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Sugato Banerjee - One of the best experts on this subject based on the ideXlab platform.
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Effect of Withinia Somnifera and Shilajit on Alcohol Addiction in Mice.
Pharmacognosy magazine, 2016Co-Authors: Priya Bansal, Sugato BanerjeeAbstract:Alcohol addiction is a social problem leading to both loss of health and economic prosperity among addicted individuals. Common properties of anti-addictive compounds include anti-anxiety, anticonvulsants, anti-depressant, and nootropic actions primarily through modulation of gamma-aminobutyric acid (GABA) and serotonergic systems. Here, we screen ashwagandha and shilajit known ethnopharmacologically as nervine tonic and adaptogenic herbs for possible anti-addictive potential. Effect of ashwagandha churna and shilajit was measured on ethanol withdrawal anxiety using elevated plus maze. Role of ashwagandha and shilajit on chronic ethanol consumption (21 days) was measured using two bottle choice protocol of voluntary drinking. We also measured the effect of the above herbs on corticohippocampal GABA, dopamine, and serotonin levels. Both ashwagandha and shilajit were found to reduce alcohol withdrawal anxiety in a dose-dependent manner. These herbs alone or in combination also decreased ethanol intake and increased water intake significantly after 21 days of chronic administration. Chronic administration of ashwagandha was found to significantly increase GABA and serotonin levels whereas shilajit altered cortico-hippocampal dopamine in mice. These central nervous system active herbs alone or in combination reduced both alcohol dependence and withdrawal thus showing promising anti-addictive potential. Withinia Somnifera alone and in combination with Shilajeet prevented ethanol withdrawal and alcohol addiction Abbreviations used: GABA: Gama aminobutyric acid, CNS: Central Nervous System, CPP:Condition place preference, DA: Dopamine, 5-HT: 5-hydroxytryptamine, NMDA:N-methyl-D-aspartate.
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Effect of withinia somnifera and shilajit on alcohol addiction in mice
Pharmacognosy Magazine, 2016Co-Authors: Priya Bansal, Sugato BanerjeeAbstract:Background: Alcohol addiction is a social problem leading to both loss of health and economic prosperity among addicted individuals. Common properties of anti-addictive compounds include anti-anxiety, anticonvulsants, anti-depressant, and nootropic actions primarily through modulation of gamma-aminobutyric acid (GABA) and serotonergic systems. Objective: Here, we screen ashwagandha and shilajit known ethnopharmacologically as nervine tonic and adaptogenic herbs for possible anti-addictive potential. Materials and Methods: Effect of ashwagandha churna and shilajit was measured on ethanol withdrawal anxiety using elevated plus maze. Role of ashwagandha and shilajit on chronic ethanol consumption (21 days) was measured using two bottle choice protocol of voluntary drinking. We also measured the effect of the above herbs on corticohippocampal GABA, dopamine, and serotonin levels. Results: Both ashwagandha and shilajit were found to reduce alcohol withdrawal anxiety in a dose-dependent manner. These herbs alone or in combination also decreased ethanol intake and increased water intake significantly after 21 days of chronic administration. Chronic administration of ashwagandha was found to significantly increase GABA and serotonin levels whereas shilajit altered cortico-hippocampal dopamine in mice. Conclusion: These central nervous system active herbs alone or in combination reduced both alcohol dependence and withdrawal thus showing promising anti-addictive potential. SUMMARY Withinia Somnifera alone and in combination with Shilajeet prevented ethanol withdrawal and alcohol addiction Abbreviations used: GABA: Gama aminobutyric acid, CNS: Central Nervous System, CPP:Condition place preference, DA: Dopamine, 5-HT: 5-hydroxytryptamine, NMDA:N-methyl-D-aspartate Sugato Banerjee
Priya Bansal - One of the best experts on this subject based on the ideXlab platform.
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Effect of Withinia Somnifera and Shilajit on Alcohol Addiction in Mice.
