The Experts below are selected from a list of 327 Experts worldwide ranked by ideXlab platform
Thomas J. Webster - One of the best experts on this subject based on the ideXlab platform.
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Selenium Nanoparticle protection of fibroblast stress activation of atf4 and bcl xl expression
International Journal of Nanomedicine, 2019Co-Authors: Stanley Chung, Amit K Roy, Thomas J. WebsterAbstract:Background In recent years, Selenium nanostructures have been researched due to their antibacterial properties, low toxicity to mammalian cells, and high biological efficacy. However, the clinical implementation of the use of Selenium has received mixed results, and there is much work needed to improve the understanding of the biological mechanisms involved in the observed cellular responses. Materials and methods In this work, an investigation into the mechanistic pathways of Selenium Nanoparticles (SeNPs) in biological systems was conducted by studying the changes in gene expression of ATF4, Bcl-xL, BAD2, HSP70, and SOD2 in non-cancerous human dermal fibroblasts (HDF) under oxidative stress, nutrient deprivation stress, and no treatment (control) conditions. Results This study revealed that SeNP incubation led to reduced internal reactive oxygen species (ROS) generation for all conditions tested, thus, providing a protective environment for HDF. At the stress conditions, the expression of ATF4 and Bcl-xL increased for cells treated with SeNP incubation, leading to attenuation of the cells under stress. These results also hint at reductive stress causing a detrimental impact to cell proliferation under routine cell passaging conditions. Conclusion In summary, this study highlights some possible mechanistic pathways implicated in the action of SeNPs that warrant further investigation (specifically, reducing stress conditions for HDF) and continues to support the promise of SeNPs in a wide range of medical applications.
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inhibition of various gram positive and gram negative bacteria growth on Selenium Nanoparticle coated paper towels
International Journal of Nanomedicine, 2015Co-Authors: Qi Wang, Philip Laresecasanova, Thomas J. WebsterAbstract:There are wide spread bacterial contamination issues on various paper products, such as paper towels hanging in sink splash zones or those used to clean surfaces, filter papers used in water and air purifying systems, and wrappings used in the food industry; such contamination may lead to the potential spread of bacteria and consequent severe health concerns. In this study, Selenium Nanoparticles were coated on normal paper towel surfaces through a quick precipitation method, introducing antibacterial properties to the paper towels in a healthy way. Their effectiveness at preventing biofilm formation was tested in bacterial assays involving Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus epidermidis. The results showed significant and continuous bacteria inhibition with about a 90% reduction from 24 to 72 hours for gram-positive bacteria including S. aureus and S. epidermidis. The Selenium coated paper towels also showed significant inhibition of gram-negative bacteria like P. aeruginosa and E. coli growth at about 57% and 84%, respectively, after 72 hours of treatment. Therefore, this study established a promising Selenium-based antibacterial strategy to prevent bacterial growth on paper products, which may lead to the avoidance of bacteria spreading and consequent severe health concerns.
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Selenium Nanoparticles Inhibit Various Bacterial Growth on Paper Towels
MRS Online Proceedings Library, 2014Co-Authors: Qi Wang, Thomas J. WebsterAbstract:Bacterial infections are commonly found on paper towels and other paper products leading to the potential spread of bacteria and consequent health concerns. The objective of this in vitro study was to introduce antibacterial properties to paper towel surfaces by coating them with Selenium Nanoparticles. Results showed that the Selenium Nanoparticle coated paper towels inhibited the growth of S. Aureus and P. aeruginosa by 80%∼90% after 72 hours compared with the uncoated paper towels. Thus, the study showed that nano-Selenium coated paper towels may lead to an increased eradication of bacteria to more effectively clean a wide-range of clinical environments, thus, improving health.
