The Experts below are selected from a list of 312 Experts worldwide ranked by ideXlab platform
Masatsugu Nakamura - One of the best experts on this subject based on the ideXlab platform.
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Tear volume estimation using a modified Schirmer Test: a randomized, multicenter, double-blind trial comparing 3% diquafosol ophthalmic solution and artificial tears in dry eye patients
Clinical Ophthalmology, 2016Co-Authors: Hideki Miyake, Yuri Kawano, Akihiro Iwata, Takahiro Imanaka, Hiroshi Tanaka, Masatsugu NakamuraAbstract:Purpose We aimed to evaluate the feasibility of using a modified Schirmer Test to determine the increase in tear volume after administration of 3% diquafosol ophthalmic solution (diquafosol 3%) in dry eye patients.
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tear volume estimation using a modified Schirmer Test a randomized multicenter double blind trial comparing 3 diquafosol ophthalmic solution and artificial tears in dry eye patients
Clinical Ophthalmology, 2016Co-Authors: Hideki Miyake, Yuri Kawano, Akihiro Iwata, Takahiro Imanaka, Hiroshi Tanaka, Masatsugu NakamuraAbstract:PURPOSE: We aimed to evaluate the feasibility of using a modified Schirmer Test to determine the increase in tear volume after administration of 3% diquafosol ophthalmic solution (diquafosol 3%) in dry eye patients. PATIENTS AND METHODS: A randomized, multicenter, prospective, double-blind clinical study recruited 50 qualified subjects. They received diquafosol 3% in one eye and artificial tears in the other eye. The study protocol comprised a screening and treatment procedure completed within 1 day. The Schirmer Test was performed on closed eyes three times a day. The primary efficacy end points were the second Schirmer Test scores 10 minutes after the single dose. Secondary end points were the third Schirmer Test scores 3 hours and 40 minutes after the single dose and the symptom scores prior to the second and third Schirmer Tests. RESULTS: According to the Schirmer Test, 10 minutes after administration, diquafosol 3% significantly increased tear volume compared to artificial tears. Diquafosol 3% and artificial tears both showed significant improvements in the symptom scores compared to baseline. However, there was no significant difference in the symptoms score between diquafosol 3% and artificial tears. CONCLUSION: The modified Schirmer Test can detect a minute change in tear volume in dry eye patients. These findings will be useful in the diagnosis of dry eye, assessment of treatment benefits in daily clinical practice, and the development of possible tear-secreting compounds for dry eye.
Ak Khurana - One of the best experts on this subject based on the ideXlab platform.
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Study of tear film flow and break up time (BUT) in trachoma.
Acta Ophthalmologica, 2009Co-Authors: Shyam S Moudgil, I. P. S. Parmar, M. Singh, Ak KhuranaAbstract:: Tear film flow and stability studies were carried out in patients suffering from cicatrizing trachoma by Schirmer Test I and tear film break-up-time (BUT) measurements, respectively. Both Schirmer Test I and BUT values were decreased significantly (t-Test, P less than 0.001) depicting aqueous as well as mucin deficiency and hence, an unstable tear film in this condition.
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Tear film flow and stability in herpes simplex keratitis and chronic blepharitis.
Acta ophthalmologica, 2009Co-Authors: Shyam S Moudgil, M. Singh, Ak KhuranaAbstract:Tear film flow and stability studies were carried out in patients suffering from herpes simplex keratitis and chronic blepharitis by performing Schirmer Test I and tear film break-up-time (BUT) measurements. In herpes simplex keratitis the values of BUT were within normal limits. Values of Schirmer Test I were significantly higher (t-Test, P less than 0.001) in these patients and are considered to be due to reflex hypersecretion of tears. Schirmer Test I was found to be unaffected, whereas the values of BUT seen were significantly lower (t-Test, P less than 0.001) in patients suffering from chronic blepharitis. These lower values of BUT can perhaps be attributed to the altered resurfacing of precorneal tear film as a result of changes in the lid margins.
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Study of tear film flow and stability in chronic dacryocystitis.
Acta ophthalmologica, 2009Co-Authors: Ak Khurana, Shyam S Moudgil, B. K. AhluwaliaAbstract:. Tear film flow and stability studies were carried out in patients suffering from chronic dacryocystitis by performing Schirmer Test-I and tear film break-up-time (BUT) measurements. The results of Schirmer's Test corroborated the theory that a reduced out flow of tears causes a compensatory reduced tear secretion. The results of break-up-time confirm the fact that BUT is independent of outflow of tears in patients with epiphora.
