The Experts below are selected from a list of 288 Experts worldwide ranked by ideXlab platform
Elysa J Marco - One of the best experts on this subject based on the ideXlab platform.
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diffusion tensor tractography in children with Sensory Processing Disorder potentials for devising machine learning classifiers
NeuroImage: Clinical, 2019Co-Authors: Teresa Tavassoli, Seyedmehdi Payabvash, Eva M Palacios, Julia P Owen, Maxwell B Wang, Molly Rae Gerdes, Anne Brandesaitken, Elysa J MarcoAbstract:Abstract The “Sensory Processing Disorder” (SPD) refers to brain's inability to organize Sensory input for appropriate use. In this study, we determined the diffusion tensor imaging (DTI) microstructural and connectivity correlates of SPD, and apply machine learning algorithms for identification of children with SPD based on DTI/tractography metrics. A total of 44 children with SPD and 41 typically developing children (TDC) were prospectively recruited and scanned. In addition to fractional anisotropy (FA), mean diffusivity (MD), and radial diffusivity (RD), we applied probabilistic tractography to generate edge density (ED) and track density (TD) from DTI maps. For identification of children with SPD, accurate classification rates from a combination of DTI microstructural (FA, MD, AD, and RD), connectivity (TD) and connectomic (ED) metrics with different machine learning algorithms – including naive Bayes, random forest, support vector machine, and neural networks – were determined. In voxel-wise analysis, children with SPD had lower FA, ED, and TD but higher MD and RD compared to TDC – predominantly in posterior white matter tracts including posterior corona radiata, posterior thalamic radiation, and posterior body and splenium of corpus callosum. In stepwise penalized logistic regression, the only independent variable distinguishing children with SPD from TDC was the average TD in the splenium (p
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White Matter Microstructure is Associated with Auditory and Tactile Processing in Children with and without Sensory Processing Disorder
Frontiers in Neuroanatomy, 2016Co-Authors: Yishin Chang, Julia P Owen, Elysa J Marco, Shivani S. Desai, Julia Harris, Susanna S. Hill, Mathilde Gratiot, Anne Brandes-aitken, Anne B. Arnett, Pratik MukherjeeAbstract:Sensory Processing Disorders (SPDs) affect up to 16% of school-aged children, and contribute to cognitive and behavioral deficits impacting affected individuals and their families. While Sensory Processing differences are now widely recognized in children with autism, children with Sensory-based dysfunction who do not meet autism criteria based on social communication deficits remain virtually unstudied. In a previous pilot diffusion tensor imaging (DTI) study, we demonstrated that boys with SPD have altered white matter microstructure primarily affecting the posterior cerebral tracts, which subserve Sensory Processing and integration. This disrupted microstructural integrity, measured as reduced white matter fractional anisotropy (FA), correlated with parent report measures of atypical Sensory behavior. In this present study, we investigate white matter microstructure as it relates to tactile and auditory function in depth with a larger, mixed-gender cohort of children 8–12 years of age. We continue to find robust alterations of posterior white matter microstructure in children with SPD relative to typically developing children (TDC), along with more spatially distributed alterations. We find strong correlations of FA with both parent report and direct measures of tactile and auditory Processing across children, with the direct assessment measures of tactile and auditory Processing showing a stronger and more continuous mapping to the underlying white matter integrity than the corresponding parent report measures. Based on these findings of microstructure as a neural correlate of Sensory Processing ability, diffusion MRI merits further investigation as a tool to find biomarkers for diagnosis, prognosis and treatment response in children with SPD. To our knowledge, this work is the first to demonstrate associations of directly measured tactile and non-linguistic auditory function with white matter microstructural integrity – not just in children with SPD, but also in TDC.
