The Experts below are selected from a list of 12 Experts worldwide ranked by ideXlab platform
Pavel Rozsíval - One of the best experts on this subject based on the ideXlab platform.
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Schlemms Canal in OCT Images in Glaucoma Patients and Healthy Subjects
Journal of Clinical & Experimental Ophthalmology, 2013Co-Authors: Viera Forgačova, Jan Lestak, Šárka Pitrová, Pavel RozsívalAbstract:Objective: To determine by means of optical coherence tomography (OCT) whether there are changes in Schlemm’s Canal (SC) in primary open-angle glaucoma (POAG) compared to healthy controls and whether the SC dimension varies during the treatment facilitating the outflow of intraocular humor through the uveoscleral pathway. Patients and methods of examination: 62 eyes of 31 POAG patients (22 women aged 27-83 and 9 men aged 26-80) were included in our set. The patients did not suffer from any other disease of the anterior segment of the eye. Intraocular pressure (IOP) was compensated by drug treatment and its values were in the range of 10-20 mmHg. The group was compared with 92 eyes of 46 healthy subjects (33 women aged 19-71 and 13 men aged 39-79). The SC of all of them was examined by anterior segment OCT-system with a Visante OCT Carl Zeiss Meditec Inc. in horizontal meridian No. 3 and 9. Results: The comparisons show that the values of right and left eyes of controls (p=0.474) and patients (p=0.143) did not differ. The re-external (0.00029), le-external (p=0.0031), re-internal (p=0.0015), le-internal (p=0.0002) SC dimensions between the control and patient groups differed significantly with the controls always having values significantly higher than the glaucoma patients. Treatment by prostaglandins and beta-blockers did not affect the size of the SC (p=0.23 to 0.95). Conclusion: In POAG eyes, SC size is smaller than in the eyes of the control group. Eyes on prostaglandin treatment had the same size than those on beta blockers.
Viera Forgačova - One of the best experts on this subject based on the ideXlab platform.
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Schlemms Canal in OCT Images in Glaucoma Patients and Healthy Subjects
Journal of Clinical & Experimental Ophthalmology, 2013Co-Authors: Viera Forgačova, Jan Lestak, Šárka Pitrová, Pavel RozsívalAbstract:Objective: To determine by means of optical coherence tomography (OCT) whether there are changes in Schlemm’s Canal (SC) in primary open-angle glaucoma (POAG) compared to healthy controls and whether the SC dimension varies during the treatment facilitating the outflow of intraocular humor through the uveoscleral pathway. Patients and methods of examination: 62 eyes of 31 POAG patients (22 women aged 27-83 and 9 men aged 26-80) were included in our set. The patients did not suffer from any other disease of the anterior segment of the eye. Intraocular pressure (IOP) was compensated by drug treatment and its values were in the range of 10-20 mmHg. The group was compared with 92 eyes of 46 healthy subjects (33 women aged 19-71 and 13 men aged 39-79). The SC of all of them was examined by anterior segment OCT-system with a Visante OCT Carl Zeiss Meditec Inc. in horizontal meridian No. 3 and 9. Results: The comparisons show that the values of right and left eyes of controls (p=0.474) and patients (p=0.143) did not differ. The re-external (0.00029), le-external (p=0.0031), re-internal (p=0.0015), le-internal (p=0.0002) SC dimensions between the control and patient groups differed significantly with the controls always having values significantly higher than the glaucoma patients. Treatment by prostaglandins and beta-blockers did not affect the size of the SC (p=0.23 to 0.95). Conclusion: In POAG eyes, SC size is smaller than in the eyes of the control group. Eyes on prostaglandin treatment had the same size than those on beta blockers.
Jan Lestak - One of the best experts on this subject based on the ideXlab platform.
