The Experts below are selected from a list of 204 Experts worldwide ranked by ideXlab platform
Michael Mattey - One of the best experts on this subject based on the ideXlab platform.
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Simple Diffusion is the primary mechanism for glucose uptake during the production phase of the Aspergillus niger citric acid process.
Biotechnology and Bioengineering, 2000Co-Authors: F. M. Wayman, Michael MatteyAbstract:Models for the known glucose transporters in Aspergillus niger and for Simple Diffusion of glucose through the hyphal membrane were prepared. The results from the models were compared with fermentation data from published studies on citric acid. It was found that the purely physical and uncontrolled process of Diffusion could explain the specific rate of glucose uptake observed during the production phase in several different types of fermentation. © 2000 John Wiley & Sons, Inc. Biotechnol Bioeng 67: 451–456, 2000.
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Simple Diffusion is the primary mechanism for glucose uptake during the production phase of the Aspergillus niger citric acid process.
Biotechnology and bioengineering, 2000Co-Authors: F. M. Wayman, Michael MatteyAbstract:Models for the known glucose transporters in Aspergillus niger and for Simple Diffusion of glucose through the hyphal membrane were prepared. The results from the models were compared with fermentation data from published studies on citric acid. It was found that the purely physical and uncontrolled process of Diffusion could explain the specific rate of glucose uptake observed during the production phase in several different types of fermentation.
Dong Han - One of the best experts on this subject based on the ideXlab platform.
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a green pathway different from Simple Diffusion in soft matter fast molecular transport within micro nanoscale multiphase porous systems
Nano Research, 2014Co-Authors: Jiantao Feng, Fang Wang, Xinxiao Han, Quanmei Sun, Wenda Hua, Peipei Chen, Tianwei Jing, Dong HanAbstract:Soft matter has attracted extensive attention due to its special physical/chemical properties and holds great promise in many applications. However, obtaining a detailed understanding of both complex fluid and mass transport in soft matter, especially in hierarchical porous media of biological tissues, still remains a huge challenge. Herein, inspired by fast tracer transport in loose connective tissues of living systems, we observed an interesting phenomenon of fast molecular transport in situ in an artificial hierarchical multiphase porous medium (a micrometer scale hydrophobic fiber network filled with nanometer scale hydrophilic porous medium), which was simply fabricated through electrospinning technology and polymerization. The transportation speed of molecules in the micrometer fiber network is larger than Simple Diffusion in nanometer media, which is better described by Fick’s law. We further proved that the phenomenon is based on the nanoconfined air/water/solid interface around the micrometer hydrophobic fibers. We focus on the key factors, referring to SA, (the confined multiphase area around the microfibers) and NG (the connectivity node degree of the skeletal portion in the nanometer hydrogel medium). Next, a quantitative parameter, VTCM (transport chance mean-value), was introduced to describe the molecular transport capability of the fiber network within hierarchical multiphase porous systems. These fundamental advances can be applied de novo to understand the process of so-called Simple Diffusion in biological systems, and even to re-describe many molecular events in biologically nanoconfined spaces. Open image in new window
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A ＂green pathway＂ different from Simple Diffusion in soft matter： Fast molecular transport within micro/nanoscale multiphase porous systems
Nano Research, 2014Co-Authors: Jiantao Feng, Fang Wang, Xinxiao Han, Quanmei Sun, Wenda Hua, Peipei Chen, Tianwei Jing, Dong HanAbstract:Soft matter has attracted extensive attention due to its special physical/chemical properties and holds great promise in many applications. However, obtaining a detailed understanding of both complex fluid and mass transport in soft matter, especially in hierarchical porous media of biological tissues, still remains a huge challenge. Herein, inspired by fast tracer transport in loose connective tissues of living systems, we observed an interesting phenomenon of fast molecular transport in situ in an artificial hierarchical multiphase porous medium (a micrometer scale hydrophobic fiber network filled with nanometer scale hydrophilic porous medium), which was simply fabricated through electrospinning technology and polymerization. The transportation speed of molecules in the micrometer fiber network is larger than Simple Diffusion in nanometer media, which is better described by Fick’s law. We further proved that the phenomenon is based on the nanoconfined air/water/solid interface around the micrometer hydrophobic fibers. We focus on the key factors, referring to SA, (the confined multiphase area around the microfibers) and NG (the connectivity node degree of the skeletal portion in the nanometer hydrogel medium). Next, a quantitative parameter, VTCM (transport chance mean-value), was introduced to describe the molecular transport capability of the fiber network within hierarchical multiphase porous systems. These fundamental advances can be applied de novo to understand the process of so-called Simple Diffusion in biological systems, and even to re-describe many molecular events in biologically nanoconfined spaces. Open image in new window