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Abnormal White Matter Connectivity In Children With Autism Or Sensory Processing Disorder: Overlap And Divergence. (P6.012)
Neurology, 2014Co-Authors: Elysa J Marco, Julia P Owen, Yishin Chang, Shivani S. Desai, Julia Harris, Susanna S. Hill, Anne Arnette, Pratik MukherjeeAbstract:OBJECTIVE: To investigate the overlap and divergence of white matter microstructure between children with autism spectrum Disorders(ASD), Sensory Processing Disorders(SPD), and neurotypical controls. BACKGROUND: Over 90% of children with ASD demonstrate atypical Sensory behaviors. In fact, hyper- or hyporeactivity to Sensory input or unusual interest in Sensory aspects of the environment is included in the DSM-5 diagnostic criteria. However, there are children with SPD who do not meet an ASD diagnosis but do show atypical Sensory behaviors to the same or greater degree as ASD children. We have reported abnormal white matter microstructure in children with SPD predominantly affecting posterior regions and correlating with atypical Sensory behavior. In this study, we explore white matter connectivity in boys (8-11 years) with ASD(n=15), SPD(n=16), and controls(n=23). METHODS: We used probabilistic diffusion fiber tractography to define white matter tracts. Strength of tract connectivity was measured using mean fractional anisotropy. Group differences were determined with nonparametric permutation testing (p
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abnormal white matter connectivity in children with autism or Sensory Processing Disorder overlap and divergence p6 012
Neurology, 2014Co-Authors: Elysa J Marco, Julia P Owen, Yishin Chang, Shivani S. Desai, Julia Harris, Susanna S. Hill, Anne Arnette, Pratik MukherjeeAbstract:OBJECTIVE: To investigate the overlap and divergence of white matter microstructure between children with autism spectrum Disorders(ASD), Sensory Processing Disorders(SPD), and neurotypical controls. BACKGROUND: Over 90% of children with ASD demonstrate atypical Sensory behaviors. In fact, hyper- or hyporeactivity to Sensory input or unusual interest in Sensory aspects of the environment is included in the DSM-5 diagnostic criteria. However, there are children with SPD who do not meet an ASD diagnosis but do show atypical Sensory behaviors to the same or greater degree as ASD children. We have reported abnormal white matter microstructure in children with SPD predominantly affecting posterior regions and correlating with atypical Sensory behavior. In this study, we explore white matter connectivity in boys (8-11 years) with ASD(n=15), SPD(n=16), and controls(n=23). METHODS: We used probabilistic diffusion fiber tractography to define white matter tracts. Strength of tract connectivity was measured using mean fractional anisotropy. Group differences were determined with nonparametric permutation testing (p<0.05). RESULTS: Both SPD and ASD cohorts have decreased connectivity relative to controls in parieto- and temporo-occipital tracts subserving Sensory perception and multiSensory integration. In SPD, there is worse dysconnectivity than ASD in the occipito-inferior parietal tract of the dorsal visual stream. The SPD group alone shows decreased connectivity in the splenium of the corpus callosum and in the thalamo-prefrontal cortex pathway, whereas the ASD group alone shows lower connectivity in the lingual-orbitofrontal tract as well as the fusiform-amygdala and fusiform-hippocampus tracts essential to face Processing. CONCLUSIONS: There is overlap of abnormal white matter connectivity between children with ASD and SPD in Sensory Processing pathways, but abnormal connectivity in tracts thought to subserve social and emotional Processing is found only in the ASD group. These observations help clarify the roles of specific neural circuits among the widespread white matter microstructural abnormalities observed in children with ASD and SPD. Study Supported by: the Wallace Research Foundation, Gates Family Foundation, Simons Foundation, and the NIH. Disclosure: Dr. Marco has nothing to disclose. Dr. Chang has nothing to disclose. Dr. Owen has nothing to disclose. Dr. Desai has nothing to disclose. Dr. Harris has nothing to disclose. Dr. Hill has nothing to disclose. Dr. Arnette has nothing to disclose. Dr. Mukherjee has nothing to disclose.
Pratik Mukherjee - One of the best experts on this subject based on the ideXlab platform.
