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Alissa Old Crow - One of the best experts on this subject based on the ideXlab platform.
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relation between tag position and degree of visualized cerebrospinal fluid reflux into the lateral ventricles in time spatial labeling inversion pulse magnetic resonance imaging at the foramen of monro
Fluids and Barriers of the CNS, 2015Co-Authors: Erik H Middlebrooks, Jeffrey Bennett, Alissa Old CrowAbstract:Time-spatial labeling inversion pulse (Time-SLIP) magnetic resonance imaging allows non-invasive visualization of cerebrospinal fluid (CSF) movement. Our study evaluated the sensitivity of the Time-SLIP tag placement on the measurement of CSF reflux from the third ventricle into the lateral ventricles via the foramen of Monro. Multiple Time-SLIP MRI scans were obtained in three healthy volunteers (23–55 years of age) evaluating the observed CSF pulsation and reflux from the third ventricle into the lateral ventricles while varying the placement of the tag. Linear regression was performed to evaluate the effects of tag position on the amount of visualized reflux and pulsation. Variation in the position of the tag relative to the plane of the free margin of the Septum Pellucidum produced a significant inverse variation in the observed reflux into the lateral ventricles (R2 = 0.74). The further the distance of the top (superior edge) of the tag from the plane of the free margin of the Septum Pellucidum, the less reflux into the lateral ventricles was observed (P = 0.006). The amount of observed CSF reflux into the lateral ventricles in Time-SLIP MR imaging is dependent on the positioning of the CSF tag with decreasing amount of visualized reflux the further caudal the CSF tag is relative to the free margin of the Septum Pellucidum.
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Additional file 2: of Relation between tag position and degree of visualized cerebrospinal fluid reflux into the lateral ventricles in time-spatial labeling inversion pulse magnetic resonance imaging at the foramen of Monro
2015Co-Authors: Erik H Middlebrooks, Jeffrey Bennett, Alissa Old CrowAbstract:Figure S2. (A) MR images showing the plane of the free margin of the Septum Pellucidum (line) perpendicular to the free margin of the Septum Pellucidum (arrow). (B) Normal reflux into the lateral ventricle is demonstrated (arrow)
Ahmed Gilani - One of the best experts on this subject based on the ideXlab platform.
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myxoid glioneuronal tumor pdgfra p k385l mutant arising in midbrain tectum with multifocal csf dissemination
Brain Pathology, 2021Co-Authors: B K Kleinschmidtdemasters, Jason Chiang, Andrew M Donson, Thomas T Borges, Ahmed GilaniAbstract:This myxoid glioneuronal tumor, PDGFRA p.K385L-mutant, arose in the midbrain tectum rather than in the Septum Pellucidum, as in the previously-reported cases.
Erik H Middlebrooks - One of the best experts on this subject based on the ideXlab platform.
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relation between tag position and degree of visualized cerebrospinal fluid reflux into the lateral ventricles in time spatial labeling inversion pulse magnetic resonance imaging at the foramen of monro
Fluids and Barriers of the CNS, 2015Co-Authors: Erik H Middlebrooks, Jeffrey Bennett, Alissa Old CrowAbstract:Time-spatial labeling inversion pulse (Time-SLIP) magnetic resonance imaging allows non-invasive visualization of cerebrospinal fluid (CSF) movement. Our study evaluated the sensitivity of the Time-SLIP tag placement on the measurement of CSF reflux from the third ventricle into the lateral ventricles via the foramen of Monro. Multiple Time-SLIP MRI scans were obtained in three healthy volunteers (23–55 years of age) evaluating the observed CSF pulsation and reflux from the third ventricle into the lateral ventricles while varying the placement of the tag. Linear regression was performed to evaluate the effects of tag position on the amount of visualized reflux and pulsation. Variation in the position of the tag relative to the plane of the free margin of the Septum Pellucidum produced a significant inverse variation in the observed reflux into the lateral ventricles (R2 = 0.74). The further the distance of the top (superior edge) of the tag from the plane of the free margin of the Septum Pellucidum, the less reflux into the lateral ventricles was observed (P = 0.006). The amount of observed CSF reflux into the lateral ventricles in Time-SLIP MR imaging is dependent on the positioning of the CSF tag with decreasing amount of visualized reflux the further caudal the CSF tag is relative to the free margin of the Septum Pellucidum.
