Salacia

14,000,000 Leading Edge Experts on the ideXlab platform

Scan Science and Technology

Contact Leading Edge Experts & Companies

Scan Science and Technology

Contact Leading Edge Experts & Companies

The Experts below are selected from a list of 981 Experts worldwide ranked by ideXlab platform

Osamu Muraoka - One of the best experts on this subject based on the ideXlab platform.

  • A review of antidiabetic active thiosugar sulfoniums, salacinol and neokotalanol, from plants of the genus Salacia
    Journal of Natural Medicines, 2021
    Co-Authors: Toshio Morikawa, Genzoh Tanabe, Masayuki Yoshikawa, Hisashi Matsuda, Kiyofumi Ninomiya, Osamu Muraoka
    Abstract:

    During our studies characterizing functional substances from food resources for the prevention and treatment of lifestyle-related diseases, we isolated the active constituents, salacinol ( 1 ) and neokotalanol ( 4 ), and related thiosugar sulfoniums, from the roots and stems of the genus Salacia plants [Celastraceae (Hippocrateaceae)] such as Salacia reticulata Wight, S. oblonga Wall., and S. chinensis L., and observed their antidiabetic effects. These plant materials have been used traditionally in Ayurvedic medicine as a specific remedy at the early stage of diabetes, and have been extensively consumed in Japan, the United States, and other countries as a food supplement for the prevention of obesity and diabetes. Here, we review our studies on the antidiabetic effects of plants from the genus Salacia , from basic chemical and pharmacological research to their application and development as new functional food ingredients. Graphic abstract

  • dose dependent suppression of postprandial hyperglycemia and improvement of blood glucose parameters by Salacia chinensis extract two randomized double blind placebo controlled studies
    Journal of Medicinal Food, 2021
    Co-Authors: Masakazu Kobayashi, Osamu Muraoka, Masayuki Yoshikawa, Toshio Morikawa, Junji Akaki, Kiyofumi Ninomiya, Masato Odawara
    Abstract:

    The number of diabetes mellitus and borderline diabetes cases is increasing and poses a serious problem worldwide. Plants of the genus Salacia are known to have α-glucosidase inhibitory activity an...

  • Highly Diastereoselective Route to α‑Glucosidase Inhibitors, Neosalacinol and Neoponkoranol
    2016
    Co-Authors: Genzoh Tanabe, Nozomi Tsutsui, Gorre Balakishan, Youya Matsuda, Misato Oka, Yousuke Kunikata, Weija Xie, Mumen F. A. Amer, Shinsuke Marumoto, Osamu Muraoka
    Abstract:

    A facile and highly diastereoselective route to potent natural α-glucosidase inhibitors, i.e., neosalacinol (4) and neoponkoranol (6), isolated from the traditional Ayurvedic medicine “Salacia” was developed by intramolecular cyclization of appropriately substituted sulfides (9 and 12)

  • evaluation of Salacia species as anti diabetic natural resources based on quantitative analysis of eight sulphonium constituents a new class of α glucosidase inhibitors
    Phytochemical Analysis, 2014
    Co-Authors: Junji Akaki, Genzoh Tanabe, Masayuki Yoshikawa, Toshio Morikawa, Sohachiro Miyake, Kiyofumi Ninomiya, Yutana Pongpiriyadacha, Mayumi Okada, Osamu Muraoka
    Abstract:

