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Kornélia Tekes - One of the best experts on this subject based on the ideXlab platform.
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A hormonális imprinting humán patológiai hatásainak modellezése állatkísérletekben = Model experiments of the human pathological effects of hormonal imprinting
2007Co-Authors: György Csaba, Péter Kovács, Karabélyos C, Barbara Knippel, Ágnes Inczefiné Gonda, Kornélia TekesAbstract:A hormonalis imprinting a kozponti idegrendszerre is hat, akar perinatalisan, akar kesőbbi erzekenysegi időpontban tortenik meg. Endorfin imprinting csokkenti az agyi szerotonin szintet, ami befolyasolja az agresszivitast es szexualis magatartast es extrem modon megnoveli a nocistatin szintet, ami a fajdalomtűresre lehet hatassal. Perinatalis szerotonin imprinting csokkenti a striatum szerotonin szintjet es noveli himekben a szexualis aktivitast. Az immunsejtekben (feherversejtek es hizosejtek) szamos hormon van jelen. Az allatok neme befolyasolja a hormon tartalmat. Ujszulottkori endorfin imprinting utan a nőstenyek hizosejtjei kevesebb endorfint, szerotonint es EGF-et tartlmaztak. A kesői terhessegi korban bekovetkező endorfin imprinting immunsejt szerotonin es hisztaminra valo hatasa transzgeneraciosan is kovethető az F2 generacioig. Kozvetett imprinting is lehetseges, amennyiben stressz (elvalasztasi vagy felnőtt korban) vagy alkohol fogyasztas (terhesseg vagy szoptatas alatt) maradandoan befolyasolja az immunsejtek hormon tartalmat. Egyes hormonok (szerotonin, hisztamin)a sejtmagban is jelen vannak. HDC-gen kiutott egerekben az immunsejtek szerotonin tartalma megnőtt, de a sejtmagbol hianyzott. A kiserletek eredmenyeiből egy, az immunrendszerben jelen levő endokrin halozatra is lehet kovetkeztetni. | Perinatal as well as later (at weaning or at adult age) hormonal imprinting influences also the central nervous system. Endorphin imprinting reduces the Serotonin Level of the brain, which influences the animals? aggressivity and sexual behavior and extremly elevates the nocistatin Level which affects pain tolerance. Perinatal Serotonin imprinting reduces the Serotonin Level of striatum and increases males? sexual activity. Immune cells (white blood cells and mast cells) contain numerous hormones. There are differences in the hormone contents of males and females. After neonatal endorphin imprinting females? mast cells contain less endorphin, Serotonin and EGF. The effects of endorphin imprinting in late pregnancy on the Serotonin and histamine concentration can be followed up to the second filial generation.There is also a possibility of indirect imprinting when stress (at weaning or in adult age) or alcohol consumption (during pregnancy or lactation) durably influence the hormone content of immune cells. Certain hormones (histamine and Serotonin) are present also in the nucleus of mast cells. In HDC-KO mice the Serotonin content of immune cells increases, however it was absent in the nucleus. Considering the results, an endocrine network inside the immune system can be surmized.
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a hormonalis imprinting human patologiai hatasainak modellezese allatkiserletekben model experiments of the human pathological effects of hormonal imprinting
2007Co-Authors: György Csaba, Péter Kovács, Cs. Karabélyos, Barbara Knippel, Ágnes Inczefiné Gonda, Kornélia TekesAbstract:A hormonalis imprinting a kozponti idegrendszerre is hat, akar perinatalisan, akar kesőbbi erzekenysegi időpontban tortenik meg. Endorfin imprinting csokkenti az agyi szerotonin szintet, ami befolyasolja az agresszivitast es szexualis magatartast es extrem modon megnoveli a nocistatin szintet, ami a fajdalomtűresre lehet hatassal. Perinatalis szerotonin imprinting csokkenti a striatum szerotonin szintjet es noveli himekben a szexualis aktivitast. Az immunsejtekben (feherversejtek es hizosejtek) szamos hormon van jelen. Az allatok neme befolyasolja a hormon tartalmat. Ujszulottkori endorfin imprinting utan a nőstenyek hizosejtjei kevesebb endorfint, szerotonint es EGF-et tartlmaztak. A kesői terhessegi korban bekovetkező endorfin imprinting immunsejt szerotonin es hisztaminra valo hatasa transzgeneraciosan is kovethető az F2 generacioig. Kozvetett imprinting is lehetseges, amennyiben stressz (elvalasztasi vagy felnőtt korban) vagy alkohol fogyasztas (terhesseg vagy szoptatas alatt) maradandoan befolyasolja az immunsejtek hormon tartalmat. Egyes hormonok (szerotonin, hisztamin)a sejtmagban is jelen vannak. HDC-gen kiutott egerekben az immunsejtek szerotonin tartalma megnőtt, de a sejtmagbol hianyzott. A kiserletek eredmenyeiből egy, az immunrendszerben jelen levő endokrin halozatra is lehet kovetkeztetni. | Perinatal as well as later (at weaning or at adult age) hormonal imprinting influences also the central nervous system. Endorphin imprinting reduces the Serotonin Level of the brain, which influences the animals? aggressivity and sexual behavior and extremly elevates the nocistatin Level which affects pain tolerance. Perinatal Serotonin imprinting reduces the Serotonin Level of striatum and increases males? sexual activity. Immune cells (white blood cells and mast cells) contain numerous hormones. There are differences in the hormone contents of males and females. After neonatal endorphin imprinting females? mast cells contain less endorphin, Serotonin and EGF. The effects of endorphin imprinting in late pregnancy on the Serotonin and histamine concentration can be followed up to the second filial generation.There is also a possibility of indirect imprinting when stress (at weaning or in adult age) or alcohol consumption (during pregnancy or lactation) durably influence the hormone content of immune cells. Certain hormones (histamine and Serotonin) are present also in the nucleus of mast cells. In HDC-KO mice the Serotonin content of immune cells increases, however it was absent in the nucleus. Considering the results, an endocrine network inside the immune system can be surmized.
