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Villa Collar César - One of the best experts on this subject based on the ideXlab platform.
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Rebound Effect in the Misight Assessment Study Spain (Mass)
'Informa UK Limited', 2021Co-Authors: Ruiz Pomeda Alicia, Prieto Garrido, Francisco Luis, Hernández Verdejo, José Luis, Villa Collar CésarAbstract:Purpose: To investigate whether cessation of MiSight contact lens (CLs) wear for myopia control produces rebound effect. Material and Methods: This study recruited participants who had just completed the MASS Study, a two-year randomized clinical trial designed to assess the efficacy of MiSight® CLs versus distance Single Vision (SV) Spectacles in myopic children. To assess the rebound effect, axial length progression was taken into account in those children that continued one more year of follow-up. At this visit, children were divided into three groups: MiSight-C group, in which children from the original study group continued MiSight CLs wear for the duration of the study; MiSight-D group, in which children from the original study group discontinued MiSight CLs wear in the last year; and SV-C group, in which children from the original control group continued wearing Single-Vision Spectacles for the duration of the study. The last group was considered as the control group. Results: Of the 74 children who completed the MASS study, 55 children completed the 1-year follow-up and were included in the analysis. Thirteen children were included in the MiSight-C group, 18 in the MiSight-D group, and 24 in the Single Vision-C group. Axial length and myopia progression in the last year were 0.15± 0.11 mm, 0.22± 0.11 mm, 0.21± 0.10 mm and -0.37±0.44D, -0.46±0.39D and -0.55±0.45D for the three groups, respectively. No significant differences in axial elongation and myopia progression were found among the three groups of participants. Conclusions: Over a one-year period, neither myopia progression nor eye growth was faster for the subjects who discontinued MiSight contact lens wear compared to those who continued to wear MiSight contact lenses or those who continued to wear Single-Vision Spectacles, indicating no rebound effect with MiSight contact lenses for 2 years. ClinicalTrials.gov Identifier: NCT01917110.Sin financiación1.754 JCR (2019) Q3, 35/60 Ophthalmology0.822 SJR (2019) Q2, 41/124 OphthalmologyNo data IDR 2019UE
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Rebound Effect in the Misight Assessment Study Spain (Mass)
'Informa UK Limited', 2021Co-Authors: Ruiz Pomeda Alicia, Prieto Garrido, Francisco Luis, Hernández Verdejo, José Luis, Villa Collar CésarAbstract:Purpose: To investigate whether cessation of MiSight contact lens (CLs) wear for myopia control produces rebound effect. Material and Methods: This study recruited participants who had just completed the MASS Study, a two-year randomized clinical trial designed to assess the efficacy of MiSight® CLs versus distance Single Vision (SV) Spectacles in myopic children. To assess the rebound effect, axial length progression was taken into account in those children that continued one more year of follow-up. At this visit, children were divided into three groups: MiSight-C group, in which children from the original study group continued MiSight CLs wear for the duration of the study; MiSight-D group, in which children from the original study group discontinued MiSight CLs wear in the last year; and SV-C group, in which children from the original control group continued wearing Single-Vision Spectacles for the duration of the study. The last group was considered as the control group. Results: Of the 74 children who completed the MASS study, 55 children completed the 1-year follow-up and were included in the analysis. Thirteen children were included in the MiSight-C group, 18 in the MiSight-D group, and 24 in the Single Vision-C group. Axial length and myopia progression in the last year were 0.15± 0.11 mm, 0.22± 0.11 mm, 0.21± 0.10 mm and −0.37±0.44D, −0.46±0.39D and −0.55±0.45D for the three groups, respectively. No significant differences in axial elongation and myopia progression were found among the three groups of participants. Conclusions: Over a one-year period, neither myopia progression nor eye growth was faster for the subjects who discontinued MiSight contact lens wear compared to those who continued to wear MiSight contact lenses or those who continued to wear Single-Vision Spectacles, indicating no rebound effect with MiSight contact lenses for 2 years