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White Matter Microstructure is Associated with Auditory and Tactile Processing in Children with and without Sensory Processing Disorder
Frontiers in Neuroanatomy, 2016Co-Authors: Yishin Chang, Julia P Owen, Elysa J Marco, Shivani S. Desai, Julia Harris, Susanna S. Hill, Mathilde Gratiot, Anne Brandes-aitken, Anne B. Arnett, Pratik MukherjeeAbstract:Sensory Processing Disorders (SPDs) affect up to 16% of school-aged children, and contribute to cognitive and behavioral deficits impacting affected individuals and their families. While Sensory Processing differences are now widely recognized in children with autism, children with Sensory-based dysfunction who do not meet autism criteria based on social communication deficits remain virtually unstudied. In a previous pilot diffusion tensor imaging (DTI) study, we demonstrated that boys with SPD have altered white matter microstructure primarily affecting the posterior cerebral tracts, which subserve Sensory Processing and integration. This disrupted microstructural integrity, measured as reduced white matter fractional anisotropy (FA), correlated with parent report measures of atypical Sensory behavior. In this present study, we investigate white matter microstructure as it relates to tactile and auditory function in depth with a larger, mixed-gender cohort of children 8–12 years of age. We continue to find robust alterations of posterior white matter microstructure in children with SPD relative to typically developing children (TDC), along with more spatially distributed alterations. We find strong correlations of FA with both parent report and direct measures of tactile and auditory Processing across children, with the direct assessment measures of tactile and auditory Processing showing a stronger and more continuous mapping to the underlying white matter integrity than the corresponding parent report measures. Based on these findings of microstructure as a neural correlate of Sensory Processing ability, diffusion MRI merits further investigation as a tool to find biomarkers for diagnosis, prognosis and treatment response in children with SPD. To our knowledge, this work is the first to demonstrate associations of directly measured tactile and non-linguistic auditory function with white matter microstructural integrity – not just in children with SPD, but also in TDC.
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Abnormal White Matter Connectivity In Children With Autism Or Sensory Processing Disorder: Overlap And Divergence. (P6.012)
Neurology, 2014Co-Authors: Elysa J Marco, Julia P Owen, Yishin Chang, Shivani S. Desai, Julia Harris, Susanna S. Hill, Anne Arnette, Pratik MukherjeeAbstract:OBJECTIVE: To investigate the overlap and divergence of white matter microstructure between children with autism spectrum Disorders(ASD), Sensory Processing Disorders(SPD), and neurotypical controls. BACKGROUND: Over 90% of children with ASD demonstrate atypical Sensory behaviors. In fact, hyper- or hyporeactivity to Sensory input or unusual interest in Sensory aspects of the environment is included in the DSM-5 diagnostic criteria. However, there are children with SPD who do not meet an ASD diagnosis but do show atypical Sensory behaviors to the same or greater degree as ASD children. We have reported abnormal white matter microstructure in children with SPD predominantly affecting posterior regions and correlating with atypical Sensory behavior. In this study, we explore white matter connectivity in boys (8-11 years) with ASD(n=15), SPD(n=16), and controls(n=23). METHODS: We used probabilistic diffusion fiber tractography to define white matter tracts. Strength of tract connectivity was measured using mean fractional anisotropy. Group differences were determined with nonparametric permutation testing (p
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abnormal white matter connectivity in children with autism or Sensory Processing Disorder overlap and divergence p6 012
