The Experts below are selected from a list of 27 Experts worldwide ranked by ideXlab platform
Jose Manuel R. Ferrer - One of the best experts on this subject based on the ideXlab platform.
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SCH 23390 decreases Self-Stimulation of the medial prefrontal cortex in the rat
European Journal of Pharmacology, 1993Co-Authors: Raimundo Sabater, Joséantonio Saez, Jose Manuel R. FerrerAbstract:Abstract We studied the effects of peripheral and central administration of SCH 23390, a selective antagonist of dopamine D 1 receptors, on intracranial Self-Stimulation of the medial prefrontal cortex of the rat. Intraperitoneal injections of SCH 23390 produced a dose-related decrease in Self-Stimulation. Unilateral microinjections of SCH 23390 into the medial prefrontal cortex also produced a dose-related decrease in Self-Stimulation in the ipsilateral medial prefrontal cortex. However, Self-Stimulation of the contralateral, noninjected prefrontal cortex, used as control, was not affected. Together with previous data, the present results suggest that the dopamine neutotransmission involved in Self-Stimulation of the prefrontal cortex of the rat is mediated by dopamine D 1 receptors.
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Neurotensin participates in Self-Stimulation of the medial prefrontal cortex in the rat
European Journal of Pharmacology, 1993Co-Authors: Jose Manuel R. Ferrer, Raimundo Sabater, José A. SáezAbstract:Abstract The effects of intracerebral microinjections of neurotensin and xenopsin on Self-Stimulation of the medial prefrontal cortex of the rat were studied. Unilateral microinjections into the medical prefrontal cortex of neurotensin at doses of 0.625, 1.25, 2.5, 5 and 10 nmol produced a dose-related decrease of Self-Stimulation in the ipsilateral medial prefrontal cortex. Self-Stimulation of the contralateral medial prefrontal contex, used as control, was not affected by the microinjections. Similar results were found with the neurotension-like octapeptide, xenopsin. Unilateral microinjections of xenoposin into the medial prefrontal cortex, at doses of 1.8, 3.6, 7.2 and 14.4 nmol produced a dose-related decrease of Self-Stimulation of the ipsilateral medial prefrontal cortex. Self-Stimulation of the contralateral medial prefrontal cortex was not affected. These results suggest that neurotensin is part of the neurochemical substrate of Self-Stimulation in this cortical area.
Raimundo Sabater - One of the best experts on this subject based on the ideXlab platform.
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SCH 23390 decreases Self-Stimulation of the medial prefrontal cortex in the rat
European Journal of Pharmacology, 1993Co-Authors: Raimundo Sabater, Joséantonio Saez, Jose Manuel R. FerrerAbstract:Abstract We studied the effects of peripheral and central administration of SCH 23390, a selective antagonist of dopamine D 1 receptors, on intracranial Self-Stimulation of the medial prefrontal cortex of the rat. Intraperitoneal injections of SCH 23390 produced a dose-related decrease in Self-Stimulation. Unilateral microinjections of SCH 23390 into the medial prefrontal cortex also produced a dose-related decrease in Self-Stimulation in the ipsilateral medial prefrontal cortex. However, Self-Stimulation of the contralateral, noninjected prefrontal cortex, used as control, was not affected. Together with previous data, the present results suggest that the dopamine neutotransmission involved in Self-Stimulation of the prefrontal cortex of the rat is mediated by dopamine D 1 receptors.
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Neurotensin participates in Self-Stimulation of the medial prefrontal cortex in the rat
European Journal of Pharmacology, 1993Co-Authors: Jose Manuel R. Ferrer, Raimundo Sabater, José A. SáezAbstract:Abstract The effects of intracerebral microinjections of neurotensin and xenopsin on Self-Stimulation of the medial prefrontal cortex of the rat were studied. Unilateral microinjections into the medical prefrontal cortex of neurotensin at doses of 0.625, 1.25, 2.5, 5 and 10 nmol produced a dose-related decrease of Self-Stimulation in the ipsilateral medial prefrontal cortex. Self-Stimulation of the contralateral medial prefrontal contex, used as control, was not affected by the microinjections. Similar results were found with the neurotension-like octapeptide, xenopsin. Unilateral microinjections of xenoposin into the medial prefrontal cortex, at doses of 1.8, 3.6, 7.2 and 14.4 nmol produced a dose-related decrease of Self-Stimulation of the ipsilateral medial prefrontal cortex. Self-Stimulation of the contralateral medial prefrontal cortex was not affected. These results suggest that neurotensin is part of the neurochemical substrate of Self-Stimulation in this cortical area.
José A. Sáez - One of the best experts on this subject based on the ideXlab platform.
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Neurotensin participates in Self-Stimulation of the medial prefrontal cortex in the rat
European Journal of Pharmacology, 1993Co-Authors: Jose Manuel R. Ferrer, Raimundo Sabater, José A. SáezAbstract:Abstract The effects of intracerebral microinjections of neurotensin and xenopsin on Self-Stimulation of the medial prefrontal cortex of the rat were studied. Unilateral microinjections into the medical prefrontal cortex of neurotensin at doses of 0.625, 1.25, 2.5, 5 and 10 nmol produced a dose-related decrease of Self-Stimulation in the ipsilateral medial prefrontal cortex. Self-Stimulation of the contralateral medial prefrontal contex, used as control, was not affected by the microinjections. Similar results were found with the neurotension-like octapeptide, xenopsin. Unilateral microinjections of xenoposin into the medial prefrontal cortex, at doses of 1.8, 3.6, 7.2 and 14.4 nmol produced a dose-related decrease of Self-Stimulation of the ipsilateral medial prefrontal cortex. Self-Stimulation of the contralateral medial prefrontal cortex was not affected. These results suggest that neurotensin is part of the neurochemical substrate of Self-Stimulation in this cortical area.
