The Experts below are selected from a list of 192 Experts worldwide ranked by ideXlab platform
Kevin J Cummings - One of the best experts on this subject based on the ideXlab platform.
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Short communication: Oral and intranasal administration of a modified-live Salmonella Dublin vaccine in dairy calves: Clinical efficacy and serologic response.
Journal of dairy science, 2019Co-Authors: Kevin J Cummings, Lorraine D. Rodriguez-rivera, M. B. Capel, Shelley C. Rankin, Daryl V. NydamAbstract:Our objectives were to evaluate the clinical efficacy of oral and intranasal administration of a commercial modified-live Salmonella Dublin vaccine in dairy calves and to determine the serologic response associated with these extralabel routes of administration. We conducted a randomized field trial with calves from a New York dairy farm following an outbreak of Salmonella Dublin. A total of 399 Holstein calves were allocated by pen to 3 treatment groups: oral vaccination, intranasal vaccination, and an unvaccinated control group. Administration of the vaccine through oral and intranasal routes did not have a significant effect on pneumonia incidence risk or weight gain; however, calves vaccinated orally and intranasally had lower mortality risk as compared with control calves. Among calves tested using a Salmonella Dublin ELISA, vaccination did not induce an increase in antibody production relative to control calves, indicating that oral and intranasal administration will not hinder diagnosis based on this assay.
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herd level prevalence of Salmonella Dublin among new york dairy farms based on antibody testing of bulk tank milk
Zoonoses and Public Health, 2018Co-Authors: Kevin J Cummings, P D Virkler, Bettina Wagner, Elizabeth A Lussier, Belinda ThompsonAbstract:Salmonella Dublin is an important cause of salmonellosis among dairy cattle and poses a considerable threat to public health. This serotype is increasingly being identified among bovine Salmonella isolates from clinical samples in the north-eastern United States, and these isolates are generally multidrug resistant. Our objective was to estimate the herd-level prevalence of Salmonella Dublin among dairy cattle herds throughout New York. Bulk tank milk samples from nearly all commercial dairy herds in New York were collected from milk quality testing laboratories during the first half of 2013. Antibody testing of bulk tank milk was performed using a Salmonella Dublin ELISA kit. Samples representing 4,896 commercial dairies were collected, and antibodies against Salmonella Dublin were detected in 46 herds (0.9%; 95% CI, 0.7%-1.3%). Given the herd-level sensitivity of ELISA testing for Salmonella Dublin in bulk tank milk at a single timepoint, this approach presumably underestimated the true prevalence. Some Salmonella Dublin-positive herds had both positive and negative bulk tanks at the same sampling time, indicating that herds with multiple tanks should test all of them when using this ELISA. Further research is needed to better understand the epidemiologic features of Salmonella Dublin in the north-eastern United States, including risk factors for introduction into dairy herds and principal transmission pathways.
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Herd‐level prevalence of Salmonella Dublin among New York dairy farms based on antibody testing of bulk tank milk
Zoonoses and public health, 2018Co-Authors: Kevin J Cummings, P D Virkler, Bettina Wagner, Elizabeth A Lussier, Belinda ThompsonAbstract:Salmonella Dublin is an important cause of salmonellosis among dairy cattle and poses a considerable threat to public health. This serotype is increasingly being identified among bovine Salmonella isolates from clinical samples in the north-eastern United States, and these isolates are generally multidrug resistant. Our objective was to estimate the herd-level prevalence of Salmonella Dublin among dairy cattle herds throughout New York. Bulk tank milk samples from nearly all commercial dairy herds in New York were collected from milk quality testing laboratories during the first half of 2013. Antibody testing of bulk tank milk was performed using a Salmonella Dublin ELISA kit. Samples representing 4,896 commercial dairies were collected, and antibodies against Salmonella Dublin were detected in 46 herds (0.9%; 95% CI, 0.7%-1.3%). Given the herd-level sensitivity of ELISA testing for Salmonella Dublin in bulk tank milk at a single timepoint, this approach presumably underestimated the true prevalence. Some Salmonella Dublin-positive herds had both positive and negative bulk tanks at the same sampling time, indicating that herds with multiple tanks should test all of them when using this ELISA. Further research is needed to better understand the epidemiologic features of Salmonella Dublin in the north-eastern United States, including risk factors for introduction into dairy herds and principal transmission pathways.
