The Experts below are selected from a list of 201 Experts worldwide ranked by ideXlab platform
Joop M. Grevelink - One of the best experts on this subject based on the ideXlab platform.
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Treatment of benign and atypical nevi with the normal-mode Ruby Laser and the Q-switched Ruby Laser: clinical improvement but failure to completely eliminate nevomelanocytes.
Archives of dermatology, 1999Co-Authors: Daniella Duke, R. Rox Anderson, H. Randolph Byers, Arthur J. Sober, Joop M. GrevelinkAbstract:Objective To evaluate the effect of normal-mode and Q-switched Ruby Laser light (694 nm) on nevomelanocytes of benign, atypical, and congenital nevi. Design Half of the lesion of each of 31 nevi was treated with either the Q-switched Ruby Laser or the normal-mode Ruby Laser or both; the other half of the lesion was covered with aluminum foil and was not treated. Setting A university-affiliated, hospital-based Laser center. Patients Sixteen patients with a total of 31 melanocytic nevi were enrolled in the study. Interventions All nevi were evaluated by at least 2 dermatologists to assess the degree of clinical atypia. Photographs were taken before and immediately after treatment and at each follow-up visit. The digital imaging system was used to evaluate the number of melanocytes in a measured length of basement membrane zone. Main Outcome Measure Three individual readings (number of melanocytes per unit length) were taken on both the control and treated halves and then compared to quantitate treatment effect. All analyses used averages from 3 measurements. A Student paired t test was used to compare the treated and untreated sides. Results Sixteen (52%) of the nevi showed a clinically visible decrease in pigment on the treatment side at the 4-week follow-up visit. Conclusion No lesions had complete histologic removal of all nevomelanocytes. Therefore, 1 or 2 Laser treatments are not sufficient to cause complete removal of a lesion either clinically or histologically.
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Treatment of small nevomelanocytic nevi with a Q-switched Ruby Laser
Journal of the American Academy of Dermatology, 1997Co-Authors: Chitralada Vibhagool, H. Randolph Byers, Joop M. GrevelinkAbstract:Background: Small nevomelanocytic nevi are common and some are of cosmetic concern. Conventional therapy may cause a scar or permanent hypopigmentation. Objective: Our purpose was to determine whether selective photothermolysis of pigmented cells by Q-switched Ruby Laser treatment removes small nevomelanocytic nevi in a nonscarring fashion. Methods: Twelve patients with 18 small nevomelanocytic nevi were treated with a Q-switched Ruby Laser (694 nm, 28 nsec) at fluences of 8 J/cm 2 . Biopsy specimens were obtained after treatment at varying time intervals. Results: Twelve lesions (67%) showed a complete response and six lesions (33%) had a partial response. The only adverse sequela observed was mild fibrosis of the papillary dermis, without loss of papillary architecture. Conclusion: The Q-switched Ruby Laser is effective in removing small melanocytic nevi. However, some might recur depending on the depth of the nevomelanocytic nests.
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Treatment of small nevomelanocytic nevi with a Q-switched Ruby Laser.
Journal of the American Academy of Dermatology, 1997Co-Authors: Chitralada Vibhagool, H. Randolph Byers, Joop M. GrevelinkAbstract:Small nevomelanocytic nevi are common and some are of cosmetic concern. Conventional therapy may cause a scar or permanent hypopigmentation. Our purpose was to determine whether selective photothermolysis of pigmented cells by Q-switched Ruby Laser treatment removes small nevomelanocytic nevi in a nonscarring fashion. Twelve patients with 18 small nevomelanocytic nevi were treated with a Q-switched Ruby Laser (694 nm, 28 nsec) at fluences of 8 J/cm2. Biopsy specimens were obtained after treatment at varying time intervals. Twelve lesions (67%) showed a complete response and six lesions (33%) had a partial response. The only adverse sequela observed was mild fibrosis of the papillary dermis, without loss of papillary architecture. The Q-switched Ruby Laser is effective in removing small melanocytic nevi. However, some might recur depending on the depth of the nevomelanocytic nests.
Chitralada Vibhagool - One of the best experts on this subject based on the ideXlab platform.