Pharmacognosy magazine, 2016Co-Authors: Priya Bansal, Sugato BanerjeeAbstract:Alcohol addiction is a social problem leading to both loss of health and economic prosperity among addicted individuals. Common properties of anti-addictive compounds include anti-anxiety, anticonvulsants, anti-depressant, and nootropic actions primarily through modulation of gamma-aminobutyric acid (GABA) and serotonergic systems. Here, we screen ashwagandha and shilajit known ethnopharmacologically as nervine tonic and adaptogenic herbs for possible anti-addictive potential. Effect of ashwagandha churna and shilajit was measured on ethanol withdrawal anxiety using elevated plus maze. Role of ashwagandha and shilajit on chronic ethanol consumption (21 days) was measured using two bottle choice protocol of voluntary drinking. We also measured the effect of the above herbs on corticohippocampal GABA, dopamine, and serotonin levels. Both ashwagandha and shilajit were found to reduce alcohol withdrawal anxiety in a dose-dependent manner. These herbs alone or in combination also decreased ethanol intake and increased water intake significantly after 21 days of chronic administration. Chronic administration of ashwagandha was found to significantly increase GABA and serotonin levels whereas shilajit altered cortico-hippocampal dopamine in mice. These central nervous system active herbs alone or in combination reduced both alcohol dependence and withdrawal thus showing promising anti-addictive potential. Withinia Somnifera alone and in combination with Shilajeet prevented ethanol withdrawal and alcohol addiction Abbreviations used: GABA: Gama aminobutyric acid, CNS: Central Nervous System, CPP:Condition place preference, DA: Dopamine, 5-HT: 5-hydroxytryptamine, NMDA:N-methyl-D-aspartate.
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Effect of withinia somnifera and shilajit on alcohol addiction in mice
Pharmacognosy Magazine, 2016Co-Authors: Priya Bansal, Sugato BanerjeeAbstract:Background: Alcohol addiction is a social problem leading to both loss of health and economic prosperity among addicted individuals. Common properties of anti-addictive compounds include anti-anxiety, anticonvulsants, anti-depressant, and nootropic actions primarily through modulation of gamma-aminobutyric acid (GABA) and serotonergic systems. Objective: Here, we screen ashwagandha and shilajit known ethnopharmacologically as nervine tonic and adaptogenic herbs for possible anti-addictive potential. Materials and Methods: Effect of ashwagandha churna and shilajit was measured on ethanol withdrawal anxiety using elevated plus maze. Role of ashwagandha and shilajit on chronic ethanol consumption (21 days) was measured using two bottle choice protocol of voluntary drinking. We also measured the effect of the above herbs on corticohippocampal GABA, dopamine, and serotonin levels. Results: Both ashwagandha and shilajit were found to reduce alcohol withdrawal anxiety in a dose-dependent manner. These herbs alone or in combination also decreased ethanol intake and increased water intake significantly after 21 days of chronic administration. Chronic administration of ashwagandha was found to significantly increase GABA and serotonin levels whereas shilajit altered cortico-hippocampal dopamine in mice. Conclusion: These central nervous system active herbs alone or in combination reduced both alcohol dependence and withdrawal thus showing promising anti-addictive potential. SUMMARY Withinia Somnifera alone and in combination with Shilajeet prevented ethanol withdrawal and alcohol addiction Abbreviations used: GABA: Gama aminobutyric acid, CNS: Central Nervous System, CPP:Condition place preference, DA: Dopamine, 5-HT: 5-hydroxytryptamine, NMDA:N-methyl-D-aspartate Sugato Banerjee
Aarti Sankhla - One of the best experts on this subject based on the ideXlab platform.
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Comparative efficacy of Shilajeet and gum guggal (commiphora mukul) in preventing diet induced hypercholesterolemia in wistar rats
Indian Journal of Clinical Biochemistry, 1992Co-Authors: Aarti Sankhla, P. N. Mathur, P. K. DashoraAbstract:Shilajeet, a polycrest ayurvedic drug hitherto unknown for its hypolipidemic effect has been shown to lower serum cholesterol, liver cholesterol, serum triglycerides and serum phosphlipids of wistar rats fed on a cholesterol (1%) supplemented diet, by 39, 55, 47 and 25 per cent respectively, when 0.2 per cent of it was incorporated in the diet. In comparison, gum guggal (2.0 per cent in the diet) lowered the serum cholesterol, liver cholesterol, serum triglycerides and serum phospholipids by 36, 60, 49 and 8 per cent respectively. The increase in HDL-cholesterol by Shilajeet was much higher (53%) compared to that by gum guggal (29%).
Kapil Deo Yadav - One of the best experts on this subject based on the ideXlab platform.
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Pharmaceutical Postulates for Standard Operative Procedures to Prepare SAHAJ VATI
International Journal of Pharmaceutical & Biological Archive, 2015Co-Authors: Kapil Deo YadavAbstract:Obesity is an important contributor of various non communicable disorders like diabetes, heart disease, osteoarthritis etc. in developed and developing country. In Ayurvedic science numerous herbs, metals and minerals are available for management of obesity as single agent or compound formulations. For the management of obesity, we selected Shilajeet, Guggul, Haridra and Chitrak form vast literature of Ayurveda and prepare vati named as Sahaj vati and develop standard operative process for their preparation. Before preparation of Sahaj vati, Shodhan of Shilajeet and Guggul was done and two batches of Sahaj vati was prepared having Shilajeet, Guggul, Haridra and Chitrak as main ingredients and seven bhavana of Agnimantha with slight modification of processing technology and tablets & vati was prepared for batch I and batch II respectively. In this way three samples of each batch were prepared. After Shodhan, 32.96 % and 72.80% of suddha Shilajeet and suddha Guggul was obtained from raw materials and after completion of process 1.052, 1.060 & 1.054 Kg and 0.559, 0.564, 0.572 Kg of Sahaj vati was prepared for batch I & II respectively. In this way total 3.166 and 1.695 Kg of Sahaj vati was prepared from 3.00 Kg of raw material in batch I and II respectively.
