The Experts below are selected from a list of 243 Experts worldwide ranked by ideXlab platform
Thifhelimbilu I Munzhelele - One of the best experts on this subject based on the ideXlab platform.
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oral mucocele ranula another human immunodeficiency virus related Salivary Gland Disease
Laryngoscope, 2015Co-Authors: Kabunda Syebele, Thifhelimbilu I MunzheleleAbstract:Objectives/Hypothesis To describe clinical characteristics of oral mucoceles/ranulas, with a focus on human immunodeficiency virus (HIV)-related Salivary Gland Diseases. Study Design A descriptive and clinical study, with review of patient data. Material and Methods We reviewed 113 referred cases of oral mucocele. The following anatomical sites were identified: lip, tongue, and floor of the mouth (simple ranulas), as well as plunging ranulas. The age and gender data of the patients with oral mucoceles were recorded. The HIV status of the patients and other information were reviewed. Results There were 30 (26.5%) males and 83 (73.5%) females. Most patients were below 30 years of age, with the peak frequency in the first and second decade. Ranula (simple and plunging) represented 84.1% of the mucocele locations. Mucocele on the lips represented 10.6%. Seventy-two (63.7%) patients were HIV positive; and 97.2% of them had ranulas. Thirty-eight (33.6%) patients presented with plunging ranulas; and 92.1% of them were HIV positive, compared with two patients presenting with plunging ranulas in the HIV-negative group. These results strongly suggest that an HIV-positive patient is statistically (P < 0.001) more at risk of presenting with not only a simple, but also a plunging ranula type. Conclusion This study presents a different clinical picture of oral mucoceles/ranulas, as observed in HIV-positive patients. Additionally, it suggests a possible clinical link between the two pathologies. The authors strongly support the suggestion that oral mucocele/ranula is an HIV-related Salivary Gland Disease. Level of Evidence 4. Laryngoscope, 125:1130–1136, 2015
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Oral mucocele/ranula: Another human immunodeficiency virus‐related Salivary Gland Disease?
Laryngoscope, 2014Co-Authors: Kabunda Syebele, Thifhelimbilu I MunzheleleAbstract:Objectives/Hypothesis To describe clinical characteristics of oral mucoceles/ranulas, with a focus on human immunodeficiency virus (HIV)-related Salivary Gland Diseases. Study Design A descriptive and clinical study, with review of patient data. Material and Methods We reviewed 113 referred cases of oral mucocele. The following anatomical sites were identified: lip, tongue, and floor of the mouth (simple ranulas), as well as plunging ranulas. The age and gender data of the patients with oral mucoceles were recorded. The HIV status of the patients and other information were reviewed. Results There were 30 (26.5%) males and 83 (73.5%) females. Most patients were below 30 years of age, with the peak frequency in the first and second decade. Ranula (simple and plunging) represented 84.1% of the mucocele locations. Mucocele on the lips represented 10.6%. Seventy-two (63.7%) patients were HIV positive; and 97.2% of them had ranulas. Thirty-eight (33.6%) patients presented with plunging ranulas; and 92.1% of them were HIV positive, compared with two patients presenting with plunging ranulas in the HIV-negative group. These results strongly suggest that an HIV-positive patient is statistically (P < 0.001) more at risk of presenting with not only a simple, but also a plunging ranula type. Conclusion This study presents a different clinical picture of oral mucoceles/ranulas, as observed in HIV-positive patients. Additionally, it suggests a possible clinical link between the two pathologies. The authors strongly support the suggestion that oral mucocele/ranula is an HIV-related Salivary Gland Disease. Level of Evidence 4. Laryngoscope, 125:1130–1136, 2015
Kabunda Syebele - One of the best experts on this subject based on the ideXlab platform.