Liza Rosenbaum Nielsen - One of the best experts on this subject based on the ideXlab platform.
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Dynamic changes in antibody levels as an early warning of Salmonella Dublin in bovine dairy herds.
Journal of dairy science, 2013Co-Authors: Anders Stockmarr, Rene Bødker, Liza Rosenbaum NielsenAbstract:Abstract Salmonella Dublin is a bacterium that causes disease and production losses in cattle herds. In Denmark, a surveillance and control program was initiated in 2002 to monitor and reduce the prevalence of Salmonella Dublin. In dairy herds, the surveillance includes herd classification based on bulk tank milk measurements of antibodies directed against Salmonella Dublin at 3-mo intervals. In this study, an "alarm herd" concept, based on the dynamic progression of these repeated measurements, was formulated such that it contains predictive power for Salmonella Dublin herd classification change from "likely free of infection" to "likely infected" in the following quarter of the year, thus warning the farmer 3mo earlier than the present system. The alarm herd concept was defined through aberrations from a stable development over time of antibody levels. For suitable parameter choices, alarm herd status was a positive predictor for Salmonella Dublin status change in dairy herds, in that alarm herds had a higher risk of changing status in the following quarter compared with nonalarm herds. This was despite the fact that both alarm and nonalarm herds had antibody levels that did not indicate the herds being "likely infected" according to the existing classification system in the present quarter. The alarm herd concept can be used as a new early warning element in the existing surveillance program. Additionally, to improve accuracy of herd classification, the alarm herd concept could be incorporated into a model including other known risk factors for change in herd classification. Furthermore, the model could be extended to other diseases monitored in similar ways.
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Within-herd prevalence of Salmonella Dublin in endemically infected dairy herds.
Epidemiology and infection, 2013Co-Authors: Liza Rosenbaum NielsenAbstract:In this study within-herd prevalence of Salmonella Dublin was investigated in three age groups (calves, young stock, adult cows) during five herd visits at 3-month intervals of 14 endemically infected dairy herds. A total of 10162 paired faecal cultures and antibody measurements were used to calculate the age and temporal dynamics of seroprevalence and prevalence of positive faecal cultures. Faecal culture-positive prevalence was generally low. It was highest (5.4%) in calves during December to February. Seroprevalence varied from 0% to 70% between herds, but was generally more stable in young stock and adult cows than in calves. Hierarchical mixed-model results showed that seroprevalence was associated with the bacteriological status in calves and cows, but not in young stock. These results can be used to develop and validate theoretical infection dynamics models and to design effective control programmes for Salmonella Dublin in dairy herds.
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Salmonella Dublin faecal excretion probabilities in cattle with different temporal antibody profiles in 14 endemically infected dairy herds.
Epidemiology and infection, 2012Co-Authors: Liza Rosenbaum NielsenAbstract:This longitudinal field study investigated the hypothesis that persistently high antibody levels indicate a high risk of Salmonella Dublin shedding in animals in 14 endemically infected dairy herds. A hierarchical multivariable logistic regression was used to analyse 6614 paired faecal cultures and four types of temporal antibody profiles from cattle aged ≥180 days. Age and repeated measurements on animals nested within herds were taken into account. Overall, the prevalence of faecal shedders was low (0·3% and 2·8% in the lowest and highest risk groups, respectively). An important predictor of faecal shedding was young age. There was a significant, but modest increase in risk in cattle with persistently high or recently increased antibody levels, but no difference between these two groups. Contrary to previous recommendations, the detection of carriers by the use of repeated antibody testing is not likely to be a plausible control option in most Salmonella Dublin-infected dairy herds.