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understanding the wetting properties of nanostructured Selenium coatings the role of nanostructured surface roughness and air pocket formation
International Journal of Nanomedicine, 2013Co-Authors: Phong A. Tran, Thomas J. WebsterAbstract:Wetting properties of biomaterials, in particular nanomaterials, play an important role, as these influence interactions with biological elements, such as proteins, bacteria, and cells. In this study, the wetting phenomenon of titanium substrates coated with Selenium Nanoparticles was studied using experimental and mathematical modeling tools. Importantly, these Selenium-coated titanium substrates were previously reported to increase select protein adsorption (such as vitronectin and fibronectin), to decrease bacteria growth, and increase bone cell growth. Increased Selenium Nanoparticle coating density resulted in higher contact angles but remained within the hydrophilic regime. This trend was found in disagreement with the Wenzel model, which is widely used to understand the wetting properties of rough surfaces. The trend also did not fit well with the Cassie–Baxter model, which was developed to understand the wetting properties of composite surfaces. A modified wetting model was thus proposed in this study, to understand the contributing factors of material properties to the hydrophilicity/hydrophobicity of these nanostructured Selenium-coated surfaces. The analysis and model created in this study can be useful in designing and/or understanding the wetting behavior of numerous biomedical materials and in turn, biological events (such as protein adsorption as well as bacteria and mammalian cell functions).
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Short communication: inhibiting biofilm formation on paper towels through the use of Selenium Nanoparticles coatings
International journal of nanomedicine, 2013Co-Authors: Qi Wang, Thomas J. WebsterAbstract:Bacterial infections are commonly found on paper towels and other paper products, leading to the potential spread of bacteria and consequent health concerns. The objective of this in vitro study was to introduce antibacterial properties to standard paper towel surfaces by coating them with Selenium Nanoparticles. Scanning electron microscopy was used to measure the size and distribution of the Selenium coatings on the paper towels. Atomic force microscopy was used to measure the surface roughness of paper towels before and after they were coated with Selenium Nanoparticles. The amount of Selenium precipitated on the paper towels was measured by atomic absorption spectroscopy. In vitro bacterial studies with Staphylococcus aureus were conducted to assess the effectiveness of the Selenium coating at inhibiting bacterial growth. Results showed that the Selenium Nanoparticles coated on the paper towel surface were well distributed with semispherical geometries about 50 nm in diameter. Most importantly, the Selenium Nanoparticle-coated paper towels inhibited S. aureus growth by 90% after 24 and 72 hours compared with the uncoated paper towels. Thus, the study showed that Nanoparticle Selenium-coated paper towels may lead to an increased eradication of bacteria in a wider range of clinical environments and in the food industry, thus improving human health.
Sudin Bhattacharya - One of the best experts on this subject based on the ideXlab platform.
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Nano-Se as a novel candidate in the management of oxidative stress related disorders and cancer
The Nucleus, 2017Co-Authors: Arin Bhattacharjee, Jaydip Biswas, Abhishek Basu, Sudin BhattacharyaAbstract:Oxidative stress occurs when the antioxidant defense of the cellular system is unable to counteract the formation of reactive oxygen species and/or oxidants, as a result, reactive oxygen species prevails in the system. Oxidative stress leads to damages at macromolecular level and hence is involved in various forms of diseases and disorders. Nanotechnology is a booming field with tremendous potential in biology, biotechnology, medicines and medical technology. Novel nanomaterials and nanodevices are designed and controlled by nanotechnological tools and systems, which inspect and tune the properties, and functions of both living- and non-living materials, at sizes below 100 nm. Selenium (Se) is of fundamental importance to human health. As a potential chemoprotectant, its administration necessitates consumption for a long term, thus the toxicity of Selenium is always a crucial concern. Recently, nanotechnology based new form of Selenium, i.e., Selenium Nanoparticle (Nano-Se) has attracted attention of researchers owing to its low toxicity and high bioavailability, because at nano range Selenium particles exhibit excellent characteristics, for example great surface area, effective surface activity, lots of surface active centers, high catalytic efficiency, strong adsorbing ability and minor toxicity. This review presents an overview on the novel use of Nano-Se in the management and therapy of oxidative stress related disorders.