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Schlemms Canal in OCT Images in Glaucoma Patients and Healthy Subjects
Journal of Clinical & Experimental Ophthalmology, 2013Co-Authors: Viera Forgačova, Jan Lestak, Šárka Pitrová, Pavel RozsívalAbstract:Objective: To determine by means of optical coherence tomography (OCT) whether there are changes in Schlemm’s Canal (SC) in primary open-angle glaucoma (POAG) compared to healthy controls and whether the SC dimension varies during the treatment facilitating the outflow of intraocular humor through the uveoscleral pathway. Patients and methods of examination: 62 eyes of 31 POAG patients (22 women aged 27-83 and 9 men aged 26-80) were included in our set. The patients did not suffer from any other disease of the anterior segment of the eye. Intraocular pressure (IOP) was compensated by drug treatment and its values were in the range of 10-20 mmHg. The group was compared with 92 eyes of 46 healthy subjects (33 women aged 19-71 and 13 men aged 39-79). The SC of all of them was examined by anterior segment OCT-system with a Visante OCT Carl Zeiss Meditec Inc. in horizontal meridian No. 3 and 9. Results: The comparisons show that the values of right and left eyes of controls (p=0.474) and patients (p=0.143) did not differ. The re-external (0.00029), le-external (p=0.0031), re-internal (p=0.0015), le-internal (p=0.0002) SC dimensions between the control and patient groups differed significantly with the controls always having values significantly higher than the glaucoma patients. Treatment by prostaglandins and beta-blockers did not affect the size of the SC (p=0.23 to 0.95). Conclusion: In POAG eyes, SC size is smaller than in the eyes of the control group. Eyes on prostaglandin treatment had the same size than those on beta blockers.
Šárka Pitrová - One of the best experts on this subject based on the ideXlab platform.
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Schlemms Canal in OCT Images in Glaucoma Patients and Healthy Subjects
Journal of Clinical & Experimental Ophthalmology, 2013Co-Authors: Viera Forgačova, Jan Lestak, Šárka Pitrová, Pavel RozsívalAbstract:Objective: To determine by means of optical coherence tomography (OCT) whether there are changes in Schlemm’s Canal (SC) in primary open-angle glaucoma (POAG) compared to healthy controls and whether the SC dimension varies during the treatment facilitating the outflow of intraocular humor through the uveoscleral pathway. Patients and methods of examination: 62 eyes of 31 POAG patients (22 women aged 27-83 and 9 men aged 26-80) were included in our set. The patients did not suffer from any other disease of the anterior segment of the eye. Intraocular pressure (IOP) was compensated by drug treatment and its values were in the range of 10-20 mmHg. The group was compared with 92 eyes of 46 healthy subjects (33 women aged 19-71 and 13 men aged 39-79). The SC of all of them was examined by anterior segment OCT-system with a Visante OCT Carl Zeiss Meditec Inc. in horizontal meridian No. 3 and 9. Results: The comparisons show that the values of right and left eyes of controls (p=0.474) and patients (p=0.143) did not differ. The re-external (0.00029), le-external (p=0.0031), re-internal (p=0.0015), le-internal (p=0.0002) SC dimensions between the control and patient groups differed significantly with the controls always having values significantly higher than the glaucoma patients. Treatment by prostaglandins and beta-blockers did not affect the size of the SC (p=0.23 to 0.95). Conclusion: In POAG eyes, SC size is smaller than in the eyes of the control group. Eyes on prostaglandin treatment had the same size than those on beta blockers.
Thomas M. Deserno - One of the best experts on this subject based on the ideXlab platform.
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Medical Imaging: Computer-Aided Diagnosis - Automated detection of Schlemm's Canal in spectral-domain optical coherence tomography
Medical Imaging 2015: Computer-Aided Diagnosis, 2015Co-Authors: Manu Tom, Vignesh Ramakrishnan, Christian Van Oterendorp, Thomas M. DesernoAbstract:Recent advances in optical coherence tomography (OCT) technology allow in vivo imaging of the complex network of intra-scleral aqueous veins in the anterior segment of the eye. Pathological changes in this network, draining the aqueous humor from the eye, are considered to play a role in intraocular pressure elevation, which can lead to glaucoma, one of the major causes of blindness in the world. Through acquisition of OCT volume scans of the anterior eye segment, we aim at reconstructing the three dimensional network of aqueous veins in healthy and glaucomatous subjects. A novel algorithm for segmentation of the three-dimensional (3D) vessel system in human Schlemms Canal is presented analyzing frames of spectral domain OCT (SD-OCT) of the eyes surface in either horizontal or vertical orientation. Distortions such as vertical stripes are caused by the superficial blood vessels in the conjunctiva and the episclera. They are removed in the discrete Fourier domain (DFT) masking particular frequencies. Feature-based rigid registration of these noise-filtered images is then performed using the scale invariant feature transform (SIFT). Segmentation of the vessels deep in the sclera originating at or in the vicinity of or having indirect connection to the Schlemm's Canal is then performed with 3D region growing technique. The segmented vessels are visualized in 3D providing diagnostically relevant information to the physicians. A proof-of-concept study was performed on a healthy volunteer before and after a pharmaceutical narrowing of Schlemm's Canal. A relative decreases 17% was measured based on manual ground truth and the image processing method.
