The Experts below are selected from a list of 5835 Experts worldwide ranked by ideXlab platform
William H Westra - One of the best experts on this subject based on the ideXlab platform.
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secretory Carcinoma of the skin harboring etv6 gene fusions a cutaneous analogue to secretory Carcinomas of the breast and Salivary Glands
The American Journal of Surgical Pathology, 2017Co-Authors: Justin A Bishop, Janis M Taube, Scott W Binder, Dmitry V Kazakov, Michal Michal, William H WestraAbstract:Mammary analogue secretory Carcinoma is a low-grade Salivary Gland Carcinoma that exhibits analogous features to secretory Carcinoma of the breast including the presence of a t(12;15) translocation resulting in the ETV6-NTRK3 gene fusion. Rare cases of purported secretory Carcinoma of the skin adnex
Zhi-yuan Zhang - One of the best experts on this subject based on the ideXlab platform.
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Salivary Gland Carcinoma in Shanghai (2003-2012): an epidemiological study of incidence, site and pathology.
BMC cancer, 2019Co-Authors: Shu-kun Shen, Ying Zheng, Chen-ping Zhang, Zhi-yuan ZhangAbstract:Salivary Gland Carcinoma ranks the sixth in head and neck cancers while it is relatively rare in its incidence. Epidemiological studies have been based mostly on institutional data, leading to selection bias in incidence evaluation. Most population-based cancer registries have grouped cancers of the minor Salivary Glands with oral cancer instead of with Salivary Gland Carcinoma as a whole, because of the international disease coding. Thus, the incidence of Salivary Gland Carcinoma has not been well assessed. The aim of the study is to evaluate the incidence of both minor and major Salivary Gland cancers in Shanghai during the years 2003–2012, and to analyse the site and histological distributions. Data from the Shanghai Cancer Registry system were extracted for patients diagnosed with malignancies of the major or minor Salivary Glands for the year 2003 to 2012. Pertinent socio-demographic data were obtained from the Shanghai Municipal Bureau of Public Security. The age-standardized incidence rates were calculated directly according to the world standard population. The change in incidence during the study period was analysed by comparing the rates during the first and next five years. The distributions of anatomic subsites and histology were also analysed. A total of 1831 cases were identified, representing 0.35% of all malignancies during the study period. The median age was 59 and 57 years for men and women, respectively. The age-standardized incidence was 7.99 per 1,000,000 person-year, with a male-to-female ratio of 1.10. There was no significant change in the incidence during the 10-year period. The anatomic distribution confirmed the 4:1:2 rule for the parotid, submandibular, and minor Glands. In men, adenoCarcinoma not otherwise specified was the most common histological type followed by mucoepidermoid; in women, the mucoepidermoid was the most common histotype, followed by the adenoid cystic. Salivary Gland Carcinoma is relatively rare in incidence. However, the variations in age and sex distribution in sites and histology types suggest differences in aetiology which warrants further investigation.
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Salivary Gland Carcinoma in Shanghai (2003–2012): an epidemiological study of incidence, site and pathology
BMC, 2019Co-Authors: Shu-kun Shen, Ying Zheng, Chen-ping Zhang, Zhi-yuan ZhangAbstract:Abstract Background Salivary Gland Carcinoma ranks the sixth in head and neck cancers while it is relatively rare in its incidence. Epidemiological studies have been based mostly on institutional data, leading to selection bias in incidence evaluation. Most population-based cancer registries have grouped cancers of the minor Salivary Glands with oral cancer instead of with Salivary Gland Carcinoma as a whole, because of the international disease coding. Thus, the incidence of Salivary Gland Carcinoma has not been well assessed. The aim of the study is to evaluate the incidence of both minor and major Salivary Gland cancers in Shanghai during the years 2003–2012, and to analyse the site and histological distributions. Methods Data from the Shanghai Cancer Registry system were extracted for patients diagnosed with malignancies of the major or minor Salivary Glands for the year 2003 to 2012. Pertinent socio-demographic data were obtained from the Shanghai Municipal Bureau of Public Security. The age-standardized incidence rates were calculated directly according to the world standard population. The change in incidence during the study period was analysed by comparing the rates during the first and next five years. The distributions of anatomic subsites and histology were also analysed. Results A total of 1831 cases were identified, representing 0.35% of all malignancies during the study period. The median age was 59 and 57 years for men and women, respectively. The age-standardized incidence was 7.99 per 1,000,000 person-year, with a male-to-female ratio of 1.10. There was no significant change in the incidence during the 10-year period. The anatomic distribution confirmed the 4:1:2 rule for the parotid, submandibular, and minor Glands. In men, adenoCarcinoma not otherwise specified was the most common histological type followed by mucoepidermoid; in women, the mucoepidermoid was the most common histotype, followed by the adenoid cystic. Conclusion Salivary Gland Carcinoma is relatively rare in incidence. However, the variations in age and sex distribution in sites and histology types suggest differences in aetiology which warrants further investigation
Justin A Bishop - One of the best experts on this subject based on the ideXlab platform.
