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M. Kršiak - One of the best experts on this subject based on the ideXlab platform.
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The synergistic interaction between rilmenidine and paracetamol in the writhing Test in mice
Naunyn-Schmiedeberg's Archives of Pharmacology, 2009Co-Authors: M. Soukupová, T. Doležal, M. KršiakAbstract:The aim of the study was to ascertain antinociceptive effects of rilmenidine, a second-generation imidazoline-alpha-2-adrenoreceptor agonist, and to see whether rilmenidine was able to increase the analgesic effects of paracetamol in the writhing Test in mice. An acetic acid (0.7%) solution was injected into the peritoneal cavity and the number of writhes was counted. The influence on locomotor performance was Tested using the Rotarod Test. Rilmenidine, paracetamol, and rilmenidine–paracetamol fixed-ratio combinations produced dose-dependent antinociceptive effects. ED_50 values were estimated for the individual drugs and an isobologram was constructed. The derived theoretical additive ED_50 value for the rilmenidine–paracetamol combination was 109.23 ± 35.05 mg/kg. This value was significantly greater than the observed ED_50 value which was 56.35 ± 20.86 mg/kg, indicating a synergistic interaction. Rilmenidine did not impair motor coordination, as measured by the Rotarod Test, at antinociceptive and higher doses.
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Synergistic interaction between rilmenidine and ibuprofen in the writhing Test in mice.
Neuro endocrinology letters, 2009Co-Authors: M. Soukupová, T. Doležal, M. KršiakAbstract:OBJECTIVES: The aim of the study was to ascertain whether rilmenidine, a second generation imidazoline-alpha-2-adrenoreceptor agonist, is able to increase analgesic effects of ibuprofen in the writhing Test in mice. Experimental studies combining these agents have not yet been published. METHODS: An acetic acid (0.7%) solution was injected into the peritoneal cavity and the number of writhes was counted. The influence on locomotor performance was Tested using the Rotarod Test. RESULTS: Rilmenidine, ibuprofen, and rilmenidine-ibuprofen fixed-ratio combinations produced dose-dependent antinociceptive effects. ED 50 values were estimated for the individual drugs and an isobologram was constructed. The derived theoretical additive ED 50 value for the rilmenidine-ibuprofen combination was 34.00 ± 9.39 mg/kg. This value was significantly greater than the observed ED 50 value which was 18.07 ± 5.41 mg/kg, indicating a synergistic interaction. Rilmenidine did not impair motor coordination, as measured by the Rotarod Test, at antinociceptive and higher doses. CONCLUSIONS: The present results suggest that rilmenidine enhances the analgesic activity of ibuprofen. If rilmenidine produces antinociception in humans, then the synergistic antinociception of rilmenidine with ibuprofen could offer therapeutic advantage for clinical treatment of pain.
Stanisław J. Czuczwar - One of the best experts on this subject based on the ideXlab platform.
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levetiracetam selectively potentiates the acute neurotoxic effects of topiramate and carbamazepine in the Rotarod Test in mice
European Neuropsychopharmacology, 2005Co-Authors: Jarogniew J Luszczki, Marta M Andres, Piotr Czuczwar, Anna Cioczekczuczwar, Joanna Wojcikcwikla, Neville Ratnaraj, Philip N Patsalos, Stanisław J. CzuczwarAbstract:The effect of levetiracetam (LEV) on the acute neurotoxic profiles of various antiepileptic drugs (carbamazepine [CBZ), phenytoin [PHT], phenobarbital [PB], valproate [VPA], lamotrigine [LTG], topiramate [TPM], oxcarbazepine [OXC], and felbamate [FBM]) was evaluated in the Rotarod Test, allowing the determination of median toxic doses (TD50 values) with respect to impairment of motor coordination in mice. The TD50 of LEV administered singly was 1601 mg/kg. Whilst LEV at 150 mg/kg, being its TID50 (a dose increasing the electroconvulsive threshold by 50%), was without effect with regards to motor coordination impairment associated with PHT, PB, VIA, LTG, OXC, and FBM, it significantly enhanced that associated with CBZ and TPM co-administration. Thus LEV (150 mg/kg) significantly decreased the TD50 of CBZ from 53.6 to 37.3 mg/kg (P<0.01) and that of TPM from 423 to 246 mg/kg (P<0.01). In addition LEV (75 mg/kg) significantly decreased the TD50 of TPM from 423 to 278 (P<0.01). That concurrent measurement of total brain LEV, CBZ, and TPM concentrations showed that concentrations were not significantly different when AEDs were administered singly compared to when they were administered in combination would suggest that there is no pharmacokinetic interaction between these AEDs. Thus, the observed potentialization of the acute neurotoxic effects of CBZ and TPM by LEV is the consequence of a pharmacodynamic interaction. These data support both experimental and clinical published data advocating that LEV may interact with some AEDs by pharmacodynamic mechanisms. (c) 2005 Elsevier B.V. and ECNP. All rights reserved.
