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R Kumar - One of the best experts on this subject based on the ideXlab platform.
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effect of experimentally induced subchronic Selenosis on thyroid hormones and biochemical indices in calves
Iranian Journal of Veterinary Research, 2008Co-Authors: R Kumar, S Rampal, R JindalAbstract:Summary The present investigation was performed to determine the effect of long-term administration of sodium selenite on the biochemical indices and concentration of thyroid hormones in calves. Sodium selenite solution was drenched at 0.1 and 0.25 mg per kg body weight for 12 weeks. Higher dose produced characteristic symptoms of Selenosis whereas mild symptoms were observed with lower dose. The toxic symptoms appeared when blood selenium level was 1.68 ± 0.13 µg per ml. There was a significant (P<0.05) increase in the activities of the aspartate aminotransferase, alkaline phosphatase, blood urea nitrogen and creatinine levels in the treated animals. The repeated administration of sodium selenite resulted in a significant p-value decline in thyroxine levels on the 10th week and increase in triiodothyronine on the 8th week of treatment. The findings of the present study suggested that sodium selenite induced Selenosis alters thyroid hormone levels in plasma.
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Effect of experimentally induced subchronic Selenosis on thyroid hormones and biochemical indices in calves
Iranian Journal of Veterinary Research, 2008Co-Authors: R Kumar, S Rampal, R JindalAbstract:Summary The present investigation was performed to determine the effect of long-term administration of sodium selenite on the biochemical indices and concentration of thyroid hormones in calves. Sodium selenite solution was drenched at 0.1 and 0.25 mg per kg body weight for 12 weeks. Higher dose produced characteristic symptoms of Selenosis whereas mild symptoms were observed with lower dose. The toxic symptoms appeared when blood selenium level was 1.68 ± 0.13 µg per ml. There was a significant (P
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studies on the effect of sodium selenite induced sub chronic Selenosis on immune response in cow calves
Toxicology International, 2008Co-Authors: R Kumar, Satyavan RampalAbstract:The present investigation reports the effect of long-term administration of sodium selenite on immune response in calves. Sodium selenite was administered orally at dose rate of 0.1 and 0.25 mg/kg b.wt. for 98 consecutive days. Higher dose produced characteristic symptoms of Selenosis whereas mild symptoms were observed with the lower dose. The toxic signs appeared when blood selenium levels were 1.68 ± 0.13mg/ml. The forced anti-body titre against the alum precipitate Haemorrhagic septicemia vaccine was significantly higher in the treated animals. The cell-mediated immune response studied by delayed type hypersensitivity test was significantly higher in the treated animals. Thus, raised blood selenium levels augmented the immune response i.e. humoral and cell mediated immune response in the treated animals. Prolonged exposure to selenium also produced marked histopathological changes in the lymph nodes of treated animals.
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maturation arrest of neutrophils a possible reason for the leucopenia in sodium selenite induced sub chronic Selenosis in cow calves
Environmental Toxicology and Pharmacology, 2008Co-Authors: Satyavan Rampal, R Kumar, C S Randhawa, N K SoodAbstract:Abstract The effect of long-term administration of sodium selenite on leucocyte indices of peripheral blood of calves was determined. Nine calves, 9–12 months old, with an average body weight of 104 kg were divided into three groups. Calves of groups 2 and 3 were administered with sodium selenite at 0.1 and 0.25 mg/kg body weight for 98 consecutive days. The clinical signs characteristic of Selenosis viz. alopecia, cracking of hooves, intradigital lesions and discoloration of hard palate, started appearing from 45 to 60 days onwards with high dose, whereas only subtle indications of toxicosis were observed in the low-dose group. The prolonged administration of sodium selenite produced a progressive and dose-dependent decline in the circulating leucocyte count with concomitant decline in the circulating neutrophil count. There was a high negative correlation (0.94) between blood selenium levels and neutrophils. Granulocyte/agranulocyte ratio was also significantly reduced in the treated animals. Evaluation of bone marrow smears revealed a decline in the myeloid to erythroid ratio. In addition, there was also maturation arrest of neutrophils at promyelocyte or myelocyte level as shown by differential granulocyte count in the bone marrow. The results indicated that host's immune response may be adversely affected.
Satyavan Rampal - One of the best experts on this subject based on the ideXlab platform.