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oral mucocele ranula another human immunodeficiency virus related Salivary Gland Disease
Laryngoscope, 2015Co-Authors: Kabunda Syebele, Thifhelimbilu I MunzheleleAbstract:Objectives/Hypothesis To describe clinical characteristics of oral mucoceles/ranulas, with a focus on human immunodeficiency virus (HIV)-related Salivary Gland Diseases. Study Design A descriptive and clinical study, with review of patient data. Material and Methods We reviewed 113 referred cases of oral mucocele. The following anatomical sites were identified: lip, tongue, and floor of the mouth (simple ranulas), as well as plunging ranulas. The age and gender data of the patients with oral mucoceles were recorded. The HIV status of the patients and other information were reviewed. Results There were 30 (26.5%) males and 83 (73.5%) females. Most patients were below 30 years of age, with the peak frequency in the first and second decade. Ranula (simple and plunging) represented 84.1% of the mucocele locations. Mucocele on the lips represented 10.6%. Seventy-two (63.7%) patients were HIV positive; and 97.2% of them had ranulas. Thirty-eight (33.6%) patients presented with plunging ranulas; and 92.1% of them were HIV positive, compared with two patients presenting with plunging ranulas in the HIV-negative group. These results strongly suggest that an HIV-positive patient is statistically (P < 0.001) more at risk of presenting with not only a simple, but also a plunging ranula type. Conclusion This study presents a different clinical picture of oral mucoceles/ranulas, as observed in HIV-positive patients. Additionally, it suggests a possible clinical link between the two pathologies. The authors strongly support the suggestion that oral mucocele/ranula is an HIV-related Salivary Gland Disease. Level of Evidence 4. Laryngoscope, 125:1130–1136, 2015
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Oral mucocele/ranula: Another human immunodeficiency virus‐related Salivary Gland Disease?
Laryngoscope, 2014Co-Authors: Kabunda Syebele, Thifhelimbilu I MunzheleleAbstract:Objectives/Hypothesis To describe clinical characteristics of oral mucoceles/ranulas, with a focus on human immunodeficiency virus (HIV)-related Salivary Gland Diseases. Study Design A descriptive and clinical study, with review of patient data. Material and Methods We reviewed 113 referred cases of oral mucocele. The following anatomical sites were identified: lip, tongue, and floor of the mouth (simple ranulas), as well as plunging ranulas. The age and gender data of the patients with oral mucoceles were recorded. The HIV status of the patients and other information were reviewed. Results There were 30 (26.5%) males and 83 (73.5%) females. Most patients were below 30 years of age, with the peak frequency in the first and second decade. Ranula (simple and plunging) represented 84.1% of the mucocele locations. Mucocele on the lips represented 10.6%. Seventy-two (63.7%) patients were HIV positive; and 97.2% of them had ranulas. Thirty-eight (33.6%) patients presented with plunging ranulas; and 92.1% of them were HIV positive, compared with two patients presenting with plunging ranulas in the HIV-negative group. These results strongly suggest that an HIV-positive patient is statistically (P < 0.001) more at risk of presenting with not only a simple, but also a plunging ranula type. Conclusion This study presents a different clinical picture of oral mucoceles/ranulas, as observed in HIV-positive patients. Additionally, it suggests a possible clinical link between the two pathologies. The authors strongly support the suggestion that oral mucocele/ranula is an HIV-related Salivary Gland Disease. Level of Evidence 4. Laryngoscope, 125:1130–1136, 2015
Deborah Greenspan - One of the best experts on this subject based on the ideXlab platform.