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Effect of neonatal benzpyrene imprinting on the brain Serotonin content and nocistatin Level in adult male rats.
Acta physiologica Hungarica, 2007Co-Authors: Kornélia Tekes, M. Hantos, Laszlo Tothfalusi, György CsabaAbstract:Single neonatal treatment (imprinting) with 20 μg benzpyrene results in significant increase of the brain Serotonin Level in the striatum, while in the other four regions (cortex, brainstem, hippocampus, hypothalamus) when measured in adults can be detected. The nocistatin Level of cerebrospinal fluid (CSF) significantly decreases, while there is no change in the plasma nocistatin Level. The results call attention to the comprehensive imprinting effect of benzpyrene, which in addition to receptorial, hormonal and sexual behavioral disturbances causes lasting differences in the brain Serotonin and nocistatin Levels, probably influencing mood and pain tolerance.
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endorphin excess at weaning durably influences sexual activity uterine estrogen receptor s binding capacity and brain Serotonin Level of female rats
Hormone and Metabolic Research, 2004Co-Authors: György Csaba, M. Hantos, Cs. Karabélyos, Barbara Knippel, Agnes Inczefigonda, Kornélia TekesAbstract:Perinatally, the first encounter between the maturing receptor and its target hormone results in hormonal imprinting, which adjusts the binding capacity of the receptor for life. In the presence of an excess of the target hormone or foreign molecules than can be bound by the receptor, faulty imprinting carries life-long consequences. In cytogenic organs, imprinting could also be provoked in other periods of life (late imprinting). Imprinting also durably influences the production of the imprinter and related hormones. In the present study, single beta-endorphin doses was given to three-week old female rats at 3 microg/animal, and the Serotonin in five brain regions (frontal cortex, striatum, hippocampus, hypothalamus and brain stem) and uterine estrogen receptor content were determined, thymic glucocorticoid receptor binding capacity was measured, and sexual behavior was tested at five months of age. Brain Serotonin Levels highly significantly decreased, while sexual activity (Meyerson index and lordosis quotient) increased. At the same time, uterine estrogen receptor affinity decreased. There was no change in receptor binding capacity in the thymus. We will go on to discuss interrelations between the results. The experiments demonstrate that a non-perinatal treatment with a molecule acting at receptor Level (late imprinting) can also lastingly influence various indexes in non-cytogenic organs. The results call attention to the possible long-lasting influence of an endorphin surge (caused, for example, by pain) on brain Serotonin content and sexual behavior.
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Impact of single neonatal Serotonin treatment (hormonal imprinting) on the brain Serotonin content and sexual behavior of adult rats.
Life sciences, 2003Co-Authors: György Csaba, Ágnes Inczefi-gonda, M. Hantos, Cs. Karabélyos, Barbara Knippel, Kornélia TekesAbstract:Hormonal imprinting takes place perinatally at the first encounter between the developing receptor and its target hormone. As a consequence of imprinting the receptor accomplishes its maturation and reaches the binding capacity characteristic to the adult age. In the excess of target hormone or presence of molecules similar to the target hormone, which are able to bind to the unmatured receptors, faulty imprinting develops with life-long consequences. At present, Serotonin was given to neonatal rats and their sexual activity, brain Serotonin Level and steroid receptor's binding capacity was measured in adult age. Brain Serotonin Level was significantly reduced in male's striatum and parallel with this, male's sexual activity significantly increased. In other regions of the male brain (prefrontal cortex, hypothalamus, hippocampus) there was a statistically non-significant tendency for a decrease in Serotonin Level. No significant differences were detected in female brain values, and there was only slight change in female's sexual activity. There was also no change in the binding capacity of thymic glucocorticoid and uterine estrogen receptors. The experiments call attention to the possibility of perinatal imprinting by a neurotransmitter causing changes in brain neurotransmitter Level for life, which is manifested in altered sexual activity.
Lipa Cicinsain - One of the best experts on this subject based on the ideXlab platform.