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A structured approach to control of Salmonella Dublin in 10 Danish dairy herds based on risk scoring and test-and-manage procedures
Food Research International, 2012Co-Authors: Liza Rosenbaum Nielsen, Søren Saxmose NielsenAbstract:Abstract The aim of this study was to describe a structured approach to effectively reduce Salmonella Dublin prevalence in infected dairy herds based on a step-wise procedure. Furthermore, the aim was to describe tools for management and monitoring, and to report on development in prevalence among young stock and adult cattle in 10 case herds that were followed for more than three years. The five steps in the structured approach were: 1) risk scoring to determine transmission routes within the herd and into the herd; 2) determining a plan of action; 3) performing management changes to close important routes of infection; 4) interpretation of repeated testing of individual animals to detect high-risk animals for special hygienic management or culling; and 5) diagnostic testing of different age groups and bulk tank milk to evaluate progress of control over time. Serology, true prevalence estimates and changes in herd classification in the Danish surveillance programme for Salmonella Dublin were used to assess the progress in the herds during and after the control period. Effective control of Salmonella Dublin was achieved in all participating herds through management that focused on closing infection routes mainly in the calving areas and the young calf areas of the herds. It took on average three years to control the infection in the case herds. Bulk tank milk recordings from the four following years indicated that most of the herds might have eradicated the infection.
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Spatial patterns in surveillance data during control of Salmonella Dublin in bovine dairy herds in Jutland, Denmark 2003-2009.
Spatial and spatio-temporal epidemiology, 2011Co-Authors: Annette Kjær Ersbøll, Liza Rosenbaum NielsenAbstract:Salmonella Dublin is the most commonly isolated Salmonella serotype in Danish cattle and leads to economic and welfare losses in infected herds. Furthermore, it leads to high mortality in human cases. A national surveillance program for Salmonella Dublin was initiated in Denmark in October 2002. This study aimed at modelling the progress and spatial patterns during the control of Salmonella Dublin in dairy herds in the Jutland peninsula in Denmark, especially differences between regions and years. A total of 6331 dairy herds were included during 2003-2009. Antibody measurements of bulk-tank milk samples were used for testing herd-level Salmonella status in these dairy herds. Risk maps were estimated as prevalence intensity maps. Spatial clustering was analysed using scan statistics and SMR was estimated. In 2003, the prevalence of Salmonella Dublin test-positive dairy herds was 24%. It decreased to 12% in 2009. Prevalence intensity maps showed large differences in the reduction of Salmonella Dublin test-positive herds. The number of clusters reduced during the study period. However, throughout the study period two clusters remained significant. Differences were seen in the progress of the control between regions over the years. The implementation and effectiveness of the control program was different between regions. The progress of control was seen to vary not only between regions, but also over time influencing infection dynamics. Thus, recommendations and regionally targeted efforts during control campaigns are needed.
Belinda Thompson - One of the best experts on this subject based on the ideXlab platform.
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herd level prevalence of Salmonella Dublin among new york dairy farms based on antibody testing of bulk tank milk
Zoonoses and Public Health, 2018Co-Authors: Kevin J Cummings, P D Virkler, Bettina Wagner, Elizabeth A Lussier, Belinda ThompsonAbstract:Salmonella Dublin is an important cause of salmonellosis among dairy cattle and poses a considerable threat to public health. This serotype is increasingly being identified among bovine Salmonella isolates from clinical samples in the north-eastern United States, and these isolates are generally multidrug resistant. Our objective was to estimate the herd-level prevalence of Salmonella Dublin among dairy cattle herds throughout New York. Bulk tank milk samples from nearly all commercial dairy herds in New York were collected from milk quality testing laboratories during the first half of 2013. Antibody testing of bulk tank milk was performed using a Salmonella Dublin ELISA kit. Samples representing 4,896 commercial dairies were collected, and antibodies against Salmonella Dublin were detected in 46 herds (0.9%; 95% CI, 0.7%-1.3%). Given the herd-level sensitivity of ELISA testing for Salmonella Dublin in bulk tank milk at a single timepoint, this approach presumably underestimated the true prevalence. Some Salmonella Dublin-positive herds had both positive and negative bulk tanks at the same sampling time, indicating that herds with multiple tanks should test all of them when using this ELISA. Further research is needed to better understand the epidemiologic features of Salmonella Dublin in the north-eastern United States, including risk factors for introduction into dairy herds and principal transmission pathways.