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secretory Carcinoma of the skin harboring etv6 gene fusions a cutaneous analogue to secretory Carcinomas of the breast and Salivary Glands
The American Journal of Surgical Pathology, 2017Co-Authors: Justin A Bishop, Janis M Taube, Scott W Binder, Dmitry V Kazakov, Michal Michal, William H WestraAbstract:Mammary analogue secretory Carcinoma is a low-grade Salivary Gland Carcinoma that exhibits analogous features to secretory Carcinoma of the breast including the presence of a t(12;15) translocation resulting in the ETV6-NTRK3 gene fusion. Rare cases of purported secretory Carcinoma of the skin adnex
Chen-ping Zhang - One of the best experts on this subject based on the ideXlab platform.
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anatomic extent of lymph node metastases as an independent prognosticator in node positive major Salivary Gland Carcinoma a study of the us seer database and a chinese multicenter cohort
Ejso, 2019Co-Authors: Xiao Shi, Xue Kui Liu, Chen-ping Zhang, Wenjun Wei, Naisi Huang, Yungan Tao, Yan Zhang, Wei Han, Jin Cai Xue, Xi YangAbstract:Abstract Background We aimed to explore whether the anatomic extent of lymph node metastases (AE-LNM) could independently predict prognosis of node-positive major Salivary Gland Carcinoma (MaSGC). Methods A total of 376 pathologically node-positive MaSGC patients were identified from the Surveillance, Epidemiology and End Results database and constituted the training cohort. Using the X-Tile program, these patients were divided into three groups based on AE-LNM degrees. Discrimination of overall survival (OS) and disease-specific survival (DSS) was evaluated and compared with the 8th American Joint Committee on Cancer (AJCC) pN classification. The results were externally validated by 220 patients in a Chinese multicenter cohort (Validation cohort). Results Using the training cohort, AE-LNM was divided into Extent 1 (spread to parotid LNs or level I), Extent 2 (spread to level II-IV) and Extent 3 (spread to level V or bilateral LNs or rare LNs). Regarding both OS and DSS, the AE-LNM model revealed clear separation of survival curves, while the pN classification failed to discriminate the prognosis of pN1 and pN2 patients. When we incorporated both the AE-LNM model and AJCC pN classification into the same multivariate Cox analyses, AE-LNM was still an independent prognostic factor, while the AJCC pN classification lost its significance. These results were externally validated by the validation cohort. Conclusion AE-LNM is an independent nodal prognosticator for node-positive MaSGC and may have improved discriminative ability over the current AJCC pN classification. Integration of anatomic extent of LNM into the current AJCC N classification could be considered.
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Salivary Gland Carcinoma in Shanghai (2003-2012): an epidemiological study of incidence, site and pathology.
BMC cancer, 2019Co-Authors: Shu-kun Shen, Ying Zheng, Chen-ping Zhang, Zhi-yuan ZhangAbstract:Salivary Gland Carcinoma ranks the sixth in head and neck cancers while it is relatively rare in its incidence. Epidemiological studies have been based mostly on institutional data, leading to selection bias in incidence evaluation. Most population-based cancer registries have grouped cancers of the minor Salivary Glands with oral cancer instead of with Salivary Gland Carcinoma as a whole, because of the international disease coding. Thus, the incidence of Salivary Gland Carcinoma has not been well assessed. The aim of the study is to evaluate the incidence of both minor and major Salivary Gland cancers in Shanghai during the years 2003–2012, and to analyse the site and histological distributions. Data from the Shanghai Cancer Registry system were extracted for patients diagnosed with malignancies of the major or minor Salivary Glands for the year 2003 to 2012. Pertinent socio-demographic data were obtained from the Shanghai Municipal Bureau of Public Security. The age-standardized incidence rates were calculated directly according to the world standard population. The change in incidence during the study period was analysed by comparing the rates during the first and next five years. The distributions of anatomic subsites and histology were also analysed. A total of 1831 cases were identified, representing 0.35% of all malignancies during the study period. The median age was 59 and 57 years for men and women, respectively. The age-standardized incidence was 7.99 per 1,000,000 person-year, with a male-to-female ratio of 1.10. There was no significant change in the incidence during the 10-year period. The anatomic distribution confirmed the 4:1:2 rule for the parotid, submandibular, and minor Glands. In men, adenoCarcinoma not otherwise specified was the most common histological type followed by mucoepidermoid; in women, the mucoepidermoid was the most common histotype, followed by the adenoid cystic. Salivary Gland Carcinoma is relatively rare in incidence. However, the variations in age and sex distribution in sites and histology types suggest differences in aetiology which warrants further investigation.
