The Experts below are selected from a list of 600 Experts worldwide ranked by ideXlab platform
Lucy Sun Hwang - One of the best experts on this subject based on the ideXlab platform.
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Effect of roasting condition on the antioxidative activity of the methanolic extract from defatted Sesame Meal.
Journal of Food and Drug Analysis, 2020Co-Authors: Yung-shin Shyu, Jean-yu Hwang, Lucy Sun HwangAbstract:Sesame seeds are usually roasted prior to expelling oil. The defatted Sesame Meal contains lignan glycosides in its methanolic extract. The objective of this study was to investigate the antioxidative activity of methanolic extract from defatted black Sesame Meal roasted at three different temperatures (180, 200, 220℃) for different durations (5-30 min). The antioxidative activities were evaluated by the 2,2-diphenyl-1-picrylhydrazyl hydrate (DPPH) radical scavenging ability and the inhibition of Cu(superscript 2+) induced oxidation of human low-density lipoprotein (LDL). The effects of roasting condition on the browning index of Sesame Meal and the total phenolic content of the methanolic extract were also investigated. Results showed that as roasting temperature and time increased, the DPPH radical scavenging ability and the inhibition of Cu(superscript 2+) induced oxidation of human LDL also increased. Meanwhile, the total phenolic content in the methanolic extract from defatted Sesame Meal and the browning level of Sesame Meal also increased with roasting temperature and time. These results suggested that the enhancement of antioxidative activity would probably be due to total phenolic compounds and Maillard reaction products formed during roasting process.
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lignan glycosides from Sesame Meal exhibit higher oral bioavailability and antioxidant activity in rat after nano submicrosizing
Journal of Functional Foods, 2016Co-Authors: Chia Ding Liao, Wei Lun Hung, Lucy Sun HwangAbstract:Lignan glycosides are one of the major bioactive components in Sesame Meal. In the current study, we evaluated whether the absorption efficiency of lignan glycosides from Sesame Meal (LGSM) increases after wet milling. The current data show that oral bioavailability of LGSM significantly elevated from 0.18 to 0.26% after nano/submicro-sizing due to the smaller particle size and larger surface area. Oral administration of nano/submicro-sized LGSM (N-LGSM) significantly increased the concentrations of sesaminol triglucoside and sesaminol glucuronide in rat urine compared to administration of LGSM that was not nano/submicro-sized. More importantly, oral administration of N-LGSM increased the concentrations of enterolactone and enterodiol found in the plasma, liver, kidney, small intestine and urine of rats, suggesting that the nano/submicro-sizing process greatly improved the accessibility of intestinal microbiota to LGSM. In addition, oral administration of N-LGSM remarkably alleviated lipid peroxidation and increased antioxidant enzyme activities against tert-butyl hydroperoxide-induced oxidative damage in rats.
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Lignan glycosides from Sesame Meal exhibit higher oral bioavailability and antioxidant activity in rat after nano/submicrosizing
Journal of Functional Foods, 2016Co-Authors: Wei Lun Hung, Chia Ding Liao, Lucy Sun HwangAbstract:Lignan glycosides are one of the major bioactive components in Sesame Meal. In the current study, we evaluated whether the absorption efficiency of lignan glycosides from Sesame Meal (LGSM) increases after wet milling. The current data show that oral bioavailability of LGSM significantly elevated from 0.18 to 0.26% after nano/submicro-sizing due to the smaller particle size and larger surface area. Oral administration of nano/submicro-sized LGSM (N-LGSM) significantly increased the concentrations of sesaminol triglucoside and sesaminol glucuronide in rat urine compared to administration of LGSM that was not nano/submicro-sized. More importantly, oral administration of N-LGSM increased the concentrations of enterolactone and enterodiol found in the plasma, liver, kidney, small intestine and urine of rats, suggesting that the nano/submicro-sizing process greatly improved the accessibility of intestinal microbiota to LGSM. In addition, oral administration of N-LGSM remarkably alleviated lipid peroxidation and increased antioxidant enzyme activities against tert-butyl hydroperoxide-induced oxidative damage in rats.
