The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Yuhai Zhang - One of the best experts on this subject based on the ideXlab platform.
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metal halide perovskite nanosheet for x ray high resolution scintillation imaging screens
ACS Nano, 2019Co-Authors: Qiushui Chen, Yuhai Zhang, Ruijia Sun, Yuchong Ding, Lingmei Liu, Yu Han, Anton V Malko, Xiaogang Liu, Huanghao YangAbstract:Scintillators, which are capable of converting ionizing radiation into visible photons, are an integral part of medical, security, and commercial diagnostic technologies such as X-ray imaging, nuclear cameras, and computed tomography. Conventional Scintillator fabrication typically involves high-temperature sintering, generating agglomerated powders or large bulk crystals, which pose major challenges for device integration and processability. On the other hand, colloidal quantum dot Scintillators cannot be cast into compact solid films with the necessary thickness required for most X-ray applications. Here, we report the room-temperature synthesis of a colloidal Scintillator comprising CsPbBr3 nanosheets of large concentration (up to 150 mg/mL). The CsPbBr3 colloid exhibits a light yield (∼21000 photons/MeV) higher than that of the commercially available Ce:LuAG single-crystal Scintillator (∼18000 photons/MeV). Scintillators based on these nanosheets display both strong radioluminescence (RL) and long-term stability under X-ray illumination. Importantly, the colloidal Scintillator can be readily cast into a uniform crack-free large-area film (8.5 × 8.5 cm2 in area) with the requisite thickness for high-resolution X-ray imaging applications. We showcase prototype applications of these high-quality scintillating films as X-ray imaging screens for a cellphone panel and a standard central processing unit chip. Our radiography prototype combines large-area processability with high resolution and a strong penetration ability to sheath materials, such as resin and silicon. We reveal an energy transfer process inside those stacked nanosheet solids that is responsible for their superb scintillation performance. Our findings demonstrate a large-area solution-processed Scintillator of stable and efficient RL as a promising approach for low-cost radiography and X-ray imaging applications.
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Metal Halide Perovskite Nanosheet for X‑ray High-Resolution Scintillation Imaging Screens
2019Co-Authors: Yuhai Zhang, Qiushui Chen, Ruijia Sun, Yuchong Ding, Lingmei Liu, Yu Han, Anton V MalkoAbstract:Scintillators, which are capable of converting ionizing radiation into visible photons, are an integral part of medical, security, and commercial diagnostic technologies such as X-ray imaging, nuclear cameras, and computed tomography. Conventional Scintillator fabrication typically involves high-temperature sintering, generating agglomerated powders or large bulk crystals, which pose major challenges for device integration and processability. On the other hand, colloidal quantum dot Scintillators cannot be cast into compact solid films with the necessary thickness required for most X-ray applications. Here, we report the room-temperature synthesis of a colloidal Scintillator comprising CsPbBr3 nanosheets of large concentration (up to 150 mg/mL). The CsPbBr3 colloid exhibits a light yield (∼21000 photons/MeV) higher than that of the commercially available Ce:LuAG single-crystal Scintillator (∼18000 photons/MeV). Scintillators based on these nanosheets display both strong radioluminescence (RL) and long-term stability under X-ray illumination. Importantly, the colloidal Scintillator can be readily cast into a uniform crack-free large-area film (8.5 × 8.5 cm2 in area) with the requisite thickness for high-resolution X-ray imaging applications. We showcase prototype applications of these high-quality scintillating films as X-ray imaging screens for a cellphone panel and a standard central processing unit chip. Our radiography prototype combines large-area processability with high resolution and a strong penetration ability to sheath materials, such as resin and silicon. We reveal an energy transfer process inside those stacked nanosheet solids that is responsible for their superb scintillation performance. Our findings demonstrate a large-area solution-processed Scintillator of stable and efficient RL as a promising approach for low-cost radiography and X-ray imaging applications
Huanghao Yang - One of the best experts on this subject based on the ideXlab platform.
