The Experts below are selected from a list of 207 Experts worldwide ranked by ideXlab platform
Rosenbluth M - One of the best experts on this subject based on the ideXlab platform.
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Serum Sickness reaction following multiple insect stings
Annals of Allergy Asthma & Immunology, 1995Co-Authors: Rosenbluth MAbstract:BACKGROUND: Anaphylaxis is the most common systemic allergic reaction caused by stinging insects. Serum Sickness reactions occur much less frequently. OBJECTIVE: To determine the level of venom-specific IgG and IgE antibodies during and after a Serum Sickness reaction to vespid venom. METHODS: Case report; ELISA determination of venom-specific IgG and IgE; complement levels and tests for immune complexes were performed. RESULTS: We report the case of a 66-year-old woman who developed a Serum Sickness reaction nine days after receiving multiple vespid stings. She developed urticaria, angioedema, fever, and arthralgias. She had elevated IgG and IgE venom-specific titers which declined during the recovery phase. Complement levels were normal and tests for immune complexes were negative. She was successfully treated with venom-specific immunotherapy without any Serum Sickness reaction. CONCLUSIONS: A Serum Sickness reaction with elevated venom-specific IgG and IgE is reported with successful immunotherapy. Language: en
Roy Patterson - One of the best experts on this subject based on the ideXlab platform.
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Severe Serum Sickness-like reaction to oral penicillin drugs: three case reports.
Annals of allergy asthma & immunology : official publication of the American College of Allergy Asthma & Immunology, 2001Co-Authors: Ashley Jerath Tatum, Anne Marie Ditto, Roy PattersonAbstract:Background Because the use of heterologous sera has diminished, the incidence of Serum Sickness has declined. However, Serum Sickness-like reactions to nonprotein drugs continue to occur. Methods We report three cases of severe Serum Sickness-like reactions in adults to oral penicillin drugs. Results In each patient, significant symptom resolution occurred within 24 hours of starting therapy with oral corticosteroids. Conclusions Serum Sickness-like reactions to oral penicillin drugs may be more common than reported in the literature and can be very severe. No specific laboratory finding is universally present or definitively diagnostic. As with classic Serum Sickness, the diagnosis of Serum Sickness-like reaction is made clinically. In severe cases such as those presented here with debilitating joint symptoms or life-threatening angioedema, a diagnostic-therapeutic trial of prednisone, 40 to 60 mg at least once daily, is warranted.
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Minocycline-induced Serum Sickness.
Allergy and asthma proceedings, 1996Co-Authors: Toby Levenson, Deeba Masood, Roy PattersonAbstract:Minocycline, a semisynthetic derivative of tetracycline, has become a commonly prescribed medication for the treatment of persistent acne. It has been associated with a variety of adverse reactions, including one published case of Serum Sickness. We describe two additional cases of Serum Sickness reactions due to minocycline, characterized by erythematous rash, arthropathy, and in one case, angioedema. Both patients recovered fully after treatment with an antihistamine in combination with a brief course of corticosteroids. Although these represent only the second and third cases in the literature of minocycline-induced Serum Sickness, it may be reported more frequently in the future with the increased use of minocycline.
Roger E.g. Schutgens - One of the best experts on this subject based on the ideXlab platform.
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Rituximab-induced Serum Sickness.
British journal of haematology, 2006Co-Authors: Roger E.g. SchutgensAbstract:A 46-year-old woman, who had suffered from Sjogren syndrome for over 25 years, developed an extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue of her right parotic gland. She was treated with monotherapy rituximab, 375 mg/m weekly with premedication consisting of 1000 mg paracetamol, 1 mg clemastin and 25 mg prednisolone. Two days after the second course of rituximab, she developed severe arthralgia of multiple joints. After a further 2 d, she had progressive skin lesions of her legs that were clinically suggestive of vasculitis (top, bottom). Her temperature was 38 C. Laboratory investigations showed normal values for blood count and creatinine. A diagnosis of Serum Sickness was made. A short course of prednisone 20 mg/d was given and the symptoms resolved over the next 5 d. Serum Sickness is a type III hypersensitivity reaction resulting from the injection of foreign protein and subsequent formation of antibodies, occurring 4–10 after exposure. Clinical symptoms can include fever, arthralgia, lymphadenopathy and skin eruptions. Serum Sickness caused by rituximab has been reported, but is uncommon.
Adekola O. Alao - One of the best experts on this subject based on the ideXlab platform.
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Serum Sickness Induced by Bupropion
The Annals of pharmacotherapy, 1999Co-Authors: Jennifer C Yolles, Wendy Armenta, Adekola O. AlaoAbstract:To describe the first reported case of Serum Sickness induced by exposure to bupropion. Bupropion was administered to a 45-year-old white man being treated for depression with psychosis. Within 24 hours after his first dose of bupropion, the patient became delirious and then developed fever, myalgia, arthralgia, and a rash. Bupropion was discontinued after the second dose. With supportive measures, symptoms remitted over two weeks. A thorough search for other etiologies of the patient's symptoms was unrevealing, and a clinical diagnosis of Serum Sickness was made. Given the temporal association between the illness and the introduction of bupropion, this was felt to be the causal agent. No previous reports of Serum Sickness induced by bupropion were found in the literature. The previously unreported adverse drug reaction of Serum Sickness associated with the use of bupropion is demonstrated by this case, based on the temporal relationship and the results of stopping the drug, in light of no other identifiable etiology.
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Serum Sickness Induced by Bupropion
The Annals of pharmacotherapy, 1999Co-Authors: Jennifer C Yolles, Wendy Armenta, Adekola O. AlaoAbstract:OBJECTIVE:To describe the first reported case of Serum Sickness induced by exposure to bupropion.CASE SUMMARY:Bupropion was administered to a 45-year-old white man being treated for depression with psychosis. Within 24 hours after his first dose of bupropion, the patient became delirious and then developed fever, myalgia, arthralgia, and a rash. Bupropion was discontinued after the second dose. With supportive measures, symptoms remitted over two weeks.DISCUSSION:A thorough search for other etiologies of the patient's symptoms was unrevealing, and a clinical diagnosis of Serum Sickness was made. Given the temporal association between the illness and the introduction of bupropion, this was felt to be the causal agent. No previous reports of Serum Sickness induced by bupropion were found in the literature.CONCLUSIONS:The previously unreported adverse drug reaction of Serum Sickness associated with the use of bupropion is demonstrated by this case, based on the temporal relationship and the results of stoppi...
Simon M. Helfgott - One of the best experts on this subject based on the ideXlab platform.
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Serum Sickness following treatment with rituximab
Journal of Rheumatology, 2007Co-Authors: Derrick J Todd, Simon M. HelfgottAbstract:Serum Sickness, an illness characterized by fever, rash, and arthralgias, can occur in patients who receive chimeric monoclonal antibody therapy. Rituximab, a B cell-depleting chimeric anti-CD20 monoclonal antibody, has been used with increasing frequency in the treatment of rheumatologic illnesses such as rheumatoid arthritis and systemic lupus erythematosus. Serum Sickness has only rarely been reported following rituximab therapy. All prior reported cases have been in patients with autoimmune conditions. We describe a case of Serum Sickness in a patient treated with rituximab for mantle cell lymphoma. We also review the literature of rituximab-induced Serum Sickness.