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Herd‐level prevalence of Salmonella Dublin among New York dairy farms based on antibody testing of bulk tank milk
Zoonoses and public health, 2018Co-Authors: Kevin J Cummings, P D Virkler, Bettina Wagner, Elizabeth A Lussier, Belinda ThompsonAbstract:Salmonella Dublin is an important cause of salmonellosis among dairy cattle and poses a considerable threat to public health. This serotype is increasingly being identified among bovine Salmonella isolates from clinical samples in the north-eastern United States, and these isolates are generally multidrug resistant. Our objective was to estimate the herd-level prevalence of Salmonella Dublin among dairy cattle herds throughout New York. Bulk tank milk samples from nearly all commercial dairy herds in New York were collected from milk quality testing laboratories during the first half of 2013. Antibody testing of bulk tank milk was performed using a Salmonella Dublin ELISA kit. Samples representing 4,896 commercial dairies were collected, and antibodies against Salmonella Dublin were detected in 46 herds (0.9%; 95% CI, 0.7%-1.3%). Given the herd-level sensitivity of ELISA testing for Salmonella Dublin in bulk tank milk at a single timepoint, this approach presumably underestimated the true prevalence. Some Salmonella Dublin-positive herds had both positive and negative bulk tanks at the same sampling time, indicating that herds with multiple tanks should test all of them when using this ELISA. Further research is needed to better understand the epidemiologic features of Salmonella Dublin in the north-eastern United States, including risk factors for introduction into dairy herds and principal transmission pathways.
P D Virkler - One of the best experts on this subject based on the ideXlab platform.
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herd level prevalence of Salmonella Dublin among new york dairy farms based on antibody testing of bulk tank milk
Zoonoses and Public Health, 2018Co-Authors: Kevin J Cummings, P D Virkler, Bettina Wagner, Elizabeth A Lussier, Belinda ThompsonAbstract:Salmonella Dublin is an important cause of salmonellosis among dairy cattle and poses a considerable threat to public health. This serotype is increasingly being identified among bovine Salmonella isolates from clinical samples in the north-eastern United States, and these isolates are generally multidrug resistant. Our objective was to estimate the herd-level prevalence of Salmonella Dublin among dairy cattle herds throughout New York. Bulk tank milk samples from nearly all commercial dairy herds in New York were collected from milk quality testing laboratories during the first half of 2013. Antibody testing of bulk tank milk was performed using a Salmonella Dublin ELISA kit. Samples representing 4,896 commercial dairies were collected, and antibodies against Salmonella Dublin were detected in 46 herds (0.9%; 95% CI, 0.7%-1.3%). Given the herd-level sensitivity of ELISA testing for Salmonella Dublin in bulk tank milk at a single timepoint, this approach presumably underestimated the true prevalence. Some Salmonella Dublin-positive herds had both positive and negative bulk tanks at the same sampling time, indicating that herds with multiple tanks should test all of them when using this ELISA. Further research is needed to better understand the epidemiologic features of Salmonella Dublin in the north-eastern United States, including risk factors for introduction into dairy herds and principal transmission pathways.
