The Experts below are selected from a list of 210804 Experts worldwide ranked by ideXlab platform
Eugenia E Calle - One of the best experts on this subject based on the ideXlab platform.
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no association of single nucleotide Polymorphisms in one carbon metabolism genes with prostate cancer risk
Cancer Epidemiology Biomarkers & Prevention, 2008Co-Authors: Victoria L Stevens, Jeffrey T Talbot, Michael J Thun, Carmen Rodríguez, Eugenia E CalleAbstract:One-carbon metabolism mediates the interconversion of folates for the synthesis of precursors used in DNA synthesis, repair, and methylation. Inadequate folate nutrition or compromised metabolism can disrupt these processes and facilitate carcinogenesis. In this study, we investigated associations of 39 candidate single nucleotide Polymorphisms (SNP) in 9 one-carbon metabolism genes with risk of prostate cancer using 1,144 cases and 1,144 controls from the Cancer Prevention Study-II Nutrition Cohort. None of these SNPs were significantly associated with prostate cancer risk, either overall or in cases with advanced prostate cancer. Thus, our findings do not support the hypothesis that common genetic variation in one-carbon metabolism genes influences prostate cancer risk. (Cancer Epidemiol Biomarkers Prev 2008;17(12):3612–4)
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no association of single nucleotide Polymorphisms in one carbon metabolism genes with prostate cancer risk
Cancer Epidemiology Biomarkers & Prevention, 2008Co-Authors: Victoria L Stevens, Jeffrey T Talbot, Michael J Thun, Carmen Rodríguez, Eugenia E CalleAbstract:One-carbon metabolism mediates the interconversion of folates for the synthesis of precursors used in DNA synthesis, repair, and methylation. Inadequate folate nutrition or compromised metabolism can disrupt these processes and facilitate carcinogenesis. In this study, we investigated associations of 39 candidate single nucleotide Polymorphisms (SNP) in 9 one-carbon metabolism genes with risk of prostate cancer using 1,144 cases and 1,144 controls from the Cancer Prevention Study-II Nutrition Cohort. None of these SNPs were significantly associated with prostate cancer risk, either overall or in cases with advanced prostate cancer. Thus, our findings do not support the hypothesis that common genetic variation in one-carbon metabolism genes influences prostate cancer risk. (Cancer Epidemiol Biomarkers Prev 2008;17(12):3612–4)
Bjorn A Nexo - One of the best experts on this subject based on the ideXlab platform.
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multiple single nucleotide Polymorphisms on human chromosome 19q13 2 3 associate with risk of basal cell carcinoma
Cancer Epidemiology Biomarkers & Prevention, 2002Co-Authors: Eszter Rockenbauer, Mohammad Hedayati, Nicklas Raun Jacobsen, Ulla Vogel, Lawrence Grossman, Lars Bolund, Bjorn A NexoAbstract:In this paper, we present evidence that alleles of several Polymorphisms in the chromosomal region 19q13.2–3, encompassing the genes RAI and XPD , are associated with occurrence of basal cell carcinoma in Caucasian Americans. The association of one of these, RAI- intron1, is sufficiently strong to make mass significance unlikely ( P = 0.004, χ2). We interpret our combined data to indicate that a specific haplotype partly defined by the alleles of three single nucleotide Polymorphisms, RAI intron1G, RAI exon6T, and XPD exon 6C, is associated with a protective gene variant in a region spanning from XPD to ERCC1 .
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multiple single nucleotide Polymorphisms on human chromosome 19q13 2 3 associate with risk of basal cell carcinoma
Cancer Epidemiology Biomarkers & Prevention, 2002Co-Authors: Jiaoyang Yin, Eszter Rockenbauer, Mohammad Hedayati, Nicklas Raun Jacobsen, Ulla Vogel, Lawrence Grossman, Lars Bolund, Bjorn A NexoAbstract:In this paper, we present evidence that alleles of several Polymorphisms in the chromosomal region 19q13.2-3, encompassing the genes RAI and XPD, are associated with occurrence of basal cell carcinoma in Caucasian Americans. The association of one of these, RAI-intron1, is sufficiently strong to make mass significance unlikely (P = 0.004, chi(2)). We interpret our combined data to indicate that a specific haplotype partly defined by the alleles of three single nucleotide Polymorphisms, RAI intron1(G), RAI exon6(T), and XPD exon 6(C), is associated with a protective gene variant in a region spanning from XPD to ERCC1.
Ann-christine Syvänen - One of the best experts on this subject based on the ideXlab platform.