    Introduction Stems and roots of Salacia genus plants have been used in Ayurveda as a specific remedy for early stage diabetes. Previous investigations identified four sulphonium sulphates, that is, salacinol (1), kotalanol (3), ponkoranol (5) and salaprinol (7), as the compounds responsible for the anti-diabetic activity. Their desulphonates (2, 4, 6 and 8) were also isolated as active constituents. Two separate quantitative analytical protocols, that is, for 1 and 3 and for 2 and 4, have been developed recently. Objective To: validate the two analytical protocols with respect to all eight sulphoniums; evaluate the quality of a variety of Salacia samples collected in different geographical regions, that is, Thailand, Sri Lanka and India; and determine their distribution in each part of the plant, that is, stems/roots, leaves and fruits. Methods Analyses of four sulphonium sulphates in 32 Salacia extracts were carried out on an Asahipak NH2P-50 column, and those of the corresponding desulphonates were conducted on an Inertsil ODS-3 column. Results Neokotalanol (4) was the major constituent in Salacia samples from Thailand, whereas 1 was the primary constituent in extracts of the stems/roots of plants from Sri Lanka and India. These sulphoniums were only present in trace amounts in leaves and fruits of the plants. Conclusion Two analytical protocols were successfully applied to analyse 32 Salacia samples, and revealed that sulphoniums (1–8) had characteristic distributions due to the plant part and/or due to geographical region. Copyright © 2014 John Wiley & Sons, Ltd.

  • quantitative analysis of neosalacinol and neokotalanol another two potent α glucosidase inhibitors from Salacia species by lc ms with ion pair chromatography
    Journal of Natural Medicines, 2011
    Co-Authors: Osamu Muraoka, Toshio Morikawa, Sohachiro Miyake, Junji Akaki, Kiyofumi Ninomiya, Yutana Pongpiriyadacha, Masayuki Yoshikawa
    Abstract:

    A quantitative analytical method for the highly polar sulfonium pseudo-sugar constituents neosalacinol (3) and neokotalanol (4), another two potent α-glucosidase inhibitors isolated from Ayurvedic traditional medicine Salacia species, was developed by employing an ion pair reagent upon chromatographic separation. The optimum conditions for separation and detection of these two constituents were achieved on an ODS column (3-µm particle size, 2.1-mm i.d. × 100 mm) with 5 mM undecafluorohexanoic acid–MeOH (99:1, v/v) as the mobile phase and using MS equipped with an electrospray ionization source. More than ten samples of Salacia from different origins were analyzed, and the results indicated that the assay was reproducible and precise and could be readily utilized for evaluation of α-glucosidase inhibitory activity of Salacia species. By combining this assay with the quantitative analytical method previously developed for salacinol (1) and kotalanol (2), a more precise and strict evaluation of α-glucosidase inhibitory activities of extracts from Salacia species (R = 0.959 for maltase and 0.795 for sucrase) was achieved.

Masayuki Yoshikawa - One of the best experts on this subject based on the ideXlab platform.

  • A review of antidiabetic active thiosugar sulfoniums, salacinol and neokotalanol, from plants of the genus Salacia
    Journal of Natural Medicines, 2021
    Co-Authors: Toshio Morikawa, Genzoh Tanabe, Masayuki Yoshikawa, Hisashi Matsuda, Kiyofumi Ninomiya, Osamu Muraoka
    Abstract:

    During our studies characterizing functional substances from food resources for the prevention and treatment of lifestyle-related diseases, we isolated the active constituents, salacinol ( 1 ) and neokotalanol ( 4 ), and related thiosugar sulfoniums, from the roots and stems of the genus Salacia plants [Celastraceae (Hippocrateaceae)] such as Salacia reticulata Wight, S. oblonga Wall., and S. chinensis L., and observed their antidiabetic effects. These plant materials have been used traditionally in Ayurvedic medicine as a specific remedy at the early stage of diabetes, and have been extensively consumed in Japan, the United States, and other countries as a food supplement for the prevention of obesity and diabetes. Here, we review our studies on the antidiabetic effects of plants from the genus Salacia , from basic chemical and pharmacological research to their application and development as new functional food ingredients. Graphic abstract

  • dose dependent suppression of postprandial hyperglycemia and improvement of blood glucose parameters by Salacia chinensis extract two randomized double blind placebo controlled studies
    Journal of Medicinal Food, 2021
    Co-Authors: Masakazu Kobayashi, Osamu Muraoka, Masayuki Yoshikawa, Toshio Morikawa, Junji Akaki, Kiyofumi Ninomiya, Masato Odawara
    Abstract:

    The number of diabetes mellitus and borderline diabetes cases is increasing and poses a serious problem worldwide. Plants of the genus Salacia are known to have α-glucosidase inhibitory activity an...

