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Swarnlata Saraf - One of the best experts on this subject based on the ideXlab platform.
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Development and in vitro evaluation of polar lipid based lipospheres for oral delivery of peptide drugs
International Journal of Drug Delivery, 2009Co-Authors: Manju Rawat Singh, Deependra Singh, Swarnlata SarafAbstract:A 32 factorial design was employed to produce oral sustained release lipospheres prepared by modified double emulsion solvent evaporation technique for Serratiopeptidase (acid-labile enzyme) using wax and polar lipid combination as retardants. The effects of formulation variables selected through preliminary trials namely peptide and stabilizer (Tween® 80) concentration was evaluated by F-test on the drug content and size of lipospheres. The results of analysis of variance tests for both effects indicated that the test is significant (p < 0.05). The effect of Tween® 80 concentration (SSY1- 41.66; SSY2 – 25.30) was found to be higher than peptide amount (SSY1- 3.94; SSY2 – 4.03) on the size and drug content of lipospheres. Characterization was carried out through photomicroscopy, scanning electron microscopy, particle size analysis and in vitro drug release study. The effect of formulation variables on the integrity of enzyme was confirmed by in vitro proteolytic activity. The drug release from lipospheres followed first-order kinetics and was characterized by the Higuchi diffusion and Ritger-Peppas model. Lipospheres having maximum drug content (11.93±0.89) released 3-4% enzyme at pH 1.2 in 4 h. In phosphate buffer, lipospheres showed an initial burst release of 20.89±1.87% to 27.89±2.03% in one hour with additional 73.22±2.36% to 94.75±2.78% in next 12 hours. Thus, peptide loaded lipospheres with desirable characters in terms of maximum peptide content and diffusion release pattern were successfully prepared with formulation optimization approach. Keywords: Cetyl alcohol, Enzyme, factorial design, Lipospheres; Peptide, Serratiopeptidase
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Formulation optimization of Serratiopeptidase-loaded PLGA microspheres using selected variables.
Pda Journal of Pharmaceutical Science and Technology, 2009Co-Authors: Deependra Singh, Vinod Kumar Dixit, Swarnlata SarafAbstract:Serratiopeptidase-loaded poly (D,L-lactic-co-glycolic acid) (PLGA) microspheres were prepared using the modified double emulsion method. The effect of polymer concentration and external aqueous phase volume on microsphere size and entrapment efficiency was studied by 32 full factorial experiments. The results of analysis of variance test for measured responses indicated the test9s significance (P
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Derivative Spectrophotometric Method For Simultaneous Estimation Of Nimesulide And Serratiopeptidase From Tablet Dosage Form
Analytical chemistry an Indian journal, 2007Co-Authors: S. J. Daharwal, Saraf Swarnlata, Swarnlata SarafAbstract:The first derivative spectrophotometric method for simultaneous estimation of nimesulide(NL) and Serratiopeptidase(SP) in two component solid dosage forms has been developed. The method utilizes phosphate buffer pH 7.4 as a solvent. In this solvent system, the first derivative spectrum of NL shows the equal absorbance at 223nm and 250 nm and for the estimation of SP, the difference between the absorbance at 223nm and 250nm was used. The spectrum of SP shows the zero absorbance at 360.5nm, this zero crossing point was used for the estimation of NL. The linearity ranges for NL and SP were 10-90 μg/ml and 2-90 μg/ml, respectively.
Purushottam S. Karelia - One of the best experts on this subject based on the ideXlab platform.