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Additional file 2: of Relation between tag position and degree of visualized cerebrospinal fluid reflux into the lateral ventricles in time-spatial labeling inversion pulse magnetic resonance imaging at the foramen of Monro
2015Co-Authors: Erik H Middlebrooks, Jeffrey Bennett, Alissa Old CrowAbstract:Figure S2. (A) MR images showing the plane of the free margin of the Septum Pellucidum (line) perpendicular to the free margin of the Septum Pellucidum (arrow). (B) Normal reflux into the lateral ventricle is demonstrated (arrow)
Peter P Sun - One of the best experts on this subject based on the ideXlab platform.
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myxoid glioneuronal tumor pdgfra p k385 mutant clinical radiologic and histopathologic features
Brain Pathology, 2020Co-Authors: Calixtohope G Lucas, Mitchel S Berger, Javier Villanuevameyer, Nicholas S Whipple, Nancy Ann Oberheim Bush, Tabitha Cooney, Susan M Chang, Michael W Mcdermott, Elaine Cham, Peter P SunAbstract:"Myxoid glioneuronal tumor, PDGFRA p.K385-mutant" is a recently described tumor entity of the central nervous system with a predilection for origin in the Septum Pellucidum and a defining dinucleotide mutation at codon 385 of the PDGFRA oncogene replacing lysine with either leucine or isoleucine (p.K385L/I). Clinical outcomes and optimal treatment for this new tumor entity have yet to be defined. Here, we report a comprehensive clinical, radiologic, and histopathologic assessment of eight cases. In addition to its stereotypic location in the Septum Pellucidum, we identify that this tumor can also occur in the corpus callosum and periventricular white matter of the lateral ventricle. Tumors centered in the Septum Pellucidum uniformly were associated with obstructive hydrocephalus, whereas tumors centered in the corpus callosum and periventricular white matter did not demonstrate hydrocephalus. While multiple patients were found to have ventricular dissemination or local recurrence/progression, all patients in this series remain alive at last clinical follow-up despite only biopsy or subtotal resection without adjuvant therapy in most cases. Our study further supports "myxoid glioneuronal tumor, PDGFRA p.K385-mutant" as a distinct CNS tumor entity and expands the spectrum of clinicopathologic and radiologic features of this neoplasm.
Goncalves P Pereira - One of the best experts on this subject based on the ideXlab platform.
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two dimensional visualization and measurement of the fetal optic chiasm improving counseling for antenatal diagnosis of agenesis of the Septum Pellucidum
Ultrasound in Obstetrics & Gynecology, 2016Co-Authors: F Vinals, Pilar Ruiz, F Correa, Goncalves P PereiraAbstract:Objective To develop an objective method for visualizing and measuring the fetal optic chiasm (OC) using transvaginal two-dimensional (2D) ultrasound in the coronal plane and to report measurements in fetuses with agenesis of the Septum Pellucidum (SP). Methods This was a prospective cross-sectional study of 115 morphologically normal fetuses in low-risk pregnancies, between 21 and 30 weeks' gestation. The OC was measured in a coronal plane at the level of the third ventricle and was seen as a horizontally aligned dumbbell-shaped structure of moderate echogenicity. In addition, OC measurements from eight fetuses with agenesis of the SP and complete follow-up were compared with the reference range. Results OC measurements were obtained in 110/115 normal fetuses and showed that OC increases linearly with gestational age. Our method of measurement demonstrated good intraobserver repeatability and excellent interobserver reproducibility. Among the eight fetuses with agenesis of the SP, five had normal OC measurements and five had normal vision postnatally. Pregnancy continued to term in all cases and the follow-up period varied from 6 months to 7 years. Conclusion Our study demonstrates that it is possible to visualize and measure the OC directly on a 2D ultrasound coronal plane. In fetuses with agenesis of the SP, the morphology and width of the OC visual pathway could prove a relevant tool for assessing its development. It would also help in the difficult task of providing antenatal counseling when faced with the diagnosis of agenesis of the SP. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.
