The Experts below are selected from a list of 1788 Experts worldwide ranked by ideXlab platform
Osman Hassan Ahmed - One of the best experts on this subject based on the ideXlab platform.
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the smartphone app Rotator Cuff Injury strain by medical irehab
British Journal of Sports Medicine, 2016Co-Authors: Osman Hassan AhmedAbstract:Injury Prevention/Rehabilitation. iOS (3.0 and above), Android (V.1.6 and above). £1.84. Medical iRehab has a number of Injury-specific apps available, including one targeted towards Rotator Cuff Injury. The set-up of this app, in keeping with their other apps, is simple and straightforward. The app gives a general overview of the Injury, and provides information on aspects such as pain control and self-management. A general information section contains some brief discussions of the signs and symptoms of Rotator Cuff injuries. The app is focused towards rehabilitation and as such there is a focus towards conservative treatment, with no mention of surgical options1 for this Injury. There are a wide range of exercises included in this app (figure 1), with examples shown for mobility, strengthening …
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The smartphone app ‘Rotator Cuff Injury/Strain’ by Medical iRehab
British Journal of Sports Medicine, 2015Co-Authors: Osman Hassan AhmedAbstract:Injury Prevention/Rehabilitation. iOS (3.0 and above), Android (V.1.6 and above). £1.84. Medical iRehab has a number of Injury-specific apps available, including one targeted towards Rotator Cuff Injury. The set-up of this app, in keeping with their other apps, is simple and straightforward. The app gives a general overview of the Injury, and provides information on aspects such as pain control and self-management. A general information section contains some brief discussions of the signs and symptoms of Rotator Cuff injuries. The app is focused towards rehabilitation and as such there is a focus towards conservative treatment, with no mention of surgical options1 for this Injury. There are a wide range of exercises included in this app (figure 1), with examples shown for mobility, strengthening …
Judy E. Anderson - One of the best experts on this subject based on the ideXlab platform.
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fibrosis low vascularity and fewer slow fibers after Rotator Cuff Injury
Muscle & Nerve, 2017Co-Authors: Deanna Gigliotti, Mark Chu Xu, Michael J. Davidson, Peter B. Macdonald, Jeff Leiter, Judy E. AndersonAbstract:Introduction: Rotator-Cuff Injury (RCI) represents 50% of shoulder injuries and prevalence increases with age. Even with successful tendon repair, muscle and joint function may not return. Methods: To explain the dysfunction, supraspinatus and ipsilateral deltoid (control) muscles were biopsied during arthroscopic RCI repair for pair-wise histological and protein-expression studies. Results: Supraspinatus showed fiber atrophy (P<0.0001), fibrosis (by Sirius Red, P=0.05), reduced vascular density (P<0.001), and a lower proportion of slow fibers (P<0.0001) compared to the ipsilateral control muscle. Supraspinatus had higher levels of atrogin-1 (P=0.05), vascular endothelial growth factor (VEGF, P<0.01), and dystrophin (P<0.008, relative to fiber diameter) vs. control. Discussion: Adaptive changes in VEGF and dystrophin were likely associated with reduced vascular supply, fatigue resistance, and fibrosis accompanied by disuse atrophy from mechanical unloading of supraspinatus after tendon tear. Treatment to promote growth and vascularity in atrophic supraspinatus muscle may help improve functional outcome after surgical repair. This article is protected by copyright. All rights reserved.