  • evaluation of Salacia species as anti diabetic natural resources based on quantitative analysis of eight sulphonium constituents a new class of α glucosidase inhibitors
    Phytochemical Analysis, 2014
    Co-Authors: Junji Akaki, Genzoh Tanabe, Masayuki Yoshikawa, Toshio Morikawa, Sohachiro Miyake, Kiyofumi Ninomiya, Yutana Pongpiriyadacha, Mayumi Okada, Osamu Muraoka
    Abstract:

    Introduction Stems and roots of Salacia genus plants have been used in Ayurveda as a specific remedy for early stage diabetes. Previous investigations identified four sulphonium sulphates, that is, salacinol (1), kotalanol (3), ponkoranol (5) and salaprinol (7), as the compounds responsible for the anti-diabetic activity. Their desulphonates (2, 4, 6 and 8) were also isolated as active constituents. Two separate quantitative analytical protocols, that is, for 1 and 3 and for 2 and 4, have been developed recently. Objective To: validate the two analytical protocols with respect to all eight sulphoniums; evaluate the quality of a variety of Salacia samples collected in different geographical regions, that is, Thailand, Sri Lanka and India; and determine their distribution in each part of the plant, that is, stems/roots, leaves and fruits. Methods Analyses of four sulphonium sulphates in 32 Salacia extracts were carried out on an Asahipak NH2P-50 column, and those of the corresponding desulphonates were conducted on an Inertsil ODS-3 column. Results Neokotalanol (4) was the major constituent in Salacia samples from Thailand, whereas 1 was the primary constituent in extracts of the stems/roots of plants from Sri Lanka and India. These sulphoniums were only present in trace amounts in leaves and fruits of the plants. Conclusion Two analytical protocols were successfully applied to analyse 32 Salacia samples, and revealed that sulphoniums (1–8) had characteristic distributions due to the plant part and/or due to geographical region. Copyright © 2014 John Wiley & Sons, Ltd.

  • quantitative analysis of neosalacinol and neokotalanol another two potent α glucosidase inhibitors from Salacia species by lc ms with ion pair chromatography
    Journal of Natural Medicines, 2011
    Co-Authors: Osamu Muraoka, Toshio Morikawa, Sohachiro Miyake, Junji Akaki, Kiyofumi Ninomiya, Yutana Pongpiriyadacha, Masayuki Yoshikawa
    Abstract:

    A quantitative analytical method for the highly polar sulfonium pseudo-sugar constituents neosalacinol (3) and neokotalanol (4), another two potent α-glucosidase inhibitors isolated from Ayurvedic traditional medicine Salacia species, was developed by employing an ion pair reagent upon chromatographic separation. The optimum conditions for separation and detection of these two constituents were achieved on an ODS column (3-µm particle size, 2.1-mm i.d. × 100 mm) with 5 mM undecafluorohexanoic acid–MeOH (99:1, v/v) as the mobile phase and using MS equipped with an electrospray ionization source. More than ten samples of Salacia from different origins were analyzed, and the results indicated that the assay was reproducible and precise and could be readily utilized for evaluation of α-glucosidase inhibitory activity of Salacia species. By combining this assay with the quantitative analytical method previously developed for salacinol (1) and kotalanol (2), a more precise and strict evaluation of α-glucosidase inhibitory activities of extracts from Salacia species (R = 0.959 for maltase and 0.795 for sucrase) was achieved.

  • quantitative determination of potent α glucosidase inhibitors salacinol and kotalanol in Salacia species using liquid chromatography mass spectrometry
    Journal of Pharmaceutical and Biomedical Analysis, 2010
    Co-Authors: Osamu Muraoka, Toshio Morikawa, Sohachiro Miyake, Junji Akaki, Kiyofumi Ninomiya, Masayuki Yoshikawa
    Abstract:

    A practical HPLC-MS method for the quantitative determination of salacinol (1) and kotalanol (2), potent alpha-glucosidase inhibitors from Salacia species (Hippocrateaceae) as a specific remedy for diabetes in Ayurvedic system, was developed. The optimum conditions of separation and detection of these two constituents were achieved on a Asahipak NH2P-50 column (5 mcirom particle size, 2.0 mm i.d. x 150 mm) with a CH(3)CN-H(2)O mobile phase, associated with MS using electrospray ionization source. The overall recoveries of 1 (85.8-112.6%) and 2 (99.7-106.1%), and relative standard deviation values of intra- and inter-day precision were lower than 6.8 and 8.5%, respectively. The detection (S/N=3) and quantitation limits (S/N=10) were established to be 0.015 and 0.050 ng for 1, and 0.030 and 0.10 ng for 2, respectively. The correlation coefficients of all the calibration curves showed good linearity within test ranges. The extraction process was also optimized as 2 h immersion in water under reflux. The method was applied to evaluate extracts of three kinds of Salacia species, i.e. S. reticulata, S. oblonga, and S. chinensis, and those of four different parts, i.e. roots, stems, leaves and fruits of the same material, revealing that the extract from the roots of S. reticulata had the highest contents of these compounds. The results indicated that the assay was reproducible and precise and could be readily utilized for the evaluation of Salacia species.

Genzoh Tanabe - One of the best experts on this subject based on the ideXlab platform.

  • A review of antidiabetic active thiosugar sulfoniums, salacinol and neokotalanol, from plants of the genus Salacia
    Journal of Natural Medicines, 2021
    Co-Authors: Toshio Morikawa, Genzoh Tanabe, Masayuki Yoshikawa, Hisashi Matsuda, Kiyofumi Ninomiya, Osamu Muraoka
    Abstract:

    During our studies characterizing functional substances from food resources for the prevention and treatment of lifestyle-related diseases, we isolated the active constituents, salacinol ( 1 ) and neokotalanol ( 4 ), and related thiosugar sulfoniums, from the roots and stems of the genus Salacia plants [Celastraceae (Hippocrateaceae)] such as Salacia reticulata Wight, S. oblonga Wall., and S. chinensis L., and observed their antidiabetic effects. These plant materials have been used traditionally in Ayurvedic medicine as a specific remedy at the early stage of diabetes, and have been extensively consumed in Japan, the United States, and other countries as a food supplement for the prevention of obesity and diabetes. Here, we review our studies on the antidiabetic effects of plants from the genus Salacia , from basic chemical and pharmacological research to their application and development as new functional food ingredients. Graphic abstract

  • Highly Diastereoselective Route to α‑Glucosidase Inhibitors, Neosalacinol and Neoponkoranol
    2016
    Co-Authors: Genzoh Tanabe, Nozomi Tsutsui, Gorre Balakishan, Youya Matsuda, Misato Oka, Yousuke Kunikata, Weija Xie, Mumen F. A. Amer, Shinsuke Marumoto, Osamu Muraoka
    Abstract:

    A facile and highly diastereoselective route to potent natural α-glucosidase inhibitors, i.e., neosalacinol (4) and neoponkoranol (6), isolated from the traditional Ayurvedic medicine “Salacia” was developed by intramolecular cyclization of appropriately substituted sulfides (9 and 12)

  • evaluation of Salacia species as anti diabetic natural resources based on quantitative analysis of eight sulphonium constituents a new class of α glucosidase inhibitors
    Phytochemical Analysis, 2014
    Co-Authors: Junji Akaki, Genzoh Tanabe, Masayuki Yoshikawa, Toshio Morikawa, Sohachiro Miyake, Kiyofumi Ninomiya, Yutana Pongpiriyadacha, Mayumi Okada, Osamu Muraoka
    Abstract:

    Introduction Stems and roots of Salacia genus plants have been used in Ayurveda as a specific remedy for early stage diabetes. Previous investigations identified four sulphonium sulphates, that is, salacinol (1), kotalanol (3), ponkoranol (5) and salaprinol (7), as the compounds responsible for the anti-diabetic activity. Their desulphonates (2, 4, 6 and 8) were also isolated as active constituents. Two separate quantitative analytical protocols, that is, for 1 and 3 and for 2 and 4, have been developed recently. Objective To: validate the two analytical protocols with respect to all eight sulphoniums; evaluate the quality of a variety of Salacia samples collected in different geographical regions, that is, Thailand, Sri Lanka and India; and determine their distribution in each part of the plant, that is, stems/roots, leaves and fruits. Methods Analyses of four sulphonium sulphates in 32 Salacia extracts were carried out on an Asahipak NH2P-50 column, and those of the corresponding desulphonates were conducted on an Inertsil ODS-3 column. Results Neokotalanol (4) was the major constituent in Salacia samples from Thailand, whereas 1 was the primary constituent in extracts of the stems/roots of plants from Sri Lanka and India. These sulphoniums were only present in trace amounts in leaves and fruits of the plants. Conclusion Two analytical protocols were successfully applied to analyse 32 Salacia samples, and revealed that sulphoniums (1–8) had characteristic distributions due to the plant part and/or due to geographical region. Copyright © 2014 John Wiley & Sons, Ltd.

  • in silico design synthesis and evaluation of 3 o benzylated analogs of salacinol a potent α glucosidase inhibitor isolated from an ayurvedic traditional medicine Salacia
    Chemical Communications, 2012
    Co-Authors: Genzoh Tanabe, Weijia Xie, Toshio Morikawa, Junji Akaki, Kiyofumi Ninomiya, Shinya Nakamura, Nozomi Tsutsui, Gorre Balakishan, Satoshi Tsuchiya, Isao Nakanishi
    Abstract:

    With the aid of an in silico method, α-glucosidase inhibitors with far more potent activities than salacinol (1), a potent natural α-glucosidase inhibitor isolated from an Ayurvedic traditional medicine Salacia reticulata, have been developed.

  • characteristic alkaline catalyzed degradation of kotalanol a potent α glucosidase inhibitor isolated from ayurvedic traditional medicine Salacia reticulata leading to anhydroheptitols another structural proof
    Tetrahedron, 2010
    Co-Authors: Osamu Muraoka, Weijia Xie, Genzoh Tanabe, Mumen F. A. Amer, Toshie Minematsu, Toshio Morikawa, Satomi Osaki, Ayumi Kagawa, Masayuki Yoshikawa
    Abstract:

    Stereochemical structure of kotalanol (2), a highly potent α-glucosidase inhibitor isolated from an Ayurvedic traditional medicine Salacia reticulata, was proved by alkaline catalyzed degradation of natural kotalanol (2), in which characteristic stereospecific cyclization of the degradative side chain leading to anhydroheptitols (10 and 11) was involved.

Toshio Morikawa - One of the best experts on this subject based on the ideXlab platform.

  • A review of antidiabetic active thiosugar sulfoniums, salacinol and neokotalanol, from plants of the genus Salacia
    Journal of Natural Medicines, 2021
    Co-Authors: Toshio Morikawa, Genzoh Tanabe, Masayuki Yoshikawa, Hisashi Matsuda, Kiyofumi Ninomiya, Osamu Muraoka
    Abstract:

    During our studies characterizing functional substances from food resources for the prevention and treatment of lifestyle-related diseases, we isolated the active constituents, salacinol ( 1 ) and neokotalanol ( 4 ), and related thiosugar sulfoniums, from the roots and stems of the genus Salacia plants [Celastraceae (Hippocrateaceae)] such as Salacia reticulata Wight, S. oblonga Wall., and S. chinensis L., and observed their antidiabetic effects. These plant materials have been used traditionally in Ayurvedic medicine as a specific remedy at the early stage of diabetes, and have been extensively consumed in Japan, the United States, and other countries as a food supplement for the prevention of obesity and diabetes. Here, we review our studies on the antidiabetic effects of plants from the genus Salacia , from basic chemical and pharmacological research to their application and development as new functional food ingredients. Graphic abstract

  • dose dependent suppression of postprandial hyperglycemia and improvement of blood glucose parameters by Salacia chinensis extract two randomized double blind placebo controlled studies
    Journal of Medicinal Food, 2021
    Co-Authors: Masakazu Kobayashi, Osamu Muraoka, Masayuki Yoshikawa, Toshio Morikawa, Junji Akaki, Kiyofumi Ninomiya, Masato Odawara
    Abstract:

    The number of diabetes mellitus and borderline diabetes cases is increasing and poses a serious problem worldwide. Plants of the genus Salacia are known to have α-glucosidase inhibitory activity an...

