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Tommaso Iannitti - One of the best experts on this subject based on the ideXlab platform.
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a dietary supplement improves facial photoaging and skin sebum hydration and tonicity modulating serum fibronectin neutrophil elastase 2 hyaluronic acid and carbonylated proteins
Journal of Photochemistry and Photobiology B-biology, 2015Co-Authors: Alessandro Di Cerbo, Beniamino Palmieri, Carmen Laurino, Tommaso IannittiAbstract:Abstract Background and aims Excessive exposure to the sun can cause severe photoaging as early as the second decade of life resulting in a loss of physiological elastic fiber functions. We designed a first study to assess differences in facial skin pH, sebum, elasticity, hydration and tonicity and serum levels of fibronectin, elastin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins between patients affected by facial photoaging and healthy controls. In a second study we tested the hypothesis that a dietary supplement would improve facial photoaging, also promoting changes in the above mentioned skin and serum parameters. Methods In the first study we enrolled 30 women [age: 47.5 ± 1.6 years (mean ± standard error of the mean)] affected by moderate facial photoaging (4 cm ≤ Visual Analogue Scale (VAS) n = 22) and severe (VAS ≥ 7 cm; n = 8) facial photoaging, who were randomized to receive a pharmaceutical formulation (VISCODERM® Pearls; IBSA FARMACEUTICI ITALIA Srl, Lodi, Italy) containing Pycnogenol®, collagen, coenzyme Q10, low-molecular-weight hyaluronic acid, chondroitin sulfate and glucosamine sulfate ( n = 15) or placebo ( n = 15). Dietary supplement and placebo were administered 2 times a day for 4 weeks. Facial photoaging was assessed by VAS in the first cohort of patients affected by facial photoaging and healthy controls and, at baseline and 2 weeks after the end of treatment, in the second cohort of patients who underwent treatment with VISCODERM® Pearls and placebo. Skin Tester was used to analyze differences in facial skin parameters between patients affected by facial photoaging and healthy controls. Skin Tester was also used to assess the effect of VISCODERM® Pearls on facial skin parameters and compared with placebo 2 weeks after the end of treatment. Serum levels of fibronectin, elastin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins were measured by enzyme-linked immunosorbent assay in the first cohort of patients affected by facial photoaging and healthy controls and, at baseline and 2 weeks after the end of treatment, in the second cohort of patients who underwent treatment with VISCODERM® Pearls and placebo. Results VAS photoaging score was higher in patients affected by photoaging, if compared with healthy controls ( p p p p p p p p p p p p p p p Conclusions We found significantly increased serum levels of neutrophil elastase 2, elastin and carbonylated proteins and decreased levels of hyaluronic acid and fibronectin in patients affected by facial photoaging, if compared with healthy controls. These findings coupled with a significant decrease in skin hydration, tonicity and elasticity and increased skin pH and sebum. Treatment with the dietary supplement VISCODERM® Pearls significantly improved VAS photoaging score and skin hydration, sebum and tonicity 2 weeks after the end of a 4-week treatment period in patients affected by moderate to severe facial photoaging. These findings coupled with a significant increase in serum fibronectin and hyaluronic acid and a decrease in serum carbonylated proteins and neutrophil elastase 2 in the active treatment group, if compared with placebo. Our findings suggest that VISCODERM® Pearls is effective for treatment of facial photoaging but further studies in larger cohorts of patients are required.
Ingebrigt Talstad - One of the best experts on this subject based on the ideXlab platform.
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Day-to-day variations in serum iron, serum iron binding capacity, serum ferritin and erythrocyte protoporphyrin concentrations in anaemic subjects.
European journal of haematology, 2009Co-Authors: Inge Romslo, Ingebrigt TalstadAbstract:Day-to-day variations in serum iron, serum iron binding capacity, serum ferritin and erythrocyte protoporphyrin were determined on 2 successive days in 48 patients with anaemia. The correlation coefficients between the paired determinations were 0.86, 0.89, 0.95 and 0.95, and the day-to-day coefficients of variation (in per cent) were 33, 11, 12 and 13 for serum iron, serum iron binding capacity, erythrocyte protoporphyrin and serum ferritin, respectively. Thus, in patients with anaemia, day-to-day variations in serum iron, serum iron binding capacity, erythrocyte protoporphyrin and serum ferritin are at least as high as in healthy controls. The results indicate important limitations in the use, particularly, of serum iron in the clinical investigation of anaemia.
