The Experts below are selected from a list of 1875 Experts worldwide ranked by ideXlab platform
Pradeep Kumar - One of the best experts on this subject based on the ideXlab platform.
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An Asymmetric Dihydroxylation route to (−)-bulgecinine
Tetrahedron: Asymmetry, 2011Co-Authors: Krishanu Show, Puspesh Kumar Upadhyay, Pradeep KumarAbstract:Abstract The stereoselective synthesis of (−)-bulgecinine is reported from l -aspartic acid using Sharpless Asymmetric Dihydroxylation and intramolecular cyclization via nucleophilic displacement of α-tosylate as key steps.
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A Concise Synthesis of (-)-Deoxoprosopinine
Synlett, 2007Co-Authors: Satyendra Kumar Pandey, Pradeep KumarAbstract:A simple and highly efficient approach to (-)-deoxo-prosopinine from racemic epoxide as a starting material is described employing a Jacobsen’s hydrolytic kinetic resolution (HKR) and Sharpless Asymmetric Dihydroxylation (AD) as key steps.
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Formal synthesis of herbarumin III
Tetrahedron: Asymmetry, 2007Co-Authors: Priti Gupta, Pradeep KumarAbstract:Abstract An enantioselective synthesis of herbarumin III is described employing Jacobsen’s hydrolytic kinetic resolution and Sharpless Asymmetric Dihydroxylation as the key steps.
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Enantioselective synthesis of (2R,3R)- and (2S,3S)-β-hydroxyornithine ☆
Tetrahedron Letters, 2006Co-Authors: Satyendra Kumar Pandey, Pradeep KumarAbstract:An efficient and short synthesis of (2R,3R)- and (2S,3S)-β-hydroxyornithine 1a–b is described using Sharpless Asymmetric Dihydroxylation and regioselective nucleophilic opening of a cyclic sulfite as the key steps.
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Efficient total synthesis of sapinofuranone B.
The Journal of organic chemistry, 2005Co-Authors: Pradeep Kumar, Gupta PAbstract:An efficient enantioselective synthesis of sapinofuranone B (1) using Sharpless Asymmetric Dihydroxylation, Sonogashira coupling, and Wittig olefination as the key steps is described.
Gary A. Sulikowski - One of the best experts on this subject based on the ideXlab platform.
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synthesis of 4 o acetyl l rhodinopyranose via a tandem Sharpless Asymmetric Dihydroxylation lipase catalyzed transesterification
Tetrahedron Letters, 1995Co-Authors: Aditya Sobti, Gary A. SulikowskiAbstract:Abstract An enantioselective synthesis of the trideoxy sugar 4-O- acetyl- l -rhodinopyranose ( 7 ) is described. A key feature of the synthetic strategy is a Sharpless Asymmetric Dihydroxylation followed by a lipase-mediated mono-esterification of the resultant diol ( 3→4→6 ).
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Synthesis of 4-O-acetyl-l-rhodinopyranose via a tandem Sharpless Asymmetric Dihydroxylation/lipase-catalyzed transesterification
Tetrahedron Letters, 1995Co-Authors: Aditya Sobti, Gary A. SulikowskiAbstract:Abstract An enantioselective synthesis of the trideoxy sugar 4-O- acetyl- l -rhodinopyranose ( 7 ) is described. A key feature of the synthetic strategy is a Sharpless Asymmetric Dihydroxylation followed by a lipase-mediated mono-esterification of the resultant diol ( 3→4→6 ).
Arumugam Sudalai - One of the best experts on this subject based on the ideXlab platform.
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enantioselective synthesis of guggultetrol and d ribo phytosphingosine tetraacetate via l proline catalyzed sequential α aminooxylation horner wardsworth emmons olefination Sharpless Asymmetric Dihydroxylation strategy
Tetrahedron-asymmetry, 2015Co-Authors: V. Venkataramasubramanian, Senthil B Kumar, Arumugam SudalaiAbstract:Abstract An efficient enantioselective synthesis of two bioactive molecules, that is, guggultetrol and d - ribo -phytosphingosine, is described with high enantioselectivity (>98% ee) starting from commercially available 1-hexadecanol. The synthesis comprises organocatalyzed sequential α-aminooxylation of an aldehyde followed by Horner–Wardsworth–Emmons olefination and Sharpless Asymmetric Dihydroxylation as the key chiral inducing steps. For both syntheses, γ-hydroxy-α,β-unsaturated ester serves as the common intermediate obtained from proline catalysis.
