The Experts below are selected from a list of 1290 Experts worldwide ranked by ideXlab platform
C Creuzotgarcher - One of the best experts on this subject based on the ideXlab platform.
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ocular surface assessment in soft contact lens wearers the contribution of Tear Osmolarity among other tests
Acta Ophthalmologica, 2014Co-Authors: Aurore Museliermathieu, B. Mathieu, M. Souchier, Lionel Bretillon, Alain M. Bron, Niyazi Acar, Francoise Brignolebaudouin, C CreuzotgarcherAbstract:: Purpose: To determine whether Tear Osmolarity contributes to the assessment of the ocular surface in soft contact lens (CL) wearers. Methods: Prospective, case–control series in 44 CL wearers (28 tolerant and 16 intolerant) and 34 healthy subjects. Every patient underwent a thorough ophthalmic examination with a Tear Osmolarity test (TearLab System), conjunctival impression cytology and meibomian lipid sampling. Symptoms, break-up time (BUT), Tear Osmolarity, conjunctival expression of HLA-DR and meibomian fatty acid composition were evaluated. Results: Tear Osmolarity did not differ between controls and CL wearers (p = 0.23). Flow cytometry results expressed in antibody-binding capacity (ABC) units and percentage of positive cells revealed a significant difference between the intolerant CL wearer group and the control group (p < 0.0001). Comparisons between tolerant and intolerant CL wearers showed only a significant difference for mean fluorescence levels expressed in ABC units (p < 0.0001). The BUT was significantly shorter in intolerant and tolerant CL wearers subjects than in healthy subjects (p < 0.0001), whereas there was no significant difference in meibomian fatty acid composition (p = 0.99) between the two groups. Conclusion: Contact lens wear is responsible for ocular surface alterations whose patterns are very similar to those reported in early dry-eye syndrome. However, Tear Osmolarity was not modified in these selected CL wearers. The yield of Tear Osmolarity with TearLab™ in assessing ocular surface disorders in CL wearers deserves further investigation.
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the contribution of Tear Osmolarity measurement to ocular surface assessment in soft contact lens wearers
Acta Ophthalmologica, 2012Co-Authors: A. Muselier, B. Mathieu, Lionel Bretillon, Alain M. Bron, A Niazi, Francoise Brignolebaudouin, C CreuzotgarcherAbstract:Purpose To determine whether Tear Osmolarity using the TearLabTM Osmolarity System contributes to the assessment of the ocular surface in contact lens (CL) wearers. Methods Data were collected from 44 CL wearers (28 tolerant and 16 intolerant) and 34 healthy subjects. Every patient underwent a thorough ophthalmic examination and Tear Osmolarity test, conjunctival impression cytology and meibomian lipid sampling. Symptoms, break-up time (BUT), Tear Osmolarity, conjunctival expression of HLA-DR and meibomian fatty acid composition were evaluated. Results Tear Osmolarity was significantly higher in the controls compared to tolerant and intolerant CL wearers (p=0.0007). Flow cytometry results expressed in antibody-binding capacity (ABC) units and percentage of positive cells revealed a significant difference between intolerant CL wearers group and control group (p<0.0001). Moreover, impression cytology analysis showed similar values in the tolerant CL wearers and the control group. BUT was significantly shorter in intolerant and tolerant CL wearers subjects than in healthy subjects (p<0.0001), whereas there was no significant difference in meibomian fatty acid composition (p=0.98) between groups. Conclusion CL wear is responsible for ocular surface alterations whose patterns are very similar to those reported in dry eye syndrome. However, the yield of Tear Osmolarity with TearLabTM in assessing ocular surface disorders in CL wearers deserves further investigation.
