The Experts below are selected from a list of 2445 Experts worldwide ranked by ideXlab platform
Hansung Jung - One of the best experts on this subject based on the ideXlab platform.
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shh signaling is essential for Rugae morphogenesis in mice
Histochemistry and Cell Biology, 2011Co-Authors: Seita Miyazawa, Jeongoh Shin, Hyukjae Kwon, Daewoon Kang, Byungjai Choi, Shigeru Kondo, Hansung JungAbstract:Palatal ridges, or Rugae palatinae, are corrugated structures observed in the hard palate region. They are found in most mammalian species, but their number and arrangement are species-specific. Nine palatal Rugae are found in the mouse secondary palate. Previous studies have shown that epithelial Shh signaling in the palatal ridge plays an important role during Rugae development. Moreover, Wnt family members, including LEF1, play a functional role in orofacial morphogenesis. To explore the function of Shh during Rugae development, we utilized the maternal transfer of 5E1 (anti-Shh antibody) to mouse embryos. 5E1 induced abnormal Rugae patterning characterized by a spotted shape of palatal ridge rather than a stripe. The expression patterns of Shh and Shh-related genes, Sostdc1, Lef1 and Ptch1, were disrupted following 5E1 injection. Moreover, Rugae-specific cell proliferation and inter-Rugae-specific apoptosis were affected by inhibition of Shh signaling. We hypothesize that the altered gene expression patterns and the change in molecular events caused by the inhibition of Shh signaling may have induced abnormal Rugae patterning. Furthermore, we propose a reaction–diffusion model generated by Wnt, Shh and Sostdc1 signaling. In this study, we show that Sostdc1, a secreted inhibitor of the Wnt pathway, is a downstream target of Shh and hypothesize that the interaction of Wnt, Shh and Sostdc1 is a pivotal mechanism controlling the spatial patterning of palatal Rugae.
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importance of region specific epithelial rearrangements in mouse Rugae development
Cell and Tissue Research, 2011Co-Authors: Wernjoo Sohn, Hitoshi Yamamoto, Hongin Shin, Zae Young Ryoo, Hansung JungAbstract:Epithelial appendages on palatal Rugae develop during mouse palatogenesis through epithelial thickening and pattern formation. Recently, the patterned formation of nine Rugae was observed together with the specific expression patterns of Shh in rodents. However, no crucial evidence was found for a direct association between Shh expression and the distinct structural formation of Rugae. In order to reveal possible relationships, we investigated the morphological changes of Rugae and expression patterns of Shh directly by in vitro organ culture at embryonic day 13 (E13) for 2 days. To compare and examine the diverse growing aspects of the palate and Rugae, we carefully observed the detailed morphogenesis, with cell proliferation of the Rugae occurring between E13 and E14.5. After 2 days of cultivation at E13, DiI micro-injections revealed that the middle part of the palate, adjacent to the upper molar-forming region, contributed to the formation of the subsequent structure of Rugae by extensive cell rearrangement and proliferation within the epithelium in the preferred anteroposterior direction. The results also defined the intimate relationship between Shh expression and Rugae formation.
A Hamid - One of the best experts on this subject based on the ideXlab platform.
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morphological study of Rugae palatinae in sudanese nubians
Folia Morphologica, 2015Co-Authors: Altayeb Abdalla Ahmed, A HamidAbstract:Background: The aim of this study was to identify and compare the various morphological characteristics of Rugae palatinae in males and females of adult Sudanese Nubians and to assess the existence of side asymmetry. Furthermore, the possibility of assigning sex utilising dimensions, shapes, and orientations was explored using logistic regression. Materials and methods: In all, 100 maxillary casts were equally distributed between the sexes. All subjects belonged to a similar age group, ranging from 18 to 23 years of age, and were examined for Rugae palatinae dimensions, shapes, and orientations for the purpose of assessing sexual dimorphism and side symmetry. Results: The most dominant were the primary Rugae, and the most prevalent shapes were the wavy, curved, and straight in both sexes. The dominant direction of Rugae was the forward-directed. Furthermore, while there was no sexual dimorphism in Rugae orientation, primary Rugae and converging unified Rugae exhibited significant differences between the sexes. Significant asymmetry was observed in females’ primary and wavy shaped Rugae, a diverging unified shaped was found in males, and forward- and backward-directed Rugae were found in both sexes. Conclusions: This study provided reference data regarding the Rugae palatinae morphology among Sudanese population. A predictive value of 60% was obtained when assigning sex using dimensions and orientations, and a predictive value of 65% was determined when using only shapes. Accordingly, using the Rugae palatinae to accurately estimate sex among Sudanese Nubians is not recommended unless it is the only means available.