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Treatment of small nevomelanocytic nevi with a Q-switched Ruby Laser
Journal of the American Academy of Dermatology, 1997Co-Authors: Chitralada Vibhagool, H. Randolph Byers, Joop M. GrevelinkAbstract:Background: Small nevomelanocytic nevi are common and some are of cosmetic concern. Conventional therapy may cause a scar or permanent hypopigmentation. Objective: Our purpose was to determine whether selective photothermolysis of pigmented cells by Q-switched Ruby Laser treatment removes small nevomelanocytic nevi in a nonscarring fashion. Methods: Twelve patients with 18 small nevomelanocytic nevi were treated with a Q-switched Ruby Laser (694 nm, 28 nsec) at fluences of 8 J/cm 2 . Biopsy specimens were obtained after treatment at varying time intervals. Results: Twelve lesions (67%) showed a complete response and six lesions (33%) had a partial response. The only adverse sequela observed was mild fibrosis of the papillary dermis, without loss of papillary architecture. Conclusion: The Q-switched Ruby Laser is effective in removing small melanocytic nevi. However, some might recur depending on the depth of the nevomelanocytic nests.
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Treatment of small nevomelanocytic nevi with a Q-switched Ruby Laser.
Journal of the American Academy of Dermatology, 1997Co-Authors: Chitralada Vibhagool, H. Randolph Byers, Joop M. GrevelinkAbstract:Small nevomelanocytic nevi are common and some are of cosmetic concern. Conventional therapy may cause a scar or permanent hypopigmentation. Our purpose was to determine whether selective photothermolysis of pigmented cells by Q-switched Ruby Laser treatment removes small nevomelanocytic nevi in a nonscarring fashion. Twelve patients with 18 small nevomelanocytic nevi were treated with a Q-switched Ruby Laser (694 nm, 28 nsec) at fluences of 8 J/cm2. Biopsy specimens were obtained after treatment at varying time intervals. Twelve lesions (67%) showed a complete response and six lesions (33%) had a partial response. The only adverse sequela observed was mild fibrosis of the papillary dermis, without loss of papillary architecture. The Q-switched Ruby Laser is effective in removing small melanocytic nevi. However, some might recur depending on the depth of the nevomelanocytic nests.
H. Randolph Byers - One of the best experts on this subject based on the ideXlab platform.
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Treatment of benign and atypical nevi with the normal-mode Ruby Laser and the Q-switched Ruby Laser: clinical improvement but failure to completely eliminate nevomelanocytes.
Archives of dermatology, 1999Co-Authors: Daniella Duke, R. Rox Anderson, H. Randolph Byers, Arthur J. Sober, Joop M. GrevelinkAbstract:Objective To evaluate the effect of normal-mode and Q-switched Ruby Laser light (694 nm) on nevomelanocytes of benign, atypical, and congenital nevi. Design Half of the lesion of each of 31 nevi was treated with either the Q-switched Ruby Laser or the normal-mode Ruby Laser or both; the other half of the lesion was covered with aluminum foil and was not treated. Setting A university-affiliated, hospital-based Laser center. Patients Sixteen patients with a total of 31 melanocytic nevi were enrolled in the study. Interventions All nevi were evaluated by at least 2 dermatologists to assess the degree of clinical atypia. Photographs were taken before and immediately after treatment and at each follow-up visit. The digital imaging system was used to evaluate the number of melanocytes in a measured length of basement membrane zone. Main Outcome Measure Three individual readings (number of melanocytes per unit length) were taken on both the control and treated halves and then compared to quantitate treatment effect. All analyses used averages from 3 measurements. A Student paired t test was used to compare the treated and untreated sides. Results Sixteen (52%) of the nevi showed a clinically visible decrease in pigment on the treatment side at the 4-week follow-up visit. Conclusion No lesions had complete histologic removal of all nevomelanocytes. Therefore, 1 or 2 Laser treatments are not sufficient to cause complete removal of a lesion either clinically or histologically.
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Treatment of small nevomelanocytic nevi with a Q-switched Ruby Laser
Journal of the American Academy of Dermatology, 1997Co-Authors: Chitralada Vibhagool, H. Randolph Byers, Joop M. GrevelinkAbstract:Background: Small nevomelanocytic nevi are common and some are of cosmetic concern. Conventional therapy may cause a scar or permanent hypopigmentation. Objective: Our purpose was to determine whether selective photothermolysis of pigmented cells by Q-switched Ruby Laser treatment removes small nevomelanocytic nevi in a nonscarring fashion. Methods: Twelve patients with 18 small nevomelanocytic nevi were treated with a Q-switched Ruby Laser (694 nm, 28 nsec) at fluences of 8 J/cm 2 . Biopsy specimens were obtained after treatment at varying time intervals. Results: Twelve lesions (67%) showed a complete response and six lesions (33%) had a partial response. The only adverse sequela observed was mild fibrosis of the papillary dermis, without loss of papillary architecture. Conclusion: The Q-switched Ruby Laser is effective in removing small melanocytic nevi. However, some might recur depending on the depth of the nevomelanocytic nests.