Neurology, 2014Co-Authors: Elysa J Marco, Julia P Owen, Yishin Chang, Shivani S. Desai, Julia Harris, Susanna S. Hill, Anne Arnette, Pratik MukherjeeAbstract:OBJECTIVE: To investigate the overlap and divergence of white matter microstructure between children with autism spectrum Disorders(ASD), Sensory Processing Disorders(SPD), and neurotypical controls. BACKGROUND: Over 90% of children with ASD demonstrate atypical Sensory behaviors. In fact, hyper- or hyporeactivity to Sensory input or unusual interest in Sensory aspects of the environment is included in the DSM-5 diagnostic criteria. However, there are children with SPD who do not meet an ASD diagnosis but do show atypical Sensory behaviors to the same or greater degree as ASD children. We have reported abnormal white matter microstructure in children with SPD predominantly affecting posterior regions and correlating with atypical Sensory behavior. In this study, we explore white matter connectivity in boys (8-11 years) with ASD(n=15), SPD(n=16), and controls(n=23). METHODS: We used probabilistic diffusion fiber tractography to define white matter tracts. Strength of tract connectivity was measured using mean fractional anisotropy. Group differences were determined with nonparametric permutation testing (p<0.05). RESULTS: Both SPD and ASD cohorts have decreased connectivity relative to controls in parieto- and temporo-occipital tracts subserving Sensory perception and multiSensory integration. In SPD, there is worse dysconnectivity than ASD in the occipito-inferior parietal tract of the dorsal visual stream. The SPD group alone shows decreased connectivity in the splenium of the corpus callosum and in the thalamo-prefrontal cortex pathway, whereas the ASD group alone shows lower connectivity in the lingual-orbitofrontal tract as well as the fusiform-amygdala and fusiform-hippocampus tracts essential to face Processing. CONCLUSIONS: There is overlap of abnormal white matter connectivity between children with ASD and SPD in Sensory Processing pathways, but abnormal connectivity in tracts thought to subserve social and emotional Processing is found only in the ASD group. These observations help clarify the roles of specific neural circuits among the widespread white matter microstructural abnormalities observed in children with ASD and SPD. Study Supported by: the Wallace Research Foundation, Gates Family Foundation, Simons Foundation, and the NIH. Disclosure: Dr. Marco has nothing to disclose. Dr. Chang has nothing to disclose. Dr. Owen has nothing to disclose. Dr. Desai has nothing to disclose. Dr. Harris has nothing to disclose. Dr. Hill has nothing to disclose. Dr. Arnette has nothing to disclose. Dr. Mukherjee has nothing to disclose.
Yishin Chang - One of the best experts on this subject based on the ideXlab platform.
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Differing Patterns of Brain Connectivity in Autism Spectrum Disorder vs Sensory Processing Disorder
2019Co-Authors: Yishin ChangAbstract:Author(s): Chang, YiShin | Advisor(s): Mukherjee, Pratik | Abstract: Sensory Processing Disorders (SPD) affect 5-16% of children in the US, and have been shown to impair intellectual and social development due to disrupted Processing and integration of Sensory input. SPD exists both comorbidly with other neurpathologies such as autism spectrum Disorder (ASD) and attention deficit hyperactivity Disorder (ADHD), but often also exists in isolation. In our previous work, tract-based spatial statistics (TBSS) were used with diffusion tensor imaging (DTI) data of SPD subjects to demonstrate decreased white matter integrity in parieto-occipital white matter tracts. Autism Spectrum Disorders (ASD) are typically clinically characterized by impaired communication, social interaction, and behavioral flexibility. However, the majority of individuals with ASD also exhibit Sensory Processing differences. It is valuable to characterize the similarities and differences in Sensory Processing deficits between Sensory Processing deficits within SPD and ASD for differential diagnosis and potentially for treatment planning.We validate and expand upon previous white matter studies of ASD and our previous results in SPD by taking a tractographical approach to examining white matter tracts that we expect to be commonly and differentially affected in SPD vs ASD. Diffusion tensor imaging data was acquired in 16 boys with SPD, 15 boys with ASD, and 23 typically developing boys. Probabilistic fiber tractography was then used with this data to delineate white matter tracts of interest, and white matter structural integrity was assessed for each of these tracts using average values of fractional anisotropy, mean diffusivity, radial diffusivity, and axial diffusivity within each tract. Significant decreases in FA were found for both the SPD and ASD cohorts within the parieto-occipital tracts as compared with the control cohort, with the SPD cohort demonstrating surprisingly and pervasively more affected FAs. Significant decreases in FA were found for the ASD cohort, but not the SPD cohort, within the temporal white matter tracts. These findings validate abnormal white matter as a biological basis for SPD, demonstrate differential white matter pathology between ASD and SPD, and suggest that tracts contributing to social and emotional Processing (and implicated in ASD) are independent of Sensory Processing.