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metal halide perovskite nanosheet for x ray high resolution scintillation imaging screens
ACS Nano, 2019Co-Authors: Qiushui Chen, Yuhai Zhang, Ruijia Sun, Yuchong Ding, Lingmei Liu, Yu Han, Anton V Malko, Xiaogang Liu, Huanghao YangAbstract:Scintillators, which are capable of converting ionizing radiation into visible photons, are an integral part of medical, security, and commercial diagnostic technologies such as X-ray imaging, nuclear cameras, and computed tomography. Conventional Scintillator fabrication typically involves high-temperature sintering, generating agglomerated powders or large bulk crystals, which pose major challenges for device integration and processability. On the other hand, colloidal quantum dot Scintillators cannot be cast into compact solid films with the necessary thickness required for most X-ray applications. Here, we report the room-temperature synthesis of a colloidal Scintillator comprising CsPbBr3 nanosheets of large concentration (up to 150 mg/mL). The CsPbBr3 colloid exhibits a light yield (∼21000 photons/MeV) higher than that of the commercially available Ce:LuAG single-crystal Scintillator (∼18000 photons/MeV). Scintillators based on these nanosheets display both strong radioluminescence (RL) and long-term stability under X-ray illumination. Importantly, the colloidal Scintillator can be readily cast into a uniform crack-free large-area film (8.5 × 8.5 cm2 in area) with the requisite thickness for high-resolution X-ray imaging applications. We showcase prototype applications of these high-quality scintillating films as X-ray imaging screens for a cellphone panel and a standard central processing unit chip. Our radiography prototype combines large-area processability with high resolution and a strong penetration ability to sheath materials, such as resin and silicon. We reveal an energy transfer process inside those stacked nanosheet solids that is responsible for their superb scintillation performance. Our findings demonstrate a large-area solution-processed Scintillator of stable and efficient RL as a promising approach for low-cost radiography and X-ray imaging applications.
Guillem Pratx - One of the best experts on this subject based on the ideXlab platform.
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single cell radioluminescence microscopy with two fold higher sensitivity using dual Scintillator configuration
PLOS ONE, 2020Co-Authors: Tae Jin Kim, Qian Wang, Mark Shelor, Guillem PratxAbstract:Radioluminescence microscopy (RLM) is an imaging technique that allows quantitative analysis of clinical radiolabeled drugs and probes in single cells. However, the modality suffers from slow data acquisition (15–30 minutes), thus critically affecting experiments with short-lived radioactive drugs. To overcome this issue, we suggest an approach that significantly accelerates data collection. Instead of using a single Scintillator to image the decay of radioactive molecules, we sandwiched the radiolabeled cells between two Scintillators. As proof of concept, we imaged cells labeled with [18F]FDG, a radioactive glucose popularly used in oncology to image tumors. Results show that the double Scintillator configuration increases the microscope sensitivity by two-fold, thus reducing the image acquisition time by half to achieve the same result as the single Scintillator approach. The experimental results were also compared with Geant4 Monte Carlo simulation to confirm the two-fold increase in sensitivity with only minor degradation in spatial resolution. Overall, these findings suggest that the double Scintillator configuration can be used to perform time-sensitive studies such as cell pharmacokinetics or cell uptake of short-lived radiotracers.
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bright lu2o3 eu thin film Scintillators for high resolution radioluminescence microscopy
Advanced Healthcare Materials, 2015Co-Authors: Debanti Sengupta, Stuart R. Miller, Zsolt Marton, Frederick T. Chin, Vivek V. Nagarkar, Guillem PratxAbstract:The performance of a new thin-film Lu2O3:Eu Scintillator for single-cell radionuclide imaging is investigated. Imaging the metabolic properties of heterogeneous cell populations in real time is an important challenge with clinical implications. An innovative technique called radioluminescence microscopy has been developed to quantitatively and sensitively measure radionuclide uptake in single cells. The most important component of this technique is the Scintillator, which converts the energy released during radioactive decay into luminescent signals. The sensitivity and spatial resolution of the imaging system depend critically on the characteristics of the Scintillator, that is, the material used and its geometrical configuration. Scintillators fabricated using conventional methods are relatively thick and therefore do not provide optimal spatial resolution. A thin-film Lu2O3:Eu Scintillator is compared to a conventional 500 μm thick CdWO4 Scintillator for radioluminescence imaging. Despite its thinness, the unique scintillation properties of the Lu2O3:Eu Scintillator allow us to capture single-positron decays with fourfold higher sensitivity, which is a significant achievement. The thin-film Lu2O3:Eu Scintillators also yield radioluminescence images where individual cells appear smaller and better resolved on average than with the CdWO4 Scintillators. Coupled with the thin-film Scintillator technology, radioluminescence microscopy can yield valuable and clinically relevant data on the metabolism of single cells.