  • evaluation of Salacia species as anti diabetic natural resources based on quantitative analysis of eight sulphonium constituents a new class of α glucosidase inhibitors
    Phytochemical Analysis, 2014
    Co-Authors: Junji Akaki, Genzoh Tanabe, Masayuki Yoshikawa, Toshio Morikawa, Sohachiro Miyake, Kiyofumi Ninomiya, Yutana Pongpiriyadacha, Mayumi Okada, Osamu Muraoka
    Abstract:

    Introduction Stems and roots of Salacia genus plants have been used in Ayurveda as a specific remedy for early stage diabetes. Previous investigations identified four sulphonium sulphates, that is, salacinol (1), kotalanol (3), ponkoranol (5) and salaprinol (7), as the compounds responsible for the anti-diabetic activity. Their desulphonates (2, 4, 6 and 8) were also isolated as active constituents. Two separate quantitative analytical protocols, that is, for 1 and 3 and for 2 and 4, have been developed recently. Objective To: validate the two analytical protocols with respect to all eight sulphoniums; evaluate the quality of a variety of Salacia samples collected in different geographical regions, that is, Thailand, Sri Lanka and India; and determine their distribution in each part of the plant, that is, stems/roots, leaves and fruits. Methods Analyses of four sulphonium sulphates in 32 Salacia extracts were carried out on an Asahipak NH2P-50 column, and those of the corresponding desulphonates were conducted on an Inertsil ODS-3 column. Results Neokotalanol (4) was the major constituent in Salacia samples from Thailand, whereas 1 was the primary constituent in extracts of the stems/roots of plants from Sri Lanka and India. These sulphoniums were only present in trace amounts in leaves and fruits of the plants. Conclusion Two analytical protocols were successfully applied to analyse 32 Salacia samples, and revealed that sulphoniums (1–8) had characteristic distributions due to the plant part and/or due to geographical region. Copyright © 2014 John Wiley & Sons, Ltd.

  • in silico design synthesis and evaluation of 3 o benzylated analogs of salacinol a potent α glucosidase inhibitor isolated from an ayurvedic traditional medicine Salacia
    Chemical Communications, 2012
    Co-Authors: Genzoh Tanabe, Weijia Xie, Toshio Morikawa, Junji Akaki, Kiyofumi Ninomiya, Shinya Nakamura, Nozomi Tsutsui, Gorre Balakishan, Satoshi Tsuchiya, Isao Nakanishi
    Abstract:

    With the aid of an in silico method, α-glucosidase inhibitors with far more potent activities than salacinol (1), a potent natural α-glucosidase inhibitor isolated from an Ayurvedic traditional medicine Salacia reticulata, have been developed.

  • quantitative analysis of neosalacinol and neokotalanol another two potent α glucosidase inhibitors from Salacia species by lc ms with ion pair chromatography
    Journal of Natural Medicines, 2011
    Co-Authors: Osamu Muraoka, Toshio Morikawa, Sohachiro Miyake, Junji Akaki, Kiyofumi Ninomiya, Yutana Pongpiriyadacha, Masayuki Yoshikawa
    Abstract:

    A quantitative analytical method for the highly polar sulfonium pseudo-sugar constituents neosalacinol (3) and neokotalanol (4), another two potent α-glucosidase inhibitors isolated from Ayurvedic traditional medicine Salacia species, was developed by employing an ion pair reagent upon chromatographic separation. The optimum conditions for separation and detection of these two constituents were achieved on an ODS column (3-µm particle size, 2.1-mm i.d. × 100 mm) with 5 mM undecafluorohexanoic acid–MeOH (99:1, v/v) as the mobile phase and using MS equipped with an electrospray ionization source. More than ten samples of Salacia from different origins were analyzed, and the results indicated that the assay was reproducible and precise and could be readily utilized for evaluation of α-glucosidase inhibitory activity of Salacia species. By combining this assay with the quantitative analytical method previously developed for salacinol (1) and kotalanol (2), a more precise and strict evaluation of α-glucosidase inhibitory activities of extracts from Salacia species (R = 0.959 for maltase and 0.795 for sucrase) was achieved.