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Light disturbance analysis in the controlled randomized clinical trial MiSight Assessment Study Spain (MASS)
'Elsevier BV', 2019Co-Authors: Ruiz Pomeda Alicia, Pérez Sánchez Belén, Prieto Garrido, Francisco Luis, Fernandes Paulo, Amorim De Sousa, Ana, González Méijome, José Manuel, Villa Collar CésarAbstract:Purpose To evaluate the perception of light disturbances (LD) in children wearing Dual Focus (DF) MiSight® contact lenses (CLs) for myopia control compared with children wearing Single Vision Spectacles (SV). Methods This was a randomized, controlled clinical trial involving subjects aged 8–12 with myopia of -0.75 to -4.00D and astigmatism
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MiSight Assessment Study Spain: A Comparison of Vision-Related Quality-of-Life Measures Between MiSight Contact Lenses and Single-Vision Spectacles
'Ovid Technologies (Wolters Kluwer Health)', 2018Co-Authors: Ruiz Pomeda Alicia, Pérez Sánchez Belén, Cañadas Suárez, María Del Pilar, Prieto Garrido, Francisco Luis, Gutiérrez-ortega Ramón, Villa Collar CésarAbstract:Recent research has shown that concentric contact lenses (CLs) can be a way to control the progression of myopia. The purpose of the current study was to compare Vision-related quality-of-life measures in children wearing distance Single-Vision (SV) Spectacles versus MiSight CLs, a specific concentric design for myopia control. Subjects aged 8 to 12 with myopia from -0.75 to -4.00 diopters (D) of sphere and astigmatism less than 1.00 D of cylinder were allocated to the lenses study group (MiSight) or control group (SV). A Pediatric Refractive Error Profile (PREP) questionnaire was administered at 12- and 24-month intervals to evaluate children's perceptions in overall Vision, near Vision, far distance Vision, symptoms, appearance, satisfaction, activities, academic performance, handling, and peer perceptions. The mean score of all items was calculated as the overall score. In total, 74 children completed the study: n=41 in the MiSight group and n=33 in the SV group. In the MiSight group, the ratings at 12 and 24 months for appearance, satisfaction, effect on activities, handling, and peer perceptions were significantly better than those given by children in the SV group (P
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Long-term efficacy of orthokeratology contact lens wear in controlling the progression of childhood myopia
'Informa UK Limited', 2017Co-Authors: Santodomingo-rubido Jacinto, Villa Collar César, Gutiérrez-ortega Ramón, Gilmartin Bernard, Sugimoto KeijiAbstract:Purpose: The primary outcome of this study is to compare the axial length growth of white European myopic children wearing orthokeratology contact lenses (OK) to a control group (CT) over a 7-year period. Methods: Subjects 6–12 years of age with myopia −0.75 to −4.00DS and astigmatism ≤1.00DC were prospectively allocated OK or distance Single-Vision Spectacles (SV) correction. Measurements of axial length (Zeiss IOLMaster), corneal topography, and cycloplegic refraction were taken at 6-month intervals over a 2-year period. Subjects were invited to return to the clinic approximately 5 years later (i.e., 7 years after the beginning of the study) for assessment of their ocular refractive and biometric components. The CT consisted of 4 SV and 12 subjects who switched from SV to soft contact lens wear after the initial 2 years of SV lens wear. Changes in axial length relative to baseline over a 7-year period were compared between groups. Results: Fourteen and 16 subjects from the OK and CT groups, respectively, were examined 6.7 ± 0.5 years after the beginning of the study. Statistically significant changes in the axial length were found over time and between groups (both p
Ramon Gutierrezortega - One of the best experts on this subject based on the ideXlab platform.
