Saussurea

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Gómez De Huertas, Iris Y. - One of the best experts on this subject based on the ideXlab platform.

Hubiao Chen - One of the best experts on this subject based on the ideXlab platform.

  • comparison of the anti inflammatory and anti nociceptive effects of three medicinal plants known as snow lotus herb in traditional uighur and tibetan medicines
    Journal of Ethnopharmacology, 2010
    Co-Authors: Zhongzhen Zhao, Hubiao Chen
    Abstract:

    Abstract Ethnopharmacological relevance Saussurea involucrata (Kar. et Kir.) Sch.-Bip. (Compositae) has long been used under the herbal name “Snow Lotus” for the treatment of rheumatoid arthritis, stomachache and dysmenorrhea in Uighur folk medicine. In traditional Tibetan medicine, Saussurea laniceps Hand.-Mazz. and Saussurea medusa Maxim. have also been used under the name “Snow Lotus” and prescribed for the treatment of pain and inflammatory conditions. Aim of the study The present study evaluated the pharmacological effects of three species of “Snow Lotus” in experimental inflammation and pain models, and determined the chemical compounds that may correlate with their pharmacological activities. Materials and methods The anti-inflammatory activities of the three herbs were observed by using carrageenan-induced paw edema in rats and xylene-induced ear edema in mice. Investigations on the analgesic effects were conducted, including acetic acid-induced writhing and hot-plate test. An UPLC–MS method was developed to analyze the chemical composition of the three herbs and of plasma samples after herb administration. Results In rat paw edema model, the peak inhibitory effects of Saussurea laniceps and Saussurea involucrata (55.1% and 42.2%, respectively) were recorded with the dose of 400 mg/kg at 3 h post-carrageenan injection. In mouse ear edema model, oral administration of Saussurea laniceps , Saussurea involucrata and Saussurea medusa extract (400 mg/kg) resulted in a significant inhibition of ear edema by 40.9%, 33.3%, and 9.1%, respectively. In the writhing test, oral administration of Saussurea laniceps extract (100, 200 and 400 mg/kg) resulted in a significant inhibition of writhings by 13.5%, 22.3%, and 43.5%, respectively. In the hot-plate test, Saussurea laniceps extract significantly increased the latency of jumping response by 38.2% and 52.7% when treated orally at 200 and 400 mg/kg in mice, respectively. Flavonoids, coumarins and lignins were found to be present in plasma after administration of the extracts and may be the basis of the observed pharmacological effects. Conclusion The results clearly demonstrated that Saussurea laniceps was most effective; Saussurea involucrata exhibited a moderate potency, whereas Saussurea medusa possessed little effect against the experimental edema and pains. This study also supported discrimination among the three herbs when using them in folk medicine.

Jan Salick - One of the best experts on this subject based on the ideXlab platform.

  • human induced dwarfing of himalayan snow lotus Saussurea laniceps asteraceae
    Proceedings of the National Academy of Sciences of the United States of America, 2005
    Co-Authors: Wayne Law, Jan Salick
    Abstract:

    †Because evolutionary processes such as genetic drift and natural selection play a crucial role in determining the response that species will have to human-induced disturbances, there is increasing interest in the evolutionary aspects of conservation biology. Harvesting select individuals in natural plant populations can bring about unforeseen impacts that may negatively affect fitness. We analyzed how human harvesting affects two congeners known as snow lotus. Over a period of 100 years, there was a negative trend in plant height (r2 0.4361, P < 0.001) for the intensely collected and rare species, Saussurea laniceps, but not in the less intensely collected species, Saussurea medusa. Additionally, S. laniceps were significantly smaller in areas of high harvest than in areas with low harvest (Z 4.91, P < 0.0001), but this was not so for S. medusa. Humans can unconsciously drive evolution and must be considered when managing threatened species. conservation human selection Tibetan medicine

Heinrich Enbergs - One of the best experts on this subject based on the ideXlab platform.