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White Matter Microstructure is Associated with Auditory and Tactile Processing in Children with and without Sensory Processing Disorder
Frontiers in Neuroanatomy, 2016Co-Authors: Yishin Chang, Julia P Owen, Elysa J Marco, Shivani S. Desai, Julia Harris, Susanna S. Hill, Mathilde Gratiot, Anne Brandes-aitken, Anne B. Arnett, Pratik MukherjeeAbstract:Sensory Processing Disorders (SPDs) affect up to 16% of school-aged children, and contribute to cognitive and behavioral deficits impacting affected individuals and their families. While Sensory Processing differences are now widely recognized in children with autism, children with Sensory-based dysfunction who do not meet autism criteria based on social communication deficits remain virtually unstudied. In a previous pilot diffusion tensor imaging (DTI) study, we demonstrated that boys with SPD have altered white matter microstructure primarily affecting the posterior cerebral tracts, which subserve Sensory Processing and integration. This disrupted microstructural integrity, measured as reduced white matter fractional anisotropy (FA), correlated with parent report measures of atypical Sensory behavior. In this present study, we investigate white matter microstructure as it relates to tactile and auditory function in depth with a larger, mixed-gender cohort of children 8–12 years of age. We continue to find robust alterations of posterior white matter microstructure in children with SPD relative to typically developing children (TDC), along with more spatially distributed alterations. We find strong correlations of FA with both parent report and direct measures of tactile and auditory Processing across children, with the direct assessment measures of tactile and auditory Processing showing a stronger and more continuous mapping to the underlying white matter integrity than the corresponding parent report measures. Based on these findings of microstructure as a neural correlate of Sensory Processing ability, diffusion MRI merits further investigation as a tool to find biomarkers for diagnosis, prognosis and treatment response in children with SPD. To our knowledge, this work is the first to demonstrate associations of directly measured tactile and non-linguistic auditory function with white matter microstructural integrity – not just in children with SPD, but also in TDC.
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Abnormal White Matter Connectivity In Children With Autism Or Sensory Processing Disorder: Overlap And Divergence. (P6.012)
Neurology, 2014Co-Authors: Elysa J Marco, Julia P Owen, Yishin Chang, Shivani S. Desai, Julia Harris, Susanna S. Hill, Anne Arnette, Pratik MukherjeeAbstract:OBJECTIVE: To investigate the overlap and divergence of white matter microstructure between children with autism spectrum Disorders(ASD), Sensory Processing Disorders(SPD), and neurotypical controls. BACKGROUND: Over 90% of children with ASD demonstrate atypical Sensory behaviors. In fact, hyper- or hyporeactivity to Sensory input or unusual interest in Sensory aspects of the environment is included in the DSM-5 diagnostic criteria. However, there are children with SPD who do not meet an ASD diagnosis but do show atypical Sensory behaviors to the same or greater degree as ASD children. We have reported abnormal white matter microstructure in children with SPD predominantly affecting posterior regions and correlating with atypical Sensory behavior. In this study, we explore white matter connectivity in boys (8-11 years) with ASD(n=15), SPD(n=16), and controls(n=23). METHODS: We used probabilistic diffusion fiber tractography to define white matter tracts. Strength of tract connectivity was measured using mean fractional anisotropy. Group differences were determined with nonparametric permutation testing (p
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abnormal white matter connectivity in children with autism or Sensory Processing Disorder overlap and divergence p6 012
Neurology, 2014Co-Authors: Elysa J Marco, Julia P Owen, Yishin Chang, Shivani S. Desai, Julia Harris, Susanna S. Hill, Anne Arnette, Pratik MukherjeeAbstract:OBJECTIVE: To investigate the overlap and divergence of white matter microstructure between children with autism spectrum Disorders(ASD), Sensory Processing Disorders(SPD), and neurotypical controls. BACKGROUND: Over 90% of children with ASD demonstrate atypical Sensory behaviors. In fact, hyper- or hyporeactivity to Sensory input or unusual interest in Sensory aspects of the environment is included in the DSM-5 diagnostic criteria. However, there are children with SPD who do not meet an ASD diagnosis but do show atypical Sensory behaviors to the same or greater degree as ASD children. We have reported abnormal white matter microstructure in children with SPD predominantly affecting posterior regions and correlating with atypical Sensory behavior. In this study, we explore white matter connectivity in boys (8-11 years) with ASD(n=15), SPD(n=16), and controls(n=23). METHODS: We used probabilistic diffusion fiber tractography to define white matter tracts. Strength of tract connectivity was measured using mean fractional anisotropy. Group differences were determined with nonparametric permutation testing (p<0.05). RESULTS: Both SPD and ASD cohorts have decreased connectivity relative to controls in parieto- and temporo-occipital tracts subserving Sensory perception and multiSensory integration. In SPD, there is worse dysconnectivity than ASD in the occipito-inferior parietal tract of the dorsal visual stream. The SPD group alone shows decreased connectivity in the splenium of the corpus callosum and in the thalamo-prefrontal cortex pathway, whereas the ASD group alone shows lower connectivity in the lingual-orbitofrontal tract as well as the fusiform-amygdala and fusiform-hippocampus tracts essential to face Processing. CONCLUSIONS: There is overlap of abnormal white matter connectivity between children with ASD and SPD in Sensory Processing pathways, but abnormal connectivity in tracts thought to subserve social and emotional Processing is found only in the ASD group. These observations help clarify the roles of specific neural circuits among the widespread white matter microstructural abnormalities observed in children with ASD and SPD. Study Supported by: the Wallace Research Foundation, Gates Family Foundation, Simons Foundation, and the NIH. Disclosure: Dr. Marco has nothing to disclose. Dr. Chang has nothing to disclose. Dr. Owen has nothing to disclose. Dr. Desai has nothing to disclose. Dr. Harris has nothing to disclose. Dr. Hill has nothing to disclose. Dr. Arnette has nothing to disclose. Dr. Mukherjee has nothing to disclose.
