The Experts below are selected from a list of 264 Experts worldwide ranked by ideXlab platform
Thomas Pittelkow - One of the best experts on this subject based on the ideXlab platform.
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scale up and safety evaluation of a Sandmeyer Reaction
Organic Process Research & Development, 2004Co-Authors: Martin Anker Nielsen, Michael Kim Nielsen, Thomas PittelkowAbstract:A scale-up of a new process for the production of 2-chloro-5-trifluoromethyl-benzonitrile by a Sandmeyer Reaction of 2-Chloro-5-trifluoromethylaniline with copper cyanide/sodium cyanide is described. To ensure a safe implementation, a safety evaluation of the process was carried out, which is described in the following. The new process gives a better working environment and better productivity due to shorter Reaction time.
L Labanauskas - One of the best experts on this subject based on the ideXlab platform.
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synthesis of bromocyclopropylpyridines via the Sandmeyer Reaction
Tetrahedron Letters, 2017Co-Authors: Romualdas Striela, Gintaras Urbelis, Jurgis Sūdžius, Sigitas Stoncius, Rita Sadzevicienė, L LabanauskasAbstract:Abstract The Reactions of 2-amino-5-cyclopropylpyridine with organic nitrites in the presence of copper(II) halides in various organic solvents were investigated. Optimal Reaction conditions for the Sandmeyer Reaction were developed and successfully applied to the synthesis of useful building blocks, bromo and chlorocyclopropylpyridines. Aminocyclopropylpyridines were synthesized in high yields from the corresponding aminobromopyridines under standard Suzuki coupling conditions.
Martin Anker Nielsen - One of the best experts on this subject based on the ideXlab platform.
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scale up and safety evaluation of a Sandmeyer Reaction
Organic Process Research & Development, 2004Co-Authors: Martin Anker Nielsen, Michael Kim Nielsen, Thomas PittelkowAbstract:A scale-up of a new process for the production of 2-chloro-5-trifluoromethyl-benzonitrile by a Sandmeyer Reaction of 2-Chloro-5-trifluoromethylaniline with copper cyanide/sodium cyanide is described. To ensure a safe implementation, a safety evaluation of the process was carried out, which is described in the following. The new process gives a better working environment and better productivity due to shorter Reaction time.
Alexander S Sigeev - One of the best experts on this subject based on the ideXlab platform.
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highly efficient Sandmeyer Reaction on immobilized cui cuii based catalysts
Mendeleev Communications, 2018Co-Authors: I G Tarkhanova, Michail G Gantman, Alexander S Sigeev, K I Maslakov, V M Zelikman, I P BeletskayaAbstract:Highly effective embodiment of Sandmeyer Reaction has been revealed for Cu-based catalysts incorporating ionic liquid on Silochrom support. The most active catalyst (TOF = = 4000–8000 h–1) contains comparable amounts of cuprous and cupric chloride anions. The reported method allows one to carry out the Reaction for anilines in the one-pot mode.
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Highly efficient Sandmeyer Reaction on immobilized CuI/CuII-based catalysts
Mendeleev Communications, 2018Co-Authors: I G Tarkhanova, Michail G Gantman, Alexander S Sigeev, K I Maslakov, V M Zelikman, I P BeletskayaAbstract:Highly effective embodiment of Sandmeyer Reaction has been revealed for Cu-based catalysts incorporating ionic liquid on Silochrom support. The most active catalyst (TOF = = 4000–8000 h–1) contains comparable amounts of cuprous and cupric chloride anions. The reported method allows one to carry out the Reaction for anilines in the one-pot mode.
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cu i cu ii tmeda new effective available catalyst of Sandmeyer Reaction
ChemInform, 2013Co-Authors: Alexander S Sigeev, I. P. Beletskaya, P. V. Petrovskii, A. S. PeregudovAbstract:Reaction of aryldiazonium salts with potassium chloride, bromide, cyanide, and thiocyanate in the presence of the title catalytic system leads to the formation of the corresponding aryl halides, nitriles, and thiocyanates in moderate to high yields.
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cu i cu ii tmeda new effective available catalyst of Sandmeyer Reaction
Russian Journal of Organic Chemistry, 2012Co-Authors: Alexander S Sigeev, I. P. Beletskaya, P. V. Petrovskii, A. S. PeregudovAbstract:The system Cu(I)/Cu(II)/N,N,N′,N′-tetramethylethylenediamine is a highly efficient and accessible catalyst of Sandmeyer Reaction. The Reaction of aryldiazonium salts with chlorides, bromides,, cyanides, and thiocyanates of alkaline metals in the presence of this catalytic system leads to the formation of the corresponding aryl halides, nitriles, and thiocyanates in high yields.
Romualdas Striela - One of the best experts on this subject based on the ideXlab platform.
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synthesis of bromocyclopropylpyridines via the Sandmeyer Reaction
Tetrahedron Letters, 2017Co-Authors: Romualdas Striela, Gintaras Urbelis, Jurgis Sūdžius, Sigitas Stoncius, Rita Sadzevicienė, L LabanauskasAbstract:Abstract The Reactions of 2-amino-5-cyclopropylpyridine with organic nitrites in the presence of copper(II) halides in various organic solvents were investigated. Optimal Reaction conditions for the Sandmeyer Reaction were developed and successfully applied to the synthesis of useful building blocks, bromo and chlorocyclopropylpyridines. Aminocyclopropylpyridines were synthesized in high yields from the corresponding aminobromopyridines under standard Suzuki coupling conditions.
