The Experts below are selected from a list of 423657 Experts worldwide ranked by ideXlab platform
Myriam Carolina Montenegro - One of the best experts on this subject based on the ideXlab platform.
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dorsal root entry zone lesions for Treatment of Pain related to radiation induced plexopathy
Spine, 2007Co-Authors: Manoel Jacobsen Teixeira, Erich Talamoni Fonoff, Myriam Carolina MontenegroAbstract:STUDY DESIGN: Case series. OBJECTIVE: Presentation of results of dorsal root entry zone lesions in 10 patients suffering from severe neuropathic Pain due to brachial plexopathy or radiation-induced trigeminal neuropathy. SUMMARY of BACKGROUND DATA: Radiation-induced neuropathy is an uncommon but serious complication of radiotherapy. It may cause delayed motor and sensitive impairment associated with severe Treatment-resistant Pain. Various therapeutic approaches have been reported aimed at controlling radiation-induced neuropathy-Pain, demonstrating poor outcomes. METHODS: Eight patients with plexopathy underwent dorsal root entry zone lesion in the cervical spinal cord, while 2 other subjects received stereotactic trigeminal nucleotractotomy. Subjects were followed prospectively before and after brachial dorsal root entry zone or trigeminal caudal operations (range 0.5-36 months). RESULTS: All patients experienced improvement in Pain conditions. A total of 8 patients reported full Pain relief (visual analog scale = 0) by the end of the follow-up period. The remaining patients had partial control of Pain. One patient required reoperation to achieve optimal Pain relief. Both patients who underwent trigeminal nucleotractotomy had transient ataxia in the ipsilateral upper limb. One of the patients treated by dorsal root entry zone lesion had minor aggravation of weakness of the ipsilateral lower limb. CONCLUSION: The present results suggest that the trigeminal nucleotractotomy and dorsal root entry zone lesions in cervical spinal cord are an effective procedure for the Treatment of Pain associated with actinic peripheral neuropathy.
Manoel Jacobsen Teixeira - One of the best experts on this subject based on the ideXlab platform.
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dorsal root entry zone lesions for Treatment of Pain related to radiation induced plexopathy
Spine, 2007Co-Authors: Manoel Jacobsen Teixeira, Erich Talamoni Fonoff, Myriam Carolina MontenegroAbstract:STUDY DESIGN: Case series. OBJECTIVE: Presentation of results of dorsal root entry zone lesions in 10 patients suffering from severe neuropathic Pain due to brachial plexopathy or radiation-induced trigeminal neuropathy. SUMMARY of BACKGROUND DATA: Radiation-induced neuropathy is an uncommon but serious complication of radiotherapy. It may cause delayed motor and sensitive impairment associated with severe Treatment-resistant Pain. Various therapeutic approaches have been reported aimed at controlling radiation-induced neuropathy-Pain, demonstrating poor outcomes. METHODS: Eight patients with plexopathy underwent dorsal root entry zone lesion in the cervical spinal cord, while 2 other subjects received stereotactic trigeminal nucleotractotomy. Subjects were followed prospectively before and after brachial dorsal root entry zone or trigeminal caudal operations (range 0.5-36 months). RESULTS: All patients experienced improvement in Pain conditions. A total of 8 patients reported full Pain relief (visual analog scale = 0) by the end of the follow-up period. The remaining patients had partial control of Pain. One patient required reoperation to achieve optimal Pain relief. Both patients who underwent trigeminal nucleotractotomy had transient ataxia in the ipsilateral upper limb. One of the patients treated by dorsal root entry zone lesion had minor aggravation of weakness of the ipsilateral lower limb. CONCLUSION: The present results suggest that the trigeminal nucleotractotomy and dorsal root entry zone lesions in cervical spinal cord are an effective procedure for the Treatment of Pain associated with actinic peripheral neuropathy.
Erich Talamoni Fonoff - One of the best experts on this subject based on the ideXlab platform.
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dorsal root entry zone lesions for Treatment of Pain related to radiation induced plexopathy
Spine, 2007Co-Authors: Manoel Jacobsen Teixeira, Erich Talamoni Fonoff, Myriam Carolina MontenegroAbstract:STUDY DESIGN: Case series. OBJECTIVE: Presentation of results of dorsal root entry zone lesions in 10 patients suffering from severe neuropathic Pain due to brachial plexopathy or radiation-induced trigeminal neuropathy. SUMMARY of BACKGROUND DATA: Radiation-induced neuropathy is an uncommon but serious complication of radiotherapy. It may cause delayed motor and sensitive impairment associated with severe Treatment-resistant Pain. Various therapeutic approaches have been reported aimed at controlling radiation-induced neuropathy-Pain, demonstrating poor outcomes. METHODS: Eight patients with plexopathy underwent dorsal root entry zone lesion in the cervical spinal cord, while 2 other subjects received stereotactic trigeminal nucleotractotomy. Subjects were followed prospectively before and after brachial dorsal root entry zone or trigeminal caudal operations (range 0.5-36 months). RESULTS: All patients experienced improvement in Pain conditions. A total of 8 patients reported full Pain relief (visual analog scale = 0) by the end of the follow-up period. The remaining patients had partial control of Pain. One patient required reoperation to achieve optimal Pain relief. Both patients who underwent trigeminal nucleotractotomy had transient ataxia in the ipsilateral upper limb. One of the patients treated by dorsal root entry zone lesion had minor aggravation of weakness of the ipsilateral lower limb. CONCLUSION: The present results suggest that the trigeminal nucleotractotomy and dorsal root entry zone lesions in cervical spinal cord are an effective procedure for the Treatment of Pain associated with actinic peripheral neuropathy.