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safety evaluation of nano sub microsized lignan glycosides from Sesame Meal
Food Control, 2013Co-Authors: Wei Lun Hung, Chia Ding Liao, Lucy Sun HwangAbstract:Abstract Nanotechnology is an emerging field in the food industry, but the potential hazards and toxicities of nano-sized food ingredients are still not clear. The aim of this study was to evaluate the mutagenicity and oral toxicity of nano/submicro-sized ingredient, lignan glycosides from Sesame Meal (N-LGSM), prepared by a wet-milling method to reduce the average particle size to 189 nm. Genotoxicity assays including Ames test, chromosome aberration assay, micronuclei assay and a 28-day subacute oral toxicity assay were employed to evaluate the mutagenicity and oral toxicity. Results of the Ames test showed that neither lignan glycosides from Sesame Meal (LGSM) nor N-LGSM increased mutagenicity toward Salmonella typhimurium strains TA97, TA98, TA100, TA102 and TA1535. Furthermore, LGSM and N-LGSM were found to have no mutagenic effects on increasing chromosome aberrations in treated Chinese Hamster Ovary (CHO) cells and the number of micronuclei in mouse erythrocytes. Most importantly, in the 28-day subacute oral toxicity trial, the “no observed adverse effect levels” (NOAELs) of LGSM and N-LGSM were determined to be 1000 and 200 mg/kg/day, respectively for both male and female mice. In conclusion, the nano/submicrosizing process did not cause the mutagenicity and oral toxicity for LGSM, and therefore it is a safe processing method for Sesame lignan glycosides.
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Safety evaluation of nano/sub-microsized lignan glycosides from Sesame Meal
Food Control, 2013Co-Authors: Wei Lun Hung, Chia Ding Liao, Lucy Sun HwangAbstract:Abstract Nanotechnology is an emerging field in the food industry, but the potential hazards and toxicities of nano-sized food ingredients are still not clear. The aim of this study was to evaluate the mutagenicity and oral toxicity of nano/submicro-sized ingredient, lignan glycosides from Sesame Meal (N-LGSM), prepared by a wet-milling method to reduce the average particle size to 189 nm. Genotoxicity assays including Ames test, chromosome aberration assay, micronuclei assay and a 28-day subacute oral toxicity assay were employed to evaluate the mutagenicity and oral toxicity. Results of the Ames test showed that neither lignan glycosides from Sesame Meal (LGSM) nor N-LGSM increased mutagenicity toward Salmonella typhimurium strains TA97, TA98, TA100, TA102 and TA1535. Furthermore, LGSM and N-LGSM were found to have no mutagenic effects on increasing chromosome aberrations in treated Chinese Hamster Ovary (CHO) cells and the number of micronuclei in mouse erythrocytes. Most importantly, in the 28-day subacute oral toxicity trial, the “no observed adverse effect levels” (NOAELs) of LGSM and N-LGSM were determined to be 1000 and 200 mg/kg/day, respectively for both male and female mice. In conclusion, the nano/submicrosizing process did not cause the mutagenicity and oral toxicity for LGSM, and therefore it is a safe processing method for Sesame lignan glycosides.
T. A. El-adawy - One of the best experts on this subject based on the ideXlab platform.
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Effect of Sesame seed protein supplementation on the nutritional, physical, chemical and sensory properties of wheat flour bread
Food Chemistry, 1997Co-Authors: T. A. El-adawyAbstract:Sesame products (Sesame Meal, roasted and autoclaved Sesame Meals, Sesame protein isolate and concentrate) were added to red wheat flour to produce blends at protein levels of 14, 16, 18 and 20%. Dough properties were studied using a Brabender Farinograph. Loaves were prepared from the various blends using the straight dough procedure and then evaluated for volume, crust and crumb colour, crumb texture, flavour and overall quality. The water absorption, development time and dough weakening were increased (P 0.05) were recorded in loaf volume between control and breads containing Sesame protein isolate (up to 18% protein level) and either autoclaved Sesame Meal or Sesame protein concentrate (up to 14% protein level). Also, addition of these products increased the contents of protein, minerals, total essential amino acids, especially lysine, and also improved the in vitro protein digestibility and computed biological value.