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maturation arrest of neutrophils a possible reason for the leucopenia in sodium selenite induced sub chronic Selenosis in cow calves
Environmental Toxicology and Pharmacology, 2008Co-Authors: Satyavan Rampal, R Kumar, C S Randhawa, N K SoodAbstract:Abstract The effect of long-term administration of sodium selenite on leucocyte indices of peripheral blood of calves was determined. Nine calves, 9–12 months old, with an average body weight of 104 kg were divided into three groups. Calves of groups 2 and 3 were administered with sodium selenite at 0.1 and 0.25 mg/kg body weight for 98 consecutive days. The clinical signs characteristic of Selenosis viz. alopecia, cracking of hooves, intradigital lesions and discoloration of hard palate, started appearing from 45 to 60 days onwards with high dose, whereas only subtle indications of toxicosis were observed in the low-dose group. The prolonged administration of sodium selenite produced a progressive and dose-dependent decline in the circulating leucocyte count with concomitant decline in the circulating neutrophil count. There was a high negative correlation (0.94) between blood selenium levels and neutrophils. Granulocyte/agranulocyte ratio was also significantly reduced in the treated animals. Evaluation of bone marrow smears revealed a decline in the myeloid to erythroid ratio. In addition, there was also maturation arrest of neutrophils at promyelocyte or myelocyte level as shown by differential granulocyte count in the bone marrow. The results indicated that host's immune response may be adversely affected.
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studies on the effect of sodium selenite induced sub chronic Selenosis on immune response in cow calves
Toxicology International, 2008Co-Authors: R Kumar, Satyavan RampalAbstract:The present investigation reports the effect of long-term administration of sodium selenite on immune response in calves. Sodium selenite was administered orally at dose rate of 0.1 and 0.25 mg/kg b.wt. for 98 consecutive days. Higher dose produced characteristic symptoms of Selenosis whereas mild symptoms were observed with the lower dose. The toxic signs appeared when blood selenium levels were 1.68 ± 0.13mg/ml. The forced anti-body titre against the alum precipitate Haemorrhagic septicemia vaccine was significantly higher in the treated animals. The cell-mediated immune response studied by delayed type hypersensitivity test was significantly higher in the treated animals. Thus, raised blood selenium levels augmented the immune response i.e. humoral and cell mediated immune response in the treated animals. Prolonged exposure to selenium also produced marked histopathological changes in the lymph nodes of treated animals.
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Effect of sub-chronic selenium toxicosis on lipid peroxidation, glutathione redox cycle and antioxidant enzymes in calves
Veterinary and Human Toxicology, 2003Co-Authors: Raideep Kaur, Sucheta Sharma, Satyavan RampalAbstract:The present investigation reports the effect of sodium selenite-induced sub-chronic toxicity in crossbred cow calves on various antioxidant enzymes. Sodium selenite (0.25 mg/kg for 16 w) resulted in characteristic signs of sub-chronic Selenosis, ie alopecia, cracking and enlargement of hooves, interdigital lesions, ring formation on the coronet region, and gangrene at tip of the tail. The sodium selenite resulted in significant rise of blood selenium levels and concurrent increase in erythrocytic glutathione peroxidase (GPx) activity. Blood selenium levels and GPx activity had a high positive correlation (r = 0.97). Blood glutathione levels were lowered from 211.1 ′ 13.4 to 95.56 ′ 11.8 μg/ml. Selenosis caused oxidative stress as evidenced by a 3-fold increase in lipid peroxidation; activities of glutathione-S-transferase, glutathione reductase, superoxide dismutase and catalase were significantly increased. These findings support the hypothesis that the pro-oxidant attributes of selenium play important roles in its toxicity.
Suresh Kumar Sharma - One of the best experts on this subject based on the ideXlab platform.
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effect of reduced glutathione treatment on Selenosis blood selenium concentration and glutathione peroxidase activity after repeated short term selenium exposure in buffalo calves
Toxicology, 2005Co-Authors: Milind Devidas Deore, A K Srivastava, Suresh Kumar SharmaAbstract:Effects of repeated feeding of selenium, when given alone or along with reduced glutathione, on whole blood selenium levels, Selenosis and glutathione peroxidase activity, was studied in buffalo calves. After feeding 2.5 mg/kg of BW sodium selenite, good correlation was found between the onset of Selenosis and whole blood selenium concentrations. Adverse effects appeared when the whole blood selenium concentrations increased above 2 μg/ml and mortality occurred when they exceeded 3.4 μg/ml. Reduced glutathione, given i.v. at 5 mg/kg of BW arrested the progress of Selenosis and prevented mortality which was 100% in the sodium selenite supplemented group; also a reduced whole blood selenium concentration was noted. Whole blood selenium concentrations were a better and more sensitive indicator of selenium status than glutathione peroxidase activity alone.
N K Sood - One of the best experts on this subject based on the ideXlab platform.