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Accessing genetic variation: Genotyping single nucleotide Polymorphisms
Nature Reviews Genetics, 2001Co-Authors: Ann-christine SyvänenAbstract:Understanding the relationship between genetic variation and biological function on a genomic scale is expected to provide fundamental new insights into the biology, evolution and pathophysiology of humans and other species. The hope that single nucleotide Polymorphisms (SNPs) will allow genes that underlie complex disease to be identified, together with progress in identifying large sets of SNPs, are the driving forces behind intense efforts to establish the technology for large-scale analysis of SNPs. New genotyping methods that are high throughput, accurate and cheap are urgently needed for gaining full access to the abundant genetic variation of organisms.
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from gels to chips minisequencing primer extension for analysis of point mutations and single nucleotide Polymorphisms
Human Mutation, 1999Co-Authors: Ann-christine SyvänenAbstract:From Gels to Chips: "Minisequencing" Primer Extension for Analysis of Point Mutations and Single Nucleotide Polymorphisms
Betsy Ferguson - One of the best experts on this subject based on the ideXlab platform.
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single nucleotide Polymorphisms snps are highly conserved in rhesus macaca mulatta and cynomolgus macaca fascicularis macaques
BMC Genomics, 2007Co-Authors: Summer L Street, Randall C Kyes, Richard Grant, Betsy FergusonAbstract:Background Macaca fascicularis (cynomolgus or longtail macaques) is the most commonly used non-human primate in biomedical research. Little is known about the genomic variation in cynomolgus macaques or how the sequence variants compare to those of the well-studied related species, Macaca mulatta (rhesus macaque). Previously we identified single nucleotide Polymorphisms (SNPs) in portions of 94 rhesus macaque genes and reported that Indian and Chinese rhesus had largely different SNPs. Here we identify SNPs from some of the same genomic regions of cynomolgus macaques (from Indochina, Indonesia, Mauritius and the Philippines) and compare them to the SNPs found in rhesus.
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single nucleotide Polymorphisms snps distinguish indian origin and chinese origin rhesus macaques macaca mulatta
BMC Genomics, 2007Co-Authors: Summer L Street, Betsy Ferguson, Hollis Wright, Carlo Pearson, Yibing Jia, Shaun L Thompson, Patrick Allibone, Christopher DubayAbstract:Background Rhesus macaques serve a critical role in the study of human biomedical research. While both Indian and Chinese rhesus macaques are commonly used, genetic differences between these two subspecies affect aspects of their behavior and physiology, including response to simian immunodeficiency virus (SIV) infection. Single nucleotide Polymorphisms (SNPs) can play an important role in both establishing ancestry and in identifying genes involved in complex diseases. We sequenced the 3' end of rhesus macaque genes in an effort to identify gene-based SNPs that could distinguish between Indian and Chinese rhesus macaques and aid in association analysis.
Victoria L Stevens - One of the best experts on this subject based on the ideXlab platform.
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no association of single nucleotide Polymorphisms in one carbon metabolism genes with prostate cancer risk
Cancer Epidemiology Biomarkers & Prevention, 2008Co-Authors: Victoria L Stevens, Jeffrey T Talbot, Michael J Thun, Carmen Rodríguez, Eugenia E CalleAbstract:One-carbon metabolism mediates the interconversion of folates for the synthesis of precursors used in DNA synthesis, repair, and methylation. Inadequate folate nutrition or compromised metabolism can disrupt these processes and facilitate carcinogenesis. In this study, we investigated associations of 39 candidate single nucleotide Polymorphisms (SNP) in 9 one-carbon metabolism genes with risk of prostate cancer using 1,144 cases and 1,144 controls from the Cancer Prevention Study-II Nutrition Cohort. None of these SNPs were significantly associated with prostate cancer risk, either overall or in cases with advanced prostate cancer. Thus, our findings do not support the hypothesis that common genetic variation in one-carbon metabolism genes influences prostate cancer risk. (Cancer Epidemiol Biomarkers Prev 2008;17(12):3612–4)
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no association of single nucleotide Polymorphisms in one carbon metabolism genes with prostate cancer risk
Cancer Epidemiology Biomarkers & Prevention, 2008Co-Authors: Victoria L Stevens, Jeffrey T Talbot, Michael J Thun, Carmen Rodríguez, Eugenia E CalleAbstract:One-carbon metabolism mediates the interconversion of folates for the synthesis of precursors used in DNA synthesis, repair, and methylation. Inadequate folate nutrition or compromised metabolism can disrupt these processes and facilitate carcinogenesis. In this study, we investigated associations of 39 candidate single nucleotide Polymorphisms (SNP) in 9 one-carbon metabolism genes with risk of prostate cancer using 1,144 cases and 1,144 controls from the Cancer Prevention Study-II Nutrition Cohort. None of these SNPs were significantly associated with prostate cancer risk, either overall or in cases with advanced prostate cancer. Thus, our findings do not support the hypothesis that common genetic variation in one-carbon metabolism genes influences prostate cancer risk. (Cancer Epidemiol Biomarkers Prev 2008;17(12):3612–4)