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Effect of Sesame seed proteins supplementation on the nutritional, physical, chemical and sensory properties of wheat flour bread
Plant Foods for Human Nutrition, 1995Co-Authors: T. A. El-adawyAbstract:Sesame products (Sesame Meal, roasted and autoclaved Sesame Meal, Sesame protein isolate and concentrate) were added to Red wheat flour to produce blends at protein levels of 14, 16, 18 and 20 percent. Dough properties were studied using a Brabender Farinograph. Loaves were prepared from the various blends using the straight dough procedure and then evaluated for volume, crust and crumb colour, crumb texture, flavour and overall quality. The water absorption, development time and dough weakening were increased ( p 0.05) were recorded in loaf volume between control and breads containing Sesame protein isolate (up to 18 percent protein level) and either autoclaved Sesame Meal or Sesame protein concentrate (up to 14 percent protein level). Addition of Sesame products increased the content not only of protein but also minerals and total essential amino acids, especially lysine. The addition also improved in-vitro protein digestibility.
Wei Lun Hung - One of the best experts on this subject based on the ideXlab platform.
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lignan glycosides from Sesame Meal exhibit higher oral bioavailability and antioxidant activity in rat after nano submicrosizing
Journal of Functional Foods, 2016Co-Authors: Chia Ding Liao, Wei Lun Hung, Lucy Sun HwangAbstract:Lignan glycosides are one of the major bioactive components in Sesame Meal. In the current study, we evaluated whether the absorption efficiency of lignan glycosides from Sesame Meal (LGSM) increases after wet milling. The current data show that oral bioavailability of LGSM significantly elevated from 0.18 to 0.26% after nano/submicro-sizing due to the smaller particle size and larger surface area. Oral administration of nano/submicro-sized LGSM (N-LGSM) significantly increased the concentrations of sesaminol triglucoside and sesaminol glucuronide in rat urine compared to administration of LGSM that was not nano/submicro-sized. More importantly, oral administration of N-LGSM increased the concentrations of enterolactone and enterodiol found in the plasma, liver, kidney, small intestine and urine of rats, suggesting that the nano/submicro-sizing process greatly improved the accessibility of intestinal microbiota to LGSM. In addition, oral administration of N-LGSM remarkably alleviated lipid peroxidation and increased antioxidant enzyme activities against tert-butyl hydroperoxide-induced oxidative damage in rats.
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Lignan glycosides from Sesame Meal exhibit higher oral bioavailability and antioxidant activity in rat after nano/submicrosizing
Journal of Functional Foods, 2016Co-Authors: Wei Lun Hung, Chia Ding Liao, Lucy Sun HwangAbstract:Lignan glycosides are one of the major bioactive components in Sesame Meal. In the current study, we evaluated whether the absorption efficiency of lignan glycosides from Sesame Meal (LGSM) increases after wet milling. The current data show that oral bioavailability of LGSM significantly elevated from 0.18 to 0.26% after nano/submicro-sizing due to the smaller particle size and larger surface area. Oral administration of nano/submicro-sized LGSM (N-LGSM) significantly increased the concentrations of sesaminol triglucoside and sesaminol glucuronide in rat urine compared to administration of LGSM that was not nano/submicro-sized. More importantly, oral administration of N-LGSM increased the concentrations of enterolactone and enterodiol found in the plasma, liver, kidney, small intestine and urine of rats, suggesting that the nano/submicro-sizing process greatly improved the accessibility of intestinal microbiota to LGSM. In addition, oral administration of N-LGSM remarkably alleviated lipid peroxidation and increased antioxidant enzyme activities against tert-butyl hydroperoxide-induced oxidative damage in rats.
