The Experts below are selected from a list of 315 Experts worldwide ranked by ideXlab platform
Yushi Feng - One of the best experts on this subject based on the ideXlab platform.
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origin of profound changes in powder properties during wetting and nucleation stages of high Shear wet granulation of microcrystalline cellulose
Powder Technology, 2011Co-Authors: Yushi FengAbstract:Abstract The aim of this work was to understand the evolution of powder tabletability and flowability during wetting and nucleation stages of high-Shear wet granulation (HSWG). Microcrystalline cellulose (MCC) was granulated with water using a high-Shear Process. Granule morphology, surface texture, size, porosity, specific surface area, tabletability, and flowability were characterized. MCC granulated with 5% water showed no change in tabletability but significantly improved flowability, corresponding to smoother surfaces and lower surface area. From 5% to 25% water, tabletability decreased by 1/4 but flowability remained unchanged. Granule shape and porosity remained unchanged while surfaces were smoothened, leading to decreased surface area. From 25% to 35% water, MCC granules became more round. There was another sharp decrease in tabletability but powder flowability remained unchanged. Forty-five percent of water led to more particle rounding and commencement of nucleation, which only slightly impacted tabletability and flowability. From 0% to 45% water, granule size decreased slightly and could not explain the significant changes in powder tabletability and flowability. Deteriorated tabletability was instead caused by surface smoothing, granule densification, and granule rounding. Enhanced powder flowability was caused mostly by surface smoothing with granule rounding as a minor contributor.
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origin of profound changes in powder properties during wetting and nucleation stages of high Shear wet granulation of microcrystalline cellulose
Powder Technology, 2011Co-Authors: Yushi FengAbstract:Abstract The aim of this work was to understand the evolution of powder tabletability and flowability during wetting and nucleation stages of high-Shear wet granulation (HSWG). Microcrystalline cellulose (MCC) was granulated with water using a high-Shear Process. Granule morphology, surface texture, size, porosity, specific surface area, tabletability, and flowability were characterized. MCC granulated with 5% water showed no change in tabletability but significantly improved flowability, corresponding to smoother surfaces and lower surface area. From 5% to 25% water, tabletability decreased by 1/4 but flowability remained unchanged. Granule shape and porosity remained unchanged while surfaces were smoothened, leading to decreased surface area. From 25% to 35% water, MCC granules became more round. There was another sharp decrease in tabletability but powder flowability remained unchanged. Forty-five percent of water led to more particle rounding and commencement of nucleation, which only slightly impacted tabletability and flowability. From 0% to 45% water, granule size decreased slightly and could not explain the significant changes in powder tabletability and flowability. Deteriorated tabletability was instead caused by surface smoothing, granule densification, and granule rounding. Enhanced powder flowability was caused mostly by surface smoothing with granule rounding as a minor contributor.
Yoshiaki Mukaida - One of the best experts on this subject based on the ideXlab platform.
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The Changes of the Surface Structures of Shear Layers in Shear Process
Landslides, 1998Co-Authors: Ryojiro Kishimoto, Yoshiaki MukaidaAbstract:The authors prepared Shear layers by various Shear displacement from 5 mm to 500 mm with a new trial direct Shear apparatus, and we observed the surfaces of the layers with an electron microscope . The structures of the surfaces changed correspondingly to the stages of the Shear.In the initial stages of the Shear, soil flakes composed with many soil particles were arranged at some angles to the surfaces. In consequence the surfaces were a little flat.In the creep stages, the soil flakes and the soil particles were flat arranged on the surfaces . In conseqence, the surfaces became so flat and polished as slickenside on which many traces of the displacements of the soil flakes and the soil particles were fromed in parallel with the Shear direction.
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The Changes of Soil Structure in Shear Process
Landslides, 1997Co-Authors: Ryojiro Kishimoto, Yoshiaki Mukaida, Kenji SatoAbstract:There are problems to be studied on the changes of the soil structures in Shear Processes on the case of long creep. We studied these problems with a new trial direct Shear apparatus and X-ray photographs.The characteristics of the apparatus are that one pair of an upper and a lower Shear boxes about 600mm long is equipped, and the maximum limit of Shear displacement of the lower box is 600mm.Each test was performed as below. X-ray contrast medium was injected in eight lines at a right angle to Shear direction into soil sample compacted in the apparatus.Then Shear test was performed by Shear displacement prescribed for each sample within from 15mm to 300mm. After the test, the soil structures were observed with X-ray photographs of them.The soil structures developed through three stages in the Shear Processes as below. In the initial stage, the contineous deformation in the direction of the sample thickness appears. In the next stage (failure stage), many small and local Shear failures appear everywhere in the sample. Then some of them connect to each other, and develop into a clear and thin Shear layer as long as full length of the sample. In the last stage (creep stage), some thin soil masses only in the layer relatively slip with long distances, and the result of this phenomenon, the Shear layer gradually changes into a creep layer.
