The Experts below are selected from a list of 3447 Experts worldwide ranked by ideXlab platform
Kuo Hung Huang - One of the best experts on this subject based on the ideXlab platform.
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clinicopathological differences in Signet Ring Cell adenocarcinoma between early and advanced gastric cancer
Gastric Cancer, 2019Co-Authors: Yi Chu Kao, Wen Liang Fang, Ruei Fang Wang, Muh Hwa Yang, Yi Ming Shyr, Kuo Hung HuangAbstract:Signet Ring Cell adenocarcinoma is a histological classification based on the WHO classification. The presence of this specific histological type is associated with a worse pathological appearance. The prognosis of Signet Ring Cell adenocarcinoma in gastric cancer patients after curative surgery is still under debate. From January 1988 to December 2012, a total of 2971 patients, including 819 early and 2152 advanced gastric cancer patients underwent curative resection for gastric cancer. Among them, there were 185 cases of Signet Ring Cell adenocarcinoma in early gastric cancer patients, while there were 570 cases in advanced gastric cancer patients. The overall incidence of Signet Ring Cell adenocarcinoma was 25.4%. Our results showed that the 5-year overall survival rates of early gastric cancer patients with Signet Ring Cell adenocarcinoma and non-Signet Ring Cell adenocarcinoma were 90.7 and 83.2%, respectively (P = 0.001). The 5-year disease-free survival rates of early gastric cancer patients with Signet Ring Cell adenocarcinoma and non-Signet Ring Cell adenocarcinoma were 87.4 and 81.6%, respectively (P = 0.003). The 5-year overall survival rates of advanced gastric cancer patients with Signet Ring Cell adenocarcinoma and non-Signet Ring Cell adenocarcinoma were 32.1 and 37.9%, respectively (P = 0.041). The 5-year disease-free survival rates of advanced gastric cancer patients with Signet Ring Cell adenocarcinoma and non-Signet Ring Cell adenocarcinoma were 28.6 and 35.2%, respectively (P = 0.037). Signet Ring Cell adenocarcinoma was an independent predictor for overall survival in advanced gastric cancer (P = 0.017). The clinical features and prognosis of Signet Ring Cell adenocarcinoma are different between early and advanced gastric cancer. Signet Ring Cell adenocarcinoma is a poor prognostic factor in advanced gastric cancer after curative resection.
Massimo Loda - One of the best experts on this subject based on the ideXlab platform.
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distinct molecular features of colorectal carcinoma with Signet Ring Cell component and colorectal carcinoma with mucinous component
Modern Pathology, 2006Co-Authors: Shuji Ogino, Mohan Brahmandam, Mami Cantor, Chungdak Namgyal, Takako Kawasaki, Gregory J Kirkner, Jeffrey A Meyerhardt, Massimo LodaAbstract:Signet Ring Cell carcinoma and mucinous carcinoma are distinct subtypes of colorectal adenocarcinoma. The morphologic and molecular spectra of colorectal carcinomas with various Signet Ring Cell components and colorectal carcinomas with various mucinous components, compared to non-mucinous adenocarcinomas, have not been examined. The study groups consisted of 39 carcinomas with various Signet Ring Cell components ('the Signet group'), 167 carcinomas with various mucinous components ('the mucinous group'), and 457 nonmucinous adenocarcinoma. We visually estimated the amounts of Signet Ring Cell and mucinous components in tumors, and subclassified the Signet and mucinous groups according to the amount of each component ( or = 50%). We sequenced BRAF and KRAS, analyzed for microsatellite instability (MSI) and 18q loss of heterozygosity (LOH), and performed immunohistochemistry for TP53, cyclooxygenase-2 (COX2), MLH1, O-6-methylguanine DNA methyltransferase (MGMT), p16 (CDKN2A), and fatty acid synthase (FASN). Signet Ring Cell carcinoma (> or = 50% Signet Ring Cell tumors) and or = 50% mucinous tumors and or = 50% Signet Ring Cell or mucinous carcinoma, respectively. Signet Ring Cell carcinoma and mucinous carcinoma are related subtypes of colorectal adenocarcinoma, but have molecular features distinct from each other.
Jian Qiang Cai - One of the best experts on this subject based on the ideXlab platform.
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risk factors for lymph node metastasis in early gastric cancer with Signet Ring Cell carcinoma
Journal of Gastrointestinal Surgery, 2015Co-Authors: Chun Guang Guo, D B Zhao, Qian Liu, Zhi Xiang Zhou, Ping Zhao, Gui Qi Wang, Jian Qiang CaiAbstract:Background Gastrectomy was reported to be an excessive approach for early gastric cancer with Signet Ring Cell carcinoma. This study was conducted to explore the feasibility of endoscopic submucosal dissection for early gastric with Signet Ring Cell carcinoma.
Chunjung Lin - One of the best experts on this subject based on the ideXlab platform.
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early Signet Ring Cell gastric cancer
Digestive Diseases and Sciences, 2011Co-Authors: Chengtang Chiu, Chiajung Kuo, Tasen Yeh, Junte Hsu, Kenghao Liu, Chunnan Yeh, Tsannlong Hwang, Yiyin Jan, Chunjung LinAbstract:Background Signet Ring Cell carcinoma (SRC) is defined as a histological entity. The clinicopathological characteristics and prognosis of gastric SRC remain controversial.
K W Ryu - One of the best experts on this subject based on the ideXlab platform.
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risk factors for lymph node metastasis in patients with early gastric cancer and Signet Ring Cell histology
British Journal of Surgery, 2010Co-Authors: J H Lee, I J Choi, M C Kook, Byungho Nam, Youngwoo Kim, K W RyuAbstract:Background: Early gastric cancer with Signet Ring Cell histology has been reported as a favourable histological type. The aim of this study was to identify risk factors associated with lymph node metastasis in patients with this type of early gastric cancer. Methods: A cross-sectional study of patients with early gastric cancer with differentiated and Signet Ring Cell histology undergoing surgery was conducted. Risk factors were evaluated using multiple logistic regression analysis with odds ratios and 95 per cent confidence intervals. Results: In 1362 patients undergoing gastrectomy for early gastric cancer, the rate of lymph node metastasis was similar for tumours with Signet Ring Cell and differentiated histological findings (10·7 versus 9·0 per cent respectively; P = 0·307). Logistic regression analysis showed that depth of tumour invasion was predictive of lymph node metastasis in patients with Signet Ring Cell histology (P < 0·001). Tumour size was not associated with lymph node metastasis in either univariable or multivariable analysis. Lesions smaller than 2 cm were not uncommon in patients with Signet Ring Cell gastric tumours and lymph node metastases (six of 48; 13 per cent). Conclusion: Patients with early gastric cancer with Signet Ring Cell-type histology are probably best treated by gastrectomy with lymph node dissection. Copyright © 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