Julia P Owen - One of the best experts on this subject based on the ideXlab platform.
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diffusion tensor tractography in children with Sensory Processing Disorder potentials for devising machine learning classifiers
NeuroImage: Clinical, 2019Co-Authors: Teresa Tavassoli, Seyedmehdi Payabvash, Eva M Palacios, Julia P Owen, Maxwell B Wang, Molly Rae Gerdes, Anne Brandesaitken, Elysa J MarcoAbstract:Abstract The “Sensory Processing Disorder” (SPD) refers to brain's inability to organize Sensory input for appropriate use. In this study, we determined the diffusion tensor imaging (DTI) microstructural and connectivity correlates of SPD, and apply machine learning algorithms for identification of children with SPD based on DTI/tractography metrics. A total of 44 children with SPD and 41 typically developing children (TDC) were prospectively recruited and scanned. In addition to fractional anisotropy (FA), mean diffusivity (MD), and radial diffusivity (RD), we applied probabilistic tractography to generate edge density (ED) and track density (TD) from DTI maps. For identification of children with SPD, accurate classification rates from a combination of DTI microstructural (FA, MD, AD, and RD), connectivity (TD) and connectomic (ED) metrics with different machine learning algorithms – including naive Bayes, random forest, support vector machine, and neural networks – were determined. In voxel-wise analysis, children with SPD had lower FA, ED, and TD but higher MD and RD compared to TDC – predominantly in posterior white matter tracts including posterior corona radiata, posterior thalamic radiation, and posterior body and splenium of corpus callosum. In stepwise penalized logistic regression, the only independent variable distinguishing children with SPD from TDC was the average TD in the splenium (p
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White Matter Microstructure is Associated with Auditory and Tactile Processing in Children with and without Sensory Processing Disorder
Frontiers in Neuroanatomy, 2016Co-Authors: Yishin Chang, Julia P Owen, Elysa J Marco, Shivani S. Desai, Julia Harris, Susanna S. Hill, Mathilde Gratiot, Anne Brandes-aitken, Anne B. Arnett, Pratik MukherjeeAbstract:Sensory Processing Disorders (SPDs) affect up to 16% of school-aged children, and contribute to cognitive and behavioral deficits impacting affected individuals and their families. While Sensory Processing differences are now widely recognized in children with autism, children with Sensory-based dysfunction who do not meet autism criteria based on social communication deficits remain virtually unstudied. In a previous pilot diffusion tensor imaging (DTI) study, we demonstrated that boys with SPD have altered white matter microstructure primarily affecting the posterior cerebral tracts, which subserve Sensory Processing and integration. This disrupted microstructural integrity, measured as reduced white matter fractional anisotropy (FA), correlated with parent report measures of atypical Sensory behavior. In this present study, we investigate white matter microstructure as it relates to tactile and auditory function in depth with a larger, mixed-gender cohort of children 8–12 years of age. We continue to find robust alterations of posterior white matter microstructure in children with SPD relative to typically developing children (TDC), along with more spatially distributed alterations. We find strong correlations of FA with both parent report and direct measures of tactile and auditory Processing across children, with the direct assessment measures of tactile and auditory Processing showing a stronger and more continuous mapping to the underlying white matter integrity than the corresponding parent report measures. Based on these findings of microstructure as a neural correlate of Sensory Processing ability, diffusion MRI merits further investigation as a tool to find biomarkers for diagnosis, prognosis and treatment response in children with SPD. To our knowledge, this work is the first to demonstrate associations of directly measured tactile and non-linguistic auditory function with white matter microstructural integrity – not just in children with SPD, but also in TDC.