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Salivary Gland Carcinoma in Shanghai (2003–2012): an epidemiological study of incidence, site and pathology
BMC, 2019Co-Authors: Shu-kun Shen, Ying Zheng, Chen-ping Zhang, Zhi-yuan ZhangAbstract:Abstract Background Salivary Gland Carcinoma ranks the sixth in head and neck cancers while it is relatively rare in its incidence. Epidemiological studies have been based mostly on institutional data, leading to selection bias in incidence evaluation. Most population-based cancer registries have grouped cancers of the minor Salivary Glands with oral cancer instead of with Salivary Gland Carcinoma as a whole, because of the international disease coding. Thus, the incidence of Salivary Gland Carcinoma has not been well assessed. The aim of the study is to evaluate the incidence of both minor and major Salivary Gland cancers in Shanghai during the years 2003–2012, and to analyse the site and histological distributions. Methods Data from the Shanghai Cancer Registry system were extracted for patients diagnosed with malignancies of the major or minor Salivary Glands for the year 2003 to 2012. Pertinent socio-demographic data were obtained from the Shanghai Municipal Bureau of Public Security. The age-standardized incidence rates were calculated directly according to the world standard population. The change in incidence during the study period was analysed by comparing the rates during the first and next five years. The distributions of anatomic subsites and histology were also analysed. Results A total of 1831 cases were identified, representing 0.35% of all malignancies during the study period. The median age was 59 and 57 years for men and women, respectively. The age-standardized incidence was 7.99 per 1,000,000 person-year, with a male-to-female ratio of 1.10. There was no significant change in the incidence during the 10-year period. The anatomic distribution confirmed the 4:1:2 rule for the parotid, submandibular, and minor Glands. In men, adenoCarcinoma not otherwise specified was the most common histological type followed by mucoepidermoid; in women, the mucoepidermoid was the most common histotype, followed by the adenoid cystic. Conclusion Salivary Gland Carcinoma is relatively rare in incidence. However, the variations in age and sex distribution in sites and histology types suggest differences in aetiology which warrants further investigation
Yu Long Wang - One of the best experts on this subject based on the ideXlab platform.
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prognostic value of primary tumor surgery in minor Salivary Gland Carcinoma patients with distant metastases at diagnosis first evidence from a seer based study
Cancer management and research, 2018Co-Authors: Xiao Shi, Wenjun Wei, Naisi Huang, Rong Liang Shi, Yu Long WangAbstract:Purpose The prognostic value of primary tumor surgery (PTS) in minor Salivary-Gland Carcinoma (MiSGC) with distant metastasis (DM) at diagnosis has never been investigated. In this study, we aimed to provide the first evidence. Patients and methods The Surveillance, Epidemiology, and End Results (SEER) database was employed to identify MiSGC patients with DM at diagnosis. The prognostic value of PTS was evaluated by Kaplan-Meier methods, log-rank analyses, and multivariate Cox proportional-hazard regression models. Results Of the 152 eligible patients included in our study, 50 (32.9%) had undergone PTS. Kaplan-Meier analyses showed that the PTS group had >20% increase in 1- and 2-year overall survival (OS) and cancer-specific survival (CSS) compared with their counterparts without PTS (PTS group vs no-PTS group, 1-year OS 66.1% vs 43.9%, 1-year CSS 69.9% vs 44.9%, 2-year OS 56.6% vs 24.2%, 2-year CSS 59.9% vs 25.7%). Compared with the no-PTS group, multivariate analyses also demonstrated a significantly decreased risk of overall mortality (HR 0.601, 95% CI 0.379-0.952; P=0.031) and cancer-specific mortality (HR 0.547, 95% CI 0.336-0.891; P=0.015) in the PTS group. Subgroup multivariate analyses revealed patients with T1-T3 oropharynx, nasal cavity, or paranasal sinus primary MiSGC, especially adenoid cystic Carcinoma, might benefit from PTS (all P<0.05). Conclusion PTS is associated with improved survival in highly selected MiSGC patients and may be considered in future clinical practice. However, prospective studies with larger sample size are still necessary to validate our findings.
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prognostic significance and optimal candidates of primary tumor resection in major Salivary Gland Carcinoma patients with distant metastases at initial presentation a population based study
Oral Oncology, 2018Co-Authors: Xiao Shi, Fan Dong, Wenjun Wei, Kehan Song, Naisi Huang, Bowen Lei, Wanlin Liu, Yu Wang, Guo Hua Sun, Yu Long WangAbstract:Abstract Objectives To investigate the prognostic significance and identify optimal candidates of primary tumor resection (PTR) for patients with metastatic major Salivary Gland Carcinoma (MaSGC) at diagnosis. Materials and methods Patients with metastatic MaSGC were identified from the Surveillance, Epidemiology and End Results (SEER) database. Kaplan-Meier analyses, log-rank tests and multivariate Cox regression models were employed to evaluate the therapeutic roles of PTR in the overall cohort and different subgroups. Results Overall, 255 patients were included in our study, among whom 80 (31.4%) received PTR. PTR was associated with decreased overall mortality (OM) and cancer-specific mortality (CSM) in the overall cohort (PTR vs No-PTR, HR: 0.363, 95%CI: 0.204–0.646, p = .001 for OM; HR: 0.439, 95%CI: 0.243–0.794, p = .006 for CSM). When we focused on site-specific metastases, receipt of PTR significantly reduced the risk of OM for patients with lung, bone or distant lymph node involvement (all p Conclusion Our study for the first time verifies the favorable prognostic impact of PTR for highly-selected patients with metastatic MaSGC at diagnosis and has the potential to be adopted in future clinical practice, although long-term prospective studies are warranted.