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Herd‐level prevalence of Salmonella Dublin among New York dairy farms based on antibody testing of bulk tank milk
Zoonoses and public health, 2018Co-Authors: Kevin J Cummings, P D Virkler, Bettina Wagner, Elizabeth A Lussier, Belinda ThompsonAbstract:Salmonella Dublin is an important cause of salmonellosis among dairy cattle and poses a considerable threat to public health. This serotype is increasingly being identified among bovine Salmonella isolates from clinical samples in the north-eastern United States, and these isolates are generally multidrug resistant. Our objective was to estimate the herd-level prevalence of Salmonella Dublin among dairy cattle herds throughout New York. Bulk tank milk samples from nearly all commercial dairy herds in New York were collected from milk quality testing laboratories during the first half of 2013. Antibody testing of bulk tank milk was performed using a Salmonella Dublin ELISA kit. Samples representing 4,896 commercial dairies were collected, and antibodies against Salmonella Dublin were detected in 46 herds (0.9%; 95% CI, 0.7%-1.3%). Given the herd-level sensitivity of ELISA testing for Salmonella Dublin in bulk tank milk at a single timepoint, this approach presumably underestimated the true prevalence. Some Salmonella Dublin-positive herds had both positive and negative bulk tanks at the same sampling time, indicating that herds with multiple tanks should test all of them when using this ELISA. Further research is needed to better understand the epidemiologic features of Salmonella Dublin in the north-eastern United States, including risk factors for introduction into dairy herds and principal transmission pathways.
Elizabeth A Lussier - One of the best experts on this subject based on the ideXlab platform.
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herd level prevalence of Salmonella Dublin among new york dairy farms based on antibody testing of bulk tank milk
Zoonoses and Public Health, 2018Co-Authors: Kevin J Cummings, P D Virkler, Bettina Wagner, Elizabeth A Lussier, Belinda ThompsonAbstract:Salmonella Dublin is an important cause of salmonellosis among dairy cattle and poses a considerable threat to public health. This serotype is increasingly being identified among bovine Salmonella isolates from clinical samples in the north-eastern United States, and these isolates are generally multidrug resistant. Our objective was to estimate the herd-level prevalence of Salmonella Dublin among dairy cattle herds throughout New York. Bulk tank milk samples from nearly all commercial dairy herds in New York were collected from milk quality testing laboratories during the first half of 2013. Antibody testing of bulk tank milk was performed using a Salmonella Dublin ELISA kit. Samples representing 4,896 commercial dairies were collected, and antibodies against Salmonella Dublin were detected in 46 herds (0.9%; 95% CI, 0.7%-1.3%). Given the herd-level sensitivity of ELISA testing for Salmonella Dublin in bulk tank milk at a single timepoint, this approach presumably underestimated the true prevalence. Some Salmonella Dublin-positive herds had both positive and negative bulk tanks at the same sampling time, indicating that herds with multiple tanks should test all of them when using this ELISA. Further research is needed to better understand the epidemiologic features of Salmonella Dublin in the north-eastern United States, including risk factors for introduction into dairy herds and principal transmission pathways.
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Herd‐level prevalence of Salmonella Dublin among New York dairy farms based on antibody testing of bulk tank milk
Zoonoses and public health, 2018Co-Authors: Kevin J Cummings, P D Virkler, Bettina Wagner, Elizabeth A Lussier, Belinda ThompsonAbstract:Salmonella Dublin is an important cause of salmonellosis among dairy cattle and poses a considerable threat to public health. This serotype is increasingly being identified among bovine Salmonella isolates from clinical samples in the north-eastern United States, and these isolates are generally multidrug resistant. Our objective was to estimate the herd-level prevalence of Salmonella Dublin among dairy cattle herds throughout New York. Bulk tank milk samples from nearly all commercial dairy herds in New York were collected from milk quality testing laboratories during the first half of 2013. Antibody testing of bulk tank milk was performed using a Salmonella Dublin ELISA kit. Samples representing 4,896 commercial dairies were collected, and antibodies against Salmonella Dublin were detected in 46 herds (0.9%; 95% CI, 0.7%-1.3%). Given the herd-level sensitivity of ELISA testing for Salmonella Dublin in bulk tank milk at a single timepoint, this approach presumably underestimated the true prevalence. Some Salmonella Dublin-positive herds had both positive and negative bulk tanks at the same sampling time, indicating that herds with multiple tanks should test all of them when using this ELISA. Further research is needed to better understand the epidemiologic features of Salmonella Dublin in the north-eastern United States, including risk factors for introduction into dairy herds and principal transmission pathways.
