The Experts below are selected from a list of 60 Experts worldwide ranked by ideXlab platform
Leslie Lenert - One of the best experts on this subject based on the ideXlab platform.
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A Public Health Grid (PHGrid): Architecture and value proposition for 21st century public health.
International journal of medical informatics, 2010Co-Authors: Thomas G. Savel, Kenneth E. Hall, Brian Lee, V. Mcmullin, Moses Miles, John Stinn, Peter White, Dan Washington, Terry Boyd, Leslie LenertAbstract:Abstract Purpose This manuscript describes the value of and proposal for a high-level architectural framework for a Public Health Grid (PHGrid), which the authors feel has the capability to afford the public health community a robust technology infrastructure for secure and timely data, information, and knowledge exchange, not only within the public health domain, but between public health and the overall health care system. Methods The CDC facilitated multiple Proof-of-Concept (PoC) projects, leveraging an open-source-based software development methodology, to test four hypotheses with regard to this high-level framework. The outcomes of the four PoCs in combination with the use of the Federal Enterprise Architecture Framework (FEAF) and the newly emerging Federal Segment Architecture Methodology (FSAM) was used to develop and refine a high-level architectural framework for a Public Health Grid infrastructure. Results The authors were successful in documenting a robust high-level architectural framework for a PHGrid. The documentation generated provided a level of granularity needed to validate the proposal, and included examples of both information standards and services to be implemented. Both the results of the PoCs as well as feedback from selected public health partners were used to develop the granular documentation. Conclusions A robust high-level cohesive architectural framework for a Public Health Grid (PHGrid) has been successfully articulated, with its feasibility demonstrated via multiple PoCs. In order to successfully implement this framework for a Public Health Grid, the authors recommend moving forward with a three-pronged approach focusing on interoperability and standards, streamlining the PHGrid infrastructure, and developing robust and high-impact public health services.
Balland Olivier - One of the best experts on this subject based on the ideXlab platform.
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Short-term effects of ocular 2% dorzolamide, 0.5% timolol or 0.005% latanoprost on the anterior Segment Architecture in healthy cats: a prospective study.
Faculty of Veterinary Medicine University of Tripoli, 2020Co-Authors: Barbry Jean-baptiste, Poinsard Anne-sophie, Bastogne Thierry, Balland OlivierAbstract:International audienceDorzolamide 2%, timolol 0.5% and latanoprost 0.005% are widely used in the medical management of glaucoma in humans and pets. In this study, we wanted to evaluate the effect of these three molecules belonging to different hypotensive families on intraocular pressure (IOP) and anterior Segment Architecture in clinically healthy cats and compare these data with those obtained in a previous study under the same conditions in healthy dogs. In this prospective study 45 cats were included and divided into 3 homogeneous groups. For 7 days eye drops were instilled in the right eye (treated eye), dorzolamide 2% BID for the first group, timolol 0.5% BID for the second group and latanoprost 0.005% SID for the third group. The left (untreated) eye of all these cats constitute a control group useful for the statistical analysis of the data. On D0 and D7, the IOP was measured with Tonovet® and then, a high frequency ultrasound (ultrasound biomicroscopy UBM) was undertaken under general anesthesia. A biostatistical study of the 1440 data was then performed. Statistical test validated the use of the controlateral eye as a control, and the representativeness of a sample of 15 animals per group. At D7, the IOP of healthy cats treated with dorzolamide 2% BID decreased significantly whereas no variation was obtained with instillation of timolol 0.5% and latanoprost 0.005%. According to our protocol, these three hypotensive molecules do not significantly affect the Architecture of the anterior Segment of the clinically healthy feline eye as in dogs
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Short-term effects of topical 2% dorzolamide, 0.5% timolol and 0.005% latanoprost on the intra ocular pressure and on the anterior Segment Architecture in normotensive cats: a prospective study
HAL CCSD, 2016Co-Authors: Poinsard Anne-sophie, Bastogne Thierry, Isard Pierre-francois, Dulaurent Thomas, Balland OlivierAbstract:Abstract published in Veterinary Ophthalmology, 20(1):E1-E6, January 2017International audiencePurpose: To evaluate the effects of 2% Dorzolamide, 0.5% Timolol and 0.005% Latano- prost on the biometrics of the anterior Segment in normotensive cats. Material/Methods: Three groups of 15 clinically healthy randomly selected cats received one single molecule on the right eye during 7 days (Group 1: 2% Dorzolamide BID, Group 2: 0.5% Timolol BID, Group 3: 0.005% Latanoprost SID). Left eyes received no treatment and were used as con- trols. Complete ophthalmic examination, IOP measurement and anterior Segment assessment by Ultrasound Biomicroscopy (UBM) were performed in the same conditions at day 1 and day 7, on both eyes. Eight anatomical parameters of the anterior Segment were evaluated: the geometric iridocorneal angle (ICA) – formed by the plane of the iris root and the inter- nal corneoscleral limbus – the width of the opening of the ciliary cleft (CC), the width of the mid-CC, the length of the CC, the anterior chamber (AC) depth (distance between the corneal endothelium and the anterior lens capsule), the central and peripheral corneal thick- nesses, then the distance between the anterior lens capsule and the internal corneoscleral limbus. Results: The use of the controlateral eye as control was statistically validated, as well as the representativeness of fifteen-cat cohorts. A significant decrease of IOP was observed only for dorzolamide (5.3%). None of the eight anatomical parameters were statistically modified by the topical instillation of the three drugs. Discussion: The use of the three first-line antiglaucomatous agents does not significantly alter the anterior Segment Architecture in normotensive cats
Thomas G. Savel - One of the best experts on this subject based on the ideXlab platform.
