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Michele Carbone - One of the best experts on this subject based on the ideXlab platform.

  • The relationship between Simian virus 40 and mesothelioma.
    Current opinion in pulmonary medicine, 2008
    Co-Authors: Zeyana Rivera, Harvey I Pass, Oriana Strianese, Pietro Bertino, Haining Yang, Michele Carbone
    Abstract:

    Purpose of reviewSimian virus 40 is present in some human malignant mesotheliomas. The evidence in favor and against a pathogenic role of Simian virus 40 in malignant mesothelioma is discussed in this review.Recent findingsWhen Simian virus 40 is injected intracardially into hamsters, 60% develop an

  • Simian virus 40 like dna sequences in human pleural mesothelioma
    Oncogene, 1994
    Co-Authors: Michele Carbone, Harvey I Pass, Paola Rizzo, M Marinetti, M Di Muzio, Daphne J Y Mew, Arthur S Levine, Antonio Procopio
    Abstract:

    Mesotheliomas are pleural, pericardial, or peritoneal neoplasms frequently associated with asbestos exposure, and it is estimated that over the next twenty years up to 80,000 new cases are expected in the USA alone. We found Simian virus 40-like DNA sequences in 29 of 48 mesotheliomas studied (60%) and demonstrated Simian virus large-T antigen expression in 13 of 16 specimens. The matching lung samples did not contain Simian virus 40-like sequences; however, they contained asbestos. These findings are to our knowledge the first demonstration of a physical link between DNA virus-like sequences and human mesothelioma. We suggest that a Simian virus 40-like virus may act independently or as a co-carcinogen with asbestos. Moreover, the selective large T antigen expression by mesothelioma and not by the surrounding pulmonary parenchyma may have both diagnostic and therapeutic implications.

Harvey I Pass - One of the best experts on this subject based on the ideXlab platform.

  • The relationship between Simian virus 40 and mesothelioma.
    Current opinion in pulmonary medicine, 2008
    Co-Authors: Zeyana Rivera, Harvey I Pass, Oriana Strianese, Pietro Bertino, Haining Yang, Michele Carbone
    Abstract:

    Purpose of reviewSimian virus 40 is present in some human malignant mesotheliomas. The evidence in favor and against a pathogenic role of Simian virus 40 in malignant mesothelioma is discussed in this review.Recent findingsWhen Simian virus 40 is injected intracardially into hamsters, 60% develop an

  • Simian virus 40 like dna sequences in human pleural mesothelioma
    Oncogene, 1994
    Co-Authors: Michele Carbone, Harvey I Pass, Paola Rizzo, M Marinetti, M Di Muzio, Daphne J Y Mew, Arthur S Levine, Antonio Procopio
    Abstract:

    Mesotheliomas are pleural, pericardial, or peritoneal neoplasms frequently associated with asbestos exposure, and it is estimated that over the next twenty years up to 80,000 new cases are expected in the USA alone. We found Simian virus 40-like DNA sequences in 29 of 48 mesotheliomas studied (60%) and demonstrated Simian virus large-T antigen expression in 13 of 16 specimens. The matching lung samples did not contain Simian virus 40-like sequences; however, they contained asbestos. These findings are to our knowledge the first demonstration of a physical link between DNA virus-like sequences and human mesothelioma. We suggest that a Simian virus 40-like virus may act independently or as a co-carcinogen with asbestos. Moreover, the selective large T antigen expression by mesothelioma and not by the surrounding pulmonary parenchyma may have both diagnostic and therapeutic implications.

Antonio Procopio - One of the best experts on this subject based on the ideXlab platform.

  • Simian virus 40 like dna sequences in human pleural mesothelioma
    Oncogene, 1994
    Co-Authors: Michele Carbone, Harvey I Pass, Paola Rizzo, M Marinetti, M Di Muzio, Daphne J Y Mew, Arthur S Levine, Antonio Procopio
    Abstract:

    Mesotheliomas are pleural, pericardial, or peritoneal neoplasms frequently associated with asbestos exposure, and it is estimated that over the next twenty years up to 80,000 new cases are expected in the USA alone. We found Simian virus 40-like DNA sequences in 29 of 48 mesotheliomas studied (60%) and demonstrated Simian virus large-T antigen expression in 13 of 16 specimens. The matching lung samples did not contain Simian virus 40-like sequences; however, they contained asbestos. These findings are to our knowledge the first demonstration of a physical link between DNA virus-like sequences and human mesothelioma. We suggest that a Simian virus 40-like virus may act independently or as a co-carcinogen with asbestos. Moreover, the selective large T antigen expression by mesothelioma and not by the surrounding pulmonary parenchyma may have both diagnostic and therapeutic implications.

Richard Grant - One of the best experts on this subject based on the ideXlab platform.