Colin M. Orians - One of the best experts on this subject based on the ideXlab platform.
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Sedum groundcover variably enhances performance and phenolic concentrations of perennial culinary herbs in an urban edible green roof
Agroecology and Sustainable Food Systems, 2017Co-Authors: Selena Ahmed, Anne Elise Stratton, Feven Asefaha, Colleen Butler, Sarabeth Buckley, Matthew R. Reynolds, Colin M. OriansAbstract:ABSTRACTUrban agriculture on green roofs has tremendous potential to enhance food security, economic opportunities, and community building in cities yet faces unique ecological challenges including limited soil moisture content for crops. We compared the effects of two green roof soil moisture management practices, Sedum (Sedum album) groundcover versus watering, on performance and quality of three perennial culinary herbs: thyme, mint, and oregano. Individually and interactively, Sedum groundcover and watering significantly impacted parameters of performance (biomass, vitality, and module coverage) and quality (total phenolic concentrations) of the three culinary herbs during early stages of establishment while having variable impacts during later developmental stages. Our results suggest that Sedum groundcover can serve as a substitute for watering of hardy culinary herbs on green roofs on the basis of plant performance and quality. Findings can be applied to inform agroecological water management of he...
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Session 3.3: Natives vs. Non-Natives, The Debate on the Merits of Each Continues Sedum FACILITATES THE GROWTH OF NEIGHBORING PLANTS ON A GREEN ROOF UNDER WATER LIMITED CONDITIONS
2014Co-Authors: Colleen Butler, Colin M. OriansAbstract:Sedum species are important green roof plants because of their tolerance of high temperatures and drought conditions. There is, however, increasing interest in using a broader palette of plants to maximize the habitat value of green roofs. In some systems, such as deserts, stress tolerant plants can act as nurse plants by facilitating the growth and survival of neighboring plants. Similarly, we hypothesized that Sedum can increase the performance of less stress-tolerant plants, thus increasing plant diversity. Using a green roof at Tufts University, we tested the effect of Sedum album on the growth and survival of Agastache rupestris (Lamiaceae) and Asclepias verticillata (Asclepiadaceae) during natural wet and dry periods. We found that the effect of S. album on the performance of neighboring plants was species specific and depended on water availability. When water was limiting, S. album acted as a facilitator; in contrast, when water was abundant, S. album acted as a competitor. In conclusion Sedum can facilitate the growth of neighboring plants during water stress and may allow less tolerant plants to thrive
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Sedum cools soil and can improve neighboring plant performance during water deficit on a green roof
Ecological Engineering, 2011Co-Authors: Colleen Butler, Colin M. OriansAbstract:a b s t r a c t Green roofs have the potential to function as islands of biodiversity within urban and suburban environments. However, plant diversity is constrained by the harsh environment of a green roof, especially summertime water deficit and heat stress. We hypothesized that Sedum species, which are highly tolerant of the roof-top environment, would reduce peak soil temperature and increase performance of neighboring plants during summer water deficit. To test these hypotheses, we grew focal plant species with and without Sedum on a green roof. We then monitored growth during wet periods and drought tolerance during dry periods. During a three-year experiment, S. album reduced maximum growth of neighbor plants, Agastache rupestris and Asclepias verticillata, during favorable growth conditions, but increased performance of neighbors during summer water deficit. In a second experiment, four species of Sedum were each found to decrease peak soil temperature by 5–7 ◦C. All species decreased total growth of neighboring Agastache ‘Black Adder’ during favorable growth conditions, but again increased performance during summer water deficit. These results suggest that the palette of green roof plants can be expanded by using Sedum species as nurse plants.
Alessandro Di Cerbo - One of the best experts on this subject based on the ideXlab platform.
