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Fabrice Bartolomei - One of the best experts on this subject based on the ideXlab platform.

  • Does the Thalamo-Cortical Synchrony Play a Role in Seizure Termination?
    Frontiers in neurology, 2015
    Co-Authors: Elisa Evangelista, Christian Bénar, Francesca Bonini, Romain Carron, Bruno Colombet, Jean Régis, Fabrice Bartolomei
    Abstract:

    The mechanisms underlying Seizure Termination are still unclear despite their therapeutic importance. We studied thalamo-cortical connectivity and synchrony in human mesial temporal lobe Seizures in order to analyze their role in Seizure Termination. Twenty-two Seizures from ten patients with drug-resistant mesial temporal lobe epilepsy undergoing pre-surgical evaluation were analyzed using intracerebral recordings (stereoelectroencephalography, SEEG). We performed a measure of SEEG signal interdependencies (non-linear correlation), to estimate the functional connectivity between thalamus and cortical regions. Then we derived synchronization indices, namely global, thalamic, mesio-temporal and thalamo-mesio temporal index at the onset and the end of Seizures. In addition, an estimation of thalamic “outputs and inputs” connectivity was proposed. Thalamus was consistently involved in the last phase of all analyzed Seizures and thalamic synchronization index was significantly more elevated at the end of Seizure than at the onset. The global synchronization index at the end of Seizure negatively correlated with Seizure duration (p= 0.045) and in the same way the thalamic synchronization index showed an inverse tendency with Seizure duration. Six Seizures out of twenty-two displayed a particular thalamo-cortical spike and wave pattern (SWP) at the end. They were associated to higher values of all synchronization indices and outputs from thalamus ( p = 0.0079). SWP Seizures displayed a higher and sustained increase of cortical and thalamo-cortical synchronization with a stronger participation of thalamic outputs. We suggest that thalamo-cortical oscillations might contribute to Seizure Termination via modulation of cortical synchronization. In the subgroup of SWP Seizures thalamus may exert a control on temporal lobe structures by inducing a stable hypersynchronization that ultimately leads to Seizure Termination.

  • Does the Thalamo-Cortical Synchrony Play a Role in Seizure Termination?
    Frontiers in Neurology, 2015
    Co-Authors: Elisa Evangelista, Christian Bénar, Francesca Bonini, Romain Carron, Bruno Colombet, Jean Régis, Fabrice Bartolomei
    Abstract:

    The mechanisms underlying Seizure Termination are still unclear despite their therapeutic importance. We studied thalamo-cortical connectivity and synchrony in human mesial temporal lobe Seizures in order to analyze their role in Seizure Termination. Twenty-two Seizures from 10 patients with drug-resistant mesial temporal lobe epilepsy undergoing pre-surgical evaluation were analyzed using intracerebral recordings [stereoelectroencephalography (SEEG)]. We performed a measure of SEEG signal interdependencies (non-linear correlation), to estimate the functional connectivity between thalamus and cortical regions. Then, we derived synchronization indices, namely global, thalamic, mesio-temporal, and thala-mo-mesio temporal index at the onset and the end of Seizures. In addition, an estimation of thalamic " outputs and inputs " connectivity was proposed. Thalamus was consistently involved in the last phase of all analyzed Seizures and thalamic synchronization index was significantly more elevated at the end of Seizure than at the onset. The global synchronization index at the end of Seizure negatively correlated with Seizure duration (p = 0.045) and in the same way the thalamic synchronization index showed an inverse tendency with Seizure duration. Six Seizures out of twenty-two displayed a particular thalamo-cortical spike-and-wave pattern at the end. They were associated to higher values of all synchronization indices and outputs from thalamus (p = 0.0079). SWP Seizures displayed a higher and sustained increase of cortical and thalamo-cortical synchronization with a stronger participation of thalamic outputs. We suggest that thalamo-cortical oscillations might contribute to Seizure Termination via modulation of cortical synchronization. In the subgroup of SWP Seizures, thalamus may exert a control on temporal lobe structures by inducing a stable hypersynchronization that ultimately leads to Seizure Termination.

Elisa Evangelista - One of the best experts on this subject based on the ideXlab platform.

  • Does the Thalamo-Cortical Synchrony Play a Role in Seizure Termination?
    Frontiers in neurology, 2015
    Co-Authors: Elisa Evangelista, Christian Bénar, Francesca Bonini, Romain Carron, Bruno Colombet, Jean Régis, Fabrice Bartolomei
    Abstract:

    The mechanisms underlying Seizure Termination are still unclear despite their therapeutic importance. We studied thalamo-cortical connectivity and synchrony in human mesial temporal lobe Seizures in order to analyze their role in Seizure Termination. Twenty-two Seizures from ten patients with drug-resistant mesial temporal lobe epilepsy undergoing pre-surgical evaluation were analyzed using intracerebral recordings (stereoelectroencephalography, SEEG). We performed a measure of SEEG signal interdependencies (non-linear correlation), to estimate the functional connectivity between thalamus and cortical regions. Then we derived synchronization indices, namely global, thalamic, mesio-temporal and thalamo-mesio temporal index at the onset and the end of Seizures. In addition, an estimation of thalamic “outputs and inputs” connectivity was proposed. Thalamus was consistently involved in the last phase of all analyzed Seizures and thalamic synchronization index was significantly more elevated at the end of Seizure than at the onset. The global synchronization index at the end of Seizure negatively correlated with Seizure duration (p= 0.045) and in the same way the thalamic synchronization index showed an inverse tendency with Seizure duration. Six Seizures out of twenty-two displayed a particular thalamo-cortical spike and wave pattern (SWP) at the end. They were associated to higher values of all synchronization indices and outputs from thalamus ( p = 0.0079). SWP Seizures displayed a higher and sustained increase of cortical and thalamo-cortical synchronization with a stronger participation of thalamic outputs. We suggest that thalamo-cortical oscillations might contribute to Seizure Termination via modulation of cortical synchronization. In the subgroup of SWP Seizures thalamus may exert a control on temporal lobe structures by inducing a stable hypersynchronization that ultimately leads to Seizure Termination.

  • Does the Thalamo-Cortical Synchrony Play a Role in Seizure Termination?
    Frontiers in Neurology, 2015
    Co-Authors: Elisa Evangelista, Christian Bénar, Francesca Bonini, Romain Carron, Bruno Colombet, Jean Régis, Fabrice Bartolomei
    Abstract:

    The mechanisms underlying Seizure Termination are still unclear despite their therapeutic importance. We studied thalamo-cortical connectivity and synchrony in human mesial temporal lobe Seizures in order to analyze their role in Seizure Termination. Twenty-two Seizures from 10 patients with drug-resistant mesial temporal lobe epilepsy undergoing pre-surgical evaluation were analyzed using intracerebral recordings [stereoelectroencephalography (SEEG)]. We performed a measure of SEEG signal interdependencies (non-linear correlation), to estimate the functional connectivity between thalamus and cortical regions. Then, we derived synchronization indices, namely global, thalamic, mesio-temporal, and thala-mo-mesio temporal index at the onset and the end of Seizures. In addition, an estimation of thalamic " outputs and inputs " connectivity was proposed. Thalamus was consistently involved in the last phase of all analyzed Seizures and thalamic synchronization index was significantly more elevated at the end of Seizure than at the onset. The global synchronization index at the end of Seizure negatively correlated with Seizure duration (p = 0.045) and in the same way the thalamic synchronization index showed an inverse tendency with Seizure duration. Six Seizures out of twenty-two displayed a particular thalamo-cortical spike-and-wave pattern at the end. They were associated to higher values of all synchronization indices and outputs from thalamus (p = 0.0079). SWP Seizures displayed a higher and sustained increase of cortical and thalamo-cortical synchronization with a stronger participation of thalamic outputs. We suggest that thalamo-cortical oscillations might contribute to Seizure Termination via modulation of cortical synchronization. In the subgroup of SWP Seizures, thalamus may exert a control on temporal lobe structures by inducing a stable hypersynchronization that ultimately leads to Seizure Termination.

Gerhard Bauer - One of the best experts on this subject based on the ideXlab platform.

  • asymmetric Seizure Termination in primary and secondary generalized tonic clonic Seizures
    Epilepsia, 2009
    Co-Authors: Gerald Walser, Iris Unterberger, Judith Dobesberger, Norbert Embacher, Tina Falkenstetter, Julia Larch, Giorgi Kuchukhidze, Thaddaeus Gotwald, Martin Ortler, Gerhard Bauer
    Abstract:

    Summary Purpose:  In temporal lobe epilepsies an asymmetric Termination (AST) of the clonic phase of secondary generalized tonic–clonic Seizures (sGTCS) reliably lateralizes the side of Seizure onset. The last clonic activity occurs ipsilateral to the side of the Seizure onset zone. We compared the prevalence and lateralizing value of AST in sGTCS of frontal and temporal lobe origin as well as in primary generalized tonic–clonic Seizures (pGTCS). Methods:  We analyzed 177 Seizures in 84 consecutive patients. Forty-one patients had temporal lobe epilepsy (TLE), 24 frontal lobe epilepsy (FLE), and 19 had nonfocal (primary) generalized epilepsies (GE). All patients underwent intensive video-EEG (electroencephalography) monitoring, high-resolution magnetic resonance imaging (MRI), neuropsychological testing, and single photon emission computed tomography/positron emission tomography (SPECT/PET) when feasible. Two investigators blinded for diagnosis, EEG, and imaging data assessed frequency and side of the last clonic jerk. Results:  AST occurred in 63% of patients with TLE (47% of Seizures), in 71% with FLE (60% of Seizures), and in 42% with GE (21% of Seizures). These results were not significant for patients, but significant for Seizures in TLE versus GE and in FLE versus GE (p < 0.001). The positive predictive value (PPV) for the side of Seizure onset was 74% (p = 0.003) in TLE and 75% (p = 0.008) in FLE. Discussion:  AST in sGTCS lateralizes the side of Seizure onset in TLE and in FLE to the ipsilateral hemisphere with a high PPV. However, AST was also observed in GE. Therefore, asymmetric clinical signs should not inevitably lead to the assumption of focal epilepsy syndromes.

  • Asymmetric Seizure Termination in primary and secondary generalized tonic–clonic Seizures
    Epilepsia, 2009
    Co-Authors: Gerald Walser, Iris Unterberger, Judith Dobesberger, Norbert Embacher, Tina Falkenstetter, Julia Larch, Giorgi Kuchukhidze, Thaddaeus Gotwald, Martin Ortler, Gerhard Bauer
    Abstract:

    Summary Purpose:  In temporal lobe epilepsies an asymmetric Termination (AST) of the clonic phase of secondary generalized tonic–clonic Seizures (sGTCS) reliably lateralizes the side of Seizure onset. The last clonic activity occurs ipsilateral to the side of the Seizure onset zone. We compared the prevalence and lateralizing value of AST in sGTCS of frontal and temporal lobe origin as well as in primary generalized tonic–clonic Seizures (pGTCS). Methods:  We analyzed 177 Seizures in 84 consecutive patients. Forty-one patients had temporal lobe epilepsy (TLE), 24 frontal lobe epilepsy (FLE), and 19 had nonfocal (primary) generalized epilepsies (GE). All patients underwent intensive video-EEG (electroencephalography) monitoring, high-resolution magnetic resonance imaging (MRI), neuropsychological testing, and single photon emission computed tomography/positron emission tomography (SPECT/PET) when feasible. Two investigators blinded for diagnosis, EEG, and imaging data assessed frequency and side of the last clonic jerk. Results:  AST occurred in 63% of patients with TLE (47% of Seizures), in 71% with FLE (60% of Seizures), and in 42% with GE (21% of Seizures). These results were not significant for patients, but significant for Seizures in TLE versus GE and in FLE versus GE (p 

Christian Bénar - One of the best experts on this subject based on the ideXlab platform.

  • Does the Thalamo-Cortical Synchrony Play a Role in Seizure Termination?
    Frontiers in neurology, 2015
    Co-Authors: Elisa Evangelista, Christian Bénar, Francesca Bonini, Romain Carron, Bruno Colombet, Jean Régis, Fabrice Bartolomei
    Abstract:

    The mechanisms underlying Seizure Termination are still unclear despite their therapeutic importance. We studied thalamo-cortical connectivity and synchrony in human mesial temporal lobe Seizures in order to analyze their role in Seizure Termination. Twenty-two Seizures from ten patients with drug-resistant mesial temporal lobe epilepsy undergoing pre-surgical evaluation were analyzed using intracerebral recordings (stereoelectroencephalography, SEEG). We performed a measure of SEEG signal interdependencies (non-linear correlation), to estimate the functional connectivity between thalamus and cortical regions. Then we derived synchronization indices, namely global, thalamic, mesio-temporal and thalamo-mesio temporal index at the onset and the end of Seizures. In addition, an estimation of thalamic “outputs and inputs” connectivity was proposed. Thalamus was consistently involved in the last phase of all analyzed Seizures and thalamic synchronization index was significantly more elevated at the end of Seizure than at the onset. The global synchronization index at the end of Seizure negatively correlated with Seizure duration (p= 0.045) and in the same way the thalamic synchronization index showed an inverse tendency with Seizure duration. Six Seizures out of twenty-two displayed a particular thalamo-cortical spike and wave pattern (SWP) at the end. They were associated to higher values of all synchronization indices and outputs from thalamus ( p = 0.0079). SWP Seizures displayed a higher and sustained increase of cortical and thalamo-cortical synchronization with a stronger participation of thalamic outputs. We suggest that thalamo-cortical oscillations might contribute to Seizure Termination via modulation of cortical synchronization. In the subgroup of SWP Seizures thalamus may exert a control on temporal lobe structures by inducing a stable hypersynchronization that ultimately leads to Seizure Termination.

  • Does the Thalamo-Cortical Synchrony Play a Role in Seizure Termination?
    Frontiers in Neurology, 2015
    Co-Authors: Elisa Evangelista, Christian Bénar, Francesca Bonini, Romain Carron, Bruno Colombet, Jean Régis, Fabrice Bartolomei
    Abstract:

    The mechanisms underlying Seizure Termination are still unclear despite their therapeutic importance. We studied thalamo-cortical connectivity and synchrony in human mesial temporal lobe Seizures in order to analyze their role in Seizure Termination. Twenty-two Seizures from 10 patients with drug-resistant mesial temporal lobe epilepsy undergoing pre-surgical evaluation were analyzed using intracerebral recordings [stereoelectroencephalography (SEEG)]. We performed a measure of SEEG signal interdependencies (non-linear correlation), to estimate the functional connectivity between thalamus and cortical regions. Then, we derived synchronization indices, namely global, thalamic, mesio-temporal, and thala-mo-mesio temporal index at the onset and the end of Seizures. In addition, an estimation of thalamic " outputs and inputs " connectivity was proposed. Thalamus was consistently involved in the last phase of all analyzed Seizures and thalamic synchronization index was significantly more elevated at the end of Seizure than at the onset. The global synchronization index at the end of Seizure negatively correlated with Seizure duration (p = 0.045) and in the same way the thalamic synchronization index showed an inverse tendency with Seizure duration. Six Seizures out of twenty-two displayed a particular thalamo-cortical spike-and-wave pattern at the end. They were associated to higher values of all synchronization indices and outputs from thalamus (p = 0.0079). SWP Seizures displayed a higher and sustained increase of cortical and thalamo-cortical synchronization with a stronger participation of thalamic outputs. We suggest that thalamo-cortical oscillations might contribute to Seizure Termination via modulation of cortical synchronization. In the subgroup of SWP Seizures, thalamus may exert a control on temporal lobe structures by inducing a stable hypersynchronization that ultimately leads to Seizure Termination.

Francesca Bonini - One of the best experts on this subject based on the ideXlab platform.

  • Does the Thalamo-Cortical Synchrony Play a Role in Seizure Termination?
    Frontiers in neurology, 2015
    Co-Authors: Elisa Evangelista, Christian Bénar, Francesca Bonini, Romain Carron, Bruno Colombet, Jean Régis, Fabrice Bartolomei
    Abstract:

    The mechanisms underlying Seizure Termination are still unclear despite their therapeutic importance. We studied thalamo-cortical connectivity and synchrony in human mesial temporal lobe Seizures in order to analyze their role in Seizure Termination. Twenty-two Seizures from ten patients with drug-resistant mesial temporal lobe epilepsy undergoing pre-surgical evaluation were analyzed using intracerebral recordings (stereoelectroencephalography, SEEG). We performed a measure of SEEG signal interdependencies (non-linear correlation), to estimate the functional connectivity between thalamus and cortical regions. Then we derived synchronization indices, namely global, thalamic, mesio-temporal and thalamo-mesio temporal index at the onset and the end of Seizures. In addition, an estimation of thalamic “outputs and inputs” connectivity was proposed. Thalamus was consistently involved in the last phase of all analyzed Seizures and thalamic synchronization index was significantly more elevated at the end of Seizure than at the onset. The global synchronization index at the end of Seizure negatively correlated with Seizure duration (p= 0.045) and in the same way the thalamic synchronization index showed an inverse tendency with Seizure duration. Six Seizures out of twenty-two displayed a particular thalamo-cortical spike and wave pattern (SWP) at the end. They were associated to higher values of all synchronization indices and outputs from thalamus ( p = 0.0079). SWP Seizures displayed a higher and sustained increase of cortical and thalamo-cortical synchronization with a stronger participation of thalamic outputs. We suggest that thalamo-cortical oscillations might contribute to Seizure Termination via modulation of cortical synchronization. In the subgroup of SWP Seizures thalamus may exert a control on temporal lobe structures by inducing a stable hypersynchronization that ultimately leads to Seizure Termination.

  • Does the Thalamo-Cortical Synchrony Play a Role in Seizure Termination?
    Frontiers in Neurology, 2015
    Co-Authors: Elisa Evangelista, Christian Bénar, Francesca Bonini, Romain Carron, Bruno Colombet, Jean Régis, Fabrice Bartolomei
    Abstract:

    The mechanisms underlying Seizure Termination are still unclear despite their therapeutic importance. We studied thalamo-cortical connectivity and synchrony in human mesial temporal lobe Seizures in order to analyze their role in Seizure Termination. Twenty-two Seizures from 10 patients with drug-resistant mesial temporal lobe epilepsy undergoing pre-surgical evaluation were analyzed using intracerebral recordings [stereoelectroencephalography (SEEG)]. We performed a measure of SEEG signal interdependencies (non-linear correlation), to estimate the functional connectivity between thalamus and cortical regions. Then, we derived synchronization indices, namely global, thalamic, mesio-temporal, and thala-mo-mesio temporal index at the onset and the end of Seizures. In addition, an estimation of thalamic " outputs and inputs " connectivity was proposed. Thalamus was consistently involved in the last phase of all analyzed Seizures and thalamic synchronization index was significantly more elevated at the end of Seizure than at the onset. The global synchronization index at the end of Seizure negatively correlated with Seizure duration (p = 0.045) and in the same way the thalamic synchronization index showed an inverse tendency with Seizure duration. Six Seizures out of twenty-two displayed a particular thalamo-cortical spike-and-wave pattern at the end. They were associated to higher values of all synchronization indices and outputs from thalamus (p = 0.0079). SWP Seizures displayed a higher and sustained increase of cortical and thalamo-cortical synchronization with a stronger participation of thalamic outputs. We suggest that thalamo-cortical oscillations might contribute to Seizure Termination via modulation of cortical synchronization. In the subgroup of SWP Seizures, thalamus may exert a control on temporal lobe structures by inducing a stable hypersynchronization that ultimately leads to Seizure Termination.