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safety evaluation of nano sub microsized lignan glycosides from Sesame Meal
Food Control, 2013Co-Authors: Wei Lun Hung, Chia Ding Liao, Lucy Sun HwangAbstract:Abstract Nanotechnology is an emerging field in the food industry, but the potential hazards and toxicities of nano-sized food ingredients are still not clear. The aim of this study was to evaluate the mutagenicity and oral toxicity of nano/submicro-sized ingredient, lignan glycosides from Sesame Meal (N-LGSM), prepared by a wet-milling method to reduce the average particle size to 189 nm. Genotoxicity assays including Ames test, chromosome aberration assay, micronuclei assay and a 28-day subacute oral toxicity assay were employed to evaluate the mutagenicity and oral toxicity. Results of the Ames test showed that neither lignan glycosides from Sesame Meal (LGSM) nor N-LGSM increased mutagenicity toward Salmonella typhimurium strains TA97, TA98, TA100, TA102 and TA1535. Furthermore, LGSM and N-LGSM were found to have no mutagenic effects on increasing chromosome aberrations in treated Chinese Hamster Ovary (CHO) cells and the number of micronuclei in mouse erythrocytes. Most importantly, in the 28-day subacute oral toxicity trial, the “no observed adverse effect levels” (NOAELs) of LGSM and N-LGSM were determined to be 1000 and 200 mg/kg/day, respectively for both male and female mice. In conclusion, the nano/submicrosizing process did not cause the mutagenicity and oral toxicity for LGSM, and therefore it is a safe processing method for Sesame lignan glycosides.
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Safety evaluation of nano/sub-microsized lignan glycosides from Sesame Meal
Food Control, 2013Co-Authors: Wei Lun Hung, Chia Ding Liao, Lucy Sun HwangAbstract:Abstract Nanotechnology is an emerging field in the food industry, but the potential hazards and toxicities of nano-sized food ingredients are still not clear. The aim of this study was to evaluate the mutagenicity and oral toxicity of nano/submicro-sized ingredient, lignan glycosides from Sesame Meal (N-LGSM), prepared by a wet-milling method to reduce the average particle size to 189 nm. Genotoxicity assays including Ames test, chromosome aberration assay, micronuclei assay and a 28-day subacute oral toxicity assay were employed to evaluate the mutagenicity and oral toxicity. Results of the Ames test showed that neither lignan glycosides from Sesame Meal (LGSM) nor N-LGSM increased mutagenicity toward Salmonella typhimurium strains TA97, TA98, TA100, TA102 and TA1535. Furthermore, LGSM and N-LGSM were found to have no mutagenic effects on increasing chromosome aberrations in treated Chinese Hamster Ovary (CHO) cells and the number of micronuclei in mouse erythrocytes. Most importantly, in the 28-day subacute oral toxicity trial, the “no observed adverse effect levels” (NOAELs) of LGSM and N-LGSM were determined to be 1000 and 200 mg/kg/day, respectively for both male and female mice. In conclusion, the nano/submicrosizing process did not cause the mutagenicity and oral toxicity for LGSM, and therefore it is a safe processing method for Sesame lignan glycosides.
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Nano/sub-microsized lignan glycosides from Sesame Meal exhibit higher transport and absorption efficiency in Caco-2 cell monolayer.
Food Chemistry, 2010Co-Authors: Chia Ding Liao, Wei Lun Hung, Kuo Ching Jan, An-i Yeh, Lucy Sun HwangAbstract:Abstract In the present study, we investigated whether lignan glycosides from Sesame Meal (LGSM), after nano/sub-microsizing, will exhibit higher transport and absorption efficiencies than LGSM. The average particle size of 1% LGSM aqueous suspension reduced from approximately 2 μm–200 nm after media-milling with zirconia beads. The transport and absorption of LGSM and nano/sub-microsized LGSM (N-LGSM) using Caco-2 human epithelial colorectal adenocarcinoma cells, a model simulating human intestinal absorption was examined. The permeability of sesaminol triglucoside (ST) in N-LGSM and LGSM was 1.41 ± 0.16 and 1.07 ± 0.21 (10 −6 cm/s), respectively, indicating that ST in N-LGSM was more efficiently transported through the monolayer. In addition, N-LGSM exhibited 35.7% higher absorption efficiency than LGSM. The better performance of N-LGSM may be attributed to the (a) smaller particle size and larger surface area; (b) increased mucosal permeability, and (c) improved intestinal absorption due to the formation of nanoemulsion droplets.
