The Experts below are selected from a list of 648 Experts worldwide ranked by ideXlab platform
Falk Hiepe - One of the best experts on this subject based on the ideXlab platform.
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Shwartzman Phenomenon in a patient with active systemic lupus erythematosus preceding fatal disseminated intravascular coagulation.
Lupus, 2002Co-Authors: Gabriela Riemekasten, Sabine Ziemer, Thomas Häupl, C Melzer, K Loddenkemper, Steffen Hauptmann, G.-r. Burmester, Falk HiepeAbstract:The recurrence of widespread and diverse vascular lesions is a hallmark of systemic lupus erythematosus (SLE). Inflammatory and thrombotic mechanisms almost invariably associated with circulating antiphospholipid antibodies play a role in the pathogenesis of SLE-related vascular disease. Both mechanisms can coexist in the same patient. Vasculitis is most commonly induced by the local deposition of immune complexes. However, some SLE patients have an inflammatory complement-mediated vascular injury in the absence of immune complex deposition. We report on a fatal case of disseminated intravascular coagulation (DIC) in a young woman with active SLE. Hemorrhagic lesions due to localized intravascular coagulation (Shwartzman Phenomenon) preceded disseminated intravascular coagulation accompanied by disseminated cardiac necrosis. Immune complex 'independent' and other mechanisms of vascular injury and states of hypercoagulability will be discussed.
Gabriela Riemekasten - One of the best experts on this subject based on the ideXlab platform.
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Shwartzman Phenomenon in a patient with active systemic lupus erythematosus preceding fatal disseminated intravascular coagulation.
Lupus, 2002Co-Authors: Gabriela Riemekasten, Sabine Ziemer, Thomas Häupl, C Melzer, K Loddenkemper, Steffen Hauptmann, G.-r. Burmester, Falk HiepeAbstract:The recurrence of widespread and diverse vascular lesions is a hallmark of systemic lupus erythematosus (SLE). Inflammatory and thrombotic mechanisms almost invariably associated with circulating antiphospholipid antibodies play a role in the pathogenesis of SLE-related vascular disease. Both mechanisms can coexist in the same patient. Vasculitis is most commonly induced by the local deposition of immune complexes. However, some SLE patients have an inflammatory complement-mediated vascular injury in the absence of immune complex deposition. We report on a fatal case of disseminated intravascular coagulation (DIC) in a young woman with active SLE. Hemorrhagic lesions due to localized intravascular coagulation (Shwartzman Phenomenon) preceded disseminated intravascular coagulation accompanied by disseminated cardiac necrosis. Immune complex 'independent' and other mechanisms of vascular injury and states of hypercoagulability will be discussed.
Harry Sobotka - One of the best experts on this subject based on the ideXlab platform.
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PRODUCTION OF A REFRACTORY STATE AS CONCERNS THE Shwartzman Phenomenon BY THE IN- JECTIONS OF VENOM OF THE MOCCASIN SNAKE (ANCISTRODON PISCIVORUS)
2013Co-Authors: M. Peck, Harry SobotkaAbstract:In 1928 Shwartzman (1) described a Phenomenon of local skin reactivity to bacterial filtrates which was produced when intradermal injections of these filtrates were followed at a suitable interval by intravenous injections. This observation has been confirmed by several observers (2). Very early in his work Shwartzman noticed that all normal rabbits did not yield the Phenomenon. The number of negative animals within limits depended on the amount, concentration and the type of "agar washings " filtrates used. Therefore, in titrafing these "agar washings " filtrates and antisera by his method it was necessary to use groups of from three to five rabbits, in order to correct any error due to refractory animals. We conceived the idea of testing the reactivity of the rabbit skin to substances producing primary purpura to see if a relationship could be established between the intensity of the purpura produced and the susceptibility of the animals to the Shwartzman Phenomenon
Matthias Graw - One of the best experts on this subject based on the ideXlab platform.
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Sudden death in Sanarelli-Shwartzman Phenomenon with an unusual pathogen
Beitrage zur gerichtlichen Medizin, 1991Co-Authors: Matthias GrawAbstract:The classical generalized Sanarelli-Shwartzman Phenomenon (SSP) in animal experiments is induced by two conservative endotoxin injections. The experimental animals mostly die within 24 hours in irreversible shock. They show numerous microthrombi with as high fibrin content in the peripheral vessels of many organs (especially the kidneys) in the context of a consumption coagulopathy. In a 49-year-old man who died within one day of a condition associated with high fever, the clinical picture could be defined on the basis of the clinical and morphological findings as a human equivalent of SSP. The detection of a gram-positive bacterium (Diplococcus pneumoniae), which has been described as the causative organism of SSP only in a few exceptional cases, was noteworthy. The special features of the pathophysiology are described.
Thomas Häupl - One of the best experts on this subject based on the ideXlab platform.
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Shwartzman Phenomenon in a patient with active systemic lupus erythematosus preceding fatal disseminated intravascular coagulation.
Lupus, 2002Co-Authors: Gabriela Riemekasten, Sabine Ziemer, Thomas Häupl, C Melzer, K Loddenkemper, Steffen Hauptmann, G.-r. Burmester, Falk HiepeAbstract:The recurrence of widespread and diverse vascular lesions is a hallmark of systemic lupus erythematosus (SLE). Inflammatory and thrombotic mechanisms almost invariably associated with circulating antiphospholipid antibodies play a role in the pathogenesis of SLE-related vascular disease. Both mechanisms can coexist in the same patient. Vasculitis is most commonly induced by the local deposition of immune complexes. However, some SLE patients have an inflammatory complement-mediated vascular injury in the absence of immune complex deposition. We report on a fatal case of disseminated intravascular coagulation (DIC) in a young woman with active SLE. Hemorrhagic lesions due to localized intravascular coagulation (Shwartzman Phenomenon) preceded disseminated intravascular coagulation accompanied by disseminated cardiac necrosis. Immune complex 'independent' and other mechanisms of vascular injury and states of hypercoagulability will be discussed.