Shyam S Moudgil - One of the best experts on this subject based on the ideXlab platform.
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Study of tear film flow and break up time (BUT) in trachoma.
Acta Ophthalmologica, 2009Co-Authors: Shyam S Moudgil, I. P. S. Parmar, M. Singh, Ak KhuranaAbstract:: Tear film flow and stability studies were carried out in patients suffering from cicatrizing trachoma by Schirmer Test I and tear film break-up-time (BUT) measurements, respectively. Both Schirmer Test I and BUT values were decreased significantly (t-Test, P less than 0.001) depicting aqueous as well as mucin deficiency and hence, an unstable tear film in this condition.
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Tear film flow and stability in herpes simplex keratitis and chronic blepharitis.
Acta ophthalmologica, 2009Co-Authors: Shyam S Moudgil, M. Singh, Ak KhuranaAbstract:Tear film flow and stability studies were carried out in patients suffering from herpes simplex keratitis and chronic blepharitis by performing Schirmer Test I and tear film break-up-time (BUT) measurements. In herpes simplex keratitis the values of BUT were within normal limits. Values of Schirmer Test I were significantly higher (t-Test, P less than 0.001) in these patients and are considered to be due to reflex hypersecretion of tears. Schirmer Test I was found to be unaffected, whereas the values of BUT seen were significantly lower (t-Test, P less than 0.001) in patients suffering from chronic blepharitis. These lower values of BUT can perhaps be attributed to the altered resurfacing of precorneal tear film as a result of changes in the lid margins.
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Study of tear film flow and stability in chronic dacryocystitis.
Acta ophthalmologica, 2009Co-Authors: Ak Khurana, Shyam S Moudgil, B. K. AhluwaliaAbstract:. Tear film flow and stability studies were carried out in patients suffering from chronic dacryocystitis by performing Schirmer Test-I and tear film break-up-time (BUT) measurements. The results of Schirmer's Test corroborated the theory that a reduced out flow of tears causes a compensatory reduced tear secretion. The results of break-up-time confirm the fact that BUT is independent of outflow of tears in patients with epiphora.
Hideki Miyake - One of the best experts on this subject based on the ideXlab platform.
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Tear volume estimation using a modified Schirmer Test: a randomized, multicenter, double-blind trial comparing 3% diquafosol ophthalmic solution and artificial tears in dry eye patients
Clinical Ophthalmology, 2016Co-Authors: Hideki Miyake, Yuri Kawano, Akihiro Iwata, Takahiro Imanaka, Hiroshi Tanaka, Masatsugu NakamuraAbstract:Purpose We aimed to evaluate the feasibility of using a modified Schirmer Test to determine the increase in tear volume after administration of 3% diquafosol ophthalmic solution (diquafosol 3%) in dry eye patients.
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tear volume estimation using a modified Schirmer Test a randomized multicenter double blind trial comparing 3 diquafosol ophthalmic solution and artificial tears in dry eye patients
Clinical Ophthalmology, 2016Co-Authors: Hideki Miyake, Yuri Kawano, Akihiro Iwata, Takahiro Imanaka, Hiroshi Tanaka, Masatsugu NakamuraAbstract:PURPOSE: We aimed to evaluate the feasibility of using a modified Schirmer Test to determine the increase in tear volume after administration of 3% diquafosol ophthalmic solution (diquafosol 3%) in dry eye patients. PATIENTS AND METHODS: A randomized, multicenter, prospective, double-blind clinical study recruited 50 qualified subjects. They received diquafosol 3% in one eye and artificial tears in the other eye. The study protocol comprised a screening and treatment procedure completed within 1 day. The Schirmer Test was performed on closed eyes three times a day. The primary efficacy end points were the second Schirmer Test scores 10 minutes after the single dose. Secondary end points were the third Schirmer Test scores 3 hours and 40 minutes after the single dose and the symptom scores prior to the second and third Schirmer Tests. RESULTS: According to the Schirmer Test, 10 minutes after administration, diquafosol 3% significantly increased tear volume compared to artificial tears. Diquafosol 3% and artificial tears both showed significant improvements in the symptom scores compared to baseline. However, there was no significant difference in the symptoms score between diquafosol 3% and artificial tears. CONCLUSION: The modified Schirmer Test can detect a minute change in tear volume in dry eye patients. These findings will be useful in the diagnosis of dry eye, assessment of treatment benefits in daily clinical practice, and the development of possible tear-secreting compounds for dry eye.