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Treatment of small nevomelanocytic nevi with a Q-switched Ruby Laser.
Journal of the American Academy of Dermatology, 1997Co-Authors: Chitralada Vibhagool, H. Randolph Byers, Joop M. GrevelinkAbstract:Small nevomelanocytic nevi are common and some are of cosmetic concern. Conventional therapy may cause a scar or permanent hypopigmentation. Our purpose was to determine whether selective photothermolysis of pigmented cells by Q-switched Ruby Laser treatment removes small nevomelanocytic nevi in a nonscarring fashion. Twelve patients with 18 small nevomelanocytic nevi were treated with a Q-switched Ruby Laser (694 nm, 28 nsec) at fluences of 8 J/cm2. Biopsy specimens were obtained after treatment at varying time intervals. Twelve lesions (67%) showed a complete response and six lesions (33%) had a partial response. The only adverse sequela observed was mild fibrosis of the papillary dermis, without loss of papillary architecture. The Q-switched Ruby Laser is effective in removing small melanocytic nevi. However, some might recur depending on the depth of the nevomelanocytic nests.
Roy G. Geronemus - One of the best experts on this subject based on the ideXlab platform.
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tattoo formation from absorbable synthetic suture and successful removal with q switched Ruby Laser
Dermatologic Surgery, 1996Co-Authors: Leonard J Bernstein, David A Palaia, David Bank, Roy G. GeronemusAbstract:background Traumatic tattoos result from accidental or unintentional deposition of exogenous pigment within injured skin. Pigments may consist of heavy metals, vegetable matter, or commercial dyes. objective The clinical and histologic description of a traumatic tattoo resulting from a surgical procedure using undyed, braided, synthetic, absorbable suture material and its removal with the Q-switched Ruby Laser (694 nm, 28 nsec). methods The pigmented linear lesion was biopsied and processed using standard histological methods. Subsequently, the area was treated on two occasions with the Q-switched Ruby Laser. results The pigmented lesion was completely removed with the Q-switched Laser treatments. conclusion We report on the occurrence of a traumatic tattoo resulting from synthetic suture material and complete removal with the Q-switched Ruby Laser.
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Treatment of Small and Medium Congenital Nevi With the Q-Switched Ruby Laser
Archives of dermatology, 1996Co-Authors: Heidi A Waldorf, Arielle N.b. Kauvar, Roy G. GeronemusAbstract:Background: The Q-switched Ruby Laser has been used successfully to treat a variety of benign pigmented lesions. In this study, congenital nevi (diameter, ≤5 cm) in 18 prepubertal children were treated with the Q-switched Ruby Laser. Observations: Photographic evaluation revealed an average of 57% clearance of pigmentation in all treated nevi by the fourth treatment session and an average maximum clearance of 76% after approximately eight sessions. Greater than 90% clearance of pigment was attained in five patients. Partial repigmentation was seen in all patients who were followed up after discontinuation of therapy. Findings from histopathologic studies, obtained from one patient, revealed a reduction of nevus cells in the papillary dermis and upper reticular dermis that correlated with clinical lightening. There was no such reduction in the lower reticular dermis. Side effects were limited to transient erythema and hypopigmentation. Conclusions: The Q-switched Ruby Laser effectively lightens and may clear pigmentation and eliminate superficial nevus cells from small and medium congenital nevi safely without scarring. However, these results are not permanent. The Q-switched Ruby Laser may be a viable alternative for providing cosmetic improvement for unresectable lesions, but it should not be considered definitive treatment. Additional studies are needed to address the long-term results of this therapy. (Arch Dermatol. 1996;132:301-304)
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Treatment of small and medium congenital nevi with the Q-switched Ruby Laser
1996Co-Authors: Heidi A Waldorf, Arielle N.b. Kauvar, Roy G. GeronemusAbstract:Background : The Q-switched Ruby Laser has been used successfully to treat a variety of benign pigmented lesions. In this study, congenital nevi (diameter, ≤5 cm) in 18 prepubertal children were treated with the Q-switched Ruby Laser. Observations : Photographic evaluation revealed an average of 57% clearance of pigmentation in all treated nevi by the fourth treatment session and an average maximum clearance of 76% after approximately eight sessions. Greater than 90% clearance of pigment was attained in five patients. Partial repigmentation was seen in all patients who were followed up after discontinuation of therapy. Findings from histopathologic studies, obtained from one patient, revealed a reduction of nevus cells in the papillary dermis and upper reticular dermis that correlated with clinical lightening. There was no such reduction in the lower reticular dermis. Side effects were limited to transient erythema and hypopigmentation. Conclusions : The Q-switched Ruby Laser effectively lightens and may clear pigmentation and eliminate superficial nevus cells from small and medium congenital nevi safely without scarring. However, these results are not permanent. The Q-switched Ruby Laser may be a viable alternative for providing cosmetic improvement for unresectable lesions, but it should not be considered definitive treatment. Additional studies are needed to address the long-term results of this therapy.
