus officinalis y clotrimazol formó un halo de inhibición de 34,4mm, el aceite esencial de romero formó 23,4mm y el clotrimazól 32,30 mm. La prueba de ANOVA indica que existe diferencias significativas (p=0,0000) entre los efectos antifúngicos de los grupos. Además, la prueba HSD Tukey indica que cada efecto es diferente uno del otro. Se concluye que la combinación de aceite esencial de Rosmarinus officinalis con clotrimazol tiene mayor efecto sinérgico antifúngico contra Trichophyton rubrum que el clotrimazol sólo
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Efecto sinérgico antifúngico in vitro del aceite esencial de Rosmarinus officinalis y clotrimazol sobre Trichophyton rubrum
'Universidad Cesar Vallejo', 2019Co-Authors: Susel, Ravello AlayoAbstract:TesisTrujilloEscuela Académico Profesional de MedicinaEnfermedades infecciosas y transmisiblesEn este trabajo el objetivo fue evaluar el efecto antifúngico del aceite esencial de Rosmarinus officinalis “romero”, el clotrimazol y la sinergia de ambos, sobre Trichophyton rubrum. Se diseñó un estudio experimental in vitro. Se obtuvo el aceite esencial por el método de arrastre con vapor de agua y se evaluó mediante el método de difusión con pozos en agar; formando 4 grupos: aceite esencial de romero + clotrimazol; aceite esencial de romero; clotrimazol y DMSO, realizándose 10 repeticiones por cada grupo. Se observó que la asociación de Rosmarinus officinalis y clotrimazol formó un halo de inhibición de 34,4mm, el aceite esencial de romero formó 23,4mm y el clotrimazól 32,30 mm. La prueba de ANOVA indica que existe diferencias significativas (p=0,0000) entre los efectos antifúngicos de los grupos. Además, la prueba HSD Tukey indica que cada efecto es diferente uno del otro. Se concluye que la combinación de aceite esencial de Rosmarinus officinalis con clotrimazol tiene mayor efecto sinérgico antifúngico contra Trichophyton rubrum que el clotrimazol sólo
Miguel Valcárcel - One of the best experts on this subject based on the ideXlab platform.
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determination of the carnosic acid content in wild and cultivated Rosmarinus officinalis
Journal of Agricultural and Food Chemistry, 1998Co-Authors: Pablo J Hidalgo, J L Ubera, Maria Teresa Tena, Miguel ValcárcelAbstract:The concentration of carnosic acid in a representative selection of leaves from wild and cultivated populations of Rosmarinus officinalis was determined by reversed-phase HPLC following extraction with supercritical carbon dioxide. Different sources of variability including season, genetics, leaf age, and growing origin (wild or cultivated) were considered. Variability in the carnosic acid content among rosemary leaves appears to be largely due to seasonal and environmental factors, in addition to their individual origin (genetics). The results reveal excellent correlation (r = 0.93) between the carnosic acid concentration and photoperiod. The results presented can be used to improve the selection of raw materials for the extraction of carnosic acid from rosemary. Keywords: Rosmarinus officinalis; carnosic acid; antioxidant; supercritical fluid extraction
Mohmad Amin - One of the best experts on this subject based on the ideXlab platform.
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Defensive role of Rosmarinus officinalis in carbon tetrachloride-induced nephrotoxicity and oxidative stress in rats
Bulletin of the National Research Centre, 2019Co-Authors: Mir Ajaz Akram, Manju Tembhre, Ruqaya Jabeen, Shah Khalid, Muzafar Ahmad Sheikh, Aasia Jan, Umer Farooq, Mohmad AminAbstract:There is a growing demand for remedies from natural sources to substitute synthetic therapeutic drugs and minimize their side effects and toxicity. The present study aims to evaluate the defensive ability of an ethanolic extract of Rosmarinus officinalis L. in carbon tetrachloride (CCl4)-induced nephrotoxicity in male albino rats. Thirty-six rats were divided into 6 groups (n = 6). Group I (control) received distilled water for 30 days orally. Nephrotoxicity was induced by CCl4 (11% v/v with olive oil, i.p) 2 ml/kg body weight (b.wt.) in group II once a week for 30 days. Groups III and IV received the only herb in two doses 100 and 250 mg/kg of b.wt. respectively. Groups V and VI received an ethanolic extract of Rosmarinus officinalis (EERO, 100 and 250 mg/kg of b.wt.) along with 2 ml/kg b.wt. CCl4 weekly for 30 days. CCl4 treatment induced highly significant (P
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Defensive role of Rosmarinus officinalis in carbon tetrachloride-induced nephrotoxicity and oxidative stress in rats
Bulletin of the National Research Centre, 2019Co-Authors: Mir Ajaz Akram, Manju Tembhre, Ruqaya Jabeen, Shah Khalid, Muzafar Ahmad Sheikh, Umer Farooq, Mohmad AminAbstract:Background There is a growing demand for remedies from natural sources to substitute synthetic therapeutic drugs and minimize their side effects and toxicity. The present study aims to evaluate the defensive ability of an ethanolic extract of Rosmarinus officinalis L. in carbon tetrachloride (CCl_4)-induced nephrotoxicity in male albino rats. Materials and methods Thirty-six rats were divided into 6 groups ( n = 6). Group I (control) received distilled water for 30 days orally. Nephrotoxicity was induced by CCl_4 (11% v / v with olive oil, i.p) 2 ml/kg body weight (b.wt.) in group II once a week for 30 days. Groups III and IV received the only herb in two doses 100 and 250 mg/kg of b.wt. respectively. Groups V and VI received an ethanolic extract of Rosmarinus officinalis (EERO, 100 and 250 mg/kg of b.wt.) along with 2 ml/kg b.wt. CCl_4 weekly for 30 days. Results CCl_4 treatment induced highly significant ( P
Pablo J Hidalgo - One of the best experts on this subject based on the ideXlab platform.