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the contribution of Tear Osmolarity measurement to ocular surface assessment in contact lens wearers
Investigative Ophthalmology & Visual Science, 2012Co-Authors: A. Muselier, B. Mathieu, M. Souchier, Niazi Acar, Lionel Bretillon, Alain M. Bron, Francoise Brignolebaudouin, C CreuzotgarcherAbstract:Purpose: To determine whether Tear Osmolarity using the TearLabTM Osmolarity System contributes to the assessment of the ocular surface in contact lens (CL) wearers. Methods: Data were collected from 44 CL wearers (28 tolerant and 16 intolerant) and 34 healthy subjects. Every patient underwent a thorough ophthalmic examination and Tear Osmolarity test, conjunctival impression cytology and meibomian lipid sampling. Symptoms, break-up time (BUT), Tear Osmolarity, conjunctival expression of HLA-DR and meibomian fatty acid composition were evaluated. Results: Tear Osmolarity was significantly higher in the controls compared to tolerant and intolerant CL wearers (p=0.0007). Flow cytometry results expressed in antibody-binding capacity (ABC) units and percentage of positive cells revealed a significant difference between intolerant CL wearers group and control group (p<0.0001). Furthermore, comparisons between tolerant and intolerant CL wearers showed only a significant difference for mean fluorescence levels expressed in ABC (p<0.0001). Moreover, impression cytology analysis showed similar values in the tolerant CL wearers and the control group. Material of CL (hydrogel) was significantly correlated with the percentage of positive cells both in tolerant and intolerant CL wearers. BUT was significantly shorter in intolerant and tolerant CL wearers subjects than in healthy subjects (p<0.0001), whereas there was no significant difference in meibomian fatty acid composition (p=0.98) between groups. Conclusions: CL wear is responsible for ocular surface alterations whose patterns are very similar to those reported in dry eye syndrome. However, the yield of Tear Osmolarity with TearLabTM in assessing ocular surface disorders in CL wearers deserves further investigation.
Vatinee Y Bunya - One of the best experts on this subject based on the ideXlab platform.
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variability of Tear Osmolarity in patients with dry eye
JAMA Ophthalmology, 2015Co-Authors: Vatinee Y Bunya, Maxwell Pistilli, Nicole M Fuerst, Bridgette Mccabe, Rebecca Salvo, Ilaria Macchi, Guishuang Ying, Mina MassarogiordanoAbstract:Importance Knowledge about the variability of measurements using the TearLab Osmolarity System is necessary when evaluating the clinical utility of readings. Objective To examine the variability of Tear Osmolarity measured by the TearLab Osmolarity System in patients with Sjogren syndrome (SS), patients with blepharitis, and control participants. Design, Setting, and Participants Cross-sectional study at a tertiary care academic center from June 13, 2012, to March 21, 2013. Participants included 74 eyes of 37 patients from a volunteer sample (18 patients with SS, 11 patients with blepharitis, and 8 control participants) who were evaluated using the TearLab Osmolarity System, with 3 consecutive Osmolarity measurements taken at 1-minute intervals in a session; 15 of these patients had the same measurements taken by the same examiner in 2 additional sessions on the same day (9am-10am, 12pm-1pm, or 3pm-4pm). Most patients with SS and patients with blepharitis were taking systemic or topical dry eye medications at the time of enrollment. Main Outcomes and Measures Mean Osmolarity and its variability calculated from a linear mixed model for each disease group that accounts for the variations attributable to different patients, eyes, and sessions and measurement error specific to each disease group. Results Mean Tear Osmolarity was 307mOsm/L, 304mOsm/L, and 301mOsm/L in the SS, blepharitis, and control groups, respectively ( P = .46). The error associated with repeated measurements within a session in the patients without dry eye (10.5mOsm/L [95% CI, 9.0-12.4]) was significantly lower than in the patients with blepharitis (14.6mOsm/L [95% CI, 12.5-17.5]; P = .006) and patients with SS (15.8mOsm/L [95% CI, 14.2-17.8]; P P = .46). Conclusions and Relevance There was increased variability attributable to error in repeated measurements in patients with SS and patients with blepharitis compared with control participants. The high variability of TearLab Osmolarity readings in all groups makes the clinical interpretation of measurements unclear.