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A comparative survey study on current prescribing trends in non-steroidal anti-inflammatory drugs among practitioners in private set up and tertiary care teaching rural hospital
International Journal of Research in Medical Sciences, 2014Co-Authors: Ravi R. Alamchandani, Bhagya Manoj Sattigeri, Purushottam S. KareliaAbstract:Background: The study was conducted to compare the current prescribing trends of Non-Steroidal Anti-inflammatory drugs (NSAIDS) among private practitioners and practitioners at tertiary care teaching rural hospital. Methods: The prospective survey study was carried out by obtaining response to feedback questionnaire related to use of NSAIDs from 25 private & 25 tertiary care practitioners. Results: NSAIDs use was routine amongst private (66%) and tertiary care (77.6%) practitioners. Preferences of tertiary care practitioners were paracetamol (36%), diclofenac (20%), aceclofenac (20%), ibuprofen (20%) and etoricoxib (4%) while that of private practitioners were ibuprofen (40%), paracetamol (32%), diclofenac (16%) and aceclofenac (12%). Use of Fixed Dose Combinations (FDC) was 72% in private and 68% in tertiary care practitioners. While prescribing FDCs, private practitioners preferred NSAIDs + NSAIDs (100%) over NSAIDs + muscle relaxants (44.44%), NSAIDs + Serratiopeptidase (55.56%), and NSAIDs + antacids (44.44%) similarly tertiary care practitioners also preferred NSAIDs + NSAIDs (100%) over NSAIDs + muscle relaxants (47.06%), NSAIDs + Serratiopeptidase (36%), and NSAIDs + antacids (28%). Of the NSAIDs + NSAIDs combination ibuprofen + paracetamol (70%) was preferred by private practitioners and diclofenac + paracetamol (61%) by tertiary practitioners. Paracetamol was safely used during pregnancy by both groups. Adverse effects observed included gastritis (98%), urticaria (32%), and anaphylaxis (2%), although no fatality was observed. Conclusion: Not much of a difference was observed in prescribing habits of both groups. Though beneficial and routinely prescribed, NSAIDs with equal risk potential were observed to be cautiously used with appropriate knowledge amongst both the groups.
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A comparative survey study on current prescribing trends in non-steroidal anti-inflammatory drugs among practitioners in private set up and tertiary care teaching rural hospital
Medip Academy, 2014Co-Authors: Ravi R. Alamchandani, Bhagya Manoj Sattigeri, Purushottam S. KareliaAbstract:Background: The study was conducted to compare the current prescribing trends of Non-Steroidal Anti-inflammatory drugs (NSAIDS) among private practitioners and practitioners at tertiary care teaching rural hospital. Methods: The prospective survey study was carried out by obtaining response to feedback questionnaire related to use of NSAIDs from 25 private and 25 tertiary care practitioners. Results: NSAIDs use was routine amongst private (66%) and tertiary care (77.6%) practitioners. Preferences of tertiary care practitioners were paracetamol (36%), diclofenac (20%), aceclofenac (20%), ibuprofen (20%) and etoricoxib (4%) while that of private practitioners were ibuprofen (40%), paracetamol (32%), diclofenac (16%) and aceclofenac (12%). Use of Fixed Dose Combinations (FDC) was 72% in private and 68% in tertiary care practitioners. While prescribing FDCs, private practitioners preferred NSAIDs + NSAIDs (100%) over NSAIDs + muscle relaxants (44.44%), NSAIDs + Serratiopeptidase (55.56%), and NSAIDs + antacids (44.44%) similarly tertiary care practitioners also preferred NSAIDs + NSAIDs (100%) over NSAIDs + muscle relaxants (47.06%), NSAIDs + Serratiopeptidase (36%), and NSAIDs + antacids (28%). Of the NSAIDs + NSAIDs combination ibuprofen + paracetamol (70%) was preferred by private practitioners and diclofenac + paracetamol (61%) by tertiary practitioners. Paracetamol was safely used during pregnancy by both groups. Adverse effects observed included gastritis (98%), urticaria (32%), and anaphylaxis (2%), although no fatality was observed. Conclusion: Not much of a difference was observed in prescribing habits of both groups. Though beneficial and routinely prescribed, NSAIDs with equal risk potential were observed to be cautiously used with appropriate knowledge amongst both the groups. [Int J Res Med Sci 2014; 2(4.000): 1672-1675
Ravi R. Alamchandani - One of the best experts on this subject based on the ideXlab platform.