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morphological study of palatal Rugae in a sudanese population
International Journal of Dentistry, 2015Co-Authors: Altayeb Abdalla Ahmed, A HamidAbstract:Palatal Rugae patterns have unique characteristics and have been proposed as an alternative method to establish identity when other means, such as fingerprints and dental records, are not attainable. This study was conducted to determine the morphological characteristics of palatine Rugae and to assess the existence of side asymmetry in them in Sudanese Arabs. It also assesses the possibility of determining sex using logistic regression. One hundred dental casts for 50 males and 50 females aged between 18 and 23 were studied for palatal Rugae dimensions, shapes, and orientations, as well as sexual dimorphism and side symmetry. The most predominant Rugae were primary, and the most prevalent shapes in both sexes were wavy, curved, and straight forms. The predominant orientation was forward. Side asymmetry existed more in the orientations than in the shapes, but no side asymmetry was recorded in the dimensions. There was no significant sexual dimorphism in the Rugae dimensions, shapes, and orientations, except for forward-directed Rugae (P < 0.037). A predictive value of 60% was obtained in assigning sex using dimensions and orientations and of 58% using shapes alone. Therefore, the palatal Rugae are not recommended for assigning sex effectively among Sudanese Arabs unless it is the only means available.
K Premalatha - One of the best experts on this subject based on the ideXlab platform.
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study of palatal Rugae pattern among the student population in mangalore
Journal of Indian Academy of Forensic Medicine, 2011Co-Authors: Mahabalesh Shetty, K PremalathaAbstract:Human identification is one of the most challenging tasks in Forensic identification. In mass disasters dental records, fingerprints and DNA comparisons are probably the most used techniques. However these techniques cannot be applied always. In some cases, it is necessary to apply different and less known techniques like Rugoscopy. The purpose of this study is to determine any gender difference in palatal Rugae pattern. In this study100 subjects were randomly selected comprising 50 males and 50 females of age ranging from 17 to 25 years of student population belonging to Mangalore. The Rugae pattern were assessed by applying Thomas & Kotze classification. Association between Rugae forms and gender were tested using student unpaired T test. Gender wise, there were no significant differences in the total number of Rugae. The incidence of curved,straight and forwardly directed Rugae were more among females than males, while that of wavy,perpendicular and backwardly directed Rugae were more among males. This study clearly demonstrates the gender difference and uniqueness of Rugae pattern in different individuals. Thus it is a reliable source of identification.
N Telagi - One of the best experts on this subject based on the ideXlab platform.
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palatoscopy an adjunct to forensic odontology a comparative study among five different populations of india
Journal of natural science biology and medicine, 2014Co-Authors: Aditi Amit Byatnal, A R Kiran, Y Samata, Y Guruprasad, N TelagiAbstract:Objectives: This study was conducted to analyze and identify differences in the palatal Rugae patterns and to identify gender wise changes in the palatal Rugae shapes in populations of five different states of India. Study Design: Study was conducted in five different Indian states. 500 sample subjects from Andhra Pradesh, Tamil Nadu, Karnataka, Madhya Pradesh and Maharashtra were included. Rugae patterns with predominant shapes were analyzed and categorized according to different states and both genders, data was statistically analyzed using SPSS software 15.0 and the results were obtained by Chi-square analysis. Results: Wavy type of palatal Rugae pattern is the most predominant variant in five different study groups in both the genders. Conclusion: This study could identify variations in distribution of various palatal Rugae pattern in five different states and confirmed the wavy type of palatal Rugae patterns to be the most predominant variant in five different study groups.
Andamuthu Yamunadevi - One of the best experts on this subject based on the ideXlab platform.
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dimensional and morphological analysis of various Rugae patterns in kerala south india sample population a cross sectional study
Journal of natural science biology and medicine, 2015Co-Authors: M Selvamani, Shilpa Hosallimath, Praveen S Basandi, Andamuthu YamunadeviAbstract:Background: Analysis of palatal Rugae patterns, which are similar to fingerprints, is one of the techniques used in forensic sciences for human identification. As palatal Rugae patterns are genetically determined, they can also be used in population differentiation and gender determination. Hence, we aimed to record the distribution of the predominant Rugae pattern in Kerala population. Materials and Methods: A total of 100 maxillary study models (40 males and 60 females) recorded from Kerala population within the age group of 17-25 years were analyzed. The dental casts were examined for the interpretation of the total number, length, shape, location and unification of Rugae. Chi-square test and unpaired t -test were employed for statistical analysis. Result: The total number of Rugae was significantly ( P Conclusion: The palatal Rugae and their features of an individual may be considered as a reliable guide for identification purpose, provided antemortem casts are available. Nevertheless, gender differentiation is evident in terms of number and shape of Rugae.