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Q-switched Ruby Laser treatment of labial lentigos
Journal of the American Academy of Dermatology, 1992Co-Authors: Robin Ashinoff, Roy G. GeronemusAbstract:The Q-switched Ruby Laser causes selective damage to pigmented cells in the skin. This Laser, which has a wavelength of 694 nm and a pulse duration of 40 nsec, has shown very promising results in the treatment of both amateur and professional tattoos. Less data are available on its ability to treat benign pigmented lesions of the skin. Three patients who had labial lentigos were treated with the Q-switched Ruby Laser, and dramatic clearing occurred after one or two treatments with a fluence of 10 J/cm 2 .
Claire Linge - One of the best experts on this subject based on the ideXlab platform.
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A review of the Ruby Laser with reference to hair depilation.
Annals of plastic surgery, 2000Co-Authors: Adam Topping, David Gault, Claire Linge, Addie Grobbelaar, Roy SandersAbstract:There is a clinical need in the fields of reconstructive and cosmetic plastic surgery for a safe, simple, and effective method of hair depilation. Depilatory clinics have been established throughout the country, commonly using the Ruby Laser, to treat a cohort of the population, estimated to be between 6% and 10%, recognized as being hirsute. Clinical trials performed to date have not established a protocol that suits the previously mentioned criteria and have been, usually, small in number and short in follow-up. With the increased use that this form of Laser treatment will inevitably undergo, it is the belief of the authors that the only way of ascertaining whether the treatment is safe, simple, and effective is first to establish how the Ruby Laser works. This review relates the knowledge that is currently available regarding the function of the Ruby Laser to a number of the clinical studies that have been undertaken, including three that have used other types of Laser. Using this information, future areas in which research is required can be defined, ultimately to improve the clinical efficacy of Ruby Laser-assisted hair removal while lessening the current side effects (namely, superficial burning, and hypo- and hyperpigmentation).
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Ruby Laser assisted hair removal reduces the coarseness of regrowing hairs fallacy or fact
British Journal of Plastic Surgery, 1999Co-Authors: Se H Liew, David Gault, C. Green, Addie Grobbelaar, K Ladhani, R Sanders, Claire LingeAbstract:There have been anecdotal reports that hairs that regrow after Ruby Laser-assisted hair removal are finer in appearance. If true, this phenomenon adds to the improved aesthetic effect of Laser treatment of unwanted hair. It is the aim of this study to determine whether this phenomenon indeed occurs, and if so, assess its permanence and its mode of action. In this prospective clinical study, 71 patients with 94 treatment sites were treated with the Chromos 694 Depilation Ruby Laser. Hair diameter was measured pre-treatment, and at 3 and 7 months post-treatment. In addition, ex vivo scalp skin was used to assess if the Ruby Laser selectively damaged coarser hairs. Laser-treated and matched untreated skin samples were histologically assessed and the diameters of hair shafts (normal or obviously damaged) were measured. Results of this study were analysed using Kruskal-Wallis one-way analysis. There was no statistically significant difference between the hair diameter of non-Lasered specimens and the hair diameter of the normal hair in Lasered specimens. However, a statistically significant difference was seen between the hair diameter of non-Lasered specimens and diameters of damaged hair in Lasered specimens (P < 0.05). There was a statistically significant difference (P < 0.05) between pre-treatment and 3 month hair diameters, but no statistically significant difference was found between pre-treatment and 7 month hair diameters. In conclusion, Ruby Laser-assisted hair removal results in a temporary reduction in hair diameter of regrowing hair. This is not due to the selective targeting of larger hair follicles.