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a dietary supplement improves facial photoaging and skin sebum hydration and tonicity modulating serum fibronectin neutrophil elastase 2 hyaluronic acid and carbonylated proteins
Journal of Photochemistry and Photobiology B-biology, 2015Co-Authors: Alessandro Di Cerbo, Beniamino Palmieri, Carmen Laurino, Tommaso IannittiAbstract:Abstract Background and aims Excessive exposure to the sun can cause severe photoaging as early as the second decade of life resulting in a loss of physiological elastic fiber functions. We designed a first study to assess differences in facial skin pH, sebum, elasticity, hydration and tonicity and serum levels of fibronectin, elastin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins between patients affected by facial photoaging and healthy controls. In a second study we tested the hypothesis that a dietary supplement would improve facial photoaging, also promoting changes in the above mentioned skin and serum parameters. Methods In the first study we enrolled 30 women [age: 47.5 ± 1.6 years (mean ± standard error of the mean)] affected by moderate facial photoaging (4 cm ≤ Visual Analogue Scale (VAS) n = 22) and severe (VAS ≥ 7 cm; n = 8) facial photoaging, who were randomized to receive a pharmaceutical formulation (VISCODERM® Pearls; IBSA FARMACEUTICI ITALIA Srl, Lodi, Italy) containing Pycnogenol®, collagen, coenzyme Q10, low-molecular-weight hyaluronic acid, chondroitin sulfate and glucosamine sulfate ( n = 15) or placebo ( n = 15). Dietary supplement and placebo were administered 2 times a day for 4 weeks. Facial photoaging was assessed by VAS in the first cohort of patients affected by facial photoaging and healthy controls and, at baseline and 2 weeks after the end of treatment, in the second cohort of patients who underwent treatment with VISCODERM® Pearls and placebo. Skin Tester was used to analyze differences in facial skin parameters between patients affected by facial photoaging and healthy controls. Skin Tester was also used to assess the effect of VISCODERM® Pearls on facial skin parameters and compared with placebo 2 weeks after the end of treatment. Serum levels of fibronectin, elastin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins were measured by enzyme-linked immunosorbent assay in the first cohort of patients affected by facial photoaging and healthy controls and, at baseline and 2 weeks after the end of treatment, in the second cohort of patients who underwent treatment with VISCODERM® Pearls and placebo. Results VAS photoaging score was higher in patients affected by photoaging, if compared with healthy controls ( p p p p p p p p p p p p p p p Conclusions We found significantly increased serum levels of neutrophil elastase 2, elastin and carbonylated proteins and decreased levels of hyaluronic acid and fibronectin in patients affected by facial photoaging, if compared with healthy controls. These findings coupled with a significant decrease in skin hydration, tonicity and elasticity and increased skin pH and sebum. Treatment with the dietary supplement VISCODERM® Pearls significantly improved VAS photoaging score and skin hydration, sebum and tonicity 2 weeks after the end of a 4-week treatment period in patients affected by moderate to severe facial photoaging. These findings coupled with a significant increase in serum fibronectin and hyaluronic acid and a decrease in serum carbonylated proteins and neutrophil elastase 2 in the active treatment group, if compared with placebo. Our findings suggest that VISCODERM® Pearls is effective for treatment of facial photoaging but further studies in larger cohorts of patients are required.
Iannitti Tommaso - One of the best experts on this subject based on the ideXlab platform.
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A dietary supplement improves facial photoaging and skin sebum, hydration and tonicity modulating serum fibronectin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins
The Authors. Published by Elsevier B.V., 2015Co-Authors: Di Cerbo Alessandro, Laurino Carmen, Palmieri Beniamino, Iannitti TommasoAbstract:AbstractBackground and aimsExcessive exposure to the sun can cause severe photoaging as early as the second decade of life resulting in a loss of physiological elastic fiber functions. We designed a first study to assess differences in facial skin pH, sebum, elasticity, hydration and tonicity and serum levels of fibronectin, elastin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins between patients affected by facial photoaging and healthy controls. In a second study we tested the hypothesis that a dietary supplement would improve facial photoaging, also promoting changes in the above mentioned skin and serum parameters.MethodsIn the first study we enrolled 30 women [age: 47.5±1.6years (mean±standard error of the mean)] affected by moderate facial photoaging (4cm≤Visual Analogue Scale (VAS)
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A dietary supplement improves facial photoaging and skin sebum, hydration and tonicity modulating serum fibronectin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins