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Shilajeet for obesity a probable pharmacological postulate
International journal of research in ayurveda and pharmacy, 2015Co-Authors: Kapil Deo Yadav, Anand ChaudharyAbstract:Obesity, a multi - factorial disease caused by exce ssive accumulation of fat in adipose tissue causing impairment of routine health. It is measured in term of body mass index (BMI) and the person having more than 30 BMI is ge nerally considered as obese. Its prevalence has been increased with alarming speed over the past twenty years and recently World Health Organization (WHO) recognises it as a 'global epidemic'. Various etiological factors are concerned with pathogenesis of ob esity like energy business, serum level of iron, inflammation to adipose tissue, hypoxia etc. Shilajeet , an Ayurvedic medicines is exudates come out from rock during hot sunn y days and contains ma inly f ulvic, humic acid along wi th higher percentage of ir on. It is indicated for management of varieties of disorders like obesity, diabetes etc. as a single medicine or in combination with other herbs, metal and mineral. Shilajeet enhances energy business by improving activity of nicotinamide adenine dinucleoti de ( NADH ) dehydrogenases, succinate dehydrogenase ( SDH ) and cytochrome oxidase , enhances serum iron concentration and facilitates oxygenation to tissues by incre asing oxygen carrying capacity with facilitation of blood circulation to tissue. In this review paper it is being established that all these characters of Shilajeet may be probable reason for its effect on management of obesity.
Kamendra Singh - One of the best experts on this subject based on the ideXlab platform.
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Effect of Photoperiod in Advanced Breeding Lines of Soybean [Glycine Max (L.) Merrill]
Crop improvement, 2020Co-Authors: Kalyan Singh, Kamendra SinghAbstract:The present investigation was conducted during rabi and kharif season of 2008–09 at the Crop Research Centre, G.B. Pant University of Agriculture and Technology, Pantnagar, India. The objective of this investigation was assessment of the response of elite breeding line to different photoperiods, i.e. kharif and Rabi, because of Soybean is photosensitive crop as it responds to the critical day length of light. The experiment was carried out with 132 genotypes in Augmented Block Design (ABD) with five checks (JS 335, Shilajeet, PK 327, PS 1092 and PS 1225). In kharif season, three genotypes (ABL-28, ABL-30, and ABL-39) were found significantly superior for days to full flower, only two genotypes (ABL-49, ABL-50) for number of nodes per plant, 11 genotypes (ABL-6, ABL-10, ABL-4, ABL40, ABL-4, ABL-49, ABL-50, ABL-61, ABL-88, ABL-98 and ABL-122) for number of primary branches per plant and 15 genotypes (ABL-2, ABL-3, ABL-4, ABL-10, ABL-12, ABL-33, ABL-40, ABL-41, ABL-51, ABL-53, ABL-55, ABL-56, ABL-85 and ABL-103) for harvest index than their respective best checks Shilajeet, JS 335, PK 327 and PS1225, respectively. During kharif, seed yield per plant displayed highly significant and positive correlation with number of pods per plant, primary branches per plant, biological yield per plant, harvest index and yield per ha. (Kg.) whereas negative association with number of node per plant and in rabi seed yield per plant had highly significant positive correlation with number of pods per plant. Based on estimates of correlation between both seasons, significant correlation was observed between days to flower initiation (R1) in kharif season with days to seed initiation (R5) during rabi season, days to full flower (R2) during Kharif season with days to pod initiation (R3) and days to seed initiation (R5) in rabi, days to pod initiation (R3) in kharif with days to flower initiation (R1) and days to full flower (R2) in rabi, days to seed initiation (R5) in kharif with days to flower initiation (R1) in rabi and days to full seed (R6) in kharif season with days to flower initiation (R1) and days to full flower (R2) in rabi. Out of 137 genotypes which were studied during both the seasons, only 17 genotypes (including 13 breeding lines and 4 check varieties viz., ABL-1, ABL-3, ABL-12, ABL-13, ABL-19, ABL-23, ABL-28, ABL-39, ABL-40, ABL-41, ABL-53, ABL-87, and ABL-89 with four checks JS-335, Shilajeet, PK-327, PS-1092 got matured in both the season and considered to be photoinsensitive thus, can be further evaluated for stability parameter over the locations and years.