The Experts below are selected from a list of 4314 Experts worldwide ranked by ideXlab platform
Weilie Xiao - One of the best experts on this subject based on the ideXlab platform.
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new lignans from the leaves and stems of Schisandra chinensis and their anti hiv 1 activities
ChemInform, 2015Co-Authors: Weimao Zhong, Huan Chen, Ruirui Wang, Shanzhai Shang, Chengqin Liang, Yongtang Zheng, Weilie XiaoAbstract:Six new lignans (I), (II), (III), and (IV) are isolated along with five known ones from the leaves and stems of Schisandra chinensis.
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schicagenins a c three cagelike nortriterpenoids from leaves and stems of Schisandra chinensis
Organic Letters, 2011Co-Authors: Xingyao Li, Jianxin Pu, Xiaonian Li, Chengqin Liang, Lingmei Kong, Yan Li, Weilie XiaoAbstract:Schicagenins A-C (1-3), three unprecedented nortriterpenoids characterized with a tetracyclic oxa-cage motif and C(9) side chain, were discovered from the leaves and stems of Schisandra chinensis. Their structures were determined on the basis of extensive spectroscopic analysis, and the absolute stereochemistries were established by single-crystal X-ray diffraction and CD experiments. A plausible biosynthetic pathway of 1-3 was also discussed.
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nortriterpenoids and lignans from the fruit of Schisandra chinensis
ChemInform, 2011Co-Authors: Yanlong Zhang, Jianhong Yang, Xue Du, Jianxin Pu, Wei Zhao, Xiaonian Li, Weilie XiaoAbstract:Phytochemical investigation of the fruit of Schisandra chinensis led to the isolation of 7 new compounds together with 16 known compounds.
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nortriterpenoids and lignans from the fruit of Schisandra chinensis
Chemical & Pharmaceutical Bulletin, 2010Co-Authors: Yanlong Zhang, Jianhong Yang, Xue Du, Jianxin Pu, Wei Zhao, Xiaonian Li, Weilie XiaoAbstract:Phytochemical investigation of the fruit of Schisandra chinensis led to the isolation of a schisanartane nortriterpenoid, schindilactone H (1); an 18-norschiartane bisnortriterpenoid, wuweizidilactone I (2); two tetrahydrofuran-type lignans, schinlignins A and B (18 and 19); and three dibenzyl butane-type lignans, schineolignins A-C (20-22), together with 16 known compounds. The structures of these new compounds were elucidated on the basis of extensive analysis of spectroscopic data.
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isolation and characterization of miscellaneous terpenoids of Schisandra chinensis
Tetrahedron, 2008Co-Authors: Shengxiong Huang, Jianxin Pu, Weilie Xiao, Junlin Yu, Liumeng Yang, Hongxi Xu, Yongtang ZhengAbstract:Two new bisnortriterpenoids with 18-norschiartane skeleton, wuweizidilactones G (1) and H (2), four new highly oxygenated nortriterpenoids based on a schisanartane skeleton, schindilactones DeG (3e6), a pre-schisanartane skeleton, pre-schisanartanin B (7), and a novel 3,4-seco-21,26-olide-artane triterpenoid wuweizilactone acid (8), along with 24 known terpenoids with different carbon frameworks, have been isolated from the acetone extract of the stems and leaves of Schisandra chinensis. The terpenoids produced by this plant have chemical diversity. The structures of new compounds 1e8 have been characterized by spectroscopic data interpretation. The cytotoxicity and anti-HIV-1 activity of all the Schisandra nortriterpenoids were evaluated.
Ikhlas A. Khan - One of the best experts on this subject based on the ideXlab platform.