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Salivary Gland Disease in human immunodeficiency virus-positive women from the WIHS study
Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, 2000Co-Authors: Roseann Mulligan, Deborah Greenspan, Mahvash Navazesh, Eugene Komaroff, Maryann Redford, Mario Alves, Joan PhelanAbstract:Objective. To determine the prevalence of enlargement, tenderness, and absence of saliva on palpation as indicators of Salivary Gland Disease in women who are human immunodeficiency virus (HIV)-positive. Study design. The study subjects are participants in the Women's Interagency HIV Study (WIHS), a multicenter study examining HIV-seropositive women and at-risk HIV-seronegative women. A total of 576 HIV-positive women and 152 HIV-negative women were examined at their baseline oral visit for clinical markers of Salivary Gland Disease. Viral load levels, CD4 counts, and CD8 counts were obtained as part of the related core study. Results. HIV-positive women had higher rates of Salivary Gland enlargement (4.3%), tenderness (6.9%), and absence of saliva on palpation (26.6%) compared with HIV-negative women, who had rates of 1.3%, 4.6%, and 13.2%, respectively. Absence of saliva was significantly different (P = .001) between the 2 groups. When 2 of the 3 clinical findings were combined, comparisons between the HIV-positive women and HIV-negative women became significant at the P
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Salivary Gland Disease in human immunodeficiency virus positive women from the wihs study
Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, 2000Co-Authors: Roseann Mulligan, Deborah Greenspan, Mahvash Navazesh, Eugene Komaroff, Maryann Redford, Mario Alves, Joan PhelanAbstract:Objective. To determine the prevalence of enlargement, tenderness, and absence of saliva on palpation as indicators of Salivary Gland Disease in women who are human immunodeficiency virus (HIV)-positive. Study design. The study subjects are participants in the Women's Interagency HIV Study (WIHS), a multicenter study examining HIV-seropositive women and at-risk HIV-seronegative women. A total of 576 HIV-positive women and 152 HIV-negative women were examined at their baseline oral visit for clinical markers of Salivary Gland Disease. Viral load levels, CD4 counts, and CD8 counts were obtained as part of the related core study. Results. HIV-positive women had higher rates of Salivary Gland enlargement (4.3%), tenderness (6.9%), and absence of saliva on palpation (26.6%) compared with HIV-negative women, who had rates of 1.3%, 4.6%, and 13.2%, respectively. Absence of saliva was significantly different (P = .001) between the 2 groups. When 2 of the 3 clinical findings were combined, comparisons between the HIV-positive women and HIV-negative women became significant at the P <.05 level for every combination, except for enlargement/tenderness for the submandibular/sublingual Gland. For the HIV-positive women, the viral load was significantly related to enlargement (P =.019) and enlargement/absence of saliva on palpation (P =.037) for the parotids and enlargement (P.046), absence of saliva (P.043), and enlargement/absence of saliva (P.022) for the submandibular/sublingual Glands. Significant linear trends were found for increasing viral load and enlargement (P =.013) and enlargement/tenderness (P =.024) for the submandibular/sublingual Glands. Significance was present for submandibular/sublingual absence of saliva and tenderness/absence of saliva for CD4 and CD8 medians. Conclusions. Serostatus is related to Salivary Gland Disease as assessed by Glandular enlargement, tenderness, and absence of saliva on palpation. Furthermore, our findings indicate that a multidimensional approach to Gland assessment may provide a more complete and perhaps more adequate description of Glandular involvement with HIV infection.
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Salivary autoantibodies in hiv associated Salivary Gland Disease
Journal of Oral Pathology & Medicine, 1993Co-Authors: Jane C. Atkinson, Deborah Greenspan, Morten Schlodt, Scott Robataille, John S. GreenspanAbstract:A subset of HIV-positive patients develops Salivary Gland Disease (HIV-SGD), characterized by Salivary Gland enlargement and/or decreased Salivary flow. While clinical symptoms are similar to Sjogren's syndrome (SS). patients with HIV-SGD lack circulating anti-SS-A/Ro and anti-SS-B La. Occasionally, SS patients lacking circulating anti-SS-A/Ro and anti-SS-B'La have these antibodies in their saliva. Salivas from II patients with HIV-SGD, 13 HIV+ patients without HIV-SGD, 14 HIV-negative men controls, and 11 patients with SS were screened for autoantibodies. Five HIV-SGD salivas had antibodies recognizing the cytoplasm of a Salivary cell line. No HIV 4- controls showed reactivity. Ten of 11 SS patients had Salivary autoantibodies, and one HIV-negative control was positive for them. Salivary anti-SS-A/Ro was present in 8/11 SS patients, and 7 also contained anti-SS-B/La. No HIV-SGD Salivary samples had these specific autoantibodies. These findings suggest that while Glandular polyclonal expansion occurs in both HIV-SGD and SS, different autoantibodies are produced.