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Tear Osmolarity and dry eye symptoms in diabetics
Clinical Ophthalmology, 2014Co-Authors: Nicole M Fuerst, Nicole Langelier, Maxwell Pistilli, Mina Massarogiordano, Kalliopi Stasi, Carrie M Burns, Serena Cardillo, Vatinee Y BunyaAbstract:Purpose To assess the relationship between Tear Osmolarity and dry eye symptoms in patients with diabetes.
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Tear Osmolarity in sjogren syndrome
Cornea, 2013Co-Authors: Vatinee Y Bunya, Nicole Langelier, Sarah Chen, Maxwell Pistilli, Frederick B Vivino, Giacomina MassarogiordanoAbstract:Purpose:The Schirmer test is one of the 2 ocular surface tests included in the current classification criteria for Sjogren syndrome (SS). Tear Osmolarity may also be a useful test for the diagnosis of dry eye disease. The purpose of this study was to examine the relationship between Tear Osmolarity,
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Tear Osmolarity and dry eye symptoms in women using oral contraception and contact lenses
Cornea, 2013Co-Authors: Sarah P Chen, Giacomina Massarogiordano, Maxwell Pistilli, Courtney A Schreiber, Vatinee Y BunyaAbstract:PURPOSE:: The aim of this study was to examine the relationship among oral contraceptive pill (OCP) use contact lens wear and dry eye signs and symptoms in healthy young women. METHODS:: Fifty-two women using OCPs and 45 women not using any form of hormonal contraception were enrolled. Medical menstrual and contact lens histories were obtained and dry eye symptoms assessed using the Ocular Surface Disease Index (OSDI) and Symptom Assessment iN Dry Eye (SANDE) questionnaires. Tear Osmolarity testing was performed using the TearLab Osmolarity System. RESULTS:: The mean age of all subjects was 26.0 +/- 3.7 years. There were no significant differences in any of the measurements between the follicular and luteal phases. Although SANDE scores were significantly higher in subjects with OCP and recent contact lens use (P < 0.01) there were no significant differences in OSDI and Tear Osmolarity among the same subject groups. Subjects who reported both OCP and recent contact lens use had significantly higher OSDI and SANDE scores (P = 0.015 and P < 0.001 respectively). CONCLUSIONS:: There were no differences between the phases of the menstrual cycle. Tear Osmolarity was not affected by OCP or contact lens use in young women. However the combination of OCP use and contact lens wear may increase the severity of dry eye symptoms.
Lionel Bretillon - One of the best experts on this subject based on the ideXlab platform.
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ocular surface assessment in soft contact lens wearers the contribution of Tear Osmolarity among other tests
Acta Ophthalmologica, 2014Co-Authors: Aurore Museliermathieu, B. Mathieu, M. Souchier, Lionel Bretillon, Alain M. Bron, Niyazi Acar, Francoise Brignolebaudouin, C CreuzotgarcherAbstract:: Purpose: To determine whether Tear Osmolarity contributes to the assessment of the ocular surface in soft contact lens (CL) wearers. Methods: Prospective, case–control series in 44 CL wearers (28 tolerant and 16 intolerant) and 34 healthy subjects. Every patient underwent a thorough ophthalmic examination with a Tear Osmolarity test (TearLab System), conjunctival impression cytology and meibomian lipid sampling. Symptoms, break-up time (BUT), Tear Osmolarity, conjunctival expression of HLA-DR and meibomian fatty acid composition were evaluated. Results: Tear Osmolarity did not differ between controls and CL wearers (p = 0.23). Flow cytometry results expressed in antibody-binding capacity (ABC) units and percentage of positive cells revealed a significant difference between the intolerant CL wearer group and the control group (p < 0.0001). Comparisons between tolerant and intolerant CL wearers showed only a significant difference for mean fluorescence levels expressed in ABC units (p < 0.0001). The BUT was significantly shorter in intolerant and tolerant CL wearers subjects than in healthy subjects (p < 0.0001), whereas there was no significant difference in meibomian fatty acid composition (p = 0.99) between the two groups. Conclusion: Contact lens wear is responsible for ocular surface alterations whose patterns are very similar to those reported in early dry-eye syndrome. However, Tear Osmolarity was not modified in these selected CL wearers. The yield of Tear Osmolarity with TearLab™ in assessing ocular surface disorders in CL wearers deserves further investigation.