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Chemoprotective and chemosensitizing properties of Selenium Nanoparticle (Nano-Se) during adjuvant therapy with cyclophosphamide in tumor-bearing mice
Molecular and Cellular Biochemistry, 2017Co-Authors: Arin Bhattacharjee, Jaydip Biswas, Abhishek Basu, Sudin BhattacharyaAbstract:Cyclophosphamide (CP) is one of the widely used anticancer agents; however, it has serious deleterious effects on normal host cells due to its nonspecific action. The essential trace element Selenium (Se) is suggested to have chemopreventive and chemotherapeutic efficacy and currently used in pharmaceutical formulations. Previous report had shown Nano-Se could protect CP-induced hepatotoxicity and genotoxicity in normal Swiss albino mice; however, its role in cancer management is still not clear. The aim of present study is to investigate the chemoprotective efficacy of Nano-Se against CP-induced toxicity as well as its chemoenhancing capability when used along with CP in Swiss albino mice against Ehrlich’s ascites carcinoma (EAC) cells. CP was administered (25 mg/kg b.w., i.p.) and Nano-Se was given (2 mg Se/kg b.w., p.o.) in concomitant and pretreatment schedule. Increase levels of serum hepatic marker, hepatic lipid peroxidation, DNA damage, and chromosomal aberration in CP-treated mice were significantly ( P
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chemoprotective and chemosensitizing properties of Selenium Nanoparticle nano se during adjuvant therapy with cyclophosphamide in tumor bearing mice
Molecular and Cellular Biochemistry, 2017Co-Authors: Arin Bhattacharjee, Jaydip Biswas, Abhishek Basu, Tuhinadri Sen, Sudin BhattacharyaAbstract:Cyclophosphamide (CP) is one of the widely used anticancer agents; however, it has serious deleterious effects on normal host cells due to its nonspecific action. The essential trace element Selenium (Se) is suggested to have chemopreventive and chemotherapeutic efficacy and currently used in pharmaceutical formulations. Previous report had shown Nano-Se could protect CP-induced hepatotoxicity and genotoxicity in normal Swiss albino mice; however, its role in cancer management is still not clear. The aim of present study is to investigate the chemoprotective efficacy of Nano-Se against CP-induced toxicity as well as its chemoenhancing capability when used along with CP in Swiss albino mice against Ehrlich’s ascites carcinoma (EAC) cells. CP was administered (25 mg/kg b.w., i.p.) and Nano-Se was given (2 mg Se/kg b.w., p.o.) in concomitant and pretreatment schedule. Increase levels of serum hepatic marker, hepatic lipid peroxidation, DNA damage, and chromosomal aberration in CP-treated mice were significantly (P < 0.05) reversed by Nano-Se. The lowered status of various antioxidant enzymes in tumor-bearing mice after CP treatment was also effectively increased by Nano-Se. Administration of Nano-Se along with CP caused a significant reduction in tumor volume, packed cell volume, viable tumor cell count, and increased the survivability of the tumor-bearing hosts. The results suggest that Nano-Se exhibits significant antitumor and antioxidant effects in EAC-bearing mice. The potential for Nano-Se to ameliorate the CP-evoked toxicity as well as to improve the chemotherapeutic effect could have beneficial implications for patients undergoing chemotherapy with CP.
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protective effect of Selenium Nanoparticle against cyclophosphamide induced hepatotoxicity and genotoxicity in swiss albino mice
Journal of Biomaterials Applications, 2014Co-Authors: Arin Bhattacharjee, Jaydip Biswas, Abhishek Basu, Prosenjit Ghosh, Sudin BhattacharyaAbstract:Cyclophosphamide (CP) is the most commonly used chemotherapeutic drug for various types of cancer. However, its use causes severe cytotoxicity to normal cells in human. It is well known that the undesirable side effects are caused due to the formation of reactive oxygen species. Selenium is an essential micronutrient for both animals and humans and has antioxidant and membrane stabilizing property, but Selenium is also toxic above certain level. Nano Selenium has been well proved to be less toxic than inorganic Selenium as well as certain organoSelenium compounds. The objective of the study is to evaluate the protective role of Nano-Se against CP-induced hepatotoxicity and genotoxicity in Swiss albino mice. CP was administered intraperitoneally (25 mg/kg b.w.) and Nano-Se was given by oral gavages (2 mg Se/kg b.w.) in concomitant and pretreatment scheme. Intraperitoneal administration of CP induced hepatic damage as indicated by the serum marker enzymes aspartate and alanine transaminases and increased th...