Ryojiro Kishimoto - One of the best experts on this subject based on the ideXlab platform.
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The Changes of the Surface Structures of Shear Layers in Shear Process
Landslides, 1998Co-Authors: Ryojiro Kishimoto, Yoshiaki MukaidaAbstract:The authors prepared Shear layers by various Shear displacement from 5 mm to 500 mm with a new trial direct Shear apparatus, and we observed the surfaces of the layers with an electron microscope . The structures of the surfaces changed correspondingly to the stages of the Shear.In the initial stages of the Shear, soil flakes composed with many soil particles were arranged at some angles to the surfaces. In consequence the surfaces were a little flat.In the creep stages, the soil flakes and the soil particles were flat arranged on the surfaces . In conseqence, the surfaces became so flat and polished as slickenside on which many traces of the displacements of the soil flakes and the soil particles were fromed in parallel with the Shear direction.
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The Changes of Soil Structure in Shear Process
Landslides, 1997Co-Authors: Ryojiro Kishimoto, Yoshiaki Mukaida, Kenji SatoAbstract:There are problems to be studied on the changes of the soil structures in Shear Processes on the case of long creep. We studied these problems with a new trial direct Shear apparatus and X-ray photographs.The characteristics of the apparatus are that one pair of an upper and a lower Shear boxes about 600mm long is equipped, and the maximum limit of Shear displacement of the lower box is 600mm.Each test was performed as below. X-ray contrast medium was injected in eight lines at a right angle to Shear direction into soil sample compacted in the apparatus.Then Shear test was performed by Shear displacement prescribed for each sample within from 15mm to 300mm. After the test, the soil structures were observed with X-ray photographs of them.The soil structures developed through three stages in the Shear Processes as below. In the initial stage, the contineous deformation in the direction of the sample thickness appears. In the next stage (failure stage), many small and local Shear failures appear everywhere in the sample. Then some of them connect to each other, and develop into a clear and thin Shear layer as long as full length of the sample. In the last stage (creep stage), some thin soil masses only in the layer relatively slip with long distances, and the result of this phenomenon, the Shear layer gradually changes into a creep layer.
Zebing Xu - One of the best experts on this subject based on the ideXlab platform.
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Improved ductility of magnesium alloys by a simple Shear Process followed by annealing
Scripta Materialia, 2013Co-Authors: Hua Zhang, Guangsheng Huang, Lifei Wang, Hans Jørgen Roven, Zebing XuAbstract:Mg–3Al–1Zn (AZ31) alloy sheets were Processed at room temperature using a simple Shear Process followed by annealing. The basal texture intensity was drastically weakened and the basal pole tended to rotate 45° away from the rolling direction after simple Shearing. The simple Sheared and annealed sample exhibits larger fracture elongations regardless of directions and its Erichsen value increases by ∼53% compared with that of the as-received sheet. The microstructure evolution and properties were characterized and compared.
Jerry Y. Y. Heng - One of the best experts on this subject based on the ideXlab platform.
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Role of Surface Chemistry and Energetics in High Shear Wet Granulation
Industrial & Engineering Chemistry Research, 2011Co-Authors: Sarah E. Dilworth, Daryl R. Williams, Jerry Y. Y. HengAbstract:This article presents a detailed study of the role of solid state surface chemistry on the high Shear granulation performance of organic pharmaceutical solids. The sole effect of powder surface chemistry on granulation performance was investigated by coagglomerating untreated and silanized d-mannitol powder from a narrow sieve fraction in a high Shear Process. The wetting performance by polyvinylpyrrolidone (PVP) binder solutions was quantified using experimentally determined thermodynamic spreading coefficients, calculated from surface energy heterogeneity distributions obtained via inverse gas chromatography (IGC) measurements. Increases in binder wettability of the formulations correlated with increases in both granule size and compressive elastic moduli, which are attributed to an increase in interparticle contacts. In conclusion, starting materials surface chemistry plays a crucial role in final granule properties, even in highly agitated Processes such as high Shear granulation. The comprehensive ch...