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Ocular surface assessment in soft contact lens wearers; the contribution of Tear Osmolarity among other tests
Acta Ophthalmologica, 2013Co-Authors: Aurore Muselier-mathieu, B. Mathieu, M. Souchier, Françoise Brignole-baudouin, Lionel Bretillon, Alain M. Bron, Niyazi Acar, Catherine Creuzot-garcherAbstract:: Purpose: To determine whether Tear Osmolarity contributes to the assessment of the ocular surface in soft contact lens (CL) wearers. Methods: Prospective, case–control series in 44 CL wearers (28 tolerant and 16 intolerant) and 34 healthy subjects. Every patient underwent a thorough ophthalmic examination with a Tear Osmolarity test (TearLab System), conjunctival impression cytology and meibomian lipid sampling. Symptoms, break-up time (BUT), Tear Osmolarity, conjunctival expression of HLA-DR and meibomian fatty acid composition were evaluated. Results: Tear Osmolarity did not differ between controls and CL wearers (p = 0.23). Flow cytometry results expressed in antibody-binding capacity (ABC) units and percentage of positive cells revealed a significant difference between the intolerant CL wearer group and the control group (p
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the contribution of Tear Osmolarity measurement to ocular surface assessment in soft contact lens wearers
Acta Ophthalmologica, 2012Co-Authors: A. Muselier, B. Mathieu, Lionel Bretillon, Alain M. Bron, A Niazi, Francoise Brignolebaudouin, C CreuzotgarcherAbstract:Purpose To determine whether Tear Osmolarity using the TearLabTM Osmolarity System contributes to the assessment of the ocular surface in contact lens (CL) wearers. Methods Data were collected from 44 CL wearers (28 tolerant and 16 intolerant) and 34 healthy subjects. Every patient underwent a thorough ophthalmic examination and Tear Osmolarity test, conjunctival impression cytology and meibomian lipid sampling. Symptoms, break-up time (BUT), Tear Osmolarity, conjunctival expression of HLA-DR and meibomian fatty acid composition were evaluated. Results Tear Osmolarity was significantly higher in the controls compared to tolerant and intolerant CL wearers (p=0.0007). Flow cytometry results expressed in antibody-binding capacity (ABC) units and percentage of positive cells revealed a significant difference between intolerant CL wearers group and control group (p<0.0001). Moreover, impression cytology analysis showed similar values in the tolerant CL wearers and the control group. BUT was significantly shorter in intolerant and tolerant CL wearers subjects than in healthy subjects (p<0.0001), whereas there was no significant difference in meibomian fatty acid composition (p=0.98) between groups. Conclusion CL wear is responsible for ocular surface alterations whose patterns are very similar to those reported in dry eye syndrome. However, the yield of Tear Osmolarity with TearLabTM in assessing ocular surface disorders in CL wearers deserves further investigation.