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Ruby Laser-assisted hair removal: an ultrastructural evaluation of cutaneous damage.
British journal of plastic surgery, 1999Co-Authors: H. Liew, R. Cerio, P. Sarathchandra, Adriaan O. Grobbelaar, David Gault, Roy Sanders, C. Green, Claire LingeAbstract:Ruby Laser-assisted hair removal is thought to act via selective photothermolysis of melanin in the hair follicles. Although initial clinical trials of permanent hair removal using Ruby Lasers are promising, the exact mechanisms of hair destruction and the potential damage to other structures of skin are not known. The aim of this study was to evaluate the cutaneous ultrastructural changes following Ruby Laser hair removal. Nineteen healthy Caucasian patients with dark (brown/black) hair were treated with the Ruby Laser and biopsies taken after 0, 2, 3, 5, 7, 14 and 21 days. Specimens were examined by light and electron microscopy. Laser-treated specimens showed widespread coagulation and charring of subcutaneous hair shafts. These obviously damaged follicles were randomly dispersed amongst intact follicles within the same treatment sites. Microscopic changes were also seen in the basal epidermis where melanin was concentrated, irrespective of any obvious macroscopic damage. A low level of inflammatory response seen up to 2 weeks after treatment always followed Laser treatment. Suprabasal epidermal necrosis was only seen in patients with blister formation after treatment. Ruby Laser irradiation results in selective damage to the hair follicles, with microscopic changes to the basal epidermis. The damage is probably compounded by the inflammatory response to the damaged hair. The normal appearance and distribution of collagen in the dermal layer supported the clinical evidence that Laser-assisted hair removal, if performed correctly, does not lead to scar formation.
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The effect of Ruby Laser light on ex vivo hair follicles : Clinical implications
Annals of plastic surgery, 1999Co-Authors: H. Liew, David Gault, Roy Sanders, Addie Grobbelaar, Colin J. Green, Claire LingeAbstract:Several clinical studies on the efficacy of Ruby Laser-assisted hair removal have reported that regrowth of hair after treatment is common. One of the reasons for the regrowth of hair is the incomplete destruction of germinative hair cells due to the insufficient penetration of the Ruby Laser in the skin. It was the aim of this study to estimate the extent of damage to the hair follicles after one Ruby Laser treatment and to determine whether the Ruby Laser destroyed the bulbs and the bulge regions of hair follicles. The extent of Laser damage in hair shafts was determined by serial examination of six specimens of ex vivo scalp skin Lasered with the Chromos 694 Depilation Ruby Laser at 14 J per square centimeter and 20 J per square centimeter. Another nine specimens of ex vivo scalp skin were similarly Lasered, and monoclonal antibody LP2K was used to identify the bulge regions of the hair follicles using the immunoperoxidase technique. Damage to the bulge region was assessed from consecutive specimens, which were stained with hematoxylin-eosin stain. The mean depth of Laser damage sustained by hair follicles was 1.34 mm (14 J per square centimeter) and 1.49 mm (20 J per square centimeter) underneath the skin surface. Most of the Laser damage involved the bulge regions but fell short of the hair bulbs. The Laser damage did not seem to extend far enough down the hair shafts to result in permanent hair destruction. The clinical implications of this finding are discussed.
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The effect of Ruby Laser light on cellular proliferation of epidermal cells.
Annals of plastic surgery, 1999Co-Authors: H. Liew, David Gault, Addie Grobbelaar, Colin J. Green, Claire LingeAbstract:In Ruby Laser-assisted hair removal, microscopic damage is often seen in the basal epidermal cells, where melanosomes are concentrated. It is not known whether this treatment leads to cellular hyperproliferation. It was the aim of this study to investigate this. Ten white patients were treated with the Chromos 694-nm Depilation Ruby Laser, and biopsies taken before and after treatments to assess the presence of cell hyperproliferation, which normally accompanies epidermal damage, with immunohistochemical staining of keratin 16 and Ki67. No evidence of cell hyperproliferation was seen in all specimens examined after Ruby Laser irradiation. The authors conclude that despite the possible microscopic damages seen in the basal epidermis after Laser hair removal, there is no evidence of cellular hyperproliferation. This is in contrast to ultraviolet-irradiated cell damage, in which increased basal cell turnover is seen.