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platelet Serotonin in primary sjogren s syndrome Level and relation with disease activity
Journal of Neuroimmunology, 2012Co-Authors: Helena Sarac, Jasenka Markeljevic, Nada Bozina, Gordana Mokrovic, Viktorija Erdeljic, Lipa CicinsainAbstract:Primary Sjogren's syndrome (pSS) is chronic autoimmune disorder of unknown ethiopathogenesis. In line with the concept of neuroimmunohormonal dysregulation in inflammatory rheumatic diseases, the aim of this study was to investigate platelet Serotonin Level (PSL) in patients with pSS and its relation with the activity and duration of the disease. Significantly lower PSL in pSS patients (N=61) was shown as compared to healthy controls (N=103). No correlation was found between PSL and the actual disease activity assessed by the recently developed EULAR Sjogren's Syndrome Disease Activity Index (ESSDAI). Results suggest involvement of the Serotonin system in the pathogenesis of pSS.
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Serotonin Level and Serotonin uptake in human platelets a variable interrelation under marked physiological influences
Clinica Chimica Acta, 2011Co-Authors: Melita Balija, Tatjana Bordukaloniksic, Gordana Mokrovic, Miroslav Banovic, Lipa Cicinsain, Branimir JernejAbstract:Abstract Background Although it is known that platelet Serotonin Level (PSL) depends directly on platelet Serotonin uptake (PSU) through the plasma membrane, reports on their interrelation are inconsistent. The aim of this study was to systematically explore the relationship between these two platelet Serotonin parameters in large human population. Methods PSL and full-kinetics of PSU were determined on 318 blood donors (276 males, 42 females; 20–67 years). Results The overall correlation coefficient between PSL and maximal velocity of PSU was highly significant but unexpectedly low (r = 0.269). Further analyses revealed lack of correlation among females, and variable association among males, depending on the subject age and season of measurements. Highly significant correlations were observed in spring–winter, while association was absent during summer–autumn. Lowering of PSL–PSU correlation with increased age was also demonstrated, showing modest interrelation among younger men and no interrelation in older population. By multiple regression analyses season was identified as the only independent predictor of PSL–PSU relationship. Conclusions The results show prominent influence of biological (sex, age) and, especially, environmental (seasons) physiology on the intraindividual relationship between PSL and PSU. Although Serotonin transporter activity plays an important role in determining PSL, the observed correlations indicate that other factors may predominate.
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Serotonin transporter kinetics in rats selected for extreme values of platelet Serotonin Level
Life Sciences, 2005Co-Authors: Lipa Cicinsain, Tatjana Bordukaloniksic, Ana Froebe, Branimir JernejAbstract:Abstract By selective breeding of Wistar rats for the extreme values of platelet Serotonin (5HT) Level (PSL), we have developed earlier two sublines of animals differing markedly in this parameter. Further studies, performed on the protein and mRNA Levels, revealed platelet Serotonin transporter (5HTt) as parameter underlying mentioned differences in PSL between sublines. In this work, we have performed full-kinetic analysis of platelet Serotonin uptake (PSU) in animals from the genetically selected sublines. The results demonstrated marked differences in maximal velocity (V max ) of the 5HT transporter, as contrasted to the lack of any difference in the Michaelis constant (K m ). High correlation between PSL and V max of PSU was demonstrated, revealing that the number of membrane 5HT transporter sites is under genetic control and responsible for marked differences in PSL between high- and low-5HT sublines. These results enabled further selective breeeding of animals for the extremes of V max of platelet 5HT transporter, and so the development of more specific model “Wistar-Zagreb 5HT rats”.
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Serotonin transporter in rat platelets Level of protein expression underlies inherited differences in uptake kinetics
Life Sciences, 2001Co-Authors: Dubravka Hranilovic, Lipa Cicinsain, Carol M Herakkramberger, Ivan Sabolic, Branimir JernejAbstract:By breeding selection for the extreme values of platelet Serotonin Level (PSL), two sublines of Wistar-derived rats, with constitutionally high or low PSL and platelet Serotonin uptake (PSU), have been developed. Searching for the basis of these differences, we performed quantitative western blot analysis of Serotonin transporter (5HTt) in platelet membranes isolated from both rat sublines. A polyclonal anti-5HTt antibody labeled a single, 5HTt-related 94 kDa protein band in platelet membranes, with significantly stronger intensity in membranes from rats that exhibited a high PSL. We conclude that the inherited differences in PSL and PSU in rats, following breeding selection, are determined by the Level of 5HTt expression in platelet membranes.
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Serotonin transporter in rat platelets Level of protein expression underlies inherited differences in uptake kinetics
Croatian Ccongress of Pharmacology with international participation (3 ; 2001), 2001Co-Authors: Dubravka Hranilovic, Lipa Cicinsain, Carol M Herakkramberger, Ivan Sabolic, Branimir JernejAbstract:Abstract By breeding selection for the extreme values of platelet Serotonin Level (PSL), two sublines ofWistar-derived rats, with constitutionally high or low PSL and platelet Serotonin uptake (PSU), havebeen developed. Searching for the basis of these differences, we performed quantitative western blotanalysis of Serotonin transporter (5HTt) in platelet membranes isolated from both rat sublines. A poly-clonal anti-5HTt antibody labeled a single, 5HTt-related 94 kDa protein band in platelet membranes,with significantly stronger intensity in membranes from rats that exhibited a high PSL. We concludethat the inherited differences in PSL and PSU in rats, following breeding selection, are determined bythe Level of 5HTt expression in platelet membranes. © 2001 Elsevier Science Inc. All rights reserved. Keywords: 5-HT Transporter; Platelet Serotonin Level; Western blot; Rat sublines Introduction 5-Hydroxytryptamine transporter (5HTt) regulates serotonergic neurotransmission by re-uptaking Serotonin (5HT) into presynaptic neurons. Disturbances of the transporter functionhave been linked to the etiopathogenesis of some neuropsychiatric disorders, such as depres-sion, obsessive-compulsive disorder, anxiety, alcoholism, etc. [1]. The protein represents atarget molecule for currently used antidepressants and various substances of abuse (cocaine,amphetamine derivatives) [2,3,4].