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natural history of hiv associated Salivary Gland Disease
Oral Surgery Oral Medicine Oral Pathology, 1992Co-Authors: Morten Schiødt, Deborah Greenspan, Caroline L. Dodd, Troy E. Daniels, David Chernoff, Harry Hollander, Diane W Wara, John S. GreenspanAbstract:To describe the natural history of HIV-associated Salivary Gland Disease, which is characterized by enlarged major Salivary Glands and/or xerostomia in HIV-infected persons, we assessed 22 patients at an initial and follow-up examinations (median span of examinations, 15 months). Sixteen patients (73%) had bilateral parotid Gland enlargement, 17 had symptoms of dry mouth, and 11 had both conditions. Parotid Gland enlargement remained unchanged in 10 patients, it progressed in 2, and it regressed in 4 during treatment with zidovudine or steroids. Those patients with parotid Gland enlargement had a significantly lower mean stimulated parotid flow rate (0.27 ml/min/per Gland) than a control group of HIV+ persons without Salivary Gland Disease (0.48 ml/min/per Gland) (p < 0.05), whereas the mean unstimulated whole Salivary flow rates did not did not differ significantly between the two groups. The mean Salivary flow rate of the study group did not change during the observation period. When HIV-associated Salivary Gland Disease was diagnosed, 5 patients (23%) had AIDS, and at follow-up 10 (46%) had AIDS. Seven of these had Kaposi's sarcoma. The mean peripheral blood CD4 cell count was 280 and 225 per mm3 at the initial and follow-up examinations, respectively. The corresponding CD8 counts were 1138 and 900. The pathogenesis of HIV-associated Salivary Gland Disease may include hyperplasia of intraparotid lymphoid tissue. Because HIV-associated Salivary Gland Disease can clinically resemble Sjo¨gren's syndrome, the differential diagnosis of bilateral parotid enlargement should include HIV infection.
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Sialochemistry in human immunodeficiency virus associated Salivary Gland Disease
The Journal of Rheumatology, 1992Co-Authors: Morten Schiødt, Jane C. Atkinson, Deborah Greenspan, Caroline L. Dodd, Troy E. Daniels, John S. GreenspanAbstract:Human immunodeficiency virus (HIV) associated Salivary Gland Disease is defined as the presence of enlargement of one or more major Salivary Glands and/or diminished Salivary function in an HIV infected individual. It has a number of similarities to, as well as differences from, Sjogren's syndrome (SS). We studied the sialochemistry of stimulated parotid saliva of 11 patients with HIV associated Salivary Gland Disease and bilateral parotid Gland enlargement, and compared these findings with those of 15 HIV negative controls, 13 HIV positive individuals with no Salivary Gland involvement and 18 individuals with SS. The patients with HIV associated Salivary Gland Disease had a significant decrease in the level of Salivary protein, with increases in Salivary IgA, lysozyme and albumin compared to the HIV negative controls. There were no changes in concentration of electrolytes. The sialochemistry among the patients with HIV associated Salivary Gland Disease was unrelated to the degree of immune suppression and did not change over a 6 month period. The observed changes were similar to those of SS but less pronounced. The similar clinical, histologic and sialochemical features of HIV associated Salivary Gland Disease and SS suggest that these conditions share common pathogenetic mechanisms, which may be modified in the former by the HIV infection.
John S. Greenspan - One of the best experts on this subject based on the ideXlab platform.