Mohammad Yazdi - One of the best experts on this subject based on the ideXlab platform.
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effects of exercise training and supplementation with Selenium Nanoparticle on t helper 1 and 2 and cytokine levels in tumor tissue of mice bearing the 4 t1 mammary carcinoma
Nutrition, 2019Co-Authors: Mahdieh Molanouri Shamsi, Soodabeh Chekachak, Sara Soudi, Reza Gharakhanlou, Lebris S Quinn, Kia Ranjbar, Sajjad Rezaei, Fatemeh Jalali Shirazi, Begrouz Allahmoradi, Mohammad YazdiAbstract:Abstract Objectives Physical exercise decreases the incidence of breast cancer and also improves survival in breast cancer patients. However, the mechanistic basis of these protective effects of exercise is not well known. Changes in tumor cytokines, such as oncostatin-M (OSM), have been associated with modulation of antitumor immune responses in breast cancer. Exercise and antioxidants such as Selenium affect both antitumor immune responses as well as tumor cytokine expression. Thus, the aim of this study was to determine the effects of aerobic exercise training (AET) and Selenium Nanoparticle (SeNP) administration on T-helper 1 and 2 and tumor tissue cytokines in mice bearing the 4 T1 mammary carcinoma. Methods We examined the effects of 6 wk of AET and SeNP administration (100 μg three times/wk) on tumor size, concentration of tumor necrosis factor (TNF)-α, interleukin (IL)-6, interferon (IFN)-γ, IL-4 and OSM in tumor tissue and INF-γ and IL-4 in splenocytes of 64 mice bearing the 4 T1 mammary carcinoma. Results AET increased OSM levels in tumor tissue. Moreover, AET increased levels of TNF-α in tumor tissue, whereas SeNP supplementation decreased IL-4 levels tumor tissue. Also, the combination of AET and SeNP administration decreased tumor volume and increased T-helper 1 cytokines in the splenocytes of tumor-bearing mice. Conclusion These findings suggest that the combination of AET and SeNP supplementation effects antitumor immune responses in splenocytes, whereas AET induced antitumor cytokines, such as OSM and TNF-α in tumor tissue.
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combined effect of aerobic interval training and Selenium Nanoparticles on expression of il 15 and il 10 tnf α ratio in skeletal muscle of 4t1 breast cancer mice with cachexia
Cytokine, 2017Co-Authors: Mahdieh Molanouri Shamsi, Soodabeh Chekachak, Sara Soudi, Lebris S Quinn, Kia Ranjbar, Mohammad Yazdi, J Chenari, Mehdi MahdaviAbstract:Cancer cachexia is characterized by inflammation, loss of skeletal muscle and adipose tissue mass, and functional impairment. Oxidative stress and inflammation are believed to regulate pathways controlling skeletal muscle wasting. The aim of this study was to determine the effects of aerobic interval training and the purported antioxidant treatment, Selenium Nanoparticle supplementation, on expression of IL-15 and inflammatory cytokines in 4T1 breast cancer-bearing mice with cachexia. Selenium Nanoparticle supplementation accelerated cachexia symptoms in tumor-bearing mice, while exercise training prevented muscle wasting in tumor-bearing mice. Also, aerobic interval training enhanced the anti-inflammatory indices IL-10/TNF-α ratio and IL-15 expression in skeletal muscle in tumor-bearing mice. However, combining exercise training and antioxidant supplementation prevented cachexia and muscle wasting and additionally decreased tumor volume in 4T1 breast cancer mice. These finding suggested that combining exercise training and antioxidant supplementation could be a strategy for managing tumor volume and preventing cachexia in breast cancer.