Iain S. Mcgregor - One of the best experts on this subject based on the ideXlab platform.
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Prefrontal cortex Self-Stimulation and energy balance.
Behavioral neuroscience, 1991Co-Authors: Iain S. Mcgregor, Dale M. AtrensAbstract:The relation between sulcal prefrontal cortex (SPC) and medial prefrontal cortex (MPC) Self-Stimulation and energy balance was investigated in rats. SPC but not MPC Self-Stimulation induced feeding but not the gnawing of wooden blocks. SPC but not MPC Self-Stimulation enhanced weight gain over several weeks of exposure to Stimulation. Food deprivation (48 hr but not 24 hr) increased SPC Self-Stimulation rates under a 5-s fixed-interval reinforcement schedule and decreased current thresholds for SPC Self-Stimulation. MPC Self-Stimulation was unaffected by food deprivation. Insulin (4 U/kg) and 2-deoxy-D-glucose (300 mg/kg) inhibited both SPC and MPC Self-Stimulation, probably through interfering with performance. Satiety induced by prolonged intake of a sweetened solution or deprivation-induced feeding moderately facilitated SPC Self-Stimulation. Overall, it appears that SPC but not MPC Self-Stimulation modulates, and is modulated by, energy balance.
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Contrasting effects of stress on medial and sulcal prefrontal cortex Self-Stimulation.
Brain research bulletin, 1991Co-Authors: Iain S. McgregorAbstract:Male Wistar rats were subjected to either 25 controllable or uncontrollable footshocks and then tested for changes in fixed-interval 5-second (FI-5) Self-Stimulation of the medial prefrontal cortex (MPC), sulcal prefrontal cortex (SPC) or nucleus accumbens (NAS). Controllable footshock caused a moderate facilitation of MPC Self-Stimulation (30% above baseline rates) but inhibited SPC Self-Stimulation (32% below baseline rates). Uncontrollable footshock had no effect on MPC Self-Stimulation but inhibited SPC Self-Stimulation (52% below baseline rates). An inhibition of SPC Self-Stimulation was also evident 24 hours following controllable or uncontrollable footshock. NAS Self-Stimulation was unaffected by footshock. Changes in locomotor activity were not consistently related to changes in Self-Stimulation following footshock. These results are discussed in terms of the different effects of mild stress on the release of reward-relevant neurotransmitters in the MPC, SPC and NAS. The possible role of stress-induced hypoalgesia in determining the stress-induced facilitation of MPC Self-Stimulation is also discussed.
Dale M. Atrens - One of the best experts on this subject based on the ideXlab platform.
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Parametric manipulations and fixed-interval Self-Stimulation.
Physiology & Behavior, 1992Co-Authors: Glenn E. Hunt, Dale M. AtrensAbstract:Abstract Three experiments investigated hypothalamic Self-Stimulation under a fixed-interval (FI) reinforcement schedule. An FI 20-s schedule was chosen to reduce Stimulation density in order to minimize the influence of priming effects or Stimulation aftereffects that can affect responding under other schedules of reinforcement. The first experiment showed that the influence of train duration is greatest at levels up to 1 s and thereafter level off over a wide range of train durations (1–32 s). The second experiment showed that altering frequency, current, or pulse width produced almost identical changes in FI responding. These findings show that the neutral network subserving hypothalamic Self-Stimulation simply integrates the amount of charge over time. It is relatively insensitive to the combination of Stimulation parameters that make up a given waveform. In the third experiment, the chronaxies from the strength-duration curves indicate the neural substrate supporting Self-Stimulation has a great current-integrating capacity. Together, these experiments show that varying the amount of brain Stimulation produce large and consistent changes in a number of FI response measures. These measures effectively describe different attributes of FI performance and include response rate, the postreinforcement pause, interresponse times of short duration and the temporal distribution of responses within the interval.
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Prefrontal cortex Self-Stimulation and energy balance.
Behavioral neuroscience, 1991Co-Authors: Iain S. Mcgregor, Dale M. AtrensAbstract:The relation between sulcal prefrontal cortex (SPC) and medial prefrontal cortex (MPC) Self-Stimulation and energy balance was investigated in rats. SPC but not MPC Self-Stimulation induced feeding but not the gnawing of wooden blocks. SPC but not MPC Self-Stimulation enhanced weight gain over several weeks of exposure to Stimulation. Food deprivation (48 hr but not 24 hr) increased SPC Self-Stimulation rates under a 5-s fixed-interval reinforcement schedule and decreased current thresholds for SPC Self-Stimulation. MPC Self-Stimulation was unaffected by food deprivation. Insulin (4 U/kg) and 2-deoxy-D-glucose (300 mg/kg) inhibited both SPC and MPC Self-Stimulation, probably through interfering with performance. Satiety induced by prolonged intake of a sweetened solution or deprivation-induced feeding moderately facilitated SPC Self-Stimulation. Overall, it appears that SPC but not MPC Self-Stimulation modulates, and is modulated by, energy balance.