F. M. Wayman - One of the best experts on this subject based on the ideXlab platform.
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Simple Diffusion is the primary mechanism for glucose uptake during the production phase of the Aspergillus niger citric acid process.
Biotechnology and Bioengineering, 2000Co-Authors: F. M. Wayman, Michael MatteyAbstract:Models for the known glucose transporters in Aspergillus niger and for Simple Diffusion of glucose through the hyphal membrane were prepared. The results from the models were compared with fermentation data from published studies on citric acid. It was found that the purely physical and uncontrolled process of Diffusion could explain the specific rate of glucose uptake observed during the production phase in several different types of fermentation. © 2000 John Wiley & Sons, Inc. Biotechnol Bioeng 67: 451–456, 2000.
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Simple Diffusion is the primary mechanism for glucose uptake during the production phase of the Aspergillus niger citric acid process.
Biotechnology and bioengineering, 2000Co-Authors: F. M. Wayman, Michael MatteyAbstract:Models for the known glucose transporters in Aspergillus niger and for Simple Diffusion of glucose through the hyphal membrane were prepared. The results from the models were compared with fermentation data from published studies on citric acid. It was found that the purely physical and uncontrolled process of Diffusion could explain the specific rate of glucose uptake observed during the production phase in several different types of fermentation.
Jiantao Feng - One of the best experts on this subject based on the ideXlab platform.
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a green pathway different from Simple Diffusion in soft matter fast molecular transport within micro nanoscale multiphase porous systems
Nano Research, 2014Co-Authors: Jiantao Feng, Fang Wang, Xinxiao Han, Quanmei Sun, Wenda Hua, Peipei Chen, Tianwei Jing, Dong HanAbstract:Soft matter has attracted extensive attention due to its special physical/chemical properties and holds great promise in many applications. However, obtaining a detailed understanding of both complex fluid and mass transport in soft matter, especially in hierarchical porous media of biological tissues, still remains a huge challenge. Herein, inspired by fast tracer transport in loose connective tissues of living systems, we observed an interesting phenomenon of fast molecular transport in situ in an artificial hierarchical multiphase porous medium (a micrometer scale hydrophobic fiber network filled with nanometer scale hydrophilic porous medium), which was simply fabricated through electrospinning technology and polymerization. The transportation speed of molecules in the micrometer fiber network is larger than Simple Diffusion in nanometer media, which is better described by Fick’s law. We further proved that the phenomenon is based on the nanoconfined air/water/solid interface around the micrometer hydrophobic fibers. We focus on the key factors, referring to SA, (the confined multiphase area around the microfibers) and NG (the connectivity node degree of the skeletal portion in the nanometer hydrogel medium). Next, a quantitative parameter, VTCM (transport chance mean-value), was introduced to describe the molecular transport capability of the fiber network within hierarchical multiphase porous systems. These fundamental advances can be applied de novo to understand the process of so-called Simple Diffusion in biological systems, and even to re-describe many molecular events in biologically nanoconfined spaces. Open image in new window
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A ＂green pathway＂ different from Simple Diffusion in soft matter： Fast molecular transport within micro/nanoscale multiphase porous systems
