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Erhan Bilir - One of the best experts on this subject based on the ideXlab platform.

  • Comparison of ILAE 2010 and semiological Seizure classification in children with epilepsy.
    Epilepsy research, 2016
    Co-Authors: Tugba Hirfanoglu, Ayse Serdaroglu, Erhan Bilir, Irem Capraz, Ebru Arhan, Kürşad Aydın
    Abstract:

    Abstract Objective The aim of this study was to compare both ILAE 2010 and semiological Seizure classification (SSC) in terms of their applicability and utility and to predict epileptogenic zone in children with epilepsy. Methods Both ILAE 2010 classification and SSC which is a part of five dimensional classification were applied for a total 138 children by dividing into younger (≤6 y/o) and older (>6 y/o) age groups over the last two years as retrospectively. After the assessment of the Seizures types, epilepsy syndromes, and etiologies; the data were also compared to evaluate if having correlation between epileptogenic zone and Seizure Subtypes in both ILAE 2010 and SSC. Results ILAE 2010 indicated that 66.7% of the patients had focal Seizures, 15.9% had generalized Seizures, and 14.4% had Seizures of unknown origin. The SSC revealed that the most frequent Seizure type was simple Seizures (56.5%), second frequent one was complex motor Seizures (46.4%) and dialeptic Seizures (39.9%). To predict epileptogenic zone, SSC was found to be more specific than ILAE in terms of the more subgroups of SSC were related to the more subgroups of epileptogenic zone (p  Significance Preference of Seizure classification system is unique for each patient and depends on requirements. Therefore, one dimension cannot be sufficient for evaluation the nature of the Seizures in some patients. Furthermore, age related evolution of the Seizure types should not be ignored due to ongoing maturation state of the brain. ILAE 2010 and SSC have weak and strong points compared to each other. Semiological Seizure classification is more informative in terms of identifying the epileptogenic zone which may be important in specific occasions like pre-surgical work up, while ILAE is simple and easier method which can be applied for Seizure description and their characteristics in daily practice.

  • Sleep-wake distribution and circadian patterns of epileptic Seizures in children
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2016
    Co-Authors: Esra Gurkas, Ayse Serdaroglu, Tugba Hirfanoglu, A. Kartal, Ünsal Yılmaz, Erhan Bilir
    Abstract:

    Abstract Background Epilepsy is one of the most common chronic neurologic disorders. Daily periodicity of epileptic Seizures has been known for over a century. The diurnal patterns of epileptic Seizures have also been observed in studies. Aim To investigate the sleep/wake cycle, day/night, and 24-h periodicity of various Seizure Subtypes and Seizure onset localizations in children. Methods We analyzed the clinical Seizures of 170 consecutive epilepsy patients who underwent video-electroencephalography (EEG) monitoring over the last 5 years. Semiology of the Seizures was classified according to the semiological Seizure classification. Origin of the Seizures was defined by the onset of ictal activity on EEG. Seizures were evaluated in terms of occurrence during the day (06:00–18:00 h) or night (18:00–06:00 h), in wakefulness or in sleep, and within a 3-h time interval throughout 24 h. Results A total of 909 Seizures were analyzed. Auras, dialeptic, myoclonic, hypomotor, atonic Seizures, and epileptic spasms occurred more frequently in wakefulness; tonic, clonic, and hypermotor Seizures occurred more frequently in sleep. Auras, dialeptic, and atonic Seizures and epileptic spasms occurred more often during daytime; hypermotor Seizures occurred more often at night. Generalized Seizures were seen most frequently in wakefulness (between 12:00 and 18:00 h); frontal lobe Seizures were seen at night and in sleep (between 24:00 and 03:00 h); temporal lobe Seizures were seen in wakefulness (between 06:00 and 09:00 h and between 12:00 and 15:00 h); occipital Seizures were seen during daytime and in wakefulness (between 09:00 and 12:00 h and between 15:00 and 18:00 h, respectively); parietal Seizures were seen mostly during daytime. Conclusions Seizures in children occur in specific circadian patterns and in specific sleep/wake distributions depending on Seizure onset location and semiology.