Chia Ding Liao - One of the best experts on this subject based on the ideXlab platform.
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lignan glycosides from Sesame Meal exhibit higher oral bioavailability and antioxidant activity in rat after nano submicrosizing
Journal of Functional Foods, 2016Co-Authors: Chia Ding Liao, Wei Lun Hung, Lucy Sun HwangAbstract:Lignan glycosides are one of the major bioactive components in Sesame Meal. In the current study, we evaluated whether the absorption efficiency of lignan glycosides from Sesame Meal (LGSM) increases after wet milling. The current data show that oral bioavailability of LGSM significantly elevated from 0.18 to 0.26% after nano/submicro-sizing due to the smaller particle size and larger surface area. Oral administration of nano/submicro-sized LGSM (N-LGSM) significantly increased the concentrations of sesaminol triglucoside and sesaminol glucuronide in rat urine compared to administration of LGSM that was not nano/submicro-sized. More importantly, oral administration of N-LGSM increased the concentrations of enterolactone and enterodiol found in the plasma, liver, kidney, small intestine and urine of rats, suggesting that the nano/submicro-sizing process greatly improved the accessibility of intestinal microbiota to LGSM. In addition, oral administration of N-LGSM remarkably alleviated lipid peroxidation and increased antioxidant enzyme activities against tert-butyl hydroperoxide-induced oxidative damage in rats.
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Lignan glycosides from Sesame Meal exhibit higher oral bioavailability and antioxidant activity in rat after nano/submicrosizing
Journal of Functional Foods, 2016Co-Authors: Wei Lun Hung, Chia Ding Liao, Lucy Sun HwangAbstract:Lignan glycosides are one of the major bioactive components in Sesame Meal. In the current study, we evaluated whether the absorption efficiency of lignan glycosides from Sesame Meal (LGSM) increases after wet milling. The current data show that oral bioavailability of LGSM significantly elevated from 0.18 to 0.26% after nano/submicro-sizing due to the smaller particle size and larger surface area. Oral administration of nano/submicro-sized LGSM (N-LGSM) significantly increased the concentrations of sesaminol triglucoside and sesaminol glucuronide in rat urine compared to administration of LGSM that was not nano/submicro-sized. More importantly, oral administration of N-LGSM increased the concentrations of enterolactone and enterodiol found in the plasma, liver, kidney, small intestine and urine of rats, suggesting that the nano/submicro-sizing process greatly improved the accessibility of intestinal microbiota to LGSM. In addition, oral administration of N-LGSM remarkably alleviated lipid peroxidation and increased antioxidant enzyme activities against tert-butyl hydroperoxide-induced oxidative damage in rats.
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safety evaluation of nano sub microsized lignan glycosides from Sesame Meal
Food Control, 2013Co-Authors: Wei Lun Hung, Chia Ding Liao, Lucy Sun HwangAbstract:Abstract Nanotechnology is an emerging field in the food industry, but the potential hazards and toxicities of nano-sized food ingredients are still not clear. The aim of this study was to evaluate the mutagenicity and oral toxicity of nano/submicro-sized ingredient, lignan glycosides from Sesame Meal (N-LGSM), prepared by a wet-milling method to reduce the average particle size to 189 nm. Genotoxicity assays including Ames test, chromosome aberration assay, micronuclei assay and a 28-day subacute oral toxicity assay were employed to evaluate the mutagenicity and oral toxicity. Results of the Ames test showed that neither lignan glycosides from Sesame Meal (LGSM) nor N-LGSM increased mutagenicity toward Salmonella typhimurium strains TA97, TA98, TA100, TA102 and TA1535. Furthermore, LGSM and N-LGSM were found to have no mutagenic effects on increasing chromosome aberrations in treated Chinese Hamster Ovary (CHO) cells and the number of micronuclei in mouse erythrocytes. Most importantly, in the 28-day subacute oral toxicity trial, the “no observed adverse effect levels” (NOAELs) of LGSM and N-LGSM were determined to be 1000 and 200 mg/kg/day, respectively for both male and female mice. In conclusion, the nano/submicrosizing process did not cause the mutagenicity and oral toxicity for LGSM, and therefore it is a safe processing method for Sesame lignan glycosides.