Branimir Jernej - One of the best experts on this subject based on the ideXlab platform.
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Serotonin Level and Serotonin uptake in human platelets a variable interrelation under marked physiological influences
Clinica Chimica Acta, 2011Co-Authors: Melita Balija, Tatjana Bordukaloniksic, Gordana Mokrovic, Miroslav Banovic, Lipa Cicinsain, Branimir JernejAbstract:Abstract Background Although it is known that platelet Serotonin Level (PSL) depends directly on platelet Serotonin uptake (PSU) through the plasma membrane, reports on their interrelation are inconsistent. The aim of this study was to systematically explore the relationship between these two platelet Serotonin parameters in large human population. Methods PSL and full-kinetics of PSU were determined on 318 blood donors (276 males, 42 females; 20–67 years). Results The overall correlation coefficient between PSL and maximal velocity of PSU was highly significant but unexpectedly low (r = 0.269). Further analyses revealed lack of correlation among females, and variable association among males, depending on the subject age and season of measurements. Highly significant correlations were observed in spring–winter, while association was absent during summer–autumn. Lowering of PSL–PSU correlation with increased age was also demonstrated, showing modest interrelation among younger men and no interrelation in older population. By multiple regression analyses season was identified as the only independent predictor of PSL–PSU relationship. Conclusions The results show prominent influence of biological (sex, age) and, especially, environmental (seasons) physiology on the intraindividual relationship between PSL and PSU. Although Serotonin transporter activity plays an important role in determining PSL, the observed correlations indicate that other factors may predominate.
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Serotonin transporter kinetics in rats selected for extreme values of platelet Serotonin Level
Life Sciences, 2005Co-Authors: Lipa Cicinsain, Tatjana Bordukaloniksic, Ana Froebe, Branimir JernejAbstract:Abstract By selective breeding of Wistar rats for the extreme values of platelet Serotonin (5HT) Level (PSL), we have developed earlier two sublines of animals differing markedly in this parameter. Further studies, performed on the protein and mRNA Levels, revealed platelet Serotonin transporter (5HTt) as parameter underlying mentioned differences in PSL between sublines. In this work, we have performed full-kinetic analysis of platelet Serotonin uptake (PSU) in animals from the genetically selected sublines. The results demonstrated marked differences in maximal velocity (V max ) of the 5HT transporter, as contrasted to the lack of any difference in the Michaelis constant (K m ). High correlation between PSL and V max of PSU was demonstrated, revealing that the number of membrane 5HT transporter sites is under genetic control and responsible for marked differences in PSL between high- and low-5HT sublines. These results enabled further selective breeeding of animals for the extremes of V max of platelet 5HT transporter, and so the development of more specific model “Wistar-Zagreb 5HT rats”.
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Serotonin transporter in rat platelets Level of protein expression underlies inherited differences in uptake kinetics
Life Sciences, 2001Co-Authors: Dubravka Hranilovic, Lipa Cicinsain, Carol M Herakkramberger, Ivan Sabolic, Branimir JernejAbstract:By breeding selection for the extreme values of platelet Serotonin Level (PSL), two sublines of Wistar-derived rats, with constitutionally high or low PSL and platelet Serotonin uptake (PSU), have been developed. Searching for the basis of these differences, we performed quantitative western blot analysis of Serotonin transporter (5HTt) in platelet membranes isolated from both rat sublines. A polyclonal anti-5HTt antibody labeled a single, 5HTt-related 94 kDa protein band in platelet membranes, with significantly stronger intensity in membranes from rats that exhibited a high PSL. We conclude that the inherited differences in PSL and PSU in rats, following breeding selection, are determined by the Level of 5HTt expression in platelet membranes.
