The Experts below are selected from a list of 1836 Experts worldwide ranked by ideXlab platform
Paul E. Verweij - One of the best experts on this subject based on the ideXlab platform.
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Keratitis Caused by Scedosporium apiospermum Successfully Treated with a Cornea Transplant and Voriconazole
Journal of clinical microbiology, 2003Co-Authors: E. Nulens, Cathrien A. Eggink, Antonius J. M. M. Rijs, Pieter Wesseling, Paul E. VerweijAbstract:A case of Scedosporium apiospermum keratitis was successfully treated with oral voriconazole and penetrating keratoplasty. Voriconazole levels in the aqueous humor were 53% of the levels in plasma and exceeded the MIC for the isolate by sevenfold.
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Two cases of subcutaneous Scedosporium apiospermum infection treated with voriconazole.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2003Co-Authors: F. Bosma, Andreas Voss, H.w. Van Hamersvelt, R.g.l. De Sevaux, Jan Biert, B.j. Kullberg, W.g.j. Melchers, Paul E. VerweijAbstract:Scedosporium apiospermum is a mold that is increasingly being recognized as an opportunistic pathogen in immunocompromised patients, and treatment is complicated by intrinsic resistance to several antifungal agents. In our hospital, two cases of S. apiospermum infection occurring within 2 weeks were successfully treated with voriconazole. Since both patients were infected with an uncommon pathogen, a search for a common nosocomial source was performed. As environmental cultures yielded no S. apiospermum, and random amplified polymorphic DNA (RAPD) fingerprinting showed that the patients' strains were genotypically unrelated, we considered a common nosocomial source of S. apiospermum to be unlikely.
Yan Liu - One of the best experts on this subject based on the ideXlab platform.
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Diagnostic Direct DNA Sequencing and Systemic Treatment with Voriconazole in Scedosporium apiospermum Keratitis? A Case Report
Journal of Clinical & Experimental Ophthalmology, 2013Co-Authors: Qiao Sun, Qiang-qiang Zhang, Hai-yan Wang, Yan LiuAbstract:Scedosporium apiospermum keratitis is a rare but challenging infection because of its high misidentification rate and resistance to many antifungal agents. A 35-year-old immunocompetent man with severe Scedosporium apiospermum keratitis diagnosed by both microbiology and DNA sequencing methods, which was successfully treated with systemic voriconazole was reported. Diagnosis and drug susceptibilities were discussed.
John F Schonder - One of the best experts on this subject based on the ideXlab platform.
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Scedosporium apiospermum pseudallescheria boydii endocarditis
Journal of Infection, 2002Co-Authors: Thomas A Obryan, Frederick A Browne, John F SchonderAbstract:Scedosporium apiospermum, the asexual state of Pseudallescheria boydii, is increasingly recognized as an opportunistic pathogen. We report a case of native valve endocarditis due to this organism that developed in an elderly patient following a prolonged hospitalization. Literature on endocarditis caused by S. apiospermum and P. boydii is reviewed.
S. Doudounakis - One of the best experts on this subject based on the ideXlab platform.
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Scedosporium apiospermum complex in cystic fibrosis; should we treat?
Mycoses, 2017Co-Authors: Maria Noni, Anna Katelari, Aikaterini Kapi, Angeliki Stathi, George Dimopoulos, S. DoudounakisAbstract:Summary Species of the Scedosporium apiospermum complex are the second most frequent filamentous fungi after Aspergillus fumigatus that can be found in cystic fibrosis (CF). Mixed colonisation by S. apiospermum complex and A. fumigatus is also quite common. In this study we summarise all CF patients who were colonised by S. apiospermum complex during their childhood and we present two CF patients who were treated as fungal bronchitis due to S. apiospermum complex. The medical records of 400 CF patients were reviewed in order to identify those with positive respiratory cultures for S. apiospermum complex. Scedosporium apiospermum complex was isolated in 10 CF patients and six of them had more than two positive sputum cultures during the study period. By the time of first isolation, the median age was 14.5 years, the median BMI was 19.41 kg/m2, the median predicted FEV1% was 78.65% and six patients had a history of A. fumigatus isolation. Two patients presented symptoms of infection while they were colonised by S. apiospermum complex. A rapid remission of their symptoms was observed only when antifungal therapy was administered. Antifungal treatment should be considered in CF patients who present symptoms of infection not responding to antibacterial therapy and S. apiospermum complex is persistently growing in sputum cultures.