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Fibrosis, low vascularity, and fewer slow fibers after Rotator‐Cuff Injury
Muscle & Nerve, 2017Co-Authors: Deanna Gigliotti, Mark Chu Xu, Michael J. Davidson, Peter B. Macdonald, Jeff Leiter, Judy E. AndersonAbstract:Introduction: Rotator-Cuff Injury (RCI) represents 50% of shoulder injuries and prevalence increases with age. Even with successful tendon repair, muscle and joint function may not return. Methods: To explain the dysfunction, supraspinatus and ipsilateral deltoid (control) muscles were biopsied during arthroscopic RCI repair for pair-wise histological and protein-expression studies. Results: Supraspinatus showed fiber atrophy (P
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altered satellite cell responsiveness and denervation implicated in progression of Rotator Cuff Injury
PLOS ONE, 2016Co-Authors: Deanna Gigliotti, Peter B. Macdonald, Jeff Leiter, Jason Peeler, Judy E. AndersonAbstract:BACKGROUND: Rotator-Cuff Injury (RCI) is common and painful; even after surgery, joint stability and function may not recover. Relative contributions to atrophy from disuse, fibrosis, denervation, and satellite-cell responsiveness to activating stimuli are not known. METHODS AND FINDINGS: Potential contributions of denervation and disrupted satellite cell responses to growth signals were examined in supraspinatus (SS) and control (ipsilateral deltoid) muscles biopsied from participants with RCI (N = 27). Biopsies were prepared for explant culture (to study satellite cell activity), immunostained to localize Pax7, BrdU, and Semaphorin 3A in satellite cells, sectioning to study blood vessel density, and western blotting to measure the fetal (γ) subunit of acetylcholine receptor (γ-AchR). Principal component analysis (PCA) for 35 parameters extracted components identified variables that contributed most to variability in the dataset. γ-AchR was higher in SS than control, indicating denervation. Satellite cells in SS had a low baseline level of activity (Pax7+ cells labelled in S-phase) versus control; only satellite cells in SS showed increased proliferative activity after nitric oxide-donor treatment. Interestingly, satellite cell localization of Semaphorin 3A, a neuro-chemorepellent, was greater in SS (consistent with fiber denervation) than control muscle at baseline. PCAs extracted components including fiber atrophy, satellite cell activity, fibrosis, atrogin-1, smoking status, vascular density, γAchR, and the time between symptoms and surgery. Use of deltoid as a control for SS was supported by PCA findings since "muscle" was not extracted as a variable in the first two principal components. SS muscle in RCI is therefore atrophic, denervated, and fibrotic, and has satellite cells that respond to activating stimuli. CONCLUSIONS: Since SS satellite cells can be activated in culture, a NO-donor drug combined with stretching could promote muscle growth and improve functional outcome after RCI. PCAs suggest indices including satellite cell responsiveness, atrogin-1, atrophy, and innervation may predict surgical outcome.
Deanna Gigliotti - One of the best experts on this subject based on the ideXlab platform.
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fibrosis low vascularity and fewer slow fibers after Rotator Cuff Injury
Muscle & Nerve, 2017Co-Authors: Deanna Gigliotti, Mark Chu Xu, Michael J. Davidson, Peter B. Macdonald, Jeff Leiter, Judy E. AndersonAbstract:Introduction: Rotator-Cuff Injury (RCI) represents 50% of shoulder injuries and prevalence increases with age. Even with successful tendon repair, muscle and joint function may not return. Methods: To explain the dysfunction, supraspinatus and ipsilateral deltoid (control) muscles were biopsied during arthroscopic RCI repair for pair-wise histological and protein-expression studies. Results: Supraspinatus showed fiber atrophy (P<0.0001), fibrosis (by Sirius Red, P=0.05), reduced vascular density (P<0.001), and a lower proportion of slow fibers (P<0.0001) compared to the ipsilateral control muscle. Supraspinatus had higher levels of atrogin-1 (P=0.05), vascular endothelial growth factor (VEGF, P<0.01), and dystrophin (P<0.008, relative to fiber diameter) vs. control. Discussion: Adaptive changes in VEGF and dystrophin were likely associated with reduced vascular supply, fatigue resistance, and fibrosis accompanied by disuse atrophy from mechanical unloading of supraspinatus after tendon tear. Treatment to promote growth and vascularity in atrophic supraspinatus muscle may help improve functional outcome after surgical repair. This article is protected by copyright. All rights reserved.