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Serotonin transporter in rat platelets Level of protein expression underlies inherited differences in uptake kinetics
Croatian Ccongress of Pharmacology with international participation (3 ; 2001), 2001Co-Authors: Dubravka Hranilovic, Lipa Cicinsain, Carol M Herakkramberger, Ivan Sabolic, Branimir JernejAbstract:Abstract By breeding selection for the extreme values of platelet Serotonin Level (PSL), two sublines ofWistar-derived rats, with constitutionally high or low PSL and platelet Serotonin uptake (PSU), havebeen developed. Searching for the basis of these differences, we performed quantitative western blotanalysis of Serotonin transporter (5HTt) in platelet membranes isolated from both rat sublines. A poly-clonal anti-5HTt antibody labeled a single, 5HTt-related 94 kDa protein band in platelet membranes,with significantly stronger intensity in membranes from rats that exhibited a high PSL. We concludethat the inherited differences in PSL and PSU in rats, following breeding selection, are determined bythe Level of 5HTt expression in platelet membranes. © 2001 Elsevier Science Inc. All rights reserved. Keywords: 5-HT Transporter; Platelet Serotonin Level; Western blot; Rat sublines Introduction 5-Hydroxytryptamine transporter (5HTt) regulates serotonergic neurotransmission by re-uptaking Serotonin (5HT) into presynaptic neurons. Disturbances of the transporter functionhave been linked to the etiopathogenesis of some neuropsychiatric disorders, such as depres-sion, obsessive-compulsive disorder, anxiety, alcoholism, etc. [1]. The protein represents atarget molecule for currently used antidepressants and various substances of abuse (cocaine,amphetamine derivatives) [2,3,4].
Barbara Knippel - One of the best experts on this subject based on the ideXlab platform.
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a hormonalis imprinting human patologiai hatasainak modellezese allatkiserletekben model experiments of the human pathological effects of hormonal imprinting
2007Co-Authors: György Csaba, Péter Kovács, Cs. Karabélyos, Barbara Knippel, Ágnes Inczefiné Gonda, Kornélia TekesAbstract:A hormonalis imprinting a kozponti idegrendszerre is hat, akar perinatalisan, akar kesőbbi erzekenysegi időpontban tortenik meg. Endorfin imprinting csokkenti az agyi szerotonin szintet, ami befolyasolja az agresszivitast es szexualis magatartast es extrem modon megnoveli a nocistatin szintet, ami a fajdalomtűresre lehet hatassal. Perinatalis szerotonin imprinting csokkenti a striatum szerotonin szintjet es noveli himekben a szexualis aktivitast. Az immunsejtekben (feherversejtek es hizosejtek) szamos hormon van jelen. Az allatok neme befolyasolja a hormon tartalmat. Ujszulottkori endorfin imprinting utan a nőstenyek hizosejtjei kevesebb endorfint, szerotonint es EGF-et tartlmaztak. A kesői terhessegi korban bekovetkező endorfin imprinting immunsejt szerotonin es hisztaminra valo hatasa transzgeneraciosan is kovethető az F2 generacioig. Kozvetett imprinting is lehetseges, amennyiben stressz (elvalasztasi vagy felnőtt korban) vagy alkohol fogyasztas (terhesseg vagy szoptatas alatt) maradandoan befolyasolja az immunsejtek hormon tartalmat. Egyes hormonok (szerotonin, hisztamin)a sejtmagban is jelen vannak. HDC-gen kiutott egerekben az immunsejtek szerotonin tartalma megnőtt, de a sejtmagbol hianyzott. A kiserletek eredmenyeiből egy, az immunrendszerben jelen levő endokrin halozatra is lehet kovetkeztetni. | Perinatal as well as later (at weaning or at adult age) hormonal imprinting influences also the central nervous system. Endorphin imprinting reduces the Serotonin Level of the brain, which influences the animals? aggressivity and sexual behavior and extremly elevates the nocistatin Level which affects pain tolerance. Perinatal Serotonin imprinting reduces the Serotonin Level of striatum and increases males? sexual activity. Immune cells (white blood cells and mast cells) contain numerous hormones. There are differences in the hormone contents of males and females. After neonatal endorphin imprinting females? mast cells contain less endorphin, Serotonin and EGF. The effects of endorphin imprinting in late pregnancy on the Serotonin and histamine concentration can be followed up to the second filial generation.There is also a possibility of indirect imprinting when stress (at weaning or in adult age) or alcohol consumption (during pregnancy or lactation) durably influence the hormone content of immune cells. Certain hormones (histamine and Serotonin) are present also in the nucleus of mast cells. In HDC-KO mice the Serotonin content of immune cells increases, however it was absent in the nucleus. Considering the results, an endocrine network inside the immune system can be surmized.
