The Experts below are selected from a list of 318 Experts worldwide ranked by ideXlab platform

Peter C Holland - One of the best experts on this subject based on the ideXlab platform.

  • Consolidation of altered associability information by amygdala central nucleus.
    Neurobiology of learning and memory, 2016
    Co-Authors: Felipe L Schiffino, Peter C Holland
    Abstract:

    The surprising omission of a reinforcer can enhance the associability of the stimuli that were present when the reward prediction error was induced, so that they more readily enter into new associations in the future. Previous research from this laboratory identified brain circuit elements critical to the enhancement of stimulus associability by the omission of an expected event and to the subsequent expression of that altered associability in more rapid learning. These elements include the amygdala, the midbrain substantia nigra, the basal forebrain substantia innominata, the dorsolateral striatum, the Secondary Visual Cortex, and the posterior parietal Cortex. Here, we found that consolidation of a surprise-enhanced associability memory in a serial prediction task depends on processing in the amygdala central nucleus (CeA) after completion of sessions that included the surprising omission of an expected event. Post-surprise infusions of anisomycin, lidocaine, or muscimol prevented subsequent display of surprise-enhanced associability. Because previous studies indicated that CeA function is unnecessary for the expression of associability enhancements that were induced previously when CeA function was intact (Holland & Gallagher, 2006), we interpreted these results as indicating that post-surprise activity of CeA ("surprise replay") is necessary for the consolidation of altered associability memories elsewhere in the brain, such as the posterior parietal Cortex (Schiffino et al., 2014a).

  • Secondary Visual Cortex is critical to the expression of surprise induced enhancements in cue associability in rats
    European Journal of Neuroscience, 2016
    Co-Authors: Felipe L Schiffino, Peter C Holland
    Abstract:

    : Considerable evidence indicates that reinforcement prediction error, the difference between the obtained and expected reinforcer values, modulates attention to potential cues for reinforcement. The surprising delivery or omission of a reinforcer enhances the associability of the stimuli that were present when the error was induced, so that they more readily enter into new associations in the future. Previous research from our laboratory identified brain circuit elements critical to the enhancement of stimulus associability by omission of an expected event and to the subsequent expression of that altered associability in more rapid learning. A key finding was that the rat posterior parietal Cortex was essential during the encoding, consolidation and retrieval of associability memories that were altered by the surprising omission of an expected event in a serial prediction task. Here, we found that the function of adjacent Secondary Visual Cortex was critical only to the expression of altered cue associability in that same task. This specialization of function is discussed in the context of broader cortical and subcortical networks for modulation of attention in associative learning, as well as recent anatomical investigations that suggest that the rodent posterior parietal Cortex overlaps with and may subsume Secondary Visual Cortex.

  • Secondary Visual Cortex is critical to the expression of surprise‐induced enhancements in cue associability in rats
    The European journal of neuroscience, 2016
    Co-Authors: Felipe L Schiffino, Peter C Holland
    Abstract:

    Considerable evidence indicates that reinforcement prediction error, the difference between the obtained and expected reinforcer values, modulates attention to potential cues for reinforcement. The surprising delivery or omission of a reinforcer enhances the associability of the stimuli that were present when the error was induced, so that they more readily enter into new associations in the future. Previous research from our laboratory identified brain circuit elements critical to the enhancement of stimulus associability by omission of an expected event and to the subsequent expression of that altered associability in more rapid learning. A key finding was that the rat posterior parietal Cortex was essential during the encoding, consolidation and retrieval of associability memories that were altered by the surprising omission of an expected event in a serial prediction task. Here, we found that the function of adjacent Secondary Visual Cortex was critical only to the expression of altered cue associability in that same task. This specialization of function is discussed in the context of broader cortical and subcortical networks for modulation of attention in associative learning, as well as recent anatomical investigations that suggest that the rodent posterior parietal Cortex overlaps with and may subsume Secondary Visual Cortex.

Christophe Lançon - One of the best experts on this subject based on the ideXlab platform.