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The contribution of Tear Osmolarity measurement to ocular surface assessment in soft contact lens wearers
Acta Ophthalmologica, 2012Co-Authors: A. Muselier, B. Mathieu, Françoise Brignole-baudouin, Lionel Bretillon, Alain M. Bron, A Niazi, Catherine Creuzot-garcherAbstract:Purpose To determine whether Tear Osmolarity using the TearLabTM Osmolarity System contributes to the assessment of the ocular surface in contact lens (CL) wearers. Methods Data were collected from 44 CL wearers (28 tolerant and 16 intolerant) and 34 healthy subjects. Every patient underwent a thorough ophthalmic examination and Tear Osmolarity test, conjunctival impression cytology and meibomian lipid sampling. Symptoms, break-up time (BUT), Tear Osmolarity, conjunctival expression of HLA-DR and meibomian fatty acid composition were evaluated. Results Tear Osmolarity was significantly higher in the controls compared to tolerant and intolerant CL wearers (p=0.0007). Flow cytometry results expressed in antibody-binding capacity (ABC) units and percentage of positive cells revealed a significant difference between intolerant CL wearers group and control group (p
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The Contribution Of Tear Osmolarity Measurement To Ocular Surface Assessment In Contact Lens Wearers
Investigative Ophthalmology & Visual Science, 2012Co-Authors: A. Muselier, B. Mathieu, M. Souchier, Françoise Brignole-baudouin, Niazi Acar, Lionel Bretillon, Alain M. Bron, Catherine Creuzot-garcherAbstract:Purpose: To determine whether Tear Osmolarity using the TearLabTM Osmolarity System contributes to the assessment of the ocular surface in contact lens (CL) wearers. Methods: Data were collected from 44 CL wearers (28 tolerant and 16 intolerant) and 34 healthy subjects. Every patient underwent a thorough ophthalmic examination and Tear Osmolarity test, conjunctival impression cytology and meibomian lipid sampling. Symptoms, break-up time (BUT), Tear Osmolarity, conjunctival expression of HLA-DR and meibomian fatty acid composition were evaluated. Results: Tear Osmolarity was significantly higher in the controls compared to tolerant and intolerant CL wearers (p=0.0007). Flow cytometry results expressed in antibody-binding capacity (ABC) units and percentage of positive cells revealed a significant difference between intolerant CL wearers group and control group (p
Alain M. Bron - One of the best experts on this subject based on the ideXlab platform.
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ocular surface assessment in soft contact lens wearers the contribution of Tear Osmolarity among other tests
Acta Ophthalmologica, 2014Co-Authors: Aurore Museliermathieu, B. Mathieu, M. Souchier, Lionel Bretillon, Alain M. Bron, Niyazi Acar, Francoise Brignolebaudouin, C CreuzotgarcherAbstract:: Purpose: To determine whether Tear Osmolarity contributes to the assessment of the ocular surface in soft contact lens (CL) wearers. Methods: Prospective, case–control series in 44 CL wearers (28 tolerant and 16 intolerant) and 34 healthy subjects. Every patient underwent a thorough ophthalmic examination with a Tear Osmolarity test (TearLab System), conjunctival impression cytology and meibomian lipid sampling. Symptoms, break-up time (BUT), Tear Osmolarity, conjunctival expression of HLA-DR and meibomian fatty acid composition were evaluated. Results: Tear Osmolarity did not differ between controls and CL wearers (p = 0.23). Flow cytometry results expressed in antibody-binding capacity (ABC) units and percentage of positive cells revealed a significant difference between the intolerant CL wearer group and the control group (p < 0.0001). Comparisons between tolerant and intolerant CL wearers showed only a significant difference for mean fluorescence levels expressed in ABC units (p < 0.0001). The BUT was significantly shorter in intolerant and tolerant CL wearers subjects than in healthy subjects (p < 0.0001), whereas there was no significant difference in meibomian fatty acid composition (p = 0.99) between the two groups. Conclusion: Contact lens wear is responsible for ocular surface alterations whose patterns are very similar to those reported in early dry-eye syndrome. However, Tear Osmolarity was not modified in these selected CL wearers. The yield of Tear Osmolarity with TearLab™ in assessing ocular surface disorders in CL wearers deserves further investigation.