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A hormonális imprinting humán patológiai hatásainak modellezése állatkísérletekben = Model experiments of the human pathological effects of hormonal imprinting
2007Co-Authors: György Csaba, Péter Kovács, Karabélyos C, Barbara Knippel, Ágnes Inczefiné Gonda, Kornélia TekesAbstract:A hormonalis imprinting a kozponti idegrendszerre is hat, akar perinatalisan, akar kesőbbi erzekenysegi időpontban tortenik meg. Endorfin imprinting csokkenti az agyi szerotonin szintet, ami befolyasolja az agresszivitast es szexualis magatartast es extrem modon megnoveli a nocistatin szintet, ami a fajdalomtűresre lehet hatassal. Perinatalis szerotonin imprinting csokkenti a striatum szerotonin szintjet es noveli himekben a szexualis aktivitast. Az immunsejtekben (feherversejtek es hizosejtek) szamos hormon van jelen. Az allatok neme befolyasolja a hormon tartalmat. Ujszulottkori endorfin imprinting utan a nőstenyek hizosejtjei kevesebb endorfint, szerotonint es EGF-et tartlmaztak. A kesői terhessegi korban bekovetkező endorfin imprinting immunsejt szerotonin es hisztaminra valo hatasa transzgeneraciosan is kovethető az F2 generacioig. Kozvetett imprinting is lehetseges, amennyiben stressz (elvalasztasi vagy felnőtt korban) vagy alkohol fogyasztas (terhesseg vagy szoptatas alatt) maradandoan befolyasolja az immunsejtek hormon tartalmat. Egyes hormonok (szerotonin, hisztamin)a sejtmagban is jelen vannak. HDC-gen kiutott egerekben az immunsejtek szerotonin tartalma megnőtt, de a sejtmagbol hianyzott. A kiserletek eredmenyeiből egy, az immunrendszerben jelen levő endokrin halozatra is lehet kovetkeztetni. | Perinatal as well as later (at weaning or at adult age) hormonal imprinting influences also the central nervous system. Endorphin imprinting reduces the Serotonin Level of the brain, which influences the animals? aggressivity and sexual behavior and extremly elevates the nocistatin Level which affects pain tolerance. Perinatal Serotonin imprinting reduces the Serotonin Level of striatum and increases males? sexual activity. Immune cells (white blood cells and mast cells) contain numerous hormones. There are differences in the hormone contents of males and females. After neonatal endorphin imprinting females? mast cells contain less endorphin, Serotonin and EGF. The effects of endorphin imprinting in late pregnancy on the Serotonin and histamine concentration can be followed up to the second filial generation.There is also a possibility of indirect imprinting when stress (at weaning or in adult age) or alcohol consumption (during pregnancy or lactation) durably influence the hormone content of immune cells. Certain hormones (histamine and Serotonin) are present also in the nucleus of mast cells. In HDC-KO mice the Serotonin content of immune cells increases, however it was absent in the nucleus. Considering the results, an endocrine network inside the immune system can be surmized.
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endorphin excess at weaning durably influences sexual activity uterine estrogen receptor s binding capacity and brain Serotonin Level of female rats
Hormone and Metabolic Research, 2004Co-Authors: György Csaba, M. Hantos, Cs. Karabélyos, Barbara Knippel, Agnes Inczefigonda, Kornélia TekesAbstract:Perinatally, the first encounter between the maturing receptor and its target hormone results in hormonal imprinting, which adjusts the binding capacity of the receptor for life. In the presence of an excess of the target hormone or foreign molecules than can be bound by the receptor, faulty imprinting carries life-long consequences. In cytogenic organs, imprinting could also be provoked in other periods of life (late imprinting). Imprinting also durably influences the production of the imprinter and related hormones. In the present study, single beta-endorphin doses was given to three-week old female rats at 3 microg/animal, and the Serotonin in five brain regions (frontal cortex, striatum, hippocampus, hypothalamus and brain stem) and uterine estrogen receptor content were determined, thymic glucocorticoid receptor binding capacity was measured, and sexual behavior was tested at five months of age. Brain Serotonin Levels highly significantly decreased, while sexual activity (Meyerson index and lordosis quotient) increased. At the same time, uterine estrogen receptor affinity decreased. There was no change in receptor binding capacity in the thymus. We will go on to discuss interrelations between the results. The experiments demonstrate that a non-perinatal treatment with a molecule acting at receptor Level (late imprinting) can also lastingly influence various indexes in non-cytogenic organs. The results call attention to the possible long-lasting influence of an endorphin surge (caused, for example, by pain) on brain Serotonin content and sexual behavior.
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Impact of single neonatal Serotonin treatment (hormonal imprinting) on the brain Serotonin content and sexual behavior of adult rats.
Life sciences, 2003Co-Authors: György Csaba, Ágnes Inczefi-gonda, M. Hantos, Cs. Karabélyos, Barbara Knippel, Kornélia TekesAbstract:Hormonal imprinting takes place perinatally at the first encounter between the developing receptor and its target hormone. As a consequence of imprinting the receptor accomplishes its maturation and reaches the binding capacity characteristic to the adult age. In the excess of target hormone or presence of molecules similar to the target hormone, which are able to bind to the unmatured receptors, faulty imprinting develops with life-long consequences. At present, Serotonin was given to neonatal rats and their sexual activity, brain Serotonin Level and steroid receptor's binding capacity was measured in adult age. Brain Serotonin Level was significantly reduced in male's striatum and parallel with this, male's sexual activity significantly increased. In other regions of the male brain (prefrontal cortex, hypothalamus, hippocampus) there was a statistically non-significant tendency for a decrease in Serotonin Level. No significant differences were detected in female brain values, and there was only slight change in female's sexual activity. There was also no change in the binding capacity of thymic glucocorticoid and uterine estrogen receptors. The experiments call attention to the possibility of perinatal imprinting by a neurotransmitter causing changes in brain neurotransmitter Level for life, which is manifested in altered sexual activity.