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A comparative survey study on current prescribing trends in non-steroidal anti-inflammatory drugs among practitioners in private set up and tertiary care teaching rural hospital
International Journal of Research in Medical Sciences, 2014Co-Authors: Ravi R. Alamchandani, Bhagya Manoj Sattigeri, Purushottam S. KareliaAbstract:Background: The study was conducted to compare the current prescribing trends of Non-Steroidal Anti-inflammatory drugs (NSAIDS) among private practitioners and practitioners at tertiary care teaching rural hospital. Methods: The prospective survey study was carried out by obtaining response to feedback questionnaire related to use of NSAIDs from 25 private & 25 tertiary care practitioners. Results: NSAIDs use was routine amongst private (66%) and tertiary care (77.6%) practitioners. Preferences of tertiary care practitioners were paracetamol (36%), diclofenac (20%), aceclofenac (20%), ibuprofen (20%) and etoricoxib (4%) while that of private practitioners were ibuprofen (40%), paracetamol (32%), diclofenac (16%) and aceclofenac (12%). Use of Fixed Dose Combinations (FDC) was 72% in private and 68% in tertiary care practitioners. While prescribing FDCs, private practitioners preferred NSAIDs + NSAIDs (100%) over NSAIDs + muscle relaxants (44.44%), NSAIDs + Serratiopeptidase (55.56%), and NSAIDs + antacids (44.44%) similarly tertiary care practitioners also preferred NSAIDs + NSAIDs (100%) over NSAIDs + muscle relaxants (47.06%), NSAIDs + Serratiopeptidase (36%), and NSAIDs + antacids (28%). Of the NSAIDs + NSAIDs combination ibuprofen + paracetamol (70%) was preferred by private practitioners and diclofenac + paracetamol (61%) by tertiary practitioners. Paracetamol was safely used during pregnancy by both groups. Adverse effects observed included gastritis (98%), urticaria (32%), and anaphylaxis (2%), although no fatality was observed. Conclusion: Not much of a difference was observed in prescribing habits of both groups. Though beneficial and routinely prescribed, NSAIDs with equal risk potential were observed to be cautiously used with appropriate knowledge amongst both the groups.
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A comparative survey study on current prescribing trends in non-steroidal anti-inflammatory drugs among practitioners in private set up and tertiary care teaching rural hospital
Medip Academy, 2014Co-Authors: Ravi R. Alamchandani, Bhagya Manoj Sattigeri, Purushottam S. KareliaAbstract:Background: The study was conducted to compare the current prescribing trends of Non-Steroidal Anti-inflammatory drugs (NSAIDS) among private practitioners and practitioners at tertiary care teaching rural hospital. Methods: The prospective survey study was carried out by obtaining response to feedback questionnaire related to use of NSAIDs from 25 private and 25 tertiary care practitioners. Results: NSAIDs use was routine amongst private (66%) and tertiary care (77.6%) practitioners. Preferences of tertiary care practitioners were paracetamol (36%), diclofenac (20%), aceclofenac (20%), ibuprofen (20%) and etoricoxib (4%) while that of private practitioners were ibuprofen (40%), paracetamol (32%), diclofenac (16%) and aceclofenac (12%). Use of Fixed Dose Combinations (FDC) was 72% in private and 68% in tertiary care practitioners. While prescribing FDCs, private practitioners preferred NSAIDs + NSAIDs (100%) over NSAIDs + muscle relaxants (44.44%), NSAIDs + Serratiopeptidase (55.56%), and NSAIDs + antacids (44.44%) similarly tertiary care practitioners also preferred NSAIDs + NSAIDs (100%) over NSAIDs + muscle relaxants (47.06%), NSAIDs + Serratiopeptidase (36%), and NSAIDs + antacids (28%). Of the NSAIDs + NSAIDs combination ibuprofen + paracetamol (70%) was preferred by private practitioners and diclofenac + paracetamol (61%) by tertiary practitioners. Paracetamol was safely used during pregnancy by both groups. Adverse effects observed included gastritis (98%), urticaria (32%), and anaphylaxis (2%), although no fatality was observed. Conclusion: Not much of a difference was observed in prescribing habits of both groups. Though beneficial and routinely prescribed, NSAIDs with equal risk potential were observed to be cautiously used with appropriate knowledge amongst both the groups. [Int J Res Med Sci 2014; 2(4.000): 1672-1675
K. S. Misraulia - One of the best experts on this subject based on the ideXlab platform.
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Studies on the efficacy of non-steroidal antiinflammatory drugs and Serratiopeptidase in dogs.