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Levetiracetam selectively potentiates the acute neurotoxic effects of topiramate and carbamazepine in the Rotarod Test in mice
EUR NEUROPSYCHOPHARM, 2005Co-Authors: Stanisław J. CzuczwarAbstract:The effect of levetiracetam (LEV) on the acute neurotoxic profiles of various antiepileptic drugs (carbamazepine [CBZ), phenytoin [PHT], phenobarbital [PB], valproate [VPA], lamotrigine [LTG], topiramate [TPM], oxcarbazepine [OXC], and felbamate [FBM]) was evaluated in the Rotarod Test, allowing the determination of median toxic doses (TD50 values) with respect to impairment of motor coordination in mice. The TD50 of LEV administered singly was 1601 mg/kg. Whilst LEV at 150 mg/kg, being its TID50 (a dose increasing the electroconvulsive threshold by 50%), was without effect with regards to motor coordination impairment associated with PHT, PB, VIA, LTG, OXC, and FBM, it significantly enhanced that associated with CBZ and TPM co-administration. Thus LEV (150 mg/kg) significantly decreased the TD50 of CBZ from 53.6 to 37.3 mg/kg (P
Larry W Jenkins - One of the best experts on this subject based on the ideXlab platform.
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the Rotarod Test an evaluation of its effectiveness in assessing motor deficits following traumatic brain injury
Journal of Neurotrauma, 1994Co-Authors: Robert J Hamm, Brian R Pike, Dianne M Odell, Bruce G Lyeth, Larry W JenkinsAbstract:ABSTRACT The purpose of the present experiment was to examine the effectiveness of a modified Rotarod Test in detecting motor deficits following mild and moderate central fluid percussion brain injury. In addition, this investigation compared the performance of the Rotarod task with two other commonly used measures of motor function after brain injury (beam-balance and beam-walking latencies). Rats were either injured with a mild (n = 14) or moderate (n = 8) level of fluid percussion injury or were surgically prepared but not injured (n = 8). All rats were assessed on all tasks for 5 days following their respective treatments. Results revealed that both the mild and moderate injury levels produced significant deficits in the ability of the animals to perform the Rotarod task. Performance on the beam-balance and beam-walking tasks were not significantly impaired at the mild injury level. It was only at the moderate injury level that the beam-balance and beam-walking tasks detected deficits in motor perform...
M. Soukupová - One of the best experts on this subject based on the ideXlab platform.
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The synergistic interaction between rilmenidine and paracetamol in the writhing Test in mice
Naunyn-Schmiedeberg's Archives of Pharmacology, 2009Co-Authors: M. Soukupová, T. Doležal, M. KršiakAbstract:The aim of the study was to ascertain antinociceptive effects of rilmenidine, a second-generation imidazoline-alpha-2-adrenoreceptor agonist, and to see whether rilmenidine was able to increase the analgesic effects of paracetamol in the writhing Test in mice. An acetic acid (0.7%) solution was injected into the peritoneal cavity and the number of writhes was counted. The influence on locomotor performance was Tested using the Rotarod Test. Rilmenidine, paracetamol, and rilmenidine–paracetamol fixed-ratio combinations produced dose-dependent antinociceptive effects. ED_50 values were estimated for the individual drugs and an isobologram was constructed. The derived theoretical additive ED_50 value for the rilmenidine–paracetamol combination was 109.23 ± 35.05 mg/kg. This value was significantly greater than the observed ED_50 value which was 56.35 ± 20.86 mg/kg, indicating a synergistic interaction. Rilmenidine did not impair motor coordination, as measured by the Rotarod Test, at antinociceptive and higher doses.