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effect of neonatal β endorphin imprinting on sexual behavior and brain Serotonin Level in adult rats
Life Sciences, 2003Co-Authors: Barbara Knippel, M. Hantos, Cs. Karabélyos, Laszlo Tothfalusi, Agnes Inczefigonda, Kornélia TekesAbstract:Abstract A single dose (3 μg) β-endorphin was administered to newborn female and male rats (hormonal imprinting). In adult age (at 5 months) sexual behavior, steroid hormone binding capacity and brain Serotonin content was studied. Females' sexual activity (lordosis quotient) significantly decreased and more animals protested against mounting (ratio of kicking and crying 21/24 vs. 8/24; p
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a hormonalis imprinting human patologiai hatasainak modellezese allatkiserletekben model experiments of the human pathological effects of hormonal imprinting
2007Co-Authors: György Csaba, Péter Kovács, Cs. Karabélyos, Barbara Knippel, Ágnes Inczefiné Gonda, Kornélia TekesAbstract:A hormonalis imprinting a kozponti idegrendszerre is hat, akar perinatalisan, akar kesőbbi erzekenysegi időpontban tortenik meg. Endorfin imprinting csokkenti az agyi szerotonin szintet, ami befolyasolja az agresszivitast es szexualis magatartast es extrem modon megnoveli a nocistatin szintet, ami a fajdalomtűresre lehet hatassal. Perinatalis szerotonin imprinting csokkenti a striatum szerotonin szintjet es noveli himekben a szexualis aktivitast. Az immunsejtekben (feherversejtek es hizosejtek) szamos hormon van jelen. Az allatok neme befolyasolja a hormon tartalmat. Ujszulottkori endorfin imprinting utan a nőstenyek hizosejtjei kevesebb endorfint, szerotonint es EGF-et tartlmaztak. A kesői terhessegi korban bekovetkező endorfin imprinting immunsejt szerotonin es hisztaminra valo hatasa transzgeneraciosan is kovethető az F2 generacioig. Kozvetett imprinting is lehetseges, amennyiben stressz (elvalasztasi vagy felnőtt korban) vagy alkohol fogyasztas (terhesseg vagy szoptatas alatt) maradandoan befolyasolja az immunsejtek hormon tartalmat. Egyes hormonok (szerotonin, hisztamin)a sejtmagban is jelen vannak. HDC-gen kiutott egerekben az immunsejtek szerotonin tartalma megnőtt, de a sejtmagbol hianyzott. A kiserletek eredmenyeiből egy, az immunrendszerben jelen levő endokrin halozatra is lehet kovetkeztetni. | Perinatal as well as later (at weaning or at adult age) hormonal imprinting influences also the central nervous system. Endorphin imprinting reduces the Serotonin Level of the brain, which influences the animals? aggressivity and sexual behavior and extremly elevates the nocistatin Level which affects pain tolerance. Perinatal Serotonin imprinting reduces the Serotonin Level of striatum and increases males? sexual activity. Immune cells (white blood cells and mast cells) contain numerous hormones. There are differences in the hormone contents of males and females. After neonatal endorphin imprinting females? mast cells contain less endorphin, Serotonin and EGF. The effects of endorphin imprinting in late pregnancy on the Serotonin and histamine concentration can be followed up to the second filial generation.There is also a possibility of indirect imprinting when stress (at weaning or in adult age) or alcohol consumption (during pregnancy or lactation) durably influence the hormone content of immune cells. Certain hormones (histamine and Serotonin) are present also in the nucleus of mast cells. In HDC-KO mice the Serotonin content of immune cells increases, however it was absent in the nucleus. Considering the results, an endocrine network inside the immune system can be surmized.
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A hormonális imprinting humán patológiai hatásainak modellezése állatkísérletekben = Model experiments of the human pathological effects of hormonal imprinting
2007Co-Authors: György Csaba, Péter Kovács, Karabélyos C, Barbara Knippel, Ágnes Inczefiné Gonda, Kornélia TekesAbstract:A hormonalis imprinting a kozponti idegrendszerre is hat, akar perinatalisan, akar kesőbbi erzekenysegi időpontban tortenik meg. Endorfin imprinting csokkenti az agyi szerotonin szintet, ami befolyasolja az agresszivitast es szexualis magatartast es extrem modon megnoveli a nocistatin szintet, ami a fajdalomtűresre lehet hatassal. Perinatalis szerotonin imprinting csokkenti a striatum szerotonin szintjet es noveli himekben a szexualis aktivitast. Az immunsejtekben (feherversejtek es hizosejtek) szamos hormon van jelen. Az allatok neme befolyasolja a hormon tartalmat. Ujszulottkori endorfin imprinting utan a nőstenyek hizosejtjei kevesebb endorfint, szerotonint es EGF-et tartlmaztak. A kesői terhessegi korban bekovetkező endorfin imprinting immunsejt szerotonin es hisztaminra valo hatasa transzgeneraciosan is kovethető az F2 generacioig. Kozvetett imprinting is lehetseges, amennyiben stressz (elvalasztasi vagy felnőtt korban) vagy alkohol fogyasztas (terhesseg vagy szoptatas alatt) maradandoan befolyasolja az immunsejtek hormon tartalmat. Egyes hormonok (szerotonin, hisztamin)a sejtmagban is jelen vannak. HDC-gen kiutott egerekben az immunsejtek szerotonin tartalma megnőtt, de a sejtmagbol hianyzott. A kiserletek eredmenyeiből egy, az immunrendszerben jelen levő endokrin halozatra is lehet kovetkeztetni. | Perinatal as well as later (at weaning or at adult age) hormonal imprinting influences also the central nervous system. Endorphin imprinting reduces the Serotonin Level of the brain, which influences the animals? aggressivity and sexual behavior and extremly elevates the nocistatin Level which affects pain tolerance. Perinatal Serotonin imprinting reduces the Serotonin Level of striatum and increases males? sexual activity. Immune cells (white blood cells and mast cells) contain numerous hormones. There are differences in the hormone contents of males and females. After neonatal endorphin imprinting females? mast cells contain less endorphin, Serotonin and EGF. The effects of endorphin imprinting in late pregnancy on the Serotonin and histamine concentration can be followed up to the second filial generation.There is also a possibility of indirect imprinting when stress (at weaning or in adult age) or alcohol consumption (during pregnancy or lactation) durably influence the hormone content of immune cells. Certain hormones (histamine and Serotonin) are present also in the nucleus of mast cells. In HDC-KO mice the Serotonin content of immune cells increases, however it was absent in the nucleus. Considering the results, an endocrine network inside the immune system can be surmized.