  • Neural substrate of quality of life in patients with schizophrenia: a magnetisation transfer imaging study
    Scientific reports, 2015
    Co-Authors: Catherine Faget-agius, Laurent Boyer, Jonathan Wirsich, Raphaëlle Richieri, Elisabeth Soulier, Sylviane Confort-gouny, Pascal Auquier, Maxime Guye, Jean-philippe Ranjeva, Christophe Lançon
    Abstract:

    The aim of this study was to investigate the neural substrate underlying quality of life (QoL) and to demonstrate the microstructural abnormalities associated with impaired QoL in a large sample of patients with schizophrenia, using magnetisation transfer imaging. A total of 81 right-handed men with a diagnosis of schizophrenia and 25 age- and sex-similar healthy controls were included and underwent a 3T MRI with magnetization transfer ratio (MTR) to detect microstructural abnormalities. Compared with healthy controls, patients with schizophrenia had grey matter (GM) decreased MTR values in the temporal lobe (BA21, BA37 and BA38), the bilateral insula, the occipital lobe (BA17, BA18 and BA19) and the cerebellum. Patients with impaired QoL had lower GM MTR values relative to patients with preserved QoL in the bilateral temporal pole (BA38), the bilateral insula, the Secondary Visual Cortex (BA18), the vermis and the cerebellum. Significant correlations between MTR values and QoL scores (p 

  • Neural substrate of quality of life in patients with schizophrenia: a magnetisation transfer imaging study
    Scientific Reports, 2015
    Co-Authors: Catherine Faget-agius, Laurent Boyer, Jonathan Wirsich, Raphaëlle Richieri, Elisabeth Soulier, Sylviane Confort-gouny, Pascal Auquier, Maxime Guye, Ranjeva Jean-philippe, Christophe Lançon
    Abstract:

    The aim of this study was to investigate the neural substrate underlying quality of life (QoL) and to demonstrate the microstructural abnormalities associated with impaired QoL in a large sample of patients with schizophrenia, using magnetisation transfer imaging. A total of 81 right-handed men with a diagnosis of schizophrenia and 25 age- and sex-similar healthy controls were included and underwent a 3T MRI with magnetization transfer ratio (MTR) to detect microstructural abnormalities. Compared with healthy controls, patients with schizophrenia had grey matter (GM) decreased MTR values in the temporal lobe (BA21, BA37 and BA38), the bilateral insula, the occipital lobe (BA17, BA18 and BA19) and the cerebellum. Patients with impaired QoL had lower GM MTR values relative to patients with preserved QoL in the bilateral temporal pole (BA38), the bilateral insula, the Secondary Visual Cortex (BA18), the vermis and the cerebellum. Significant correlations between MTR values and QoL scores (p \textless 0.005) were observed in the GM of patients in the right temporal pole (BA38), the bilateral insula, the vermis and the right cerebellum. Our study shows that QoL impairment in patients with schizophrenia is related to the microstructural changes in an extensive network, suggesting that QoL is a bio-psychosocial marker.

Felipe L Schiffino - One of the best experts on this subject based on the ideXlab platform.

  • Consolidation of altered associability information by amygdala central nucleus.
    Neurobiology of learning and memory, 2016
    Co-Authors: Felipe L Schiffino, Peter C Holland
    Abstract:

    The surprising omission of a reinforcer can enhance the associability of the stimuli that were present when the reward prediction error was induced, so that they more readily enter into new associations in the future. Previous research from this laboratory identified brain circuit elements critical to the enhancement of stimulus associability by the omission of an expected event and to the subsequent expression of that altered associability in more rapid learning. These elements include the amygdala, the midbrain substantia nigra, the basal forebrain substantia innominata, the dorsolateral striatum, the Secondary Visual Cortex, and the posterior parietal Cortex. Here, we found that consolidation of a surprise-enhanced associability memory in a serial prediction task depends on processing in the amygdala central nucleus (CeA) after completion of sessions that included the surprising omission of an expected event. Post-surprise infusions of anisomycin, lidocaine, or muscimol prevented subsequent display of surprise-enhanced associability. Because previous studies indicated that CeA function is unnecessary for the expression of associability enhancements that were induced previously when CeA function was intact (Holland & Gallagher, 2006), we interpreted these results as indicating that post-surprise activity of CeA ("surprise replay") is necessary for the consolidation of altered associability memories elsewhere in the brain, such as the posterior parietal Cortex (Schiffino et al., 2014a).