Giulio Modorati - One of the best experts on this subject based on the ideXlab platform.
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tear osmolarity in ocular graft versus host disease
Cornea, 2014Co-Authors: Luigi Berchicci, Elisabetta Miserocchi, Lorenzo Iuliano, Francesco Bandello, Giulio ModoratiAbstract:PURPOSE: The aim of this study was to evaluate tear osmolarity in patients with chronic graft-versus-host disease (cGVHD) with ocular involvement. METHODS: In this observational cross-sectional study of 56 patients with ocular cGVHD referred to the tertiary-care Ocular Immunology and Uveitis Service at the San Raffaele Scientific Institute, Milan, from May 2010 to November 2013, we evaluated the following clinical parameters: Ocular Surface Disease Index (OSDI) symptoms questionnaire, tear osmolarity, Schirmer Test, tear film break-up time (TBUT), corneal and conjunctival staining. RESULTS: All patients developed systemic GVHD after undergoing allogeneic hematologic stem cell transplantation. Mean osmolarity was 314.0 ± 22.1 mOsm/L, mean OSDI score was 26.4 ± 21.2, mean TBUT was 6.50 ± 4.75 seconds, and mean Schirmer Test value was 3.8 ± 3.3 mm. Tear osmolarity significantly inversely correlated with TBUT (r = 0.681; P < 0.001). Statistically significant inverse correlation was present with the Schirmer Test (r = 0.203; P < 0.001), and positive correlation with the OSDI score (r = 0.188; P < 0.001), but both with low correlation strength. Osmolarity was statistically different in the subgroups according to the Oxford corneal staining scale (P = 0.0006) and to the van Bijsterveld conjunctival staining score (P = 0.006). CONCLUSIONS: Tear osmolarity increased in patients with ocular cGVHD, significantly correlated with TBUT and, to a lesser extent, with the Schirmer Test value and OSDI. These results emphasize the role of aqueous-deficient and evaporative dry eye disease in patients with cGVHD after undergoing allogeneic hematologic stem cell transplantation. Tear osmolarity may be considered a useful Test in diagnostic assessment of dry eye disease associated with cGVHD.
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tear film osmolarity in ocular mucous membrane pemphigoid
Cornea, 2014Co-Authors: Elisabetta Miserocchi, Lorenzo Iuliano, Luigi Berchicci, Francesco Bandello, Giulio ModoratiAbstract:PURPOSE: The aim of this study was to evaluate tear film osmolarity in patients with ocular mucous membrane pemphigoid (MMP). METHODS: This observational cross-sectional study included 40 patients with biopsy-proven ocular MMP at Foster stage III referred to the tertiary-care Ocular Immunology and Uveitis Service at the San Raffaele Scientific Institute in Milan from June 2010 to August 2013. We evaluated the following clinical parameters: tear film osmolarity, ocular surface disease symptoms (OSDI) questionnaire, Schirmer Test, tear film break-up time (TFBUT), and corneal and conjunctival staining. RESULTS: Forty patients (27 women and 13 men) were enrolled. All patients were undergoing systemic immunosuppressive therapy: 19 patients (47.5%) were on methotrexate, 9 (22.5%) were on mycophenolate mofetil, 9 (22.5%) were on low-dose corticosteroids, and 3 (7.5%) were on azathioprine. The mean osmolarity was 322.90 ± 33.39 mOsm/L, the mean OSDI score was 73.2 ± 17.9, the mean TFBUT was 6.60 ± 3.13 seconds, and the mean Schirmer Test value was 4.07 ± 3.58 seconds. Tear film osmolarity significantly correlated with the TFBUT (r = 0.80; P < 0.0001), whereas no clinical correlation was found with the Schirmer Test value (r = 0.01; P = 0.40) or with the OSDI score (r = 0.02; P = 0.29). Osmolarity did not turn out to be statistically different in the subgroups according to the Oxford corneal staining scale (P = 0.71) and to the Van Bijsterveld conjunctival staining score (P = 0.31). CONCLUSIONS: Tear osmolarity increased in patients with ocular MMP and correlated with the TFBUT. This result emphasizes the role of evaporative dry-eye condition in patients with ocular MMP. Tear osmolarity may be considered as a useful Test in the diagnostic assessment of dry eye associated with MMP and for targeting therapeutic decisions.