Takashi Yoshiike - One of the best experts on this subject based on the ideXlab platform.
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cutaneous pseudallescheria boydii Scedosporium apiospermum complex moleculartype Scedosporium apiospermum clade 4 infection a case report and literature review of cases from japan
Medical mycology journal, 2015Co-Authors: Satoko Ishii, Midori Hiruma, Yuji Hayakawa, Takashi Sugita, Koichi Makimura, Takashi YoshiikeAbstract:: We report a case of subcutaneous Pseudallescheria boydii/Scedosporium apiospermum complex infection occurring in a 77-year-old Japanese female farmer suffering from interstitial pneumonia. Seven months prior to the current presentation, she noticed nodes on her right forearm after pulling up weeds, and the nodes grew larger. Two soft dome-shaped, protruded nodes ( 15 mm and 30 mm in size ) had fused together on the extensor surface of the right forearm. Yellowish-white, rice-grain-sized pustules clustered on the surface. Histopathological examination of the skin specimen showed large and small abscesses surrounded by epithelioid granuloma; separate branching hyphae within the granulation tissue were stained with PAS. No grains were observed. Fungal culture yielded fast-growing, grayish-white, fluffy colonies which were identified as Scedosporium apiospermum (Clade 4) using sequence analysis of the β-tubulin gene. We also reviewed 28 previously reported Japanese cases of P. boydii or S. apiospermum infection presenting with skin manifestations.
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Cutaneous Pseudallescheria boydii/Scedosporium apiospermum Complex (Molecular type: Scedosporium apiospermum [Clade 4]) Infection: A Case Report and Literature Review of Cases from Japan.
Medical mycology journal, 2015Co-Authors: Satoko Ishii, Midori Hiruma, Yuji Hayakawa, Takashi Sugita, Koichi Makimura, Takashi YoshiikeAbstract:We report a case of subcutaneous Pseudallescheria boydii/Scedosporium apiospermum complex infection occurring in a 77-year-old Japanese female farmer suffering from interstitial pneumonia. Seven months prior to the current presentation, she noticed nodes on her right forearm after pulling up weeds, and the nodes grew larger. Two soft dome-shaped, protruded nodes ( 15 mm and 30 mm in size ) had fused together on the extensor surface of the right forearm. Yellowish-white, rice-grain-sized pustules clustered on the surface. Histopathological examination of the skin specimen showed large and small abscesses surrounded by epithelioid granuloma; separate branching hyphae within the granulation tissue were stained with PAS. No grains were observed. Fungal culture yielded fast-growing, grayish-white, fluffy colonies which were identified as Scedosporium apiospermum (Clade 4) using sequence analysis of the β-tubulin gene. We also reviewed 28 previously reported Japanese cases of P. boydii or S. apiospermum infection presenting with skin manifestations.
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cutaneous pseudallescheria boydii Scedosporium apiospermum complex molecular type Scedosporium apiospermum clade 4 infection a case report and literature review of cases from japan
Medical mycology journal, 2015Co-Authors: Satoko Ishii, Midori Hiruma, Yuji Hayakawa, Takashi Sugita, Koichi Makimura, Takashi YoshiikeAbstract:We report a case of subcutaneous Pseudallescheria boydii/Scedosporium apiospermum complex infection occurring in a 77-year-old Japanese female farmer suffering from interstitial pneumonia. Seven months prior to the current presentation, she noticed nodes on her right forearm after pulling up weeds, and the nodes grew larger. Two soft dome-shaped, protruded nodes ( 15 mm and 30 mm in size ) had fused together on the extensor surface of the right forearm. Yellowish-white, rice-grain-sized pustules clustered on the surface. Histopathological examination of the skin specimen showed large and small abscesses surrounded by epithelioid granuloma; separate branching hyphae within the granulation tissue were stained with PAS. No grains were observed. Fungal culture yielded fast-growing, grayish-white, fluffy colonies which were identified as Scedosporium apiospermum (Clade 4) using sequence analysis of the β-tubulin gene. We also reviewed 28 previously reported Japanese cases of P. boydii or S. apiospermum infection presenting with skin manifestations.