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Ocular surface assessment in soft contact lens wearers; the contribution of Tear Osmolarity among other tests
Acta Ophthalmologica, 2013Co-Authors: Aurore Muselier-mathieu, B. Mathieu, M. Souchier, Françoise Brignole-baudouin, Lionel Bretillon, Alain M. Bron, Niyazi Acar, Catherine Creuzot-garcherAbstract:: Purpose: To determine whether Tear Osmolarity contributes to the assessment of the ocular surface in soft contact lens (CL) wearers. Methods: Prospective, case–control series in 44 CL wearers (28 tolerant and 16 intolerant) and 34 healthy subjects. Every patient underwent a thorough ophthalmic examination with a Tear Osmolarity test (TearLab System), conjunctival impression cytology and meibomian lipid sampling. Symptoms, break-up time (BUT), Tear Osmolarity, conjunctival expression of HLA-DR and meibomian fatty acid composition were evaluated. Results: Tear Osmolarity did not differ between controls and CL wearers (p = 0.23). Flow cytometry results expressed in antibody-binding capacity (ABC) units and percentage of positive cells revealed a significant difference between the intolerant CL wearer group and the control group (p
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the contribution of Tear Osmolarity measurement to ocular surface assessment in soft contact lens wearers
Acta Ophthalmologica, 2012Co-Authors: A. Muselier, B. Mathieu, Lionel Bretillon, Alain M. Bron, A Niazi, Francoise Brignolebaudouin, C CreuzotgarcherAbstract:Purpose To determine whether Tear Osmolarity using the TearLabTM Osmolarity System contributes to the assessment of the ocular surface in contact lens (CL) wearers. Methods Data were collected from 44 CL wearers (28 tolerant and 16 intolerant) and 34 healthy subjects. Every patient underwent a thorough ophthalmic examination and Tear Osmolarity test, conjunctival impression cytology and meibomian lipid sampling. Symptoms, break-up time (BUT), Tear Osmolarity, conjunctival expression of HLA-DR and meibomian fatty acid composition were evaluated. Results Tear Osmolarity was significantly higher in the controls compared to tolerant and intolerant CL wearers (p=0.0007). Flow cytometry results expressed in antibody-binding capacity (ABC) units and percentage of positive cells revealed a significant difference between intolerant CL wearers group and control group (p<0.0001). Moreover, impression cytology analysis showed similar values in the tolerant CL wearers and the control group. BUT was significantly shorter in intolerant and tolerant CL wearers subjects than in healthy subjects (p<0.0001), whereas there was no significant difference in meibomian fatty acid composition (p=0.98) between groups. Conclusion CL wear is responsible for ocular surface alterations whose patterns are very similar to those reported in dry eye syndrome. However, the yield of Tear Osmolarity with TearLabTM in assessing ocular surface disorders in CL wearers deserves further investigation.
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The contribution of Tear Osmolarity measurement to ocular surface assessment in soft contact lens wearers
Acta Ophthalmologica, 2012Co-Authors: A. Muselier, B. Mathieu, Françoise Brignole-baudouin, Lionel Bretillon, Alain M. Bron, A Niazi, Catherine Creuzot-garcherAbstract:Purpose To determine whether Tear Osmolarity using the TearLabTM Osmolarity System contributes to the assessment of the ocular surface in contact lens (CL) wearers. Methods Data were collected from 44 CL wearers (28 tolerant and 16 intolerant) and 34 healthy subjects. Every patient underwent a thorough ophthalmic examination and Tear Osmolarity test, conjunctival impression cytology and meibomian lipid sampling. Symptoms, break-up time (BUT), Tear Osmolarity, conjunctival expression of HLA-DR and meibomian fatty acid composition were evaluated. Results Tear Osmolarity was significantly higher in the controls compared to tolerant and intolerant CL wearers (p=0.0007). Flow cytometry results expressed in antibody-binding capacity (ABC) units and percentage of positive cells revealed a significant difference between intolerant CL wearers group and control group (p
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The Contribution Of Tear Osmolarity Measurement To Ocular Surface Assessment In Contact Lens Wearers
Investigative Ophthalmology & Visual Science, 2012Co-Authors: A. Muselier, B. Mathieu, M. Souchier, Françoise Brignole-baudouin, Niazi Acar, Lionel Bretillon, Alain M. Bron, Catherine Creuzot-garcherAbstract:Purpose: To determine whether Tear Osmolarity using the TearLabTM Osmolarity System contributes to the assessment of the ocular surface in contact lens (CL) wearers. Methods: Data were collected from 44 CL wearers (28 tolerant and 16 intolerant) and 34 healthy subjects. Every patient underwent a thorough ophthalmic examination and Tear Osmolarity test, conjunctival impression cytology and meibomian lipid sampling. Symptoms, break-up time (BUT), Tear Osmolarity, conjunctival expression of HLA-DR and meibomian fatty acid composition were evaluated. Results: Tear Osmolarity was significantly higher in the controls compared to tolerant and intolerant CL wearers (p=0.0007). Flow cytometry results expressed in antibody-binding capacity (ABC) units and percentage of positive cells revealed a significant difference between intolerant CL wearers group and control group (p