  • Secondary Visual Cortex is critical to the expression of surprise induced enhancements in cue associability in rats
    European Journal of Neuroscience, 2016
    Co-Authors: Felipe L Schiffino, Peter C Holland
    Abstract:

    : Considerable evidence indicates that reinforcement prediction error, the difference between the obtained and expected reinforcer values, modulates attention to potential cues for reinforcement. The surprising delivery or omission of a reinforcer enhances the associability of the stimuli that were present when the error was induced, so that they more readily enter into new associations in the future. Previous research from our laboratory identified brain circuit elements critical to the enhancement of stimulus associability by omission of an expected event and to the subsequent expression of that altered associability in more rapid learning. A key finding was that the rat posterior parietal Cortex was essential during the encoding, consolidation and retrieval of associability memories that were altered by the surprising omission of an expected event in a serial prediction task. Here, we found that the function of adjacent Secondary Visual Cortex was critical only to the expression of altered cue associability in that same task. This specialization of function is discussed in the context of broader cortical and subcortical networks for modulation of attention in associative learning, as well as recent anatomical investigations that suggest that the rodent posterior parietal Cortex overlaps with and may subsume Secondary Visual Cortex.

  • Secondary Visual Cortex is critical to the expression of surprise‐induced enhancements in cue associability in rats
    The European journal of neuroscience, 2016
    Co-Authors: Felipe L Schiffino, Peter C Holland
    Abstract:

    Considerable evidence indicates that reinforcement prediction error, the difference between the obtained and expected reinforcer values, modulates attention to potential cues for reinforcement. The surprising delivery or omission of a reinforcer enhances the associability of the stimuli that were present when the error was induced, so that they more readily enter into new associations in the future. Previous research from our laboratory identified brain circuit elements critical to the enhancement of stimulus associability by omission of an expected event and to the subsequent expression of that altered associability in more rapid learning. A key finding was that the rat posterior parietal Cortex was essential during the encoding, consolidation and retrieval of associability memories that were altered by the surprising omission of an expected event in a serial prediction task. Here, we found that the function of adjacent Secondary Visual Cortex was critical only to the expression of altered cue associability in that same task. This specialization of function is discussed in the context of broader cortical and subcortical networks for modulation of attention in associative learning, as well as recent anatomical investigations that suggest that the rodent posterior parietal Cortex overlaps with and may subsume Secondary Visual Cortex.

Catherine Faget-agius - One of the best experts on this subject based on the ideXlab platform.

  • Neural substrate of quality of life in patients with schizophrenia: a magnetisation transfer imaging study
    Scientific reports, 2015
    Co-Authors: Catherine Faget-agius, Laurent Boyer, Jonathan Wirsich, Raphaëlle Richieri, Elisabeth Soulier, Sylviane Confort-gouny, Pascal Auquier, Maxime Guye, Jean-philippe Ranjeva, Christophe Lançon
    Abstract:

    The aim of this study was to investigate the neural substrate underlying quality of life (QoL) and to demonstrate the microstructural abnormalities associated with impaired QoL in a large sample of patients with schizophrenia, using magnetisation transfer imaging. A total of 81 right-handed men with a diagnosis of schizophrenia and 25 age- and sex-similar healthy controls were included and underwent a 3T MRI with magnetization transfer ratio (MTR) to detect microstructural abnormalities. Compared with healthy controls, patients with schizophrenia had grey matter (GM) decreased MTR values in the temporal lobe (BA21, BA37 and BA38), the bilateral insula, the occipital lobe (BA17, BA18 and BA19) and the cerebellum. Patients with impaired QoL had lower GM MTR values relative to patients with preserved QoL in the bilateral temporal pole (BA38), the bilateral insula, the Secondary Visual Cortex (BA18), the vermis and the cerebellum. Significant correlations between MTR values and QoL scores (p 

  • Neural substrate of quality of life in patients with schizophrenia: a magnetisation transfer imaging study
    Scientific Reports, 2015
    Co-Authors: Catherine Faget-agius, Laurent Boyer, Jonathan Wirsich, Raphaëlle Richieri, Elisabeth Soulier, Sylviane Confort-gouny, Pascal Auquier, Maxime Guye, Ranjeva Jean-philippe, Christophe Lançon
    Abstract:

    The aim of this study was to investigate the neural substrate underlying quality of life (QoL) and to demonstrate the microstructural abnormalities associated with impaired QoL in a large sample of patients with schizophrenia, using magnetisation transfer imaging. A total of 81 right-handed men with a diagnosis of schizophrenia and 25 age- and sex-similar healthy controls were included and underwent a 3T MRI with magnetization transfer ratio (MTR) to detect microstructural abnormalities. Compared with healthy controls, patients with schizophrenia had grey matter (GM) decreased MTR values in the temporal lobe (BA21, BA37 and BA38), the bilateral insula, the occipital lobe (BA17, BA18 and BA19) and the cerebellum. Patients with impaired QoL had lower GM MTR values relative to patients with preserved QoL in the bilateral temporal pole (BA38), the bilateral insula, the Secondary Visual Cortex (BA18), the vermis and the cerebellum. Significant correlations between MTR values and QoL scores (p \textless 0.005) were observed in the GM of patients in the right temporal pole (BA38), the bilateral insula, the vermis and the right cerebellum. Our study shows that QoL impairment in patients with schizophrenia is related to the microstructural changes in an extensive network, suggesting that QoL is a bio-psychosocial marker.

Pascal Auquier - One of the best experts on this subject based on the ideXlab platform.

  • Neural substrate of quality of life in patients with schizophrenia: a magnetisation transfer imaging study
    Scientific reports, 2015
    Co-Authors: Catherine Faget-agius, Laurent Boyer, Jonathan Wirsich, Raphaëlle Richieri, Elisabeth Soulier, Sylviane Confort-gouny, Pascal Auquier, Maxime Guye, Jean-philippe Ranjeva, Christophe Lançon
    Abstract:

    The aim of this study was to investigate the neural substrate underlying quality of life (QoL) and to demonstrate the microstructural abnormalities associated with impaired QoL in a large sample of patients with schizophrenia, using magnetisation transfer imaging. A total of 81 right-handed men with a diagnosis of schizophrenia and 25 age- and sex-similar healthy controls were included and underwent a 3T MRI with magnetization transfer ratio (MTR) to detect microstructural abnormalities. Compared with healthy controls, patients with schizophrenia had grey matter (GM) decreased MTR values in the temporal lobe (BA21, BA37 and BA38), the bilateral insula, the occipital lobe (BA17, BA18 and BA19) and the cerebellum. Patients with impaired QoL had lower GM MTR values relative to patients with preserved QoL in the bilateral temporal pole (BA38), the bilateral insula, the Secondary Visual Cortex (BA18), the vermis and the cerebellum. Significant correlations between MTR values and QoL scores (p 

  • Neural substrate of quality of life in patients with schizophrenia: a magnetisation transfer imaging study
    Scientific Reports, 2015
    Co-Authors: Catherine Faget-agius, Laurent Boyer, Jonathan Wirsich, Raphaëlle Richieri, Elisabeth Soulier, Sylviane Confort-gouny, Pascal Auquier, Maxime Guye, Ranjeva Jean-philippe, Christophe Lançon
    Abstract:

    The aim of this study was to investigate the neural substrate underlying quality of life (QoL) and to demonstrate the microstructural abnormalities associated with impaired QoL in a large sample of patients with schizophrenia, using magnetisation transfer imaging. A total of 81 right-handed men with a diagnosis of schizophrenia and 25 age- and sex-similar healthy controls were included and underwent a 3T MRI with magnetization transfer ratio (MTR) to detect microstructural abnormalities. Compared with healthy controls, patients with schizophrenia had grey matter (GM) decreased MTR values in the temporal lobe (BA21, BA37 and BA38), the bilateral insula, the occipital lobe (BA17, BA18 and BA19) and the cerebellum. Patients with impaired QoL had lower GM MTR values relative to patients with preserved QoL in the bilateral temporal pole (BA38), the bilateral insula, the Secondary Visual Cortex (BA18), the vermis and the cerebellum. Significant correlations between MTR values and QoL scores (p \textless 0.005) were observed in the GM of patients in the right temporal pole (BA38), the bilateral insula, the vermis and the right cerebellum. Our study shows that QoL impairment in patients with schizophrenia is related to the microstructural changes in an extensive network, suggesting that QoL is a bio-psychosocial marker.