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schisandrene a dibenzocyclooctadiene lignan from Schisandra chinensis structure antioxidant activity relationships of dibenzocyclooctadiene lignans
Journal of Natural Products, 2006Co-Authors: Young-whan Choi, Satoshi Takamatsu, Shabana I Khan, Pullela V Srinivas, Daneel Ferreira, Jianping Zhao, Ikhlas A. KhanAbstract:Phytochemical investigation of the fruits of Schisandra chinensis led to the isolation of 13 lignans including schisandrene (13), a new lignan based on a dibenzocyclooctadiene backbone with an exocyclic double bond. Its structure and absolute configuration were established using NMR, MS, and CD data. Antioxidant activity of the lignans was evaluated using a DCFH-DA cellular-based assay. The structure−activity relationships of the dibenzocyclooctadiene lignans showed that the exocyclic methylene functionality was essential for antioxidant activity, with the benzoyloxy group probably enhancing such effects.
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Quantitative Determination of Lignan Constituents from Schisandra chinensis by Liquid Chromatography
Chromatographia, 2005Co-Authors: B. Avula, Young-whan Choi, P. V. Srinivas, Ikhlas A. KhanAbstract:The fruits of Schisandra chinensis (Schisandraceae/Magnoliaceae) are a traditional oriental medicine possessing diverse biological activities. A simple and specific analytical method for the quantitative determination of eight lignan constituents from the methanolic extract of the fruits of Schisandra chinensis was developed. The lignan constituents present in the fruits of Schisandra chinensis were separated with an acetonitrile-water-reagent alcohol gradient at a flow rate of 1.0 mL per minute. The HPLC separation was performed on a Phenomenex Luna C18 (2) (150 × 4.6 mm I.D., particle size 5 μm) reversed phase column with detection at 215 nm. The limit of detection was in the range from 0.2 to1.5 μg mL−1. The relative standard deviation (RSD) values for the determination of lignan constituents in fruits of Schisandra chinensis were less than 2.0%. The method was successfully used to analyze different products available in the market containing Schisandra chinensis and also to study the percentage compositions of various lignans present in Schisandra chinensis procured from different regions in S. Korea.
Guoqing Zhang - One of the best experts on this subject based on the ideXlab platform.
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analysis of lignans in Schisandra chinensis and rat plasma by high performance liquid chromatography diode array detection time of flight mass spectrometry and quadrupole ion trap mass spectrometry
Rapid Communications in Mass Spectrometry, 2009Co-Authors: Hai Zhang, Chungui Gong, Liang Zhao, Yuanjie Xu, Bin Wang, Guoqing ZhangAbstract:High-performance liquid chromatography/diode-array detection (HPLC/DAD), time-of-flight mass spectrometry (HPLC/TOFMS) and quadrupole ion trap mass spectrometry (HPLC/QIT-MS) were used for separation, identification and structural analysis of lignans in Schisandra chinensis and rat plasma after oral administration of the herbal extract. Six lignans in Schisandra chinensis extract were identified unambiguously by comparing the retention time, their characteristic ultraviolet (UV) absorption and accurate mass measurement. A formula database of known lignans in Schisandra chinensis was established, against which the other 15 lignans were identified effectively based on the accurate extract masses and formulae acquired by HPLC/TOFMS. In order to distinguish the isomers, multi-stage mass spectrometry (ion trap mass spectrometry, MSn) was also used. The fragmentation behavior of the lignans in the ion trap mass spectrometer was studied by the six lignan standards, and their fragmentation rules in MSn spectra were summarized. These deduced fragmentation rules of lignans were successfully implemented in distinguishing the three groups of isomers in Schisandra chinensis by HPLC/QIT-MS. By using the three different analytical techniques, 21 lignans in Schisandra chinensis were identified within 30 min. After oral administration of the extract, 11 lignans in rat plasma were detected and identified by comparing their retention time, characteristic UV absorption and accurate mass measurement of peaks in HPLC/TOFMS chromatograms of the herbal extract. Finally, HPLC/TOFMS fingerprints of Schisandra chinensis in vitro and rat plasma in vivo were established. It is concluded that a rapid and effective method based on three analytical techniques for identification of chemical components was established, which is useful for rapid identification of multiple components in Schisandra chinensis in vitro and in vivo. In addition, it can provide help for further pharmacology and action mechanism study of lignans in Schisandra chinensis. Copyright © 2009 John Wiley & Sons, Ltd.