Haryana Veterinarian, 2013Co-Authors: K. S. Misraulia, Pawan Maheshwari, Jyoti DongreAbstract:Twenty four healthy mongrel dogs of 1-2 years ofage were divided in to four groups (group A-D). Dogs of group B were treated with ibuprofen @ 10 mg/kg b. wt orally, those of group C were treated with nimesulide @ 05 mg/kg b. wt orally and group D with Serratiopeptidase @ 02 mg/kg b. wt orally while dogs of group A acted as control. To produce hind paw oedema, 0.05 ml commercially available turpentine oil was injected subcutaneously (s/c) in the space surrounded by callosities of right hind paw of dogs of each group. The drugs were administered orally half an hour before turpentine oil injection. The paw volume was measured by modified mercury plethesmometer before and at 1 st , 2 nd , 3 rd and 4 th hour after turpentine injection.All the NSAIDs tested produced a significant reduction in hind paw oedema volume, compared with control group. However, Serratiopeptidase produced maximum anti-inflammatory activity followed by ibuprofen then nimesulide.
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Ulcerogenic activity of certain non-steroidal anti-inflammatory drugs and enzymes on gastric mucosa of rats.
Indian Journal of Field Veterinarians, 2010Co-Authors: K. S. Misraulia, P. KaskhedikarAbstract:Effect of administration of aspirin, diclofenac sodium, flurbiprofen, nimesulide, piroxicam, Serratiopeptidase and trysin-chymotrysin was evaluated on gastric mucosa for ulceration, if any. The results revealed that nimesulide, Serratiopeptidase and trypsin-chymotrypsin have safety profile, while with the remaining drugs the incidence of ulceration was 100 per cent.
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Effect of non-steroidal anti-inflammatory agents on plasma protein, platelets and coagulation time in rats.
Indian Journal of Field Veterinarians, 2010Co-Authors: K. S. Misraulia, P. KaskhedikarAbstract:A study was conducted on rats to evaluate the effect of aspirin, diclofenac sodium, flurbiprofen, piroxicam, nimesulide, trysin-chymotrypsin and Serratiopeptidase on certain haematological parameters viz. plasma protein concentration, platelet count and coagulation time. The plasma protein concentration and platelet count was significantly (P
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Clinical evaluation of meloxicam, roficoxib and their combination with serratiopeptid ase during long term administration in dogs
Indian Journal of Veterinary Research, 2006Co-Authors: K.w. Nasare, Archana Jain, K. S. MisrauliaAbstract:The side effects caused by Meloxicam, Rofecoxib and their combination with Serratiopeptidase when given I/M for a long time as anti inflammatory in 30 dogs were studied. There was no significant change in the clinical parameters like rectal temperature, pulse and respiratory rates in all treated groups when compared with the control group. It was observed that in healthy dogs meloxicam appears to be safe with regard to adverse effects on the gastro intestinal tract.
Kannan Sridharan - One of the best experts on this subject based on the ideXlab platform.
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Role of Serratiopeptidase After Surgical Removal of Impacted Molar: A Systematic Review and Meta-analysis
Journal of Maxillofacial and Oral Surgery, 2018Co-Authors: Gowri Sivaramakrishnan, Kannan SridharanAbstract:Background Serratiopeptidase for pain, facial swelling and trismus associated with surgical removal of impacted molar is under investigation. However conclusive evidence on the use of Serratiopeptidase is lacking. Hence a systematic review and meta-analysis of randomized controlled studies was carried out. Methods Electronic databases were searched for eligible studies and necessary data extracted. The data were analysed using non-Cochrane mode in RevMan 5.0. 95% confidence interval (95% CI) was used to represent the deviation from the point estimate. The heterogeneity between the studies was assessed using Forest plot visually, I^2 statistics and Chi square test with a statistical P value of
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Role of Serratiopeptidase After Surgical Removal of Impacted Molar: A Systematic Review and Meta-analysis
Journal of Maxillofacial and Oral Surgery, 2017Co-Authors: Gowri Sivaramakrishnan, Kannan SridharanAbstract:Background Serratiopeptidase for pain, facial swelling and trismus associated with surgical removal of impacted molar is under investigation. However conclusive evidence on the use of Serratiopeptidase is lacking. Hence a systematic review and meta-analysis of randomized controlled studies was carried out.