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Effect of neonatal benzpyrene imprinting on the brain Serotonin content and nocistatin Level in adult male rats.
Acta physiologica Hungarica, 2007Co-Authors: Kornélia Tekes, M. Hantos, Laszlo Tothfalusi, György CsabaAbstract:Single neonatal treatment (imprinting) with 20 μg benzpyrene results in significant increase of the brain Serotonin Level in the striatum, while in the other four regions (cortex, brainstem, hippocampus, hypothalamus) when measured in adults can be detected. The nocistatin Level of cerebrospinal fluid (CSF) significantly decreases, while there is no change in the plasma nocistatin Level. The results call attention to the comprehensive imprinting effect of benzpyrene, which in addition to receptorial, hormonal and sexual behavioral disturbances causes lasting differences in the brain Serotonin and nocistatin Levels, probably influencing mood and pain tolerance.
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endorphin excess at weaning durably influences sexual activity uterine estrogen receptor s binding capacity and brain Serotonin Level of female rats
Hormone and Metabolic Research, 2004Co-Authors: György Csaba, M. Hantos, Cs. Karabélyos, Barbara Knippel, Agnes Inczefigonda, Kornélia TekesAbstract:Perinatally, the first encounter between the maturing receptor and its target hormone results in hormonal imprinting, which adjusts the binding capacity of the receptor for life. In the presence of an excess of the target hormone or foreign molecules than can be bound by the receptor, faulty imprinting carries life-long consequences. In cytogenic organs, imprinting could also be provoked in other periods of life (late imprinting). Imprinting also durably influences the production of the imprinter and related hormones. In the present study, single beta-endorphin doses was given to three-week old female rats at 3 microg/animal, and the Serotonin in five brain regions (frontal cortex, striatum, hippocampus, hypothalamus and brain stem) and uterine estrogen receptor content were determined, thymic glucocorticoid receptor binding capacity was measured, and sexual behavior was tested at five months of age. Brain Serotonin Levels highly significantly decreased, while sexual activity (Meyerson index and lordosis quotient) increased. At the same time, uterine estrogen receptor affinity decreased. There was no change in receptor binding capacity in the thymus. We will go on to discuss interrelations between the results. The experiments demonstrate that a non-perinatal treatment with a molecule acting at receptor Level (late imprinting) can also lastingly influence various indexes in non-cytogenic organs. The results call attention to the possible long-lasting influence of an endorphin surge (caused, for example, by pain) on brain Serotonin content and sexual behavior.
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Impact of single neonatal Serotonin treatment (hormonal imprinting) on the brain Serotonin content and sexual behavior of adult rats.
Life sciences, 2003Co-Authors: György Csaba, Ágnes Inczefi-gonda, M. Hantos, Cs. Karabélyos, Barbara Knippel, Kornélia TekesAbstract:Hormonal imprinting takes place perinatally at the first encounter between the developing receptor and its target hormone. As a consequence of imprinting the receptor accomplishes its maturation and reaches the binding capacity characteristic to the adult age. In the excess of target hormone or presence of molecules similar to the target hormone, which are able to bind to the unmatured receptors, faulty imprinting develops with life-long consequences. At present, Serotonin was given to neonatal rats and their sexual activity, brain Serotonin Level and steroid receptor's binding capacity was measured in adult age. Brain Serotonin Level was significantly reduced in male's striatum and parallel with this, male's sexual activity significantly increased. In other regions of the male brain (prefrontal cortex, hypothalamus, hippocampus) there was a statistically non-significant tendency for a decrease in Serotonin Level. No significant differences were detected in female brain values, and there was only slight change in female's sexual activity. There was also no change in the binding capacity of thymic glucocorticoid and uterine estrogen receptors. The experiments call attention to the possibility of perinatal imprinting by a neurotransmitter causing changes in brain neurotransmitter Level for life, which is manifested in altered sexual activity.