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Fibrosis, low vascularity, and fewer slow fibers after Rotator‐Cuff Injury
Muscle & Nerve, 2017Co-Authors: Deanna Gigliotti, Mark Chu Xu, Michael J. Davidson, Peter B. Macdonald, Jeff Leiter, Judy E. AndersonAbstract:Introduction: Rotator-Cuff Injury (RCI) represents 50% of shoulder injuries and prevalence increases with age. Even with successful tendon repair, muscle and joint function may not return. Methods: To explain the dysfunction, supraspinatus and ipsilateral deltoid (control) muscles were biopsied during arthroscopic RCI repair for pair-wise histological and protein-expression studies. Results: Supraspinatus showed fiber atrophy (P
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altered satellite cell responsiveness and denervation implicated in progression of Rotator Cuff Injury
PLOS ONE, 2016Co-Authors: Deanna Gigliotti, Peter B. Macdonald, Jeff Leiter, Jason Peeler, Judy E. AndersonAbstract:BACKGROUND: Rotator-Cuff Injury (RCI) is common and painful; even after surgery, joint stability and function may not recover. Relative contributions to atrophy from disuse, fibrosis, denervation, and satellite-cell responsiveness to activating stimuli are not known. METHODS AND FINDINGS: Potential contributions of denervation and disrupted satellite cell responses to growth signals were examined in supraspinatus (SS) and control (ipsilateral deltoid) muscles biopsied from participants with RCI (N = 27). Biopsies were prepared for explant culture (to study satellite cell activity), immunostained to localize Pax7, BrdU, and Semaphorin 3A in satellite cells, sectioning to study blood vessel density, and western blotting to measure the fetal (γ) subunit of acetylcholine receptor (γ-AchR). Principal component analysis (PCA) for 35 parameters extracted components identified variables that contributed most to variability in the dataset. γ-AchR was higher in SS than control, indicating denervation. Satellite cells in SS had a low baseline level of activity (Pax7+ cells labelled in S-phase) versus control; only satellite cells in SS showed increased proliferative activity after nitric oxide-donor treatment. Interestingly, satellite cell localization of Semaphorin 3A, a neuro-chemorepellent, was greater in SS (consistent with fiber denervation) than control muscle at baseline. PCAs extracted components including fiber atrophy, satellite cell activity, fibrosis, atrogin-1, smoking status, vascular density, γAchR, and the time between symptoms and surgery. Use of deltoid as a control for SS was supported by PCA findings since "muscle" was not extracted as a variable in the first two principal components. SS muscle in RCI is therefore atrophic, denervated, and fibrotic, and has satellite cells that respond to activating stimuli. CONCLUSIONS: Since SS satellite cells can be activated in culture, a NO-donor drug combined with stretching could promote muscle growth and improve functional outcome after RCI. PCAs suggest indices including satellite cell responsiveness, atrogin-1, atrophy, and innervation may predict surgical outcome.
Lyle J. Micheli - One of the best experts on this subject based on the ideXlab platform.
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Upper Extremity Injuries in the Paediatric Athlete
Sports Medicine, 2000Co-Authors: Mininder S. Kocher, Peter M. Waters, Lyle J. MicheliAbstract:Injuries to the upper extremity in paediatric and adolescent athletes are increasingly being seen with expanded participation and higher competitive levels of youth sports. Injury patterns are unique to the growing musculoskeletal system and specific to the demands of the involved sport. Shoulder injuries include sternoclavicular joint Injury, clavicle fracture, acromioclavicular joint Injury, osteolysis of the distal clavicle, little league shoulder, proximal humerus fracture, glenohumeral instability and Rotator Cuff Injury. Elbow injuries include supracondylar fracture, lateral condyle fracture, radial head/neck fracture, medial epicondyle avulsion, elbow dislocation and little league elbow. Wrist and hand injuries include distal radius fracture, distal radial physeal Injury, triangular fibrocartilage tear, scaphoid fracture, wrist ligamentous Injury thumb metacarpalphalangeal ulnar collateral ligament Injury, proximal and distal interphalangeal joint injuries and finger fractures. Recognition of Injury patterns with early activity modification and the initiation of efficacious treatment can prevent deformity/disability and return the youth athlete to sport.
Jeff Leiter - One of the best experts on this subject based on the ideXlab platform.