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Selenium Nanoparticle enriched lactobacillus brevis causes more efficient immune responses in vivo and reduces the liver metastasis in metastatic form of mouse breast cancer
DARU, 2013Co-Authors: Mohammad Yazdi, Mehdi Mahdavi, Neda Setayesh, Mohammad Esfandyar, Ahmad Reza ShahverdiAbstract:Background and the purpose of the study: Selenium enriched Lactobacillus has been reported as an immunostimulatory agent which can be used to increase the life span of cancer bearing animals. Lactic acid bacteria can reduce Selenium ions to elemental Selenium Nanoparticles (SeNPs) and deposit them in intracellular spaces. In this strategy two known immunostimulators, lactic acid bacteria (LAB) and SeNPs, are concomitantly administered for enhancing of immune responses in cancer bearing mice. Methods: Forty five female inbred BALB/c mice were divided into three groups of tests and control, each containing 15 mice. Test mice were orally administered with SeNP-enriched Lactobacillus brevis or Lactobacillus brevis alone for 3 weeks before tumor induction. After that the administration was followed in three cycles of seven days on/three days off. Control group received phosphate buffer saline (PBS) at same condition. During the study the tumor growth was monitored using caliper method. At the end of study the spleen cell culture was carried out for both NK cytotoxicity assay and cytokines measurement. Delayed type hypersensitivity (DTH) responses were also assayed after 72h of tumor antigen recall. Serum lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) levels were measured, the livers of mice were removed and prepared for histopathological analysis. Results: High level of IFN-γ and IL-17 besides the significant raised in NK cytotoxicity and DTH responses were observed in SeNP-enriched L. brevis administered mice and the extended life span and decrease in the tumor metastasis to liver were also recorded in this group compared to the control mice or L.brevis alone administered mice. Conclusion: Our results suggested that the better prognosis could be achieved by oral administration of SeNP-enriched L. brevis in highly metastatic breast cancer mice model.
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the preventive oral supplementation of a Selenium Nanoparticle enriched probiotic increases the immune response and lifespan of 4t1 breast cancer bearing mice
Drug Research, 2012Co-Authors: Mohammad Yazdi, Mehdi Mahdavi, E Kheradmand, Ahmad Reza ShahverdiAbstract:The immunomodulatory effects of lactic acid bacteria have been demonstrated previously. In this study, a Lactobacillus plantarum strain was selected and enriched with Selenium Nanoparticles for use as a new immunomodulating agent in a breast cancer murine model. 30 female inbred BALB/c mice were equally divided into a test group and a control group. For 2 weeks prior to tumor induction, each mouse received a daily oral administration of 2.5×108 CFU/ml of L. plantarum enriched with Selenium Nanoparticles (SeNPs), and then 1×106 4T1 cells were injected subcutaneously. After tumor induction, daily SeNP administration was repeated for 3 cycles of 7 days on/3 days off. Immunological parameters such as levels of cytokines, NK cell activity, tumor growth, and mouse survival were evaluated. The production of the pro-inflammatory cytokines IFN-γ, TNF-α, and IL-2 in spleen cell cultures was increased in test mice administered SeNP-enriched L. plantarum. The test mice also showed significant increases in NK cell activity. The tumor volumes of treated mice were decreased and their survival rate notably increased when compared to mice that received L. plantarum alone or control mice. Administration of SeNP-enriched L. plantarum can induce an efficient immune response through the elevation of the pro-inflammatory cytokines IFN-γ, TNF-α and IL-2 levels and increased NK cell activity. Therefore, this treatment may result in better cancer prognosis.
Qi Wang - One of the best experts on this subject based on the ideXlab platform.