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maturation arrest of neutrophils a possible reason for the leucopenia in sodium selenite induced sub chronic Selenosis in cow calves
Environmental Toxicology and Pharmacology, 2008Co-Authors: Satyavan Rampal, R Kumar, C S Randhawa, N K SoodAbstract:Abstract The effect of long-term administration of sodium selenite on leucocyte indices of peripheral blood of calves was determined. Nine calves, 9–12 months old, with an average body weight of 104 kg were divided into three groups. Calves of groups 2 and 3 were administered with sodium selenite at 0.1 and 0.25 mg/kg body weight for 98 consecutive days. The clinical signs characteristic of Selenosis viz. alopecia, cracking of hooves, intradigital lesions and discoloration of hard palate, started appearing from 45 to 60 days onwards with high dose, whereas only subtle indications of toxicosis were observed in the low-dose group. The prolonged administration of sodium selenite produced a progressive and dose-dependent decline in the circulating leucocyte count with concomitant decline in the circulating neutrophil count. There was a high negative correlation (0.94) between blood selenium levels and neutrophils. Granulocyte/agranulocyte ratio was also significantly reduced in the treated animals. Evaluation of bone marrow smears revealed a decline in the myeloid to erythroid ratio. In addition, there was also maturation arrest of neutrophils at promyelocyte or myelocyte level as shown by differential granulocyte count in the bone marrow. The results indicated that host's immune response may be adversely affected.
Rattandeep Singh - One of the best experts on this subject based on the ideXlab platform.
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Clinico-haematological studies on experimentally induced chronic Selenosis in buffalo calves *
Indian Journal of Animal Sciences, 2020Co-Authors: Rattandeep Singh, S S Randhawa, K S Dhillon, Santosh DhillonAbstract:Clinico-haematological alterations in experimentally induced chronic Selenosis by feeding selenium rich wheat straw (8.54 ppm) were studied in 18 non-descript buffalo calves. The clinical signs appeared after 35-45 days. The cardinal signs of induced Selenosis were malformation of hoov.es and horns along with inflammation of coronary band, anaemia, alopecia, emaciation followed by death. Haematological indices revealed macrocytic - normochromic anaemia.
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effects of experimental induction of chronic Selenosis on plasma mineral profile in buffaloes bubalus bubalis
Indian Journal of Animal Sciences, 2003Co-Authors: Rattandeep Singh, Santosh Dhillon, S S Randhawa, C L Arora, K S DhillonAbstract:The present investigation was conducted on 23 non-descriptive healthy male buffalo of 1-1½ years of age. Chronic Selenosis was induced in 18 animals by feeding selenium (Se) enriched wheat straw (Se content 8.54 ppm) for 84 days while 5 animals were kept as healthy controls. Minerals profile of plasma samples reflected inverse relationship of Se and arsenic (As), which was associated with significant decline in mean concentration of magnesium (Mg), calcium (Ca), manganese (Mn) and potassium (K), whereas, effect on plasma copper (Cu) and sulphur (S) was over masked by their mobilization from tissues as confirmed on mineral tissue analysis. Heavy metals, viz. nickel (Ni), lead (Pb), mercury (Hg) and chromium (Cr) showed positive relationship except for cadmium (Cd) which revealed decreasing trend with increasing plasma Se levels in buffalo calves fed on Se enriched wheat straw.
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changes in blood biochemical and enzyme profile in experimental chronic Selenosis in buffalo calves bubalus bubalis
Indian Journal of Animal Sciences, 2002Co-Authors: Rattandeep Singh, S S Randhawa, K S DhillonAbstract:Blood glucose, plasma biochemicals, viz. plasma urea nitrogen, creatinine, total proteins and albumin; and plasma enzymes activities, viz. alkaline phosphatase (ALP), alanine transferase (AL T) and aspartate transferase (AST) were analysed in buffalo calves after induction of Selenosis by ad lib. feeding of selenium enriched (S.54 ppm) wheat straw for 84 days. The mean blood glucose values (48.70±1.45 mg/dl) reflected hypoglycaemia, whereas mean ALP (90.72±6.98 lU/L), ALT (43.5 1± 1.62 IU/L), AST (89.67±0.30 IU/L) activities and plasma urea nitrogen (13.08±0.69 mg/dl) showed significant increase after 14, 70, 56, 42, and 42 days, respectively, of feeding wheat straw, indicating chronic liver damage and nephritis respectively. However, mean plasma creatinine, total plasma proteins and albumin revealed nonsignificant alterations throughout the period of induction of Selenosis as compared to respective mean values of healthy controls.
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clinico haematological studies on experimentally induced chronic Selenosis in buffalo calves
Indian Journal of Animal Sciences, 2001Co-Authors: Rattandeep Singh, S S Randhawa, K S Dhillon, Santosh DhillonAbstract:Clinico-haematological alterations in experimentally induced chronic Selenosis by feeding selenium rich wheat straw (8.54 ppm) were studied in 18 non-descript buffalo calves. The clinical signs appeared after 35-45 days. The cardinal signs of induced Selenosis were malformation of hoov.es and horns along with inflammation of coronary band, anaemia, alopecia, emaciation followed by death. Haematological indices revealed macrocytic - normochromic anaemia.