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Salivary autoantibodies in hiv associated Salivary Gland Disease
Journal of Oral Pathology & Medicine, 1993Co-Authors: Jane C. Atkinson, Deborah Greenspan, Morten Schlodt, Scott Robataille, John S. GreenspanAbstract:A subset of HIV-positive patients develops Salivary Gland Disease (HIV-SGD), characterized by Salivary Gland enlargement and/or decreased Salivary flow. While clinical symptoms are similar to Sjogren's syndrome (SS). patients with HIV-SGD lack circulating anti-SS-A/Ro and anti-SS-B La. Occasionally, SS patients lacking circulating anti-SS-A/Ro and anti-SS-B'La have these antibodies in their saliva. Salivas from II patients with HIV-SGD, 13 HIV+ patients without HIV-SGD, 14 HIV-negative men controls, and 11 patients with SS were screened for autoantibodies. Five HIV-SGD salivas had antibodies recognizing the cytoplasm of a Salivary cell line. No HIV 4- controls showed reactivity. Ten of 11 SS patients had Salivary autoantibodies, and one HIV-negative control was positive for them. Salivary anti-SS-A/Ro was present in 8/11 SS patients, and 7 also contained anti-SS-B/La. No HIV-SGD Salivary samples had these specific autoantibodies. These findings suggest that while Glandular polyclonal expansion occurs in both HIV-SGD and SS, different autoantibodies are produced.
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natural history of hiv associated Salivary Gland Disease
Oral Surgery Oral Medicine Oral Pathology, 1992Co-Authors: Morten Schiødt, Deborah Greenspan, Caroline L. Dodd, Troy E. Daniels, David Chernoff, Harry Hollander, Diane W Wara, John S. GreenspanAbstract:To describe the natural history of HIV-associated Salivary Gland Disease, which is characterized by enlarged major Salivary Glands and/or xerostomia in HIV-infected persons, we assessed 22 patients at an initial and follow-up examinations (median span of examinations, 15 months). Sixteen patients (73%) had bilateral parotid Gland enlargement, 17 had symptoms of dry mouth, and 11 had both conditions. Parotid Gland enlargement remained unchanged in 10 patients, it progressed in 2, and it regressed in 4 during treatment with zidovudine or steroids. Those patients with parotid Gland enlargement had a significantly lower mean stimulated parotid flow rate (0.27 ml/min/per Gland) than a control group of HIV+ persons without Salivary Gland Disease (0.48 ml/min/per Gland) (p < 0.05), whereas the mean unstimulated whole Salivary flow rates did not did not differ significantly between the two groups. The mean Salivary flow rate of the study group did not change during the observation period. When HIV-associated Salivary Gland Disease was diagnosed, 5 patients (23%) had AIDS, and at follow-up 10 (46%) had AIDS. Seven of these had Kaposi's sarcoma. The mean peripheral blood CD4 cell count was 280 and 225 per mm3 at the initial and follow-up examinations, respectively. The corresponding CD8 counts were 1138 and 900. The pathogenesis of HIV-associated Salivary Gland Disease may include hyperplasia of intraparotid lymphoid tissue. Because HIV-associated Salivary Gland Disease can clinically resemble Sjo¨gren's syndrome, the differential diagnosis of bilateral parotid enlargement should include HIV infection.
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Sialochemistry in human immunodeficiency virus associated Salivary Gland Disease
The Journal of Rheumatology, 1992Co-Authors: Morten Schiødt, Jane C. Atkinson, Deborah Greenspan, Caroline L. Dodd, Troy E. Daniels, John S. GreenspanAbstract:Human immunodeficiency virus (HIV) associated Salivary Gland Disease is defined as the presence of enlargement of one or more major Salivary Glands and/or diminished Salivary function in an HIV infected individual. It has a number of similarities to, as well as differences from, Sjogren's syndrome (SS). We studied the sialochemistry of stimulated parotid saliva of 11 patients with HIV associated Salivary Gland Disease and bilateral parotid Gland enlargement, and compared these findings with those of 15 HIV negative controls, 13 HIV positive individuals with no Salivary Gland involvement and 18 individuals with SS. The patients with HIV associated Salivary Gland Disease had a significant decrease in the level of Salivary protein, with increases in Salivary IgA, lysozyme and albumin compared to the HIV negative controls. There were no changes in concentration of electrolytes. The sialochemistry among the patients with HIV associated Salivary Gland Disease was unrelated to the degree of immune suppression and did not change over a 6 month period. The observed changes were similar to those of SS but less pronounced. The similar clinical, histologic and sialochemical features of HIV associated Salivary Gland Disease and SS suggest that these conditions share common pathogenetic mechanisms, which may be modified in the former by the HIV infection.