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Synergistic interaction between rilmenidine and ibuprofen in the writhing Test in mice.
Neuro endocrinology letters, 2009Co-Authors: M. Soukupová, T. Doležal, M. KršiakAbstract:OBJECTIVES: The aim of the study was to ascertain whether rilmenidine, a second generation imidazoline-alpha-2-adrenoreceptor agonist, is able to increase analgesic effects of ibuprofen in the writhing Test in mice. Experimental studies combining these agents have not yet been published. METHODS: An acetic acid (0.7%) solution was injected into the peritoneal cavity and the number of writhes was counted. The influence on locomotor performance was Tested using the Rotarod Test. RESULTS: Rilmenidine, ibuprofen, and rilmenidine-ibuprofen fixed-ratio combinations produced dose-dependent antinociceptive effects. ED 50 values were estimated for the individual drugs and an isobologram was constructed. The derived theoretical additive ED 50 value for the rilmenidine-ibuprofen combination was 34.00 ± 9.39 mg/kg. This value was significantly greater than the observed ED 50 value which was 18.07 ± 5.41 mg/kg, indicating a synergistic interaction. Rilmenidine did not impair motor coordination, as measured by the Rotarod Test, at antinociceptive and higher doses. CONCLUSIONS: The present results suggest that rilmenidine enhances the analgesic activity of ibuprofen. If rilmenidine produces antinociception in humans, then the synergistic antinociception of rilmenidine with ibuprofen could offer therapeutic advantage for clinical treatment of pain.
T. Doležal - One of the best experts on this subject based on the ideXlab platform.
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The synergistic interaction between rilmenidine and paracetamol in the writhing Test in mice
Naunyn-Schmiedeberg's Archives of Pharmacology, 2009Co-Authors: M. Soukupová, T. Doležal, M. KršiakAbstract:The aim of the study was to ascertain antinociceptive effects of rilmenidine, a second-generation imidazoline-alpha-2-adrenoreceptor agonist, and to see whether rilmenidine was able to increase the analgesic effects of paracetamol in the writhing Test in mice. An acetic acid (0.7%) solution was injected into the peritoneal cavity and the number of writhes was counted. The influence on locomotor performance was Tested using the Rotarod Test. Rilmenidine, paracetamol, and rilmenidine–paracetamol fixed-ratio combinations produced dose-dependent antinociceptive effects. ED_50 values were estimated for the individual drugs and an isobologram was constructed. The derived theoretical additive ED_50 value for the rilmenidine–paracetamol combination was 109.23 ± 35.05 mg/kg. This value was significantly greater than the observed ED_50 value which was 56.35 ± 20.86 mg/kg, indicating a synergistic interaction. Rilmenidine did not impair motor coordination, as measured by the Rotarod Test, at antinociceptive and higher doses.
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Synergistic interaction between rilmenidine and ibuprofen in the writhing Test in mice.
Neuro endocrinology letters, 2009Co-Authors: M. Soukupová, T. Doležal, M. KršiakAbstract:OBJECTIVES: The aim of the study was to ascertain whether rilmenidine, a second generation imidazoline-alpha-2-adrenoreceptor agonist, is able to increase analgesic effects of ibuprofen in the writhing Test in mice. Experimental studies combining these agents have not yet been published. METHODS: An acetic acid (0.7%) solution was injected into the peritoneal cavity and the number of writhes was counted. The influence on locomotor performance was Tested using the Rotarod Test. RESULTS: Rilmenidine, ibuprofen, and rilmenidine-ibuprofen fixed-ratio combinations produced dose-dependent antinociceptive effects. ED 50 values were estimated for the individual drugs and an isobologram was constructed. The derived theoretical additive ED 50 value for the rilmenidine-ibuprofen combination was 34.00 ± 9.39 mg/kg. This value was significantly greater than the observed ED 50 value which was 18.07 ± 5.41 mg/kg, indicating a synergistic interaction. Rilmenidine did not impair motor coordination, as measured by the Rotarod Test, at antinociceptive and higher doses. CONCLUSIONS: The present results suggest that rilmenidine enhances the analgesic activity of ibuprofen. If rilmenidine produces antinociception in humans, then the synergistic antinociception of rilmenidine with ibuprofen could offer therapeutic advantage for clinical treatment of pain.