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Inbreeding depression in Rosmarinus officinalis L.
The International Journal of Developmental Biology, 2001Co-Authors: Pablo J Hidalgo, J L UberaAbstract:Rosmarinus officinalis plants are self-compatible but automatic self-pollination is prevented by strong protandry. Flowers of R. officinalis set abundant seed when cross-pollinated by hand. Nevertheless, the seed set by self-pollination is clearly lower and similar in amount to those obtained in open-pollination. Insect-mediated geitonogamy is possible, and appears to be responsible for the lower seed set in open-pollination. Seed set by male-sterile plants indicates that gynodioecy could be considered as a strategy to increase reproductive output in R. officinalis. Two different steps can be distinguished in the halting of seed selfing: early abortion of the embryo/endosperm just after fertilisation, leading to small and empty seeds; and late abortion of the embryo, leading to empty but apparently normal seeds.
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determination of the carnosic acid content in wild and cultivated Rosmarinus officinalis
Journal of Agricultural and Food Chemistry, 1998Co-Authors: Pablo J Hidalgo, J L Ubera, Maria Teresa Tena, Miguel ValcárcelAbstract:The concentration of carnosic acid in a representative selection of leaves from wild and cultivated populations of Rosmarinus officinalis was determined by reversed-phase HPLC following extraction with supercritical carbon dioxide. Different sources of variability including season, genetics, leaf age, and growing origin (wild or cultivated) were considered. Variability in the carnosic acid content among rosemary leaves appears to be largely due to seasonal and environmental factors, in addition to their individual origin (genetics). The results reveal excellent correlation (r = 0.93) between the carnosic acid concentration and photoperiod. The results presented can be used to improve the selection of raw materials for the extraction of carnosic acid from rosemary. Keywords: Rosmarinus officinalis; carnosic acid; antioxidant; supercritical fluid extraction
Steven J. Melnick - One of the best experts on this subject based on the ideXlab platform.
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NT-28NEUROPROTECTIVE EFFECTS OF BACOPA MONNIERI AND Rosmarinus officinalis SUPERCRITICAL CO2 EXTRACTS.
Neuro-oncology, 2014Co-Authors: Cheppail Ramachandran, Karl-werner Quirin, Enrique Escalon, Steven J. MelnickAbstract:Ethnobotanical evidence suggests that herbs such as brahmi (Bacopa monnieri) and rosemary (Rosmarinus officinalis) may possess anti-oxidant and neuroprotective properties. We compared the anti-oxidant and neuroprotective effects of supercritical extract of Bacopa monnieri (BM) and rosemary anti-oxidant (RA) extract obtained from Rosmarinus officinalis as well as their combination to examine the effects on human glial (U-87 MG) and embryonic mouse hypothalamus (EMH) cells. BM, RA and their combination (1:1) are not cytotoxic in both glial and EMH cell lines up to 200 µg/ml concentration. BM + RA combination has better anti-oxidant potential and anti-lipid peroxidation activity than either agent alone. Although BM + RA showed almost similar inhibition of phospho tau expression as BM or RA alone, the combination has better inhibitory effect on Amyloid Precursor Protein (APP) synthesis and higher brain-derived neurotrophic factor (BDNF) production in hypothalamus cells than single agents. These results suggest that BM + RA is more neuroprotective than BM or RA individually.
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Improved neuroprotective effects by combining Bacopa monnieri and Rosmarinus officinalis supercritical CO2 extracts.
Journal of Evidence-Based Complementary & Alternative Medicine, 2014Co-Authors: Cheppail Ramachandran, Karl-werner Quirin, Enrique Escalon, Steven J. MelnickAbstract:Ethnobotanical evidence suggests that herbs such as brahmi (Bacopa monnieri) and rosemary (Rosmarinus officinalis) may possess antioxidant and neuroprotective properties. We compared the antioxidant and neuroprotective effects of supercritical extract of Bacopa monnieri and rosemary antioxidant extract obtained from Rosmarinus officinalis as well as their combination to examine the effects on human glial (U-87 MG) and embryonic mouse hypothalamus cells. Bacopa monnieri extract, rosemary antioxidant extract, and their combination (1:1) are not cytotoxic in both glial and embryonic mouse hypothalamus cell lines up to 200 μg/mL concentration. The combination of extracts of Bacopa monnieri + rosemary antioxidant has better antioxidant potential and antilipid peroxidation activity than either agent alone. Although the extract of Bacopa monnieri + rosemary antioxidant showed almost similar inhibition of phospho tau expression as Bacopa monnieri or rosemary antioxidant extract alone, the combination has better i...