B. Mathieu - One of the best experts on this subject based on the ideXlab platform.
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ocular surface assessment in soft contact lens wearers the contribution of Tear Osmolarity among other tests
Acta Ophthalmologica, 2014Co-Authors: Aurore Museliermathieu, B. Mathieu, M. Souchier, Lionel Bretillon, Alain M. Bron, Niyazi Acar, Francoise Brignolebaudouin, C CreuzotgarcherAbstract:: Purpose: To determine whether Tear Osmolarity contributes to the assessment of the ocular surface in soft contact lens (CL) wearers. Methods: Prospective, case–control series in 44 CL wearers (28 tolerant and 16 intolerant) and 34 healthy subjects. Every patient underwent a thorough ophthalmic examination with a Tear Osmolarity test (TearLab System), conjunctival impression cytology and meibomian lipid sampling. Symptoms, break-up time (BUT), Tear Osmolarity, conjunctival expression of HLA-DR and meibomian fatty acid composition were evaluated. Results: Tear Osmolarity did not differ between controls and CL wearers (p = 0.23). Flow cytometry results expressed in antibody-binding capacity (ABC) units and percentage of positive cells revealed a significant difference between the intolerant CL wearer group and the control group (p < 0.0001). Comparisons between tolerant and intolerant CL wearers showed only a significant difference for mean fluorescence levels expressed in ABC units (p < 0.0001). The BUT was significantly shorter in intolerant and tolerant CL wearers subjects than in healthy subjects (p < 0.0001), whereas there was no significant difference in meibomian fatty acid composition (p = 0.99) between the two groups. Conclusion: Contact lens wear is responsible for ocular surface alterations whose patterns are very similar to those reported in early dry-eye syndrome. However, Tear Osmolarity was not modified in these selected CL wearers. The yield of Tear Osmolarity with TearLab™ in assessing ocular surface disorders in CL wearers deserves further investigation.
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Ocular surface assessment in soft contact lens wearers; the contribution of Tear Osmolarity among other tests
Acta Ophthalmologica, 2013Co-Authors: Aurore Muselier-mathieu, B. Mathieu, M. Souchier, Françoise Brignole-baudouin, Lionel Bretillon, Alain M. Bron, Niyazi Acar, Catherine Creuzot-garcherAbstract:: Purpose: To determine whether Tear Osmolarity contributes to the assessment of the ocular surface in soft contact lens (CL) wearers. Methods: Prospective, case–control series in 44 CL wearers (28 tolerant and 16 intolerant) and 34 healthy subjects. Every patient underwent a thorough ophthalmic examination with a Tear Osmolarity test (TearLab System), conjunctival impression cytology and meibomian lipid sampling. Symptoms, break-up time (BUT), Tear Osmolarity, conjunctival expression of HLA-DR and meibomian fatty acid composition were evaluated. Results: Tear Osmolarity did not differ between controls and CL wearers (p = 0.23). Flow cytometry results expressed in antibody-binding capacity (ABC) units and percentage of positive cells revealed a significant difference between the intolerant CL wearer group and the control group (p
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the contribution of Tear Osmolarity measurement to ocular surface assessment in soft contact lens wearers