Margita Dvorska - One of the best experts on this subject based on the ideXlab platform.
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evaluation of the antiradical activity of Schisandra chinensis lignans using different experimental models
Molecules, 2010Co-Authors: Karel Smejkal, Pavel Krmencik, Renata Kubinova, Jan Vanco, Karolina Kalvarova, Pavel Suchý, Tereza Slapetova, Stefano Dallacqua, Gabbriella Innocenti, Margita DvorskaAbstract:The in vitro antiradical activity of Schisandra chinensis lignans was investigated using DPPH, ABTS+, Fenton reaction inhibition and tyrosine-nitration inhibition assays, as were the in vivo antidiabetic activities of selected lignans in an animal model of alloxan-induced diabetes. Different degrees of antiradical activity were found, depending upon the structural parameters of the tested compounds. Unfortunately, the compounds showed no antidiabetic activity in concentration range tested.
Kaishun Bi - One of the best experts on this subject based on the ideXlab platform.
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ameliorating effect of alpinia oxyphylla Schisandra chinensis herb pair on cognitive impairment in a mouse model of alzheimer s disease
Biomedicine & Pharmacotherapy, 2018Co-Authors: Mengshi Wang, Wenchuan Bi, Tongde Li, Feng Xiao, Bosai He, Kaishun BiAbstract:Abstract Alzheimer’s disease (AD) is the most common cause of dementia. In our previous study, we found both Alpinia oxyphylla and Schisandra chinensis can improve the cognitive function of AD. To investigate whether the Alpinia oxyphylla – Schisandra chinensis herb pair (ASHP) has ameliorating effect on cognitive impairment, we used scopolamine to induce learning and memory impairments, as a mouse model of AD. Subsequently, we carried out Y-maze test and Morris water maze test to observe the behavior of mice. Finally, the level of Acetylcholine (Ach) and muscarinic receptor (M1) receptors, the activity of choline acetyltransferase (ChAT) and acetyl cholinesterase (AChE) were measured by commercial assay kits and ELISA kit. And we used hematoxylin-eosin (HE) staining to check the changes in cortex and the CA1 region of hippocampus. ASHP significantly protected against learning and memory impairments induced by scopolamine in Y-maze test and Morris water maze test. Besides, ASHP was able to increase the level of ACh and M1 receptors, and decrease the activity of AChE, but did not significantly affect the activity of ChAT. In addition, from the results of histopathological examination, we speculated ASHP may have neuroprotective effects. This study provided an experimental basis for further study of Alpinia oxyphylla − Schisandra chinensis herb pair in AD therapy.
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simultaneous lc ms quantification of 15 lignans in Schisandra chinensis turcz baill fruit
Chromatographia, 2008Co-Authors: Xinxiu Deng, Xiaohui Chen, Weiming Cheng, Zhenduo Shen, Kaishun BiAbstract:For the first time a simple, rapid, and specific liquid chromatographic–mass spectrometric (LC–MS) method for simultaneous quantification of 15 lignans from Schisandra chinensis (Turcz.) Baill. fruit has been developed and fully validated. Samples were ultrasonically extracted with methanol. Chromatographic separation was performed on a C18 column with methanol–0.1% aqueous acetic acid 72:28 (v/v) as mobile phase at a flow rate of 0.8 mL min−1; the run time was 40 min. The analytes were monitored by selected ion monitoring (SIM) with electrospray ionization (ESI). Fifteen regression equations revealed good linear relationships (r2 > 0.99) between peak area and concentration. Within-batch and between-batch precision of the method for the 15 lignans was <9.5% and accuracy was 93.1–107.5%. The validated method was successfully used to determine the 15 compounds in the fruits of Schisandrachinensis procured from different regions of China. The results indicated the method could be used for quality control of Schisandra chinensis fruit and might also useful for further studies of lignans.