  • effects of Saussurea lappa roots extract in ethanol on leukocyte phagocytic activity lymphocyte proliferation and interferon gamma ifn gamma
    Pakistan Journal of Pharmaceutical Sciences, 2007
    Co-Authors: Anas Sarwar, Heinrich Enbergs
    Abstract:

    Effects of Saussurea lappa root extracts prepared in ethanol according to the homeopathic principles were assessed on leukocyte phagocytic activity, lymphocyte transformation and mitogen-induced interferon-gamma (IFN-gamma) in the cultures of peripheral blood mononuclear cells of goats (PBMC) in vitro. Leukocyte phagocytic activity was measured by flow cytometry, lymphocyte proliferation by MTT and IFN-gamma level in cell culture supernatants was determined by ELISA. The results obtained demonstrated that all test dilutions (D4, D6, D8) of Saussurea lappa in ethanol have exerted a stimulating effect on leukocyte phagocytic activity in dose-dependent manner. A 10 microl dose of Saussurea lappa of each dilution markedly enhanced phagocytic activity, while other doses tested made only a feeble stimulating effect. The increases with 10 microl dose were found significantly (P<0.01) different between each dilution, maximal stimulation was observed by D8 dilution. Different doses (10 microl, 2 microl, 1 microl, 0.5 microl) of all test dilutions (D4, D6, D8) of Saussurea lappa in sterile 0.9% NaCl solution inhibited lymphocyte proliferation. Maximal inhibitory effect was observed with the 2 microl dose. Similarly, Saussurea lappa suppressed the secretion of IFN-gamma by mitogen-activated (PHA; 2.5 microg/ml) of peripheral mononuclear cells in dose-dependent manner. In conclusion these findings suggest that enhanced leukocyte phagocytic activity may be helpful to clear the soluble immune complexes produced during a sustained immune response against self antigens which causes chronic inflammatory injury of tissue. On the other hand, inhibition of lymphocyte proliferation and IFN-gamma by Saussurea lappa may contribute to suppress immune-mediated inflammatory reactions possibly through a cell-mediated cytokine pathway. Thus it is concievable that ethanolic extracts of Saussurea lappa roots in homeopathetic dilutions may be considered as a potential candidate for therapeutic support in autoimmune and chronic inflammatory disorders.

  • original article effects of Saussurea lappa roots extract in ethanol on leukocyte phagocytic activity lymphocyte proliferation and interferon gamma ifn γ
    2007
    Co-Authors: Anas Sarwar, Heinrich Enbergs
    Abstract:

    Effects of Saussurea lappa root extracts prepared in ethanol according to the homeopathic principles were ssessed on leukocyte phagocytic activity, lymphocyte transformation and mitogen-induced interferon-gamma (IFN-γ) in the cultures of peripheral blood mononuclear cells of goats (PBMC) in vitro. Leukocyte phagocytic activity was measured by flow cytometry, lymphocyte proliferation by MTT and IFN-γ level in cell culture supernatants was determined by ELISA. The results obtained demonstrated that all test dilutions (D4, D6, D8) of Saussurea lappa in ethanol have exerted a stimulating effect on leukocyte phagocytic activity in dosedependent manner. A 10µl dose of Saussurea lappa of each dilution markedly enhanced phagocytic activity, while other doses tested made only a feeble stimulating effect. The increases with 10µl dose were found significantly (P<0.01) different between each dilution, maximal stimulation was observed by D8 dilution. Different doses (10µl, 2µl, 1µl, 0.5µl) of all test dilutions (D4, D6, D8) of Saussurea lappa in sterile 0.9% NaCl solution inhibited lymphocyte proliferation. Maximal inhibitory effect was observed with the 2 µl dose. Similarly, Saussurea lappa suppressed the secretion of IFN-γ by mitogen-activated (PHA; 2.5µg/ml) of peripheral mononuclear cells in dose-dependent manner. In conclusion these findings suggest that enhanced leukocyte phagocytic activity may be helpful to clear the soluble immune complexes produced during a sustained immune response against self antigens which causes chronic inflammatory injury of tissue. On the other hand, inhibition of lymphocyte proliferation and IFN-γ by Saussurea lappa may contribute to suppress immune-mediated inflammatory reactions possibly through a cell-mediated cytokine pathway. Thus it is concievable that ethanolic extracts of Saussurea lappa roots in homeopathetic dilutions may be considered as a potential candidate for therapeutic support in autoimmune and chronic inflammatory disorders.

Gong Hongdong - One of the best experts on this subject based on the ideXlab platform.