The Experts below are selected from a list of 2424 Experts worldwide ranked by ideXlab platform
Jennifer S Gell - One of the best experts on this subject based on the ideXlab platform.
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Secondary Amenorrhea attributed to occlusion of microperforate transverse vaginal septum
Fertility and Sterility, 2008Co-Authors: Jennifer L Nichols, Eric J Bieber, Jennifer S GellAbstract:Objective To present a case of Secondary Amenorrhea after occlusion of microperforate transverse vaginal septum. Design Case report. Setting Academic teaching hospital. Patient(s) A 19-year-old woman with new onset of irregular menses and pelvic pain, with history of menarche at age 14. Intervention(s) Surgical evaluation and treatment, including laparoscopy, hysteroscopy, and excision of septum, followed by repeat surgery with lysis of adhesions due to agglutination of the area previously excised. Main Outcome Measure(s) Awareness of the possibility of Secondary Amenorrhea occurring due to septal scarring of a perforate transverse vaginal septum. Result(s) Imaging revealed a hematometra and hematocolpos. Examination revealed a transverse vaginal septum. Ultrasound scans and magnetic resonance imaging revealed an enlarged uterus and an endometrial cavity and cervix distended with fluid and debris. Examination under anesthesia revealed a septum approximately 5 mm thick, which was revealed to be benign fibromuscular tissue with chronic nonspecific inflammation. Conclusion(s) This case demonstrates the evolution from a microperforate transverse vaginal septum with regular menses for over 4 years to an occluded septum. Although transverse vaginal septa causing Amenorrhea are usually diagnosed at menarche, perforate septa have been shown to lead to hypomenorrhea, dysmenorrhea, dyspareunia, infertility, and issues with vaginal childbirth. We present a case in which a perforate transverse vaginal septum led to Secondary Amenorrhea.
Luca Persani - One of the best experts on this subject based on the ideXlab platform.
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Premature ovarian failure
Orphanet Journal of Rare Diseases, 2006Co-Authors: Paolo Beck-peccoz, Luca PersaniAbstract:Premature ovarian failure (POF) is a primary ovarian defect characterized by absent menarche (primary Amenorrhea) or premature depletion of ovarian follicles before the age of 40 years (Secondary Amenorrhea). It is a heterogeneous disorder affecting approximately 1% of women
Eugenios Koumantakis - One of the best experts on this subject based on the ideXlab platform.
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diagnostic role of inhibin b in resistant ovary syndrome associated with Secondary Amenorrhea
Fertility and Sterility, 2002Co-Authors: Aydin Arici, Ioannis Matalliotakis, Georgios Koumantakis, Anastasia G Goumenou, M Neonaki, Eugenios KoumantakisAbstract:To report two rare cases of gonadotropin-resistant ovary syndrome associated with Secondary Amenorrhea and normal levels of inhibin B. Case report. Two university teaching hospitals. Two women presenting with Secondary Amenorrhea and infertility. The control group for the inhibin B levels consisted of 30 cycling women of reproductive age. Medical history, physical examination, laboratory data, histologic findings, and IVF results. Diagnosis and treatment of resistant ovary syndrome. Case 1 was a 25-year-old woman with Secondary Amenorrhea and primary infertility. She had high serum levels of FSH and LH, low E(2) levels, and normal inhibin B levels (62 pg/mL). Karyotype was 46,XX, and ovarian biopsy showed primordial follicles with oocytes. Administration of GnRH analogue with hMG for 15 days did not affect E(2) levels. She had a successful pregnancy with IVF using donor oocytes. Case 2 was a 24-year-old woman with Secondary Amenorrhea. She had elevated serum levels of FSH and LH, low E(2) levels, and normal inhibin B levels (57 pg/mL). Karyotype was 46,XX and ovarian biopsy showed primordial follicles. Administration of GnRH analogue with hMG for 12 days did not affect E(2) levels. Both women were given estrogen-progestin replacement therapy. Inhibin B has a diagnostic role in women with gonadotropin-resistant ovary syndrome associated with Secondary Amenorrhea. A review of the literature confirms the uniqueness of the diagnostic role of inhibin B in these cases.
Lawrence M. Nelson - One of the best experts on this subject based on the ideXlab platform.
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meeting the needs of young women with Secondary Amenorrhea and spontaneous premature ovarian failure
Obstetrics & Gynecology, 2002Co-Authors: Nahrain H Alzubaidi, Karim A. Calis, Vien H. Vanderhoof, Heather L Chapin, Lawrence M. NelsonAbstract:Abstract OBJECTIVE: To investigate the experiences of young women with spontaneous premature ovarian failure with regard to the initial presenting symptom, promptness of diagnosis, and patient education. METHODS: We asked 50 patients previously diagnosed with spontaneous premature ovarian failure to participate in a structured interview survey consisting of 38 true-or-false, multiple-choice, and open-ended questions. RESULTS: Disturbance in menstrual pattern was the most common initial symptom in the 48 women who completed the interview (44 of 48, 92%). Over half of the 44 women who presented with this complaint reported visiting a clinician’s office three or more times before laboratory testing was performed to determine the diagnosis. Over half of them reported seeing three or more different clinicians before diagnosis. In 25% of women it took longer than 5 years for the diagnosis of premature ovarian failure to be established. Patients who spent more than 5 minutes with the clinician discussing the diagnosis were significantly more likely to be satisfied with the manner in which they were informed (P CONCLUSION: Women with spontaneous premature ovarian failure perceived a need for more aggressive evaluation of Secondary Amenorrhea and oligomenorrhea. Loss of menstrual regularity can be a sign of ovarian insufficiency, and the associated estrogen deficiency is a well-established risk factor for osteoporosis.
Ioannis Matalliotakis - One of the best experts on this subject based on the ideXlab platform.
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diagnostic role of inhibin b in resistant ovary syndrome associated with Secondary Amenorrhea
Fertility and Sterility, 2002Co-Authors: Aydin Arici, Ioannis Matalliotakis, Georgios Koumantakis, Anastasia G Goumenou, M Neonaki, Eugenios KoumantakisAbstract:To report two rare cases of gonadotropin-resistant ovary syndrome associated with Secondary Amenorrhea and normal levels of inhibin B. Case report. Two university teaching hospitals. Two women presenting with Secondary Amenorrhea and infertility. The control group for the inhibin B levels consisted of 30 cycling women of reproductive age. Medical history, physical examination, laboratory data, histologic findings, and IVF results. Diagnosis and treatment of resistant ovary syndrome. Case 1 was a 25-year-old woman with Secondary Amenorrhea and primary infertility. She had high serum levels of FSH and LH, low E(2) levels, and normal inhibin B levels (62 pg/mL). Karyotype was 46,XX, and ovarian biopsy showed primordial follicles with oocytes. Administration of GnRH analogue with hMG for 15 days did not affect E(2) levels. She had a successful pregnancy with IVF using donor oocytes. Case 2 was a 24-year-old woman with Secondary Amenorrhea. She had elevated serum levels of FSH and LH, low E(2) levels, and normal inhibin B levels (57 pg/mL). Karyotype was 46,XX and ovarian biopsy showed primordial follicles. Administration of GnRH analogue with hMG for 12 days did not affect E(2) levels. Both women were given estrogen-progestin replacement therapy. Inhibin B has a diagnostic role in women with gonadotropin-resistant ovary syndrome associated with Secondary Amenorrhea. A review of the literature confirms the uniqueness of the diagnostic role of inhibin B in these cases.