  • P52 – 2932: Sleep-wake distribution and circadian patterns of epileptic Seizures in children
    European Journal of Paediatric Neurology, 2015
    Co-Authors: Esra Gurkas, Ayse Serdaroglu, Tugba Hirfanoglu, A. Kartal, Ünsal Yılmaz, Erhan Bilir
    Abstract:

    Objective To investigate the sleep/wake cycle, day/night and 24-hour periodicity of various Seizure Subtypes and Seizure onset localizations in children. Methods We analyzed the clinical Seizures of 170 consecutive epilepsy patients who underwent video-electroencephalography (EEG) monitoring over the last 5-year period. Semiology of the Seizures was classified according to the semiological Seizure classification. Origin of the Seizures was defined by the onset of ictal activity in EEG. Seizures were evaluated in terms of occurence during the day (06:00–18:00) or night (18:00–06:00), in wakefulness or sleep and within the 3-hour time interval throughout 24 hours. Results A total of 909 Seizures were analyzed. While auras, dialeptic, myoclonic, hypomotor, atonic Seizures and epileptic spasms occurred more frequently in wakefulness; tonic, clonic, hypermotor Seizures occurred more frequently in sleep. Auras, dialeptic, atonic Seizures and epileptic spasms occurred more often during daytime, hypermotor Seizures occurred more often at night. Generalized Seizures were seen most frequently in wakefulness (between 12:00–18:00 h), frontal lob Seizures were seen at night and in sleep (between 24:00–6:00 h), temporal lobe Seizures were seen in wakefulness (between 06:00–09:00 h and 12:00 am-15:00 h), occipital Seizures were seen during daytime and in wakefulness (between 09:00–12:00 h and 15:00–18:00 h), parietal Seizures were seen mostly during daytime. Conclusion Seizures in children occur in specific circadian patterns and in specific sleep/wake distributions depending on Seizure onset location and semiology. Recognition of these daily patterns of Seizures provides new diagnostic and therapeutic options.

Samuel F. Berkovic - One of the best experts on this subject based on the ideXlab platform.

  • Genetics of febrile Seizure Subtypes and syndromes: A twin study
    Epilepsy Research, 2013
    Co-Authors: Jazmin Eckhaus, Kate M. Lawrence, Ingo Helbig, Minh Bui, Lata Vadlamudi, John L. Hopper, Ingrid E. Scheffer, Samuel F. Berkovic
    Abstract:

    Summary Purpose Febrile Seizures (FS) are the most common Seizure syndrome. A strong genetic component has been well established through family and twin studies; however, such studies have not examined the genetics of different FS types (simple, complex, febrile status epilepticus) and sub-syndromes (true FS, febrile Seizures plus (FS+), ‘FS with later epilepsy'). Here we used a community-based twin sample to analyze genetic factors within different FS Subtypes and FS syndromes. Methods Twin pairs were ascertained from the twin database of the Epilepsy Research Centre. A retrospective chart review was conducted and follow-up attempted for all subjects. Casewise concordance values were calculated for the different subgroups and intra-pair variation was analyzed. Key findings One hundred and seventy-nine twin pairs with FS were identified. Overall casewise concordance for FS in monozygotic (MZ) twins (0.62) was greater than in dizygotic (DZ) twins (0.16, p Significance These results suggest a strong genetic contribution to different FS Subtypes and sub-syndromes. They also support the existence of distinct genetic factors for different FS Subtypes and sub-syndromes, especially FS+. This information is important for the strategic planning of next generation sequencing studies of febrile Seizures.

  • Genetics of febrile Seizure Subtypes and syndromes: a twin study.
    Epilepsy research, 2013
    Co-Authors: Jazmin Eckhaus, Kate M. Lawrence, Ingo Helbig, Minh Bui, Lata Vadlamudi, John L. Hopper, Ingrid E. Scheffer, Samuel F. Berkovic
    Abstract:

    Febrile Seizures (FS) are the most common Seizure syndrome. A strong genetic component has been well established through family and twin studies; however, such studies have not examined the genetics of different FS types (simple, complex, febrile status epilepticus) and sub-syndromes (true FS, febrile Seizures plus (FS+), 'FS with later epilepsy'). Here we used a community-based twin sample to analyze genetic factors within different FS Subtypes and FS syndromes. Twin pairs were ascertained from the twin database of the Epilepsy Research Centre. A retrospective chart review was conducted and follow-up attempted for all subjects. Casewise concordance values were calculated for the different subgroups and intra-pair variation was analyzed. One hundred and seventy-nine twin pairs with FS were identified. Overall casewise concordance for FS in monozygotic (MZ) twins (0.62) was greater than in dizygotic (DZ) twins (0.16, p<0.0001). A greater concordance amongst MZ pairs than DZ twin pairs was also observed for all FS Subtypes and FS sub-syndromes, particularly in twins with FS+. Within concordant MZ pairs, we did not observe the co-occurrence of FS and FS+. These results suggest a strong genetic contribution to different FS Subtypes and sub-syndromes. They also support the existence of distinct genetic factors for different FS Subtypes and sub-syndromes, especially FS+. This information is important for the strategic planning of next generation sequencing studies of febrile Seizures. Copyright © 2013 Elsevier B.V. All rights reserved.

Tugba Hirfanoglu - One of the best experts on this subject based on the ideXlab platform.

  • Comparison of ILAE 2010 and semiological Seizure classification in children with epilepsy.
    Epilepsy research, 2016
    Co-Authors: Tugba Hirfanoglu, Ayse Serdaroglu, Erhan Bilir, Irem Capraz, Ebru Arhan, Kürşad Aydın
    Abstract:

    Abstract Objective The aim of this study was to compare both ILAE 2010 and semiological Seizure classification (SSC) in terms of their applicability and utility and to predict epileptogenic zone in children with epilepsy. Methods Both ILAE 2010 classification and SSC which is a part of five dimensional classification were applied for a total 138 children by dividing into younger (≤6 y/o) and older (>6 y/o) age groups over the last two years as retrospectively. After the assessment of the Seizures types, epilepsy syndromes, and etiologies; the data were also compared to evaluate if having correlation between epileptogenic zone and Seizure Subtypes in both ILAE 2010 and SSC. Results ILAE 2010 indicated that 66.7% of the patients had focal Seizures, 15.9% had generalized Seizures, and 14.4% had Seizures of unknown origin. The SSC revealed that the most frequent Seizure type was simple Seizures (56.5%), second frequent one was complex motor Seizures (46.4%) and dialeptic Seizures (39.9%). To predict epileptogenic zone, SSC was found to be more specific than ILAE in terms of the more subgroups of SSC were related to the more subgroups of epileptogenic zone (p  Significance Preference of Seizure classification system is unique for each patient and depends on requirements. Therefore, one dimension cannot be sufficient for evaluation the nature of the Seizures in some patients. Furthermore, age related evolution of the Seizure types should not be ignored due to ongoing maturation state of the brain. ILAE 2010 and SSC have weak and strong points compared to each other. Semiological Seizure classification is more informative in terms of identifying the epileptogenic zone which may be important in specific occasions like pre-surgical work up, while ILAE is simple and easier method which can be applied for Seizure description and their characteristics in daily practice.

  • Sleep-wake distribution and circadian patterns of epileptic Seizures in children
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2016
    Co-Authors: Esra Gurkas, Ayse Serdaroglu, Tugba Hirfanoglu, A. Kartal, Ünsal Yılmaz, Erhan Bilir
    Abstract:

    Abstract Background Epilepsy is one of the most common chronic neurologic disorders. Daily periodicity of epileptic Seizures has been known for over a century. The diurnal patterns of epileptic Seizures have also been observed in studies. Aim To investigate the sleep/wake cycle, day/night, and 24-h periodicity of various Seizure Subtypes and Seizure onset localizations in children. Methods We analyzed the clinical Seizures of 170 consecutive epilepsy patients who underwent video-electroencephalography (EEG) monitoring over the last 5 years. Semiology of the Seizures was classified according to the semiological Seizure classification. Origin of the Seizures was defined by the onset of ictal activity on EEG. Seizures were evaluated in terms of occurrence during the day (06:00–18:00 h) or night (18:00–06:00 h), in wakefulness or in sleep, and within a 3-h time interval throughout 24 h. Results A total of 909 Seizures were analyzed. Auras, dialeptic, myoclonic, hypomotor, atonic Seizures, and epileptic spasms occurred more frequently in wakefulness; tonic, clonic, and hypermotor Seizures occurred more frequently in sleep. Auras, dialeptic, and atonic Seizures and epileptic spasms occurred more often during daytime; hypermotor Seizures occurred more often at night. Generalized Seizures were seen most frequently in wakefulness (between 12:00 and 18:00 h); frontal lobe Seizures were seen at night and in sleep (between 24:00 and 03:00 h); temporal lobe Seizures were seen in wakefulness (between 06:00 and 09:00 h and between 12:00 and 15:00 h); occipital Seizures were seen during daytime and in wakefulness (between 09:00 and 12:00 h and between 15:00 and 18:00 h, respectively); parietal Seizures were seen mostly during daytime. Conclusions Seizures in children occur in specific circadian patterns and in specific sleep/wake distributions depending on Seizure onset location and semiology.

  • P52 – 2932: Sleep-wake distribution and circadian patterns of epileptic Seizures in children
    European Journal of Paediatric Neurology, 2015
    Co-Authors: Esra Gurkas, Ayse Serdaroglu, Tugba Hirfanoglu, A. Kartal, Ünsal Yılmaz, Erhan Bilir
    Abstract:

    Objective To investigate the sleep/wake cycle, day/night and 24-hour periodicity of various Seizure Subtypes and Seizure onset localizations in children. Methods We analyzed the clinical Seizures of 170 consecutive epilepsy patients who underwent video-electroencephalography (EEG) monitoring over the last 5-year period. Semiology of the Seizures was classified according to the semiological Seizure classification. Origin of the Seizures was defined by the onset of ictal activity in EEG. Seizures were evaluated in terms of occurence during the day (06:00–18:00) or night (18:00–06:00), in wakefulness or sleep and within the 3-hour time interval throughout 24 hours. Results A total of 909 Seizures were analyzed. While auras, dialeptic, myoclonic, hypomotor, atonic Seizures and epileptic spasms occurred more frequently in wakefulness; tonic, clonic, hypermotor Seizures occurred more frequently in sleep. Auras, dialeptic, atonic Seizures and epileptic spasms occurred more often during daytime, hypermotor Seizures occurred more often at night. Generalized Seizures were seen most frequently in wakefulness (between 12:00–18:00 h), frontal lob Seizures were seen at night and in sleep (between 24:00–6:00 h), temporal lobe Seizures were seen in wakefulness (between 06:00–09:00 h and 12:00 am-15:00 h), occipital Seizures were seen during daytime and in wakefulness (between 09:00–12:00 h and 15:00–18:00 h), parietal Seizures were seen mostly during daytime. Conclusion Seizures in children occur in specific circadian patterns and in specific sleep/wake distributions depending on Seizure onset location and semiology. Recognition of these daily patterns of Seizures provides new diagnostic and therapeutic options.

Ayse Serdaroglu - One of the best experts on this subject based on the ideXlab platform.

  • Comparison of ILAE 2010 and semiological Seizure classification in children with epilepsy.
    Epilepsy research, 2016
    Co-Authors: Tugba Hirfanoglu, Ayse Serdaroglu, Erhan Bilir, Irem Capraz, Ebru Arhan, Kürşad Aydın
    Abstract:

    Abstract Objective The aim of this study was to compare both ILAE 2010 and semiological Seizure classification (SSC) in terms of their applicability and utility and to predict epileptogenic zone in children with epilepsy. Methods Both ILAE 2010 classification and SSC which is a part of five dimensional classification were applied for a total 138 children by dividing into younger (≤6 y/o) and older (>6 y/o) age groups over the last two years as retrospectively. After the assessment of the Seizures types, epilepsy syndromes, and etiologies; the data were also compared to evaluate if having correlation between epileptogenic zone and Seizure Subtypes in both ILAE 2010 and SSC. Results ILAE 2010 indicated that 66.7% of the patients had focal Seizures, 15.9% had generalized Seizures, and 14.4% had Seizures of unknown origin. The SSC revealed that the most frequent Seizure type was simple Seizures (56.5%), second frequent one was complex motor Seizures (46.4%) and dialeptic Seizures (39.9%). To predict epileptogenic zone, SSC was found to be more specific than ILAE in terms of the more subgroups of SSC were related to the more subgroups of epileptogenic zone (p  Significance Preference of Seizure classification system is unique for each patient and depends on requirements. Therefore, one dimension cannot be sufficient for evaluation the nature of the Seizures in some patients. Furthermore, age related evolution of the Seizure types should not be ignored due to ongoing maturation state of the brain. ILAE 2010 and SSC have weak and strong points compared to each other. Semiological Seizure classification is more informative in terms of identifying the epileptogenic zone which may be important in specific occasions like pre-surgical work up, while ILAE is simple and easier method which can be applied for Seizure description and their characteristics in daily practice.

  • Sleep-wake distribution and circadian patterns of epileptic Seizures in children
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2016
    Co-Authors: Esra Gurkas, Ayse Serdaroglu, Tugba Hirfanoglu, A. Kartal, Ünsal Yılmaz, Erhan Bilir
    Abstract:

    Abstract Background Epilepsy is one of the most common chronic neurologic disorders. Daily periodicity of epileptic Seizures has been known for over a century. The diurnal patterns of epileptic Seizures have also been observed in studies. Aim To investigate the sleep/wake cycle, day/night, and 24-h periodicity of various Seizure Subtypes and Seizure onset localizations in children. Methods We analyzed the clinical Seizures of 170 consecutive epilepsy patients who underwent video-electroencephalography (EEG) monitoring over the last 5 years. Semiology of the Seizures was classified according to the semiological Seizure classification. Origin of the Seizures was defined by the onset of ictal activity on EEG. Seizures were evaluated in terms of occurrence during the day (06:00–18:00 h) or night (18:00–06:00 h), in wakefulness or in sleep, and within a 3-h time interval throughout 24 h. Results A total of 909 Seizures were analyzed. Auras, dialeptic, myoclonic, hypomotor, atonic Seizures, and epileptic spasms occurred more frequently in wakefulness; tonic, clonic, and hypermotor Seizures occurred more frequently in sleep. Auras, dialeptic, and atonic Seizures and epileptic spasms occurred more often during daytime; hypermotor Seizures occurred more often at night. Generalized Seizures were seen most frequently in wakefulness (between 12:00 and 18:00 h); frontal lobe Seizures were seen at night and in sleep (between 24:00 and 03:00 h); temporal lobe Seizures were seen in wakefulness (between 06:00 and 09:00 h and between 12:00 and 15:00 h); occipital Seizures were seen during daytime and in wakefulness (between 09:00 and 12:00 h and between 15:00 and 18:00 h, respectively); parietal Seizures were seen mostly during daytime. Conclusions Seizures in children occur in specific circadian patterns and in specific sleep/wake distributions depending on Seizure onset location and semiology.

  • P52 – 2932: Sleep-wake distribution and circadian patterns of epileptic Seizures in children
    European Journal of Paediatric Neurology, 2015
    Co-Authors: Esra Gurkas, Ayse Serdaroglu, Tugba Hirfanoglu, A. Kartal, Ünsal Yılmaz, Erhan Bilir
    Abstract:

    Objective To investigate the sleep/wake cycle, day/night and 24-hour periodicity of various Seizure Subtypes and Seizure onset localizations in children. Methods We analyzed the clinical Seizures of 170 consecutive epilepsy patients who underwent video-electroencephalography (EEG) monitoring over the last 5-year period. Semiology of the Seizures was classified according to the semiological Seizure classification. Origin of the Seizures was defined by the onset of ictal activity in EEG. Seizures were evaluated in terms of occurence during the day (06:00–18:00) or night (18:00–06:00), in wakefulness or sleep and within the 3-hour time interval throughout 24 hours. Results A total of 909 Seizures were analyzed. While auras, dialeptic, myoclonic, hypomotor, atonic Seizures and epileptic spasms occurred more frequently in wakefulness; tonic, clonic, hypermotor Seizures occurred more frequently in sleep. Auras, dialeptic, atonic Seizures and epileptic spasms occurred more often during daytime, hypermotor Seizures occurred more often at night. Generalized Seizures were seen most frequently in wakefulness (between 12:00–18:00 h), frontal lob Seizures were seen at night and in sleep (between 24:00–6:00 h), temporal lobe Seizures were seen in wakefulness (between 06:00–09:00 h and 12:00 am-15:00 h), occipital Seizures were seen during daytime and in wakefulness (between 09:00–12:00 h and 15:00–18:00 h), parietal Seizures were seen mostly during daytime. Conclusion Seizures in children occur in specific circadian patterns and in specific sleep/wake distributions depending on Seizure onset location and semiology. Recognition of these daily patterns of Seizures provides new diagnostic and therapeutic options.

Esra Gurkas - One of the best experts on this subject based on the ideXlab platform.

  • Sleep-wake distribution and circadian patterns of epileptic Seizures in children
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2016
    Co-Authors: Esra Gurkas, Ayse Serdaroglu, Tugba Hirfanoglu, A. Kartal, Ünsal Yılmaz, Erhan Bilir
    Abstract:

    Abstract Background Epilepsy is one of the most common chronic neurologic disorders. Daily periodicity of epileptic Seizures has been known for over a century. The diurnal patterns of epileptic Seizures have also been observed in studies. Aim To investigate the sleep/wake cycle, day/night, and 24-h periodicity of various Seizure Subtypes and Seizure onset localizations in children. Methods We analyzed the clinical Seizures of 170 consecutive epilepsy patients who underwent video-electroencephalography (EEG) monitoring over the last 5 years. Semiology of the Seizures was classified according to the semiological Seizure classification. Origin of the Seizures was defined by the onset of ictal activity on EEG. Seizures were evaluated in terms of occurrence during the day (06:00–18:00 h) or night (18:00–06:00 h), in wakefulness or in sleep, and within a 3-h time interval throughout 24 h. Results A total of 909 Seizures were analyzed. Auras, dialeptic, myoclonic, hypomotor, atonic Seizures, and epileptic spasms occurred more frequently in wakefulness; tonic, clonic, and hypermotor Seizures occurred more frequently in sleep. Auras, dialeptic, and atonic Seizures and epileptic spasms occurred more often during daytime; hypermotor Seizures occurred more often at night. Generalized Seizures were seen most frequently in wakefulness (between 12:00 and 18:00 h); frontal lobe Seizures were seen at night and in sleep (between 24:00 and 03:00 h); temporal lobe Seizures were seen in wakefulness (between 06:00 and 09:00 h and between 12:00 and 15:00 h); occipital Seizures were seen during daytime and in wakefulness (between 09:00 and 12:00 h and between 15:00 and 18:00 h, respectively); parietal Seizures were seen mostly during daytime. Conclusions Seizures in children occur in specific circadian patterns and in specific sleep/wake distributions depending on Seizure onset location and semiology.

  • P52 – 2932: Sleep-wake distribution and circadian patterns of epileptic Seizures in children
    European Journal of Paediatric Neurology, 2015
    Co-Authors: Esra Gurkas, Ayse Serdaroglu, Tugba Hirfanoglu, A. Kartal, Ünsal Yılmaz, Erhan Bilir
    Abstract:

    Objective To investigate the sleep/wake cycle, day/night and 24-hour periodicity of various Seizure Subtypes and Seizure onset localizations in children. Methods We analyzed the clinical Seizures of 170 consecutive epilepsy patients who underwent video-electroencephalography (EEG) monitoring over the last 5-year period. Semiology of the Seizures was classified according to the semiological Seizure classification. Origin of the Seizures was defined by the onset of ictal activity in EEG. Seizures were evaluated in terms of occurence during the day (06:00–18:00) or night (18:00–06:00), in wakefulness or sleep and within the 3-hour time interval throughout 24 hours. Results A total of 909 Seizures were analyzed. While auras, dialeptic, myoclonic, hypomotor, atonic Seizures and epileptic spasms occurred more frequently in wakefulness; tonic, clonic, hypermotor Seizures occurred more frequently in sleep. Auras, dialeptic, atonic Seizures and epileptic spasms occurred more often during daytime, hypermotor Seizures occurred more often at night. Generalized Seizures were seen most frequently in wakefulness (between 12:00–18:00 h), frontal lob Seizures were seen at night and in sleep (between 24:00–6:00 h), temporal lobe Seizures were seen in wakefulness (between 06:00–09:00 h and 12:00 am-15:00 h), occipital Seizures were seen during daytime and in wakefulness (between 09:00–12:00 h and 15:00–18:00 h), parietal Seizures were seen mostly during daytime. Conclusion Seizures in children occur in specific circadian patterns and in specific sleep/wake distributions depending on Seizure onset location and semiology. Recognition of these daily patterns of Seizures provides new diagnostic and therapeutic options.