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Abnormal White Matter Connectivity In Children With Autism Or Sensory Processing Disorder: Overlap And Divergence. (P6.012)
Neurology, 2014Co-Authors: Elysa J Marco, Julia P Owen, Yishin Chang, Shivani S. Desai, Julia Harris, Susanna S. Hill, Anne Arnette, Pratik MukherjeeAbstract:OBJECTIVE: To investigate the overlap and divergence of white matter microstructure between children with autism spectrum Disorders(ASD), Sensory Processing Disorders(SPD), and neurotypical controls. BACKGROUND: Over 90% of children with ASD demonstrate atypical Sensory behaviors. In fact, hyper- or hyporeactivity to Sensory input or unusual interest in Sensory aspects of the environment is included in the DSM-5 diagnostic criteria. However, there are children with SPD who do not meet an ASD diagnosis but do show atypical Sensory behaviors to the same or greater degree as ASD children. We have reported abnormal white matter microstructure in children with SPD predominantly affecting posterior regions and correlating with atypical Sensory behavior. In this study, we explore white matter connectivity in boys (8-11 years) with ASD(n=15), SPD(n=16), and controls(n=23). METHODS: We used probabilistic diffusion fiber tractography to define white matter tracts. Strength of tract connectivity was measured using mean fractional anisotropy. Group differences were determined with nonparametric permutation testing (p
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abnormal white matter connectivity in children with autism or Sensory Processing Disorder overlap and divergence p6 012
Neurology, 2014Co-Authors: Elysa J Marco, Julia P Owen, Yishin Chang, Shivani S. Desai, Julia Harris, Susanna S. Hill, Anne Arnette, Pratik MukherjeeAbstract:OBJECTIVE: To investigate the overlap and divergence of white matter microstructure between children with autism spectrum Disorders(ASD), Sensory Processing Disorders(SPD), and neurotypical controls. BACKGROUND: Over 90% of children with ASD demonstrate atypical Sensory behaviors. In fact, hyper- or hyporeactivity to Sensory input or unusual interest in Sensory aspects of the environment is included in the DSM-5 diagnostic criteria. However, there are children with SPD who do not meet an ASD diagnosis but do show atypical Sensory behaviors to the same or greater degree as ASD children. We have reported abnormal white matter microstructure in children with SPD predominantly affecting posterior regions and correlating with atypical Sensory behavior. In this study, we explore white matter connectivity in boys (8-11 years) with ASD(n=15), SPD(n=16), and controls(n=23). METHODS: We used probabilistic diffusion fiber tractography to define white matter tracts. Strength of tract connectivity was measured using mean fractional anisotropy. Group differences were determined with nonparametric permutation testing (p<0.05). RESULTS: Both SPD and ASD cohorts have decreased connectivity relative to controls in parieto- and temporo-occipital tracts subserving Sensory perception and multiSensory integration. In SPD, there is worse dysconnectivity than ASD in the occipito-inferior parietal tract of the dorsal visual stream. The SPD group alone shows decreased connectivity in the splenium of the corpus callosum and in the thalamo-prefrontal cortex pathway, whereas the ASD group alone shows lower connectivity in the lingual-orbitofrontal tract as well as the fusiform-amygdala and fusiform-hippocampus tracts essential to face Processing. CONCLUSIONS: There is overlap of abnormal white matter connectivity between children with ASD and SPD in Sensory Processing pathways, but abnormal connectivity in tracts thought to subserve social and emotional Processing is found only in the ASD group. These observations help clarify the roles of specific neural circuits among the widespread white matter microstructural abnormalities observed in children with ASD and SPD. Study Supported by: the Wallace Research Foundation, Gates Family Foundation, Simons Foundation, and the NIH. Disclosure: Dr. Marco has nothing to disclose. Dr. Chang has nothing to disclose. Dr. Owen has nothing to disclose. Dr. Desai has nothing to disclose. Dr. Harris has nothing to disclose. Dr. Hill has nothing to disclose. Dr. Arnette has nothing to disclose. Dr. Mukherjee has nothing to disclose.