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Safety evaluation of nano/sub-microsized lignan glycosides from Sesame Meal
Food Control, 2013Co-Authors: Wei Lun Hung, Chia Ding Liao, Lucy Sun HwangAbstract:Abstract Nanotechnology is an emerging field in the food industry, but the potential hazards and toxicities of nano-sized food ingredients are still not clear. The aim of this study was to evaluate the mutagenicity and oral toxicity of nano/submicro-sized ingredient, lignan glycosides from Sesame Meal (N-LGSM), prepared by a wet-milling method to reduce the average particle size to 189 nm. Genotoxicity assays including Ames test, chromosome aberration assay, micronuclei assay and a 28-day subacute oral toxicity assay were employed to evaluate the mutagenicity and oral toxicity. Results of the Ames test showed that neither lignan glycosides from Sesame Meal (LGSM) nor N-LGSM increased mutagenicity toward Salmonella typhimurium strains TA97, TA98, TA100, TA102 and TA1535. Furthermore, LGSM and N-LGSM were found to have no mutagenic effects on increasing chromosome aberrations in treated Chinese Hamster Ovary (CHO) cells and the number of micronuclei in mouse erythrocytes. Most importantly, in the 28-day subacute oral toxicity trial, the “no observed adverse effect levels” (NOAELs) of LGSM and N-LGSM were determined to be 1000 and 200 mg/kg/day, respectively for both male and female mice. In conclusion, the nano/submicrosizing process did not cause the mutagenicity and oral toxicity for LGSM, and therefore it is a safe processing method for Sesame lignan glycosides.
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Nano/sub-microsized lignan glycosides from Sesame Meal exhibit higher transport and absorption efficiency in Caco-2 cell monolayer.
Food Chemistry, 2010Co-Authors: Chia Ding Liao, Wei Lun Hung, Kuo Ching Jan, An-i Yeh, Lucy Sun HwangAbstract:Abstract In the present study, we investigated whether lignan glycosides from Sesame Meal (LGSM), after nano/sub-microsizing, will exhibit higher transport and absorption efficiencies than LGSM. The average particle size of 1% LGSM aqueous suspension reduced from approximately 2 μm–200 nm after media-milling with zirconia beads. The transport and absorption of LGSM and nano/sub-microsized LGSM (N-LGSM) using Caco-2 human epithelial colorectal adenocarcinoma cells, a model simulating human intestinal absorption was examined. The permeability of sesaminol triglucoside (ST) in N-LGSM and LGSM was 1.41 ± 0.16 and 1.07 ± 0.21 (10 −6 cm/s), respectively, indicating that ST in N-LGSM was more efficiently transported through the monolayer. In addition, N-LGSM exhibited 35.7% higher absorption efficiency than LGSM. The better performance of N-LGSM may be attributed to the (a) smaller particle size and larger surface area; (b) increased mucosal permeability, and (c) improved intestinal absorption due to the formation of nanoemulsion droplets.
Kuo Ching Jan - One of the best experts on this subject based on the ideXlab platform.