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inhibition of various gram positive and gram negative bacteria growth on Selenium Nanoparticle coated paper towels
International Journal of Nanomedicine, 2015Co-Authors: Qi Wang, Philip Laresecasanova, Thomas J. WebsterAbstract:There are wide spread bacterial contamination issues on various paper products, such as paper towels hanging in sink splash zones or those used to clean surfaces, filter papers used in water and air purifying systems, and wrappings used in the food industry; such contamination may lead to the potential spread of bacteria and consequent severe health concerns. In this study, Selenium Nanoparticles were coated on normal paper towel surfaces through a quick precipitation method, introducing antibacterial properties to the paper towels in a healthy way. Their effectiveness at preventing biofilm formation was tested in bacterial assays involving Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus epidermidis. The results showed significant and continuous bacteria inhibition with about a 90% reduction from 24 to 72 hours for gram-positive bacteria including S. aureus and S. epidermidis. The Selenium coated paper towels also showed significant inhibition of gram-negative bacteria like P. aeruginosa and E. coli growth at about 57% and 84%, respectively, after 72 hours of treatment. Therefore, this study established a promising Selenium-based antibacterial strategy to prevent bacterial growth on paper products, which may lead to the avoidance of bacteria spreading and consequent severe health concerns.
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Selenium Nanoparticles Inhibit Various Bacterial Growth on Paper Towels
MRS Online Proceedings Library, 2014Co-Authors: Qi Wang, Thomas J. WebsterAbstract:Bacterial infections are commonly found on paper towels and other paper products leading to the potential spread of bacteria and consequent health concerns. The objective of this in vitro study was to introduce antibacterial properties to paper towel surfaces by coating them with Selenium Nanoparticles. Results showed that the Selenium Nanoparticle coated paper towels inhibited the growth of S. Aureus and P. aeruginosa by 80%∼90% after 72 hours compared with the uncoated paper towels. Thus, the study showed that nano-Selenium coated paper towels may lead to an increased eradication of bacteria to more effectively clean a wide-range of clinical environments, thus, improving health.
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Short communication: inhibiting biofilm formation on paper towels through the use of Selenium Nanoparticles coatings
International journal of nanomedicine, 2013Co-Authors: Qi Wang, Thomas J. WebsterAbstract:Bacterial infections are commonly found on paper towels and other paper products, leading to the potential spread of bacteria and consequent health concerns. The objective of this in vitro study was to introduce antibacterial properties to standard paper towel surfaces by coating them with Selenium Nanoparticles. Scanning electron microscopy was used to measure the size and distribution of the Selenium coatings on the paper towels. Atomic force microscopy was used to measure the surface roughness of paper towels before and after they were coated with Selenium Nanoparticles. The amount of Selenium precipitated on the paper towels was measured by atomic absorption spectroscopy. In vitro bacterial studies with Staphylococcus aureus were conducted to assess the effectiveness of the Selenium coating at inhibiting bacterial growth. Results showed that the Selenium Nanoparticles coated on the paper towel surface were well distributed with semispherical geometries about 50 nm in diameter. Most importantly, the Selenium Nanoparticle-coated paper towels inhibited S. aureus growth by 90% after 24 and 72 hours compared with the uncoated paper towels. Thus, the study showed that Nanoparticle Selenium-coated paper towels may lead to an increased eradication of bacteria in a wider range of clinical environments and in the food industry, thus improving human health.
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Bacteria Fighting Paper Towels: The Influence of Selenium Nanoparticles
2013 39th Annual Northeast Bioengineering Conference, 2013Co-Authors: Qi Wang, Thomas J. WebsterAbstract:Bacterial infections are commonly found on paper towels and other paper products leading to the potential spread of bacteria and consequent health concerns. The objective of this in vitro study was to introduce antibacterial properties to standard paper towel surfaces by coating them with Selenium Nanoparticles. Scanning electron microscopy was used to measure the size and distribution of the Selenium coatings on the paper towels. The amount of Selenium precipitated on the paper towels was measured by atomic absorption spectroscopy. In vitro bacterial studies with S. aureus were conducted to assess the effectiveness of the Selenium coatings at inhibiting bacterial growth. Results showed that the Selenium Nanoparticles coated on the paper towel surfaces were well distributed and were semi spherical 50nm in diameter. Most importantly, the Selenium Nanoparticle coated paper towels inhibited S. aureus growth by 90% after 24, 48 and 72 hours compared with uncoated paper towels. Thus, this study showed that nano-Selenium coated paper towels may lead to an increased eradication of bacteria to clean a more wide-range of clinical environments and for the food industry, thus, improving health.