Onofre T Dejesus - One of the best experts on this subject based on the ideXlab platform.
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pet measures of d1 d2 and dat binding are associated with heightened tactile responsivity in rhesus macaques implications for Sensory Processing Disorder
Frontiers in Integrative Neuroscience, 2019Co-Authors: Mary L Schneider, Colleen F Moore, Elizabeth O Ahlers, Todd E Barnhart, Bradley T Christian, Onofre T Dejesus, Jonathan W Engle, James E Holden, Julie A Larson, Jeffrey M MoiranoAbstract:Sensory Processing Disorder (SPD), a developmental regulatory condition characterized by marked under- or over-responsivity to non-noxious Sensory stimulation, is a common but poorly understood Disorder that can profoundly affect mood, cognition, social behavior and adaptive life skills. Little is known about the etiology and neural underpinnings. Clinical research indicates that children with SPD show greater prevalence of difficulties in complex cognitive behavior including working memory, behavioral flexibility, and regulation of Sensory and affective functions, which are related to prefrontal cortex (PFC), striatal, and midbrain regions. Neuroimaging may provide insight into mechanisms underlying SPD, and animal experiments provide important evidence that is not available in human studies. Rhesus monkeys (N = 73) were followed over a 20-year period from birth into old age. We focused on a single Sensory modality, the tactile system, measured at 5-7 years, because of its critical importance for nourishment, attachment, and social reward in development. Positron emission tomography imaging was conducted at ages 12-18 years to quantify the availability of the D1 and D2 subtypes of the DA receptor (D1R and D2R), and the DA transporter (DAT). Heightened tactile responsivity was related to (a) elevated D1R in PFC overall, including lateral, ventrolateral, medial, anterior cingulate (aCg), frontopolar, and orbitofrontal (OFC) subregions, as well as nucleus accumbens (Acb), (b) reduced D2R in aCg, OFC, and substantia nigra / ventral tegmental area, and (c) elevated DAT in putamen. These findings suggest a mechanism by which DA pathways may be altered in SPD. These pathways are associated with reward Processing and pain regulation, providing top-down regulation of Sensory and affective processes. The balance between top-down cognitive control in the PFC-Acb pathway and bottom-up motivational function of the VTA-Acb-PFC pathway is critical for successful adaptive function. An imbalance in these two systems might explain DA-related symptoms in children with SPD, including reduced top-down regulatory function and exaggerated responsivity to stimuli. These results provide more direct evidence that SPD may involve altered DA receptor and transporter function in PFC, striatal, and midbrain regions. More work is needed to extend these results to humans.
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Sensory Processing Disorder in a primate model evidence from a longitudinal study of prenatal alcohol and prenatal stress effects
Child Development, 2008Co-Authors: Mary L Schneider, Colleen F Moore, Julie A Larson, Lisa L Gajewski, Andrew D Roberts, Alexander K Converse, Onofre T DejesusAbstract:Disrupted Sensory Processing, characterized by over- or underresponsiveness to environmental stimuli, has been reported in children with a variety of developmental disabilities. This study examined the effects of prenatal stress and moderate-level prenatal alcohol exposure on tactile sensitivity and its relationship to striatal dopamine system function in thirty-eight 5- to 7-year-old rhesus monkeys. The monkeys were from four experimental conditions: (a) prenatal alcohol exposed, (b) prenatal stress, (c) prenatal alcohol exposed + prenatal stress, and (d) sucrose controls. Increased D2 receptor binding in the striatum, evaluated using positron emission tomography neuroimaging, was related to increased withdrawal (aversion) responses to repetitive tactile stimuli and reduced habituation across trials. Moreover, prenatal stress significantly increased overall withdrawal responses to repetitive tactile stimulation compared to no prenatal stress.