Douglas R. Macfarlane - One of the best experts on this subject based on the ideXlab platform.
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Eu-activated fluorochlorozirconate glass-ceramic Scintillators
Journal of Applied Physics, 2006Co-Authors: Jacqueline A. Johnson, Stefan Schweizer, P. J. Newman, B. Henke, Gang Chen, John Woodford, Douglas R. MacfarlaneAbstract:Rare-earth-doped fluorochlorozirconate (FCZ) glass-ceramic materials have been developed as Scintillators and their properties investigated as a function of dopant level. The paper presents the relative scintillation efficiency in comparison to single-crystal cadmium tungstate, the scintillation intensity as a function of x-ray intensity and x-ray energy, and the spatial resolution (modulation transfer function). Images obtained with the FCZ glass-ceramic Scintillator and with cadmium tungstate are also presented. Comparison shows that the image quality obtained using the glass ceramic is close to that from cadmium tungstate. Therefore, the glass-ceramic Scintillator could be used as an alternative material for image formation resulting from scintillation. Other inorganic Scintillators such as single crystals or polycrystalline films have limitations in resolution or size, but the transparent glass-ceramic can be scaled to any shape or size with excellent resolution.
Stuart R. Miller - One of the best experts on this subject based on the ideXlab platform.
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bright lu2o3 eu thin film Scintillators for high resolution radioluminescence microscopy
Advanced Healthcare Materials, 2015Co-Authors: Debanti Sengupta, Stuart R. Miller, Zsolt Marton, Frederick T. Chin, Vivek V. Nagarkar, Guillem PratxAbstract:The performance of a new thin-film Lu2O3:Eu Scintillator for single-cell radionuclide imaging is investigated. Imaging the metabolic properties of heterogeneous cell populations in real time is an important challenge with clinical implications. An innovative technique called radioluminescence microscopy has been developed to quantitatively and sensitively measure radionuclide uptake in single cells. The most important component of this technique is the Scintillator, which converts the energy released during radioactive decay into luminescent signals. The sensitivity and spatial resolution of the imaging system depend critically on the characteristics of the Scintillator, that is, the material used and its geometrical configuration. Scintillators fabricated using conventional methods are relatively thick and therefore do not provide optimal spatial resolution. A thin-film Lu2O3:Eu Scintillator is compared to a conventional 500 μm thick CdWO4 Scintillator for radioluminescence imaging. Despite its thinness, the unique scintillation properties of the Lu2O3:Eu Scintillator allow us to capture single-positron decays with fourfold higher sensitivity, which is a significant achievement. The thin-film Lu2O3:Eu Scintillators also yield radioluminescence images where individual cells appear smaller and better resolved on average than with the CdWO4 Scintillators. Coupled with the thin-film Scintillator technology, radioluminescence microscopy can yield valuable and clinically relevant data on the metabolism of single cells.
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a new lutetia based ceramic Scintillator for x ray imaging
Nuclear Instruments & Methods in Physics Research Section A-accelerators Spectrometers Detectors and Associated Equipment, 2002Co-Authors: A Lempicki, C Brecher, P Szupryczynski, Helmut Lingertat, V V Nagarkar, S V Tipnis, Stuart R. MillerAbstract:Abstract We report a new Scintillator based on a transparent ceramic of Lu 2 O 3 :Eu. The material has an extremely high density of 9.4 g/cm 3 , a light output comparable to CsI:Tl, and a narrow band emission at 610 nm that falls close to the maximum of the response curve of CCDs. Pixelation of the Scintillator to prevent lateral spread of light enhances the spatial and contrast resolution, providing imaging performance that equals or surpasses all other currently known Scintillators. Upon further development of readout technologies to take full advantage of its transparency, the new Scintillator should play a major role in digital radiographic systems.