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Introducing Antibacterial Properties to Paper Towels Through the Use of Selenium Nanoparticles
MRS Online Proceedings Library, 2012Co-Authors: Qi Wang, J. Webster ThomasAbstract:Bacterial infections are commonly found on paper towels and other paper products leading to the potential spread of bacteria and consequent health concerns. The objective of this in vitro study was to introduce antibacterial properties to paper towel surfaces by coating them with Selenium Nanoparticles. Scanning electron microscopy was used to measure the size and distribution of the Selenium coatings on the paper towels. Atomic force microscopy was used to measure the surface roughness of paper towels before and after coated with Selenium Nanoparticles. The amount of Selenium precipitated on the paper towels was measured by atomic absorption spectroscopy. In vitro bacterial studies with Staphylococcus aureus were conducted to assess the effectiveness of the Selenium coating at inhibiting bacterial growth. Results showed that the Selenium Nanoparticles coated on the paper towel surface were well distributed and semispherical about 50nm in diameter. Most importantly, the Selenium Nanoparticle coated paper towels inhibited S. aureus growth by 90% after 24 hours and 72 hours compared with the uncoated paper towels. Thus, the study showed that nano-Selenium coated paper towels may lead to an increased eradication of bacteria to more effectively clean a wide-range of clinical environments, thus, improving health.
Arin Bhattacharjee - One of the best experts on this subject based on the ideXlab platform.
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Nano-Se as a novel candidate in the management of oxidative stress related disorders and cancer
The Nucleus, 2017Co-Authors: Arin Bhattacharjee, Jaydip Biswas, Abhishek Basu, Sudin BhattacharyaAbstract:Oxidative stress occurs when the antioxidant defense of the cellular system is unable to counteract the formation of reactive oxygen species and/or oxidants, as a result, reactive oxygen species prevails in the system. Oxidative stress leads to damages at macromolecular level and hence is involved in various forms of diseases and disorders. Nanotechnology is a booming field with tremendous potential in biology, biotechnology, medicines and medical technology. Novel nanomaterials and nanodevices are designed and controlled by nanotechnological tools and systems, which inspect and tune the properties, and functions of both living- and non-living materials, at sizes below 100 nm. Selenium (Se) is of fundamental importance to human health. As a potential chemoprotectant, its administration necessitates consumption for a long term, thus the toxicity of Selenium is always a crucial concern. Recently, nanotechnology based new form of Selenium, i.e., Selenium Nanoparticle (Nano-Se) has attracted attention of researchers owing to its low toxicity and high bioavailability, because at nano range Selenium particles exhibit excellent characteristics, for example great surface area, effective surface activity, lots of surface active centers, high catalytic efficiency, strong adsorbing ability and minor toxicity. This review presents an overview on the novel use of Nano-Se in the management and therapy of oxidative stress related disorders.