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nano sub microsized lignan glycosides from Sesame Meal exhibit higher transport and absorption efficiency in caco 2 cell monolayer
Food Chemistry, 2010Co-Authors: Chia Ding Liao, Wei Lun Hung, Kuo Ching Jan, An-i Yeh, Lucy Sun HwangAbstract:Abstract In the present study, we investigated whether lignan glycosides from Sesame Meal (LGSM), after nano/sub-microsizing, will exhibit higher transport and absorption efficiencies than LGSM. The average particle size of 1% LGSM aqueous suspension reduced from approximately 2 μm–200 nm after media-milling with zirconia beads. The transport and absorption of LGSM and nano/sub-microsized LGSM (N-LGSM) using Caco-2 human epithelial colorectal adenocarcinoma cells, a model simulating human intestinal absorption was examined. The permeability of sesaminol triglucoside (ST) in N-LGSM and LGSM was 1.41 ± 0.16 and 1.07 ± 0.21 (10 −6 cm/s), respectively, indicating that ST in N-LGSM was more efficiently transported through the monolayer. In addition, N-LGSM exhibited 35.7% higher absorption efficiency than LGSM. The better performance of N-LGSM may be attributed to the (a) smaller particle size and larger surface area; (b) increased mucosal permeability, and (c) improved intestinal absorption due to the formation of nanoemulsion droplets.
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Nano/sub-microsized lignan glycosides from Sesame Meal exhibit higher transport and absorption efficiency in Caco-2 cell monolayer.
Food Chemistry, 2010Co-Authors: Chia Ding Liao, Wei Lun Hung, Kuo Ching Jan, An-i Yeh, Lucy Sun HwangAbstract:Abstract In the present study, we investigated whether lignan glycosides from Sesame Meal (LGSM), after nano/sub-microsizing, will exhibit higher transport and absorption efficiencies than LGSM. The average particle size of 1% LGSM aqueous suspension reduced from approximately 2 μm–200 nm after media-milling with zirconia beads. The transport and absorption of LGSM and nano/sub-microsized LGSM (N-LGSM) using Caco-2 human epithelial colorectal adenocarcinoma cells, a model simulating human intestinal absorption was examined. The permeability of sesaminol triglucoside (ST) in N-LGSM and LGSM was 1.41 ± 0.16 and 1.07 ± 0.21 (10 −6 cm/s), respectively, indicating that ST in N-LGSM was more efficiently transported through the monolayer. In addition, N-LGSM exhibited 35.7% higher absorption efficiency than LGSM. The better performance of N-LGSM may be attributed to the (a) smaller particle size and larger surface area; (b) increased mucosal permeability, and (c) improved intestinal absorption due to the formation of nanoemulsion droplets.
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Differential Tissue Distribution of Sesaminol Triglucoside and Its Metabolites in Rats Fed with Lignan Glycosides from Sesame Meal with or without Nano/Submicrosizing
Journal of agricultural and food chemistry, 2010Co-Authors: Chia Ding Liao, Wei Lun Hung, Kuo Ching Jan, Daniel Yang Chih Shih, An-i Yeh, Lucy Sun HwangAbstract:Lignan glycosides are important functional compounds in Sesame Meal. In the present study, we investigated whether the tissue distribution of nano/submicrosized lignan glycosides from Sesame Meal (N-LGSM) differs from lignan glycosides from Sesame Meal (LGSM). LGSM was nano/submicrosized with 0.3 mm zirconia beads as the milling media. The average particle size of the 4% LGSM aqueous suspension reduced rapidly from approximately 2 microm to 200 nm after media milling at an agitation speed of 3600 rpm for 30 min. We examined the tissue distribution of sesaminol triglucoside (ST), the main component in LGSM, in Sprague-Dawley (SD) rats. The concentrations of ST were determined in various tissues and plasma within a 24 h period after oral administration of N-LGSM and LGSM (800 mg/kg of body weight). The results showed that higher concentrations of ST and its metabolites (sesaminol, sesaminol sulfate, and sesaminol glucuronide) were found in N-LGSM compared to those in LGSM in most tissues, especially liver and small intestine. Sesaminol glucuronide was the main metabolite in rats. After 3 h of oral administration, around 70% higher concentration of sesaminol glucuronide was found in N-LGSM compared to that in LGSM. This study clearly showed that LGSM is more bioavailable after nano/submicrosizing.