'Elsevier BV', 2015Co-Authors: Di Cerbo Alessandro, Laurino Carmen, Palmieri Beniamino, Iannitti TommasoAbstract:Excessive exposure to the sun can cause severe photoaging as early as the second decade of life resulting in a loss of physiological elastic fiber functions. We designed a first study to assess differences in facial skin pH, sebum, elasticity, hydration and tonicity and serum levels of fibronectin, elastin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins between patients affected by facial photoaging and healthy controls. In a second study we tested the hypothesis that a dietary supplement would improve facial photoaging, also promoting changes in the above mentioned skin and serum parameters. In the first study we enrolled 30 women [age: 47.5 ± 1.6 years (mean ± standard error of the mean)] affected by moderate facial photoaging (4 cm ≤ Visual Analogue Scale (VAS)<7 cm) and 30 healthy women [age: 45.9 ± 1.6 years (mean ± standard error of the mean)]. In the second study we enrolled a cohort of 30 women [age: 43.6 ± 1.2 years (mean ± standard error of the mean)], affected by moderate (n = 22) and severe (VAS ≥ 7 cm; n = 8) facial photoaging, who were randomized to receive a pharmaceutical formulation (VISCODERM Pearls; IBSA FARMACEUTICI ITALIA Srl, Lodi, Italy) containing Pycnogenol, collagen, coenzyme Q10, low-molecular-weight hyaluronic acid, chondroitin sulfate and glucosamine sulfate (n = 15) or placebo (n = 15). Dietary supplement and placebo were administered 2 times a day for 4 weeks. Facial photoaging was assessed by VAS in the first cohort of patients affected by facial photoaging and healthy controls and, at baseline and 2 weeks after the end of treatment, in the second cohort of patients who underwent treatment with VISCODERM Pearls and placebo. Skin Tester was used to analyze differences in facial skin parameters between patients affected by facial photoaging and healthy controls. Skin Tester was also used to assess the effect of VISCODERM Pearls on facial skin parameters and compared with placebo 2 weeks after the end of treatment. Serum levels of fibronectin, elastin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins were measured by enzyme-linked immunosorbent assay in the first cohort of patients affected by facial photoaging and healthy controls and, at baseline and 2 weeks after the end of treatment, in the second cohort of patients who underwent treatment with VISCODERM Pearls and placebo. VAS photoaging score was higher in patients affected by photoaging, if compared with healthy controls (p < 0.0001). pH and sebum were increased in patients affected by photoaging, if compared with healthy controls (both p < 0.0001), while elasticity, hydration and tonicity were decreased in patients affected by photoaging, if compared with healthy controls (all p < 0.0001). Serum fibronectin and hyaluronic acid concentrations were lower in patients affected by photoaging, if compared with healthy controls (both p < 0.0001). Serum neutrophil elastase 2, elastin and carbonylated protein concentrations were higher in patients affected by photoaging, if compared with healthy controls (p < 0.01, p < 0.01 and p < 0.0001, respectively). Dietary supplement administration resulted in an improvement in VAS photoaging score, if compared with placebo (p < 0.0001), as observed 2 weeks after the end of treatment. Facial sebum, hydration and tonicity were increased in the active treatment group vs. placebo (p < 0.0001, p < 0.0001 and p < 0.05, respectively) 2 weeks after the end of treatment. Serum fibronectin and hyaluronic acid concentrations were increased in the dietary supplement group, if compared with placebo (p < 0.01 and p < 0.001) 2 weeks after the end of treatment, while no statistical difference in serum elastin concentration was observed between the two groups. Serum neutrophil elastase 2 and carbonylated protein concentrations were decreased in the dietary supplement group 2 weeks after the end of treatment, if compared with placebo (p < 0.001 and p < 0.0001). We found significantly increased serum levels of neutrophil elastase 2, elastin and carbonylated proteins and decreased levels of hyaluronic acid and fibronectin in patients affected by facial photoaging, if compared with healthy controls. These findings coupled with a significant decrease in skin hydration, tonicity and elasticity and increased skin pH and sebum. Treatment with the dietary supplement VISCODERM Pearls significantly improved VAS photoaging score and skin hydration, sebum and tonicity 2 weeks after the end of a 4-week treatment period in patients affected by moderate to severe facial photoaging. These findings coupled with a significant increase in serum fibronectin and hyaluronic acid and a decrease in serum carbonylated proteins and neutrophil elastase 2 in the active treatment group, if compared with placebo. Our findings suggest that VISCODERM Pearls is effective for treatment of facial photoaging but further studies in larger cohorts of patients are required
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A dietary supplement improves facial photoaging and skin sebum, hydration and tonicity modulating serum fibronectin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins
'Elsevier BV', 2015Co-Authors: Di Cerbo Alessandro, Laurino Carmen, Palmieri Beniamino, Iannitti TommasoAbstract:Background and aims Excessive exposure to the sun can cause severe photoaging as early as the second decade of life resulting in a loss of physiological elastic fiber functions. We designed a first study to assess differences in facial skin pH, sebum, elasticity, hydration and tonicity and serum levels of fibronectin, elastin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins between patients affected by facial photoaging and healthy controls. In a second study we tested the hypothesis that a dietary supplement would improve facial photoaging, also promoting changes in the above mentioned skin and serum parameters. Methods In the first study we enrolled 30 women [age: 47.5 \ub1 1.6 years (mean \ub1 standard error of the mean)] affected by moderate facial photoaging (4 cm 64 Visual Analogue Scale (VAS) < 7 cm) and 30 healthy women [age: 45.9 \ub1 1.6 years (mean \ub1 standard error of the mean)]. In the second study we enrolled a cohort of 30 women [age: 43.6 \ub1 1.2 years (mean \ub1 standard error of the mean)], affected by moderate (n = 22) and severe (VAS 65 7 cm; n = 8) facial photoaging, who were randomized to receive a pharmaceutical formulation (VISCODERM\uae Pearls IBSA FARMACEUTICI ITALIA Srl, Lodi, Italy) containing Pycnogenol\uae, collagen, coenzyme Q10, low-molecular-weight hyaluronic acid, chondroitin sulfate and glucosamine sulfate (n = 15) or placebo (n = 15). Dietary supplement and placebo were administered 2 times a day for 4 weeks. Facial photoaging was assessed by VAS in the first cohort of patients affected by facial photoaging and healthy controls and, at baseline and 2 weeks after the end of treatment, in the second cohort of patients who underwent treatment with VISCODERM\uae Pearls and placebo. Skin Tester was used to analyze differences in facial skin parameters between patients affected by facial photoaging and healthy controls. Skin Tester was also used to assess the effect of VISCODERM\uae Pearls on facial skin parameters and compared with placebo 2 weeks after the end of treatment. Serum levels of fibronectin, elastin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins were measured by enzyme-linked immunosorbent assay in the first cohort of patients affected by facial photoaging and healthy controls and, at baseline and 2 weeks after the end of treatment, in the second cohort of patients who underwent treatment with VISCODERM\uae Pearls and placebo. Results VAS photoaging score was higher in patients affected by photoaging, if compared with healthy controls (p < 0.0001). pH and sebum were increased in patients affected by photoaging, if compared with healthy controls (both p < 0.0001), while elasticity, hydration and tonicity were decreased in patients affected by photoaging, if compared with healthy controls (all p < 0.0001). Serum fibronectin and hyaluronic acid concentrations were lower in patients affected by photoaging, if compared with healthy controls (both p < 0.0001). Serum neutrophil elastase 2, elastin and carbonylated protein concentrations were higher in patients affected by photoaging, if compared with healthy controls (p < 0.01, p < 0.01 and p < 0.0001, respectively). Dietary supplement administration resulted in an improvement in VAS photoaging score, if compared with placebo (p < 0.0001), as observed 2 weeks after the end of treatment. Facial sebum, hydration and tonicity were increased in the active treatment group vs. placebo (p < 0.0001, p < 0.0001 and p < 0.05, respectively) 2 weeks after the end of treatment. Serum fibronectin and hyaluronic acid concentrations were increased in the dietary supplement group, if compared with placebo (p < 0.01 and p < 0.001) 2 weeks after the end of treatment, while no statistical difference in serum elastin concentration was observed between the two groups. Serum neutrophil elastase 2 and carbonylated protein concentrations were decreased in the dietary supplement group 2 weeks after the end of treatment, if compared with placebo (p < 0.001 and p < 0.0001). Conclusions We found significantly increased serum levels of neutrophil elastase 2, elastin and carbonylated proteins and decreased levels of hyaluronic acid and fibronectin in patients affected by facial photoaging, if compared with healthy controls. These findings coupled with a significant decrease in skin hydration, tonicity and elasticity and increased skin pH and sebum. Treatment with the dietary supplement VISCODERM\uae Pearls significantly improved VAS photoaging score and skin hydration, sebum and tonicity 2 weeks after the end of a 4-week treatment period in patients affected by moderate to severe facial photoaging. These findings coupled with a significant increase in serum fibronectin and hyaluronic acid and a decrease in serum carbonylated proteins and neutrophil elastase 2 in the active treatment group, if compared with placebo. Our findings suggest that VISCODERM\uae Pearls is effective for treatment of facial photoaging but further studies in larger cohorts of patients are required