Nano Research, 2014Co-Authors: Jiantao Feng, Fang Wang, Xinxiao Han, Quanmei Sun, Wenda Hua, Peipei Chen, Tianwei Jing, Dong HanAbstract:Soft matter has attracted extensive attention due to its special physical/chemical properties and holds great promise in many applications. However, obtaining a detailed understanding of both complex fluid and mass transport in soft matter, especially in hierarchical porous media of biological tissues, still remains a huge challenge. Herein, inspired by fast tracer transport in loose connective tissues of living systems, we observed an interesting phenomenon of fast molecular transport in situ in an artificial hierarchical multiphase porous medium (a micrometer scale hydrophobic fiber network filled with nanometer scale hydrophilic porous medium), which was simply fabricated through electrospinning technology and polymerization. The transportation speed of molecules in the micrometer fiber network is larger than Simple Diffusion in nanometer media, which is better described by Fick’s law. We further proved that the phenomenon is based on the nanoconfined air/water/solid interface around the micrometer hydrophobic fibers. We focus on the key factors, referring to SA, (the confined multiphase area around the microfibers) and NG (the connectivity node degree of the skeletal portion in the nanometer hydrogel medium). Next, a quantitative parameter, VTCM (transport chance mean-value), was introduced to describe the molecular transport capability of the fiber network within hierarchical multiphase porous systems. These fundamental advances can be applied de novo to understand the process of so-called Simple Diffusion in biological systems, and even to re-describe many molecular events in biologically nanoconfined spaces. Open image in new window
Yasuhiko Tabata - One of the best experts on this subject based on the ideXlab platform.
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Generation of Type I Collagen Gradient in Polyacrylamide Hydrogels by a Simple Diffusion-Controlled Hydrolysis of Amide Groups
Materials, 2010Co-Authors: Masaya Yamamoto, Kaoru Yanase, Yasuhiko TabataAbstract:The objective of this study is to develop an easy and Simple Diffusion-controlled fabrication technique to generate the concentration gradient of biomolecules in hydrogels. Polyacrylamide (PAAm) hydrogels with a concentration gradient of type I collagen were prepared to evaluate the cell adhesion. The PAAm hydrogel was exposed to a gradient concentration of sodium hydroxide (NaOH) solution at 52 °C to generate that of carboxyl groups in the hydrogel. The carboxyl groups generated were chemically coupled with the amino groups of type I collagen to prepare the hydrogel with a concentration gradient of collagen immobilized. The attachment of L929 fibroblasts was evaluated for the collagen-immobilized hydrogel prepared. The amount gradient of carboxyl groups in the hydrogel increased with an increase in the NaOH concentration while the carboxyl groups gradient enabled to generate a gradient of collagen immobilized in the hydrogel. On the other hand, the number of fibroblasts adhered depended on the amount of collagen immobilized. These findings indicate that the adhesion behavior of cells is modified by the concentration gradient of biomolecule in the three-dimensional scaffold of cells.
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Generation of Type I Collagen Gradient in Polyacrylamide Hydrogels by a Simple Diffusion-Controlled Hydrolysis of
2010Co-Authors: Masaya Yamamoto, Kaoru Yanase, Yasuhiko TabataAbstract:Abstract: The objective of this study is to develop an easy and Simple Diffusion-controlled fabrication technique to generate the concentration gradient of biomolecules in hydrogels. Polyacrylamide (PAAm) hydrogels with a concentration gradient of type I collagen were prepared to evaluate the cell adhesion. The PAAm hydrogel was exposed to a gradient concentration of sodium hydroxide (NaOH) solution at 52 °C to generate that of carboxyl groups in the hydrogel. The carboxyl groups generated were chemically coupled with the amino groups of type I collagen to prepare the hydrogel with a concentration gradient of collagen immobilized. The attachment of L929 fibroblasts was evaluated for the collagen-immobilized hydrogel prepared. The amount gradient of carboxyl groups in the hydrogel increased with an increase in the NaOH concentration while the carboxyl groups gradient enabled to generate a gradient of collagen immobilized in the hydrogel. On the other hand, the number of fibroblasts adhered depended on the amount of collagen immobilized. These findings indicate that the adhesion behavior of cells is modified by the concentration gradient of biomolecule in the three-dimensional scaffold of cells.