Sue A Shapses - One of the best experts on this subject based on the ideXlab platform.

  • appetite and gut hormones response to a putative α glucosidase inhibitor Salacia chinensis in overweight obese adults a double blind randomized controlled trial
    Nutrients, 2017
    Co-Authors: Lihong Hao, Yvette Schlussel, Krista Fieselmann, Stephen H Schneider, Sue A Shapses
    Abstract:

    Animal studies indicate Salacia reduces body weight, possibly due to its α-glucosidase inhibitor (α-GI) properties, but this has not been examined previously. In this study, a randomized, placebo-controlled, three-way cross-over design was used to evaluate whether Salacia Chinensis (SC) reduces appetite in healthy overweight/obese individuals (body mass index 28.8 ±3.6 kg/m²; 32 ± 12 years). Forty-eight participants were fasted overnight and consumed a dose of SC (300 or 500 mg) or placebo with a fixed breakfast meal at each visit. Appetite sensations, glycemic indices and gastrointestinal peptides were measured. Results indicated that SC had no effect on postprandial appetite. However, in women, hunger was reduced by SC compared to placebo at multiple time points (300 mg; p < 0.05), but not in men. Area under the curve (AUC) for serum glucose, insulin and amylin was attenuated with SC compared to placebo (p < 0.05). Glucagon like peptide-1 had two peaks after the meal, but the AUC did not differ between groups. The AUC of peak areas for peptide YY and ghrelin were greater for SC than placebo (p < 0.05). These findings indicate that Salacia decreases glycemic indices supporting its role as an α-GI, and affects certain gastrointestinal peptides suggesting it may be an appetite modulator.

  • a double blind randomized placebo controlled study of Salacia chinensis with alpha glucosidase inhibitor properties on post prandial glycemia
    The FASEB Journal, 2017
    Co-Authors: Lihong Hao, Yvette Schlussel, Krista Fieselmann, Stephen Schneider, Sue A Shapses
    Abstract:

    Alpha-glucosidase inhibitors are used as antidiabetic agents to slow carbohydrate absorption. We examined a medicinal plant, Salacia, with known α-glucosidase inhibitor properties. In this clinical...

  • Appetite and Gut Hormones Response to a Putative α-Glucosidase Inhibitor, Salacia Chinensis, in Overweight/Obese Adults: A Double Blind Randomized Controlled Trial
    'MDPI AG', 2017
    Co-Authors: Lihong Hao, Yvette Schlussel, Krista Fieselmann, Stephen H Schneider, Sue A Shapses
    Abstract:

    Animal studies indicate Salacia reduces body weight, possibly due to its α-glucosidase inhibitor (α-GI) properties, but this has not been examined previously. In this study, a randomized, placebo-controlled, three-way cross-over design was used to evaluate whether Salacia Chinensis (SC) reduces appetite in healthy overweight/obese individuals (body mass index 28.8 ±3.6 kg/m2; 32 ± 12 years). Forty-eight participants were fasted overnight and consumed a dose of SC (300 or 500 mg) or placebo with a fixed breakfast meal at each visit. Appetite sensations, glycemic indices and gastrointestinal peptides were measured. Results indicated that SC had no effect on postprandial appetite. However, in women, hunger was reduced by SC compared to placebo at multiple time points (300 mg; p < 0.05), but not in men. Area under the curve (AUC) for serum glucose, insulin and amylin was attenuated with SC compared to placebo (p < 0.05). Glucagon like peptide-1 had two peaks after the meal, but the AUC did not differ between groups. The AUC of peak areas for peptide YY and ghrelin were greater for SC than placebo (p < 0.05). These findings indicate that Salacia decreases glycemic indices supporting its role as an α-GI, and affects certain gastrointestinal peptides suggesting it may be an appetite modulator