Carole Mcarthur - One of the best experts on this subject based on the ideXlab platform.
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Salivary Gland Disease in HIV/AIDS and primary Sjögren's syndrome: analysis of collagen I distribution and histopathology in American and African patients.
Journal of Oral Pathology & Medicine, 2003Co-Authors: Carole Mcarthur, Charlene W.j. Africa, William J. Castellani, Nida J. Luangjamekorn, Matthew Mclaughlin, Antonio Subtil-deoliveira, Charles M. Cobb, Paul Howard, Steven Gustafson, Dennis PalmerAbstract:Background: Salivary Gland Disease (SGD) in HIV/AIDS is clinically and histopathologically very similar to Sjogren's Syndrome (SS), although the mechanism of tissue damage is unknown. The aim of this study is to determine the prevalence of SGD in primary SS and in HIV/AIDS in USA and in West African patients, and to seek distinguishing histopathologic features that may help to elucidate underlying mechanisms. Methods: Histologic sections of minor Salivary Glands from 164 HIV-positive and -negative patients from Cameroon and the US, and from 17 US patients with primary SS, were evaluated following Salivary Gland biopsy for inflammatory changes. To confirm the presence of fibrosis, collagen I, which is the most abundant collagen type, was assessed immunohistochemically in H&E-stained sections. Results: Forty-eight per cent of patients with HIV from Cameroon had severe SGD, while it was only in 6% of patients from the US. Patients with HIV in the US had less fibrosis and collagen I deposits than Cameroonians. Seventy-six per cent of US HIV-positive patients had received anti-retroviral therapy, while none of the African patients had. SS and AIDS patients had a tendency for lymphocytes to locate in a perivascular rather than in a periductal distribution. Conclusions: The prevalence of SGD and the presence of fibrosis and collagen I in Cameroonians with HIV is significantly higher than in HIV-positive American patients, and is similar to US patients with primary SS. The impact of patient selection, anti-retroviral therapy, and pathogenic mechanisms on Salivary Gland pathology is discussed.
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Salivary Gland Disease in hiv aids and primary sjogren s syndrome analysis of collagen i distribution and histopathology in american and african patients
Journal of Oral Pathology & Medicine, 2003Co-Authors: Carole Mcarthur, Charlene W.j. Africa, William J. Castellani, Nida J. Luangjamekorn, Matthew Mclaughlin, Charles M. Cobb, Paul Howard, Antonio Subtildeoliveira, Steven GustafsonAbstract:Background: Salivary Gland Disease (SGD) in HIV/AIDS is clinically and histopathologically very similar to Sjogren's Syndrome (SS), although the mechanism of tissue damage is unknown. The aim of this study is to determine the prevalence of SGD in primary SS and in HIV/AIDS in USA and in West African patients, and to seek distinguishing histopathologic features that may help to elucidate underlying mechanisms. Methods: Histologic sections of minor Salivary Glands from 164 HIV-positive and -negative patients from Cameroon and the US, and from 17 US patients with primary SS, were evaluated following Salivary Gland biopsy for inflammatory changes. To confirm the presence of fibrosis, collagen I, which is the most abundant collagen type, was assessed immunohistochemically in H&E-stained sections. Results: Forty-eight per cent of patients with HIV from Cameroon had severe SGD, while it was only in 6% of patients from the US. Patients with HIV in the US had less fibrosis and collagen I deposits than Cameroonians. Seventy-six per cent of US HIV-positive patients had received anti-retroviral therapy, while none of the African patients had. SS and AIDS patients had a tendency for lymphocytes to locate in a perivascular rather than in a periductal distribution. Conclusions: The prevalence of SGD and the presence of fibrosis and collagen I in Cameroonians with HIV is significantly higher than in HIV-positive American patients, and is similar to US patients with primary SS. The impact of patient selection, anti-retroviral therapy, and pathogenic mechanisms on Salivary Gland pathology is discussed.