Mark T. Brown - One of the best experts on this subject based on the ideXlab platform.
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efficacy and safety of tanezumab in the Treatment of Pain from bone metastases
Pain, 2015Co-Authors: Maciej Sopata, Christine R West, Gernot Wolfram, William Carey, David M Keller, Kenneth M Verburg, Nathaniel P. Katz, Michael D. Smith, Mark T. BrownAbstract:AbstractPatients with metastatic bone cancer report life-altering Pain. Nerve growth factor is involved in Pain signaling. Tanezumab, a nerve growth factor monoclonal antibody, has demonstrated efficacy in chronic Pain. Placebo-controlled parent (NCT00545129; study 1003) and noncontrolled open-label
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tanezumab for the Treatment of Pain from osteoarthritis of the knee
The New England Journal of Medicine, 2010Co-Authors: Nancy E Lane, Charles Birbara, Masoud Mokhtarani, David L Shelton, Thomas J. Schnitzer, Michael D. Smith, Mark T. BrownAbstract:Methods We randomly assigned 450 patients with osteoarthritis of the knee to receive tan ezumab (administered at a dose of 10, 25, 50, 100, or 200 µg per kilogram of body weight) or placebo on days 1 and 56. The primary efficacy measures were knee Pain while walking and the patient’s global assessment of response to therapy. We also assessed Pain, stiffness, and physical function using the Western Ontario and Mc Master Universities Osteoarthritis Index (WOMAC); the rate of response using the criteria of the Outcome Measures for Rheumatology Committee and Osteoarthritis Research Society International Standing Committee for Clinical Trials Response Criteria Initiative (OMERACT–OARSI); and safety. Results When averaged over weeks 1 through 16, the mean reductions from baseline in knee Pain while walking ranged from 45 to 62% with various doses of tanezumab, as compared with 22% with placebo (P<0.001). Tanezumab, as compared with placebo, was also associated with significantly greater improvements in the response to ther apy as assessed with the use of the patients’ global assessment measure (mean in creases in score of 29 to 47% with various doses of tanezumab, as compared with 19% with placebo; P≤0.001). The rate of response according to the OMERACT–OARSI criteria ranged from 74 to 93% with tanezumab Treatment, as compared with 44% with placebo (P<0.001). The rates of adverse events were 68% and 55% in the tanezumab and placebo groups, respectively. The most common adverse events among tanezumab-treated patients were headache (9% of the patients), upper respiratory tract infection (7%), and paresthesia (7%). Conclusions In this proof-of-concept study, Treatment with tanezumab was associated with a reduction in joint Pain and improvement in function, with mild and moderate adverse events, among patients with moderate-to-severe osteoarthritis of the knee. (Funded by Rinat Neuroscience; ClinicalTrials.gov number, NCT00394563.)
Mar Hernandez - One of the best experts on this subject based on the ideXlab platform.
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acupuncture in the Treatment of Pain in temporomandibular disorders a systematic review and meta analysis of randomized controlled trials
The Clinical Journal of Pain, 2010Co-Authors: Roy La Touche, Greg Goddard, Jose Luis Delahoz, Kelun Wang, Alba Parisalemany, Santiago Angulodiazparreno, Juan Mesa, Mar HernandezAbstract:OBJECTIVES: The aim of this study is to perform a qualitative and quantitative analysis of the scientific literature regarding the use of acupuncture in the Treatment of Pain associated with temporomandibular disorders (TMDs). METHODS: By using electronic databases, the goal was to search and evaluate all the randomized controlled trials (RCTs) in which acupuncture was used in the management of Pain attributed to these clinical entities. For the meta-analysis, an adequate description of the results' statistical data was required along with a comparison of the Treatment with a control group using a placebo or sham. Two independent reviewers evaluated the quality of the studies using the Jadad scale. RESULTS: A total of 8 RCTs were selected, and the quality of only 4 was considered acceptable. These 4 studies showed positive results such as reducing Pain, improving masticatory function, and increasing maximum interincisal opening. By combining the studies (n=96) and analyzing the results, it was concluded that acupuncture is more effective than placebo in reducing Pain intensity in TMD (standardized mean difference 0.83; 95% confidence interval, 0.41-1.25; P=0.00012). DISCUSSION: The results of this meta-analysis suggest that acupuncture is a reasonable adjunctive Treatment for producing a short-term analgesic effect in patients with Painful TMD symptoms. Although the results described are positive, the relevance of these results was limited by the fact that substantial bias was present. These findings must be confirmed by future RCTs that improve the methodologic deficiencies of the studies evaluated in this meta-analysis.