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long term efficacy of orthokeratology contact lens wear in controlling the progression of childhood myopia
Current Eye Research, 2017Co-Authors: Jacinto Santodomingorubido, Cesar Villacollar, Bernard Gilmartin, Ramon Gutierrezortega, Keiji SugimotoAbstract:Purpose: The primary outcome of this study is to compare the axial length growth of white European myopic children wearing orthokeratology contact lenses (OK) to a control group (CT) over a 7-year period. Methods: Subjects 6–12 years of age with myopia −0.75 to −4.00DS and astigmatism ≤1.00DC were prospectively allocated OK or distance Single-Vision Spectacles (SV) correction. Measurements of axial length (Zeiss IOLMaster), corneal topography, and cycloplegic refraction were taken at 6-month intervals over a 2-year period. Subjects were invited to return to the clinic approximately 5 years later (i.e., 7 years after the beginning of the study) for assessment of their ocular refractive and biometric components. The CT consisted of 4 SV and 12 subjects who switched from SV to soft contact lens wear after the initial 2 years of SV lens wear. Changes in axial length relative to baseline over a 7-year period were compared between groups. Results: Fourteen and 16 subjects from the OK and CT groups, respectively, were examined 6.7 ± 0.5 years after the beginning of the study. Statistically significant changes in the axial length were found over time and between groups (both p <0.001), but not for the time*group interaction (p = 0.125). The change in the axial length for the OK group was 22% (p = 0.328), 42% (p = 0.007), 40% (p = 0.020), 41% (p = 0.013), and 33% (p = 0.062) lower than the CT group following 6, 12, 18, 24, and 84 months of lens wear, respectively. Conclusion: A trend toward a reduction in the rate of axial elongation of the order of 33% was found in the OK group in comparison to the CT group following 7 years of lens wear.
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myopia control with orthokeratology contact lenses in spain refractive and biometric changes
Investigative Ophthalmology & Visual Science, 2012Co-Authors: Jacinto Santodomingorubido, Cesar Villacollar, Bernard Gilmartin, Ramon GutierrezortegaAbstract:PURPOSE. To compare axial length growth between white children with myopia wearing orthokeratology contact lenses (OK) and distance Single-Vision Spectacles (SV) over a 2-year period. METHODS. Subjects 6 to 12 years of age with myopia -0.75 to -4.00 diopters of sphere (DS) and astigmatism ≤1.00 diopters of cylinder (DC) were prospectively allocated OK or SV correction. Measurements of axial length (Zeiss IOLMaster), corneal topography, and cycloplegic refraction were taken at 6-month intervals. RESULTS. Thirty-one children were fitted with OK and 30 with SV. Following 24 months, axial length increased significantly over time for both the OK group (0.47 mm) and SV group (0.69 mm; P 0.05). Significantly greater corneal flattening was evident in the OK group for the flatter and steeper corneal powers and for corneal shape factor (all P ≤0.05). CONCLUSIONS. Orthokeratology contact lens wear reduces axial elongation in comparison to distance Single-Vision Spectacles in children.
Buckley, John G. - One of the best experts on this subject based on the ideXlab platform.
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Intermediate addition multifocals provide safe stair ambulation with adequate ‘short-term’ reading
'Wiley', 2015Co-Authors: Elliott, David B., Hotchkiss John, Scally, Andy J., Foster, Richard J., Buckley, John G.Abstract:YesPurpose: A recent randomised controlled trial indicated that providing long-term multifocal wearers with a pair of distance Single-Vision Spectacles for use outside the home reduced falls risk in active older people. However, it also found that participants disliked continually switching between using two pairs of glasses and adherence to the intervention was poor. In this study we determined whether intermediate addition multifocals (which could be worn most of the time inside and outside the home and thus avoid continual switching) could provide similar gait safety on stairs to distance Single Vision Spectacles whilst also providing adequate ‘short-term’ reading and near Vision. Methods: Fourteen healthy long-term multifocal wearers completed stair ascent and descent trials over a 3-step staircase wearing intermediate and full addition bifocals and progression-addition lenses (PALs) and Single-Vision distance Spectacles. Gait safety/caution was assessed using foot clearance measurements (toe on ascent, heel on descent) over the step edges and ascent and descent duration. Binocular near visual acuity, critical print size and reading speed were measured using Bailey-Lovie near charts and MNRead charts at 40 cm. Results: Gait safety/caution measures were worse with full addition bifocals and PALs compared to intermediate bifocals and PALs. The intermediate PALs provided similar gait ascent/descent measures to those with distance Single- Vision Spectacles. The intermediate addition PALs also provided good reading ability: Near word acuity and MNRead critical print size were better with the intermediate addition PALs than with the Single-Vision lenses (p < 0.0001), with a mean near visual acuity of 0.24 0.13 logMAR (~N5.5) which is satisfactory for most near Vision tasks when performed for a short period of time. Conclusions: The