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Enantioselective synthesis of guggultetrol and d-ribo-phytosphingosine tetraacetate via l-proline catalyzed sequential α-aminooxylation/Horner–Wardsworth–Emmons olefination–Sharpless Asymmetric Dihydroxylation strategy
Tetrahedron-asymmetry, 2015Co-Authors: V. Venkataramasubramanian, B. Senthil Kumar, Arumugam SudalaiAbstract:Abstract An efficient enantioselective synthesis of two bioactive molecules, that is, guggultetrol and d - ribo -phytosphingosine, is described with high enantioselectivity (>98% ee) starting from commercially available 1-hexadecanol. The synthesis comprises organocatalyzed sequential α-aminooxylation of an aldehyde followed by Horner–Wardsworth–Emmons olefination and Sharpless Asymmetric Dihydroxylation as the key chiral inducing steps. For both syntheses, γ-hydroxy-α,β-unsaturated ester serves as the common intermediate obtained from proline catalysis.
Jhillu S. Yadav - One of the best experts on this subject based on the ideXlab platform.
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First stereoselective total synthesis of seimatopolide A
Tetrahedron Letters, 2012Co-Authors: Gowravaram Sabitha, A. Yagundar Reddy, Jhillu S. YadavAbstract:The first stereoselective total synthesis of seimatopolide A (1) has been achieved. The key steps are Keck allylation, Sharpless Asymmetric Dihydroxylation, cross-, and ring-closing metathesis reactions.
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An Efficient Total Synthesisof (+)-Goniodiol
Synthesis, 2011Co-Authors: Gowravaram Sabitha, M. Bhikshapathi, N. Ranjith, N. Ashwini, Jhillu S. YadavAbstract:An efficient total synthesis of (+)-goniodiol was illustrated by using Carreira alkynylation and Sharpless Asymmetric Dihydroxylation as key steps.
Srivari Chandrasekhar - One of the best experts on this subject based on the ideXlab platform.
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Total Synthesis of (-)-Seimatopolide A.
ChemInform, 2014Co-Authors: Nerella Kavitha, Vemula Praveen Kumar, Cirandur Suresh Reddy, Srivari ChandrasekharAbstract:Title compound (I) is synthesized in a linear fashion with high yielding steps and utilizing Sharpless Asymmetric Dihydroxylation, Pd-catalyzed allylic reduction, and Kitas macrolactonization as the key steps.
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Total synthesis of (−)-seimatopolide A
Tetrahedron: Asymmetry, 2013Co-Authors: Nerella Kavitha, Vemula Praveen Kumar, Cirandur Suresh Reddy, Srivari ChandrasekharAbstract:Abstract The total synthesis of (−)-seimatopolide A is described in a linear fashion with high yielding steps. The key reactions include Lu’s isomerization, Sharpless Asymmetric Dihydroxylation and Kita’s macrolactonization.
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Stereoflexible total synthesis of (−)-epiquinamide
Tetrahedron Letters, 2009Co-Authors: Srivari Chandrasekhar, Bibhuti Bhusan Parida, Ch. RambabuAbstract:Hydroxy propiolate rearrangement to conjugated diene, Sharpless Asymmetric Dihydroxylation and one-pot quinolizine construction have been used as key steps in the total synthesis of (−)-epiquinamide.
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Synthetic studies on Ecteinascidin-743: synthesis of building blocks through Sharpless Asymmetric Dihydroxylation and aza-Michael reactions
Tetrahedron, 2006Co-Authors: Srivari Chandrasekhar, N. Ramakrishna Reddy, Y. Srinivasa RaoAbstract:A practical and an efficient synthesis of three building blocks of tetrahydroisoquinoline alkaloid Ecteinascidin-743 was accomplished, starting from readily available piperonal, 2-methyl anisole, and veratraldehyde. A combination of Vilsmeier-Haack reaction and Sharpless Asymmetric Dihydroxylation was employed for the synthesis of building blocks A and B whereas a Heck reaction in PEG-2000 and aza-Michael reactions were employed for the synthesis of building block C.
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An Efficient Synthesis of (-)-Deacetylanisomycin Starting from d-Tyrosine
Synthesis, 2002Co-Authors: Srivari Chandrasekhar, Tokala Ramachandar, M. Venkat ReddyAbstract:The antibiotic (-)-deacetylanisomycin was synthesized starting from D-tyrosine using Sharpless Asymmetric Dihydroxylation as a key reaction.