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fibrosis low vascularity and fewer slow fibers after Rotator Cuff Injury
Muscle & Nerve, 2017Co-Authors: Deanna Gigliotti, Mark Chu Xu, Michael J. Davidson, Peter B. Macdonald, Jeff Leiter, Judy E. AndersonAbstract:Introduction: Rotator-Cuff Injury (RCI) represents 50% of shoulder injuries and prevalence increases with age. Even with successful tendon repair, muscle and joint function may not return. Methods: To explain the dysfunction, supraspinatus and ipsilateral deltoid (control) muscles were biopsied during arthroscopic RCI repair for pair-wise histological and protein-expression studies. Results: Supraspinatus showed fiber atrophy (P<0.0001), fibrosis (by Sirius Red, P=0.05), reduced vascular density (P<0.001), and a lower proportion of slow fibers (P<0.0001) compared to the ipsilateral control muscle. Supraspinatus had higher levels of atrogin-1 (P=0.05), vascular endothelial growth factor (VEGF, P<0.01), and dystrophin (P<0.008, relative to fiber diameter) vs. control. Discussion: Adaptive changes in VEGF and dystrophin were likely associated with reduced vascular supply, fatigue resistance, and fibrosis accompanied by disuse atrophy from mechanical unloading of supraspinatus after tendon tear. Treatment to promote growth and vascularity in atrophic supraspinatus muscle may help improve functional outcome after surgical repair. This article is protected by copyright. All rights reserved.
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Fibrosis, low vascularity, and fewer slow fibers after Rotator‐Cuff Injury
Muscle & Nerve, 2017Co-Authors: Deanna Gigliotti, Mark Chu Xu, Michael J. Davidson, Peter B. Macdonald, Jeff Leiter, Judy E. AndersonAbstract:Introduction: Rotator-Cuff Injury (RCI) represents 50% of shoulder injuries and prevalence increases with age. Even with successful tendon repair, muscle and joint function may not return. Methods: To explain the dysfunction, supraspinatus and ipsilateral deltoid (control) muscles were biopsied during arthroscopic RCI repair for pair-wise histological and protein-expression studies. Results: Supraspinatus showed fiber atrophy (P
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altered satellite cell responsiveness and denervation implicated in progression of Rotator Cuff Injury
PLOS ONE, 2016Co-Authors: Deanna Gigliotti, Peter B. Macdonald, Jeff Leiter, Jason Peeler, Judy E. AndersonAbstract:BACKGROUND: Rotator-Cuff Injury (RCI) is common and painful; even after surgery, joint stability and function may not recover. Relative contributions to atrophy from disuse, fibrosis, denervation, and satellite-cell responsiveness to activating stimuli are not known. METHODS AND FINDINGS: Potential contributions of denervation and disrupted satellite cell responses to growth signals were examined in supraspinatus (SS) and control (ipsilateral deltoid) muscles biopsied from participants with RCI (N = 27). Biopsies were prepared for explant culture (to study satellite cell activity), immunostained to localize Pax7, BrdU, and Semaphorin 3A in satellite cells, sectioning to study blood vessel density, and western blotting to measure the fetal (γ) subunit of acetylcholine receptor (γ-AchR). Principal component analysis (PCA) for 35 parameters extracted components identified variables that contributed most to variability in the dataset. γ-AchR was higher in SS than control, indicating denervation. Satellite cells in SS had a low baseline level of activity (Pax7+ cells labelled in S-phase) versus control; only satellite cells in SS showed increased proliferative activity after nitric oxide-donor treatment. Interestingly, satellite cell localization of Semaphorin 3A, a neuro-chemorepellent, was greater in SS (consistent with fiber denervation) than control muscle at baseline. PCAs extracted components including fiber atrophy, satellite cell activity, fibrosis, atrogin-1, smoking status, vascular density, γAchR, and the time between symptoms and surgery. Use of deltoid as a control for SS was supported by PCA findings since "muscle" was not extracted as a variable in the first two principal components. SS muscle in RCI is therefore atrophic, denervated, and fibrotic, and has satellite cells that respond to activating stimuli. CONCLUSIONS: Since SS satellite cells can be activated in culture, a NO-donor drug combined with stretching could promote muscle growth and improve functional outcome after RCI. PCAs suggest indices including satellite cell responsiveness, atrogin-1, atrophy, and innervation may predict surgical outcome.