  • Identification of novel Simian endogenous retroviruses that are indistinguishable from Simian retrovirus (SRV) on current SRV diagnostic assays.
    Journal of medical primatology, 2017
    Co-Authors: Richard Grant, Robin Watanabe, Brandon F. Keele, La Rene Kuller, Alex Perret, Jeremy Smedley
    Abstract:

    Simian betaretroviruses include the well-known exogenous Simian retroviruses (SRV-1 through SRV-8), and some closely related Simian endogenous retroviruses (SERV). Here, we characterized two new viral genomes, which appear to represent novel SERVs but have characteristics of both SRV and SERV highlighting the need to develop new assays providing molecular and serologic differentiation of SERV and SRV to avoid false positives.

  • Unique pattern of enzootic primate viruses in Gibraltar macaques.
    Emerging Infectious Diseases, 2008
    Co-Authors: Gregory A Engel, Mark Pizarro, Eric K. Shaw, John Cortes, Richard Grant, Douglas L. Cohn, Agustin Fuentes, Nicholas W. Lerche, Peter A. Barry, Lisa Jones-engel
    Abstract:

    Because Gibraltar's macaques (Macaca sylvanus) have frequent contact with humans, we assayed 79 macaques for antibodies to enzootic primate viruses. All macaques were seronegative for herpesvirus B, Simian T-cell lymphotropic virus, Simian retrovirus, Simian immunodeficiency virus, and rhesus cytomegalovirus. Seroprevalence of Simian foamy virus reached 88% among adult animals.

  • temple monkeys and health implications of commensalism kathmandu nepal
    Emerging Infectious Diseases, 2006
    Co-Authors: Lisa Jonesengel, Richard Grant, Jonathan S Allan, Gregory A Engel, Peter A. Barry, John E Heidrich, Mukesh K Chalise, Narayan Poudel, Raphael P Viscidi, Randall C. Kyes
    Abstract:

    The threat of zoonotic transmission of infectious agents at monkey temples highlights the necessity of investigating the prevalence of enzootic infectious agents in these primate populations. Biological samples were collected from 39 rhesus macaques at the Swoyambhu Temple and tested by enzyme-linked immunosorbent assay, Western blot, polymerase chain reaction, or combination of these tests for evidence of infection with rhesus cytomegalovirus (RhCMV), Cercopithecine herpesvirus 1 (CHV-1), Simian virus 40 (SV40), Simian retrovirus (SRV), Simian T-cell lymphotropic virus (STLV), Simian immunodeficiency virus (SIV), and Simian foamy virus (SFV). Antibody seroprevalence was 94.9% to RhCMV (37/39), 89.7% to SV40 (35/39), 64.1% to CHV-1 (25/39), and 97.4% to SFV (38/39). Humans who come into contact with macaques at Swoyambhu risk exposure to enzootic primateborne viruses. We discuss implications for public health and primate management strategies that would reduce contact between humans and primates.

  • prevalence of enzootic Simian viruses among urban performance monkeys in indonesia
    Tropical Medicine & International Health, 2005
    Co-Authors: Michael A Schillaci, Yasmina Paramastri, Jonathan S Allan, Robin Watanabe, Randall C. Kyes, Entang Iskandar, Lisa Jonesengel, Gregory A Engel, Brenda Wilson, Richard Grant
    Abstract:

    populations. Global travel and tourism bring ever-increasing numbers of humans into contact with animals, increasing the likelihood of cross species transmission of infectious agents. Non-human primates come into contact with humans in a variety of contexts and may harbor infectious agents with zoonotic potential. We investigated the prevalence of infection with enzootic Simian viruses among 20 urban performance monkeys (Macaca fascicularis) in Jakarta, Indonesia. This report documents for the first time evidence of infection with four Simian viruses in urban performance monkeys. Simian foamy virus was detected by PCR in 52.9% of the macaques. Antibodies to Simian retrovirus were detected in 10.5% of the macaques. Antibodies to Cercopithecine Herpesvirus 1, were detected in 5.3% of the macaques. Similarly, antibodies to Simian T-cell lymphotropic virus were detected in 5.3% of the macaques. No evidence of infection with Simian immunodeficiency virus was detected in these macaques. These results suggest that urban performance monkeys are a reservoir for enzootic Simian viruses known to be capable of infecting humans.

Nicholas W. Lerche - One of the best experts on this subject based on the ideXlab platform.

  • Simultaneous detection of antibodies to five Simian viruses in nonhuman primates using recombinant viral protein based multiplex microbead immunoassays.
    Journal of virological methods, 2011
    Co-Authors: Qi Liao, Nicholas W. Lerche, Huishan Guo, Min Tang, Neal Touzjian, Jo Ann L. Yee
    Abstract:

    Routine screening for infectious agents is critical in establishing and maintaining specific pathogen free (SPF) nonhuman primate (NHP) colonies. More efficient, higher throughput, less costly reagent, and reduced sample consumption multiplex microbead immunoassays (MMIAs) using purified viral lysates have been developed previously to address some disadvantages of the traditional individual enzyme-linked immunosorbent assay (ELISA) methods. To overcome some of the technical and biosafety difficulties in preparing antigens from live viruses for viral lysate protein based MMIAs, novel MMIAs using recombinant glycoprotein D precursor (gD) protein of herpesvirus B and four viral gag proteins of Simian immunodeficiency virus (SIV), Simian T Cell lymphotropic virus (STLV), Simian foamy virus (SFV), and Simian betaretrovirus (SRV) as antigens have been developed in the current study. The data showed that the recombinant viral protein based MMIAs detected simultaneously antibodies to each of these five viruses with high sensitivity and specificity, and correlated well with viral lysate based MMIAs. Therefore, recombinant viral protein based MMIA is an effective and efficient routine screening method to determine the infection status of nonhuman primates.