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A Public Health Grid (PHGrid): Architecture and value proposition for 21st century public health.
International journal of medical informatics, 2010Co-Authors: Thomas G. Savel, Kenneth E. Hall, Brian Lee, V. Mcmullin, Moses Miles, John Stinn, Peter White, Dan Washington, Terry Boyd, Leslie LenertAbstract:Abstract Purpose This manuscript describes the value of and proposal for a high-level architectural framework for a Public Health Grid (PHGrid), which the authors feel has the capability to afford the public health community a robust technology infrastructure for secure and timely data, information, and knowledge exchange, not only within the public health domain, but between public health and the overall health care system. Methods The CDC facilitated multiple Proof-of-Concept (PoC) projects, leveraging an open-source-based software development methodology, to test four hypotheses with regard to this high-level framework. The outcomes of the four PoCs in combination with the use of the Federal Enterprise Architecture Framework (FEAF) and the newly emerging Federal Segment Architecture Methodology (FSAM) was used to develop and refine a high-level architectural framework for a Public Health Grid infrastructure. Results The authors were successful in documenting a robust high-level architectural framework for a PHGrid. The documentation generated provided a level of granularity needed to validate the proposal, and included examples of both information standards and services to be implemented. Both the results of the PoCs as well as feedback from selected public health partners were used to develop the granular documentation. Conclusions A robust high-level cohesive architectural framework for a Public Health Grid (PHGrid) has been successfully articulated, with its feasibility demonstrated via multiple PoCs. In order to successfully implement this framework for a Public Health Grid, the authors recommend moving forward with a three-pronged approach focusing on interoperability and standards, streamlining the PHGrid infrastructure, and developing robust and high-impact public health services.
Dan Washington - One of the best experts on this subject based on the ideXlab platform.
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A Public Health Grid (PHGrid): Architecture and value proposition for 21st century public health.
International journal of medical informatics, 2010Co-Authors: Thomas G. Savel, Kenneth E. Hall, Brian Lee, V. Mcmullin, Moses Miles, John Stinn, Peter White, Dan Washington, Terry Boyd, Leslie LenertAbstract:Abstract Purpose This manuscript describes the value of and proposal for a high-level architectural framework for a Public Health Grid (PHGrid), which the authors feel has the capability to afford the public health community a robust technology infrastructure for secure and timely data, information, and knowledge exchange, not only within the public health domain, but between public health and the overall health care system. Methods The CDC facilitated multiple Proof-of-Concept (PoC) projects, leveraging an open-source-based software development methodology, to test four hypotheses with regard to this high-level framework. The outcomes of the four PoCs in combination with the use of the Federal Enterprise Architecture Framework (FEAF) and the newly emerging Federal Segment Architecture Methodology (FSAM) was used to develop and refine a high-level architectural framework for a Public Health Grid infrastructure. Results The authors were successful in documenting a robust high-level architectural framework for a PHGrid. The documentation generated provided a level of granularity needed to validate the proposal, and included examples of both information standards and services to be implemented. Both the results of the PoCs as well as feedback from selected public health partners were used to develop the granular documentation. Conclusions A robust high-level cohesive architectural framework for a Public Health Grid (PHGrid) has been successfully articulated, with its feasibility demonstrated via multiple PoCs. In order to successfully implement this framework for a Public Health Grid, the authors recommend moving forward with a three-pronged approach focusing on interoperability and standards, streamlining the PHGrid infrastructure, and developing robust and high-impact public health services.
Kenneth E. Hall - One of the best experts on this subject based on the ideXlab platform.
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A Public Health Grid (PHGrid): Architecture and value proposition for 21st century public health.
International journal of medical informatics, 2010Co-Authors: Thomas G. Savel, Kenneth E. Hall, Brian Lee, V. Mcmullin, Moses Miles, John Stinn, Peter White, Dan Washington, Terry Boyd, Leslie LenertAbstract:Abstract Purpose This manuscript describes the value of and proposal for a high-level architectural framework for a Public Health Grid (PHGrid), which the authors feel has the capability to afford the public health community a robust technology infrastructure for secure and timely data, information, and knowledge exchange, not only within the public health domain, but between public health and the overall health care system. Methods The CDC facilitated multiple Proof-of-Concept (PoC) projects, leveraging an open-source-based software development methodology, to test four hypotheses with regard to this high-level framework. The outcomes of the four PoCs in combination with the use of the Federal Enterprise Architecture Framework (FEAF) and the newly emerging Federal Segment Architecture Methodology (FSAM) was used to develop and refine a high-level architectural framework for a Public Health Grid infrastructure. Results The authors were successful in documenting a robust high-level architectural framework for a PHGrid. The documentation generated provided a level of granularity needed to validate the proposal, and included examples of both information standards and services to be implemented. Both the results of the PoCs as well as feedback from selected public health partners were used to develop the granular documentation. Conclusions A robust high-level cohesive architectural framework for a Public Health Grid (PHGrid) has been successfully articulated, with its feasibility demonstrated via multiple PoCs. In order to successfully implement this framework for a Public Health Grid, the authors recommend moving forward with a three-pronged approach focusing on interoperability and standards, streamlining the PHGrid infrastructure, and developing robust and high-impact public health services.