Acta Ophthalmologica, 2012Co-Authors: A. Muselier, B. Mathieu, Lionel Bretillon, Alain M. Bron, A Niazi, Francoise Brignolebaudouin, C CreuzotgarcherAbstract:Purpose To determine whether Tear Osmolarity using the TearLabTM Osmolarity System contributes to the assessment of the ocular surface in contact lens (CL) wearers. Methods Data were collected from 44 CL wearers (28 tolerant and 16 intolerant) and 34 healthy subjects. Every patient underwent a thorough ophthalmic examination and Tear Osmolarity test, conjunctival impression cytology and meibomian lipid sampling. Symptoms, break-up time (BUT), Tear Osmolarity, conjunctival expression of HLA-DR and meibomian fatty acid composition were evaluated. Results Tear Osmolarity was significantly higher in the controls compared to tolerant and intolerant CL wearers (p=0.0007). Flow cytometry results expressed in antibody-binding capacity (ABC) units and percentage of positive cells revealed a significant difference between intolerant CL wearers group and control group (p<0.0001). Moreover, impression cytology analysis showed similar values in the tolerant CL wearers and the control group. BUT was significantly shorter in intolerant and tolerant CL wearers subjects than in healthy subjects (p<0.0001), whereas there was no significant difference in meibomian fatty acid composition (p=0.98) between groups. Conclusion CL wear is responsible for ocular surface alterations whose patterns are very similar to those reported in dry eye syndrome. However, the yield of Tear Osmolarity with TearLabTM in assessing ocular surface disorders in CL wearers deserves further investigation.
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The contribution of Tear Osmolarity measurement to ocular surface assessment in soft contact lens wearers
Acta Ophthalmologica, 2012Co-Authors: A. Muselier, B. Mathieu, Françoise Brignole-baudouin, Lionel Bretillon, Alain M. Bron, A Niazi, Catherine Creuzot-garcherAbstract:Purpose To determine whether Tear Osmolarity using the TearLabTM Osmolarity System contributes to the assessment of the ocular surface in contact lens (CL) wearers. Methods Data were collected from 44 CL wearers (28 tolerant and 16 intolerant) and 34 healthy subjects. Every patient underwent a thorough ophthalmic examination and Tear Osmolarity test, conjunctival impression cytology and meibomian lipid sampling. Symptoms, break-up time (BUT), Tear Osmolarity, conjunctival expression of HLA-DR and meibomian fatty acid composition were evaluated. Results Tear Osmolarity was significantly higher in the controls compared to tolerant and intolerant CL wearers (p=0.0007). Flow cytometry results expressed in antibody-binding capacity (ABC) units and percentage of positive cells revealed a significant difference between intolerant CL wearers group and control group (p
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The Contribution Of Tear Osmolarity Measurement To Ocular Surface Assessment In Contact Lens Wearers
Investigative Ophthalmology & Visual Science, 2012Co-Authors: A. Muselier, B. Mathieu, M. Souchier, Françoise Brignole-baudouin, Niazi Acar, Lionel Bretillon, Alain M. Bron, Catherine Creuzot-garcherAbstract:Purpose: To determine whether Tear Osmolarity using the TearLabTM Osmolarity System contributes to the assessment of the ocular surface in contact lens (CL) wearers. Methods: Data were collected from 44 CL wearers (28 tolerant and 16 intolerant) and 34 healthy subjects. Every patient underwent a thorough ophthalmic examination and Tear Osmolarity test, conjunctival impression cytology and meibomian lipid sampling. Symptoms, break-up time (BUT), Tear Osmolarity, conjunctival expression of HLA-DR and meibomian fatty acid composition were evaluated. Results: Tear Osmolarity was significantly higher in the controls compared to tolerant and intolerant CL wearers (p=0.0007). Flow cytometry results expressed in antibody-binding capacity (ABC) units and percentage of positive cells revealed a significant difference between intolerant CL wearers group and control group (p