  • Unique pattern of enzootic primate viruses in Gibraltar macaques.
    Emerging Infectious Diseases, 2008
    Co-Authors: Gregory A Engel, Mark Pizarro, Eric K. Shaw, John Cortes, Richard Grant, Douglas L. Cohn, Agustin Fuentes, Nicholas W. Lerche, Peter A. Barry, Lisa Jones-engel
    Abstract:

    Because Gibraltar's macaques (Macaca sylvanus) have frequent contact with humans, we assayed 79 macaques for antibodies to enzootic primate viruses. All macaques were seronegative for herpesvirus B, Simian T-cell lymphotropic virus, Simian retrovirus, Simian immunodeficiency virus, and rhesus cytomegalovirus. Seroprevalence of Simian foamy virus reached 88% among adult animals.

  • frequent Simian foamy virus infection in persons occupationally exposed to nonhuman primates
    Journal of Virology, 2004
    Co-Authors: William M. Switzer, Nicholas W. Lerche, Jo Ann L. Yee, Vinod Bhullar, Vedapuri Shanmugam, Mian Er Cong, Bharat Parekh, John J Ely, Roumiana S Boneva, Louisa E Chapman
    Abstract:

    The recognition that AIDS originated as a zoonosis heightens public health concerns associated with human infection by Simian retroviruses endemic in nonhuman primates (NHPs). These retroviruses include Simian immunodeficiency virus (SIV), Simian T-cell lymphotropic virus (STLV), Simian type D retrovirus (SRV), and Simian foamy virus (SFV). Although occasional infection with SIV, SRV, or SFV in persons occupationally exposed to NHPs has been reported, the characteristics and significance of these zoonotic infections are not fully defined. Surveillance for Simian retroviruses at three research centers and two zoos identified no SIV, SRV, or STLV infection in 187 participants. However, 10 of 187 persons (5.3%) tested positive for SFV antibodies by Western blot (WB) analysis. Eight of the 10 were males, and 3 of the 10 worked at zoos. SFV integrase gene (int) and gag sequences were PCR amplified from the peripheral blood lymphocytes available from 9 of the 10 persons. Phylogenetic analysis showed SFV infection originating from chimpanzees (n = 8) and baboons (n = 1). SFV seropositivity for periods of 8 to 26 years (median, 22 years) was documented for six workers for whom archived serum samples were available, demonstrating long-standing SFV infection. All 10 persons reported general good health, and secondary transmission of SFV was not observed in three wives available for WB and PCR testing. Additional phylogenetic analysis of int and gag sequences provided the first direct evidence identifying the source chimpanzees of the SFV infection in two workers. This study documents more frequent infection with SFV than with other Simian retroviruses in persons working with NHPs and provides important information on the natural history and species origin of these infections. Our data highlight the importance of studies to better define the public health implications of zoonotic SFV infections.

  • The search for human infection with Simian type D retroviruses.
    Journal of acquired immune deficiency syndromes, 1993
    Co-Authors: Walid Heneine, Nicholas W. Lerche, Woods T, Thomas J. Spira, Eley W, J. E. Kaplan, Rima F. Khabbaz
    Abstract:

    Evidence has recently been presented for an infection with a Simian type D retrovirus in a patient with AIDS and lymphoma. We tested for Simian type D infection in three groups of subjects: 375 patients with lymphoproliferative diseases (255 non-Hodgkin's, 88 Hodgkin's, and 32 chronic lymphoproliferative disease), of whom 75 were human immunodeficiency virus (HIV)-1 infected; seven persons with unexplained low CD4 lymphocyte counts with clinical conditions; and 45 blood donors, of whom 37 were human T-lymphocyte virus (HTLV)-I/II seroindeterminate and eight were HTLV-I/II and HIV-1 seronegative. Serum samples were screened for antibodies against Simian type D retroviruses by an enzyme immunoassay, and reactive samples were analyzed by Western blotting. None of the samples were seropositive, but eight (five from non-Hodgkin's and three from Hodgkin's lymphoma patients) were seroindeterminate. Polymerase chain reaction analysis of genomic DNA from peripheral blood lymphocytes of all eight of these patients was carried out using Simian type D gag generic primers with generic internal oligoprobing. All samples were negative. We conclude that Simian type D infection is rare among HIV-infected and noninfected lymphoma patients, persons with unexplained low CD4 counts, and persons with HTLV-seroindeterminate test results.