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Chemoprotective and chemosensitizing properties of Selenium Nanoparticle (Nano-Se) during adjuvant therapy with cyclophosphamide in tumor-bearing mice
Molecular and Cellular Biochemistry, 2017Co-Authors: Arin Bhattacharjee, Jaydip Biswas, Abhishek Basu, Sudin BhattacharyaAbstract:Cyclophosphamide (CP) is one of the widely used anticancer agents; however, it has serious deleterious effects on normal host cells due to its nonspecific action. The essential trace element Selenium (Se) is suggested to have chemopreventive and chemotherapeutic efficacy and currently used in pharmaceutical formulations. Previous report had shown Nano-Se could protect CP-induced hepatotoxicity and genotoxicity in normal Swiss albino mice; however, its role in cancer management is still not clear. The aim of present study is to investigate the chemoprotective efficacy of Nano-Se against CP-induced toxicity as well as its chemoenhancing capability when used along with CP in Swiss albino mice against Ehrlich’s ascites carcinoma (EAC) cells. CP was administered (25 mg/kg b.w., i.p.) and Nano-Se was given (2 mg Se/kg b.w., p.o.) in concomitant and pretreatment schedule. Increase levels of serum hepatic marker, hepatic lipid peroxidation, DNA damage, and chromosomal aberration in CP-treated mice were significantly ( P
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chemoprotective and chemosensitizing properties of Selenium Nanoparticle nano se during adjuvant therapy with cyclophosphamide in tumor bearing mice
Molecular and Cellular Biochemistry, 2017Co-Authors: Arin Bhattacharjee, Jaydip Biswas, Abhishek Basu, Tuhinadri Sen, Sudin BhattacharyaAbstract:Cyclophosphamide (CP) is one of the widely used anticancer agents; however, it has serious deleterious effects on normal host cells due to its nonspecific action. The essential trace element Selenium (Se) is suggested to have chemopreventive and chemotherapeutic efficacy and currently used in pharmaceutical formulations. Previous report had shown Nano-Se could protect CP-induced hepatotoxicity and genotoxicity in normal Swiss albino mice; however, its role in cancer management is still not clear. The aim of present study is to investigate the chemoprotective efficacy of Nano-Se against CP-induced toxicity as well as its chemoenhancing capability when used along with CP in Swiss albino mice against Ehrlich’s ascites carcinoma (EAC) cells. CP was administered (25 mg/kg b.w., i.p.) and Nano-Se was given (2 mg Se/kg b.w., p.o.) in concomitant and pretreatment schedule. Increase levels of serum hepatic marker, hepatic lipid peroxidation, DNA damage, and chromosomal aberration in CP-treated mice were significantly (P < 0.05) reversed by Nano-Se. The lowered status of various antioxidant enzymes in tumor-bearing mice after CP treatment was also effectively increased by Nano-Se. Administration of Nano-Se along with CP caused a significant reduction in tumor volume, packed cell volume, viable tumor cell count, and increased the survivability of the tumor-bearing hosts. The results suggest that Nano-Se exhibits significant antitumor and antioxidant effects in EAC-bearing mice. The potential for Nano-Se to ameliorate the CP-evoked toxicity as well as to improve the chemotherapeutic effect could have beneficial implications for patients undergoing chemotherapy with CP.
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protective effect of Selenium Nanoparticle against cyclophosphamide induced hepatotoxicity and genotoxicity in swiss albino mice
Journal of Biomaterials Applications, 2014Co-Authors: Arin Bhattacharjee, Jaydip Biswas, Abhishek Basu, Prosenjit Ghosh, Sudin BhattacharyaAbstract:Cyclophosphamide (CP) is the most commonly used chemotherapeutic drug for various types of cancer. However, its use causes severe cytotoxicity to normal cells in human. It is well known that the undesirable side effects are caused due to the formation of reactive oxygen species. Selenium is an essential micronutrient for both animals and humans and has antioxidant and membrane stabilizing property, but Selenium is also toxic above certain level. Nano Selenium has been well proved to be less toxic than inorganic Selenium as well as certain organoSelenium compounds. The objective of the study is to evaluate the protective role of Nano-Se against CP-induced hepatotoxicity and genotoxicity in Swiss albino mice. CP was administered intraperitoneally (25 mg/kg b.w.) and Nano-Se was given by oral gavages (2 mg Se/kg b.w.) in concomitant and pretreatment scheme. Intraperitoneal administration of CP induced hepatic damage as indicated by the serum marker enzymes aspartate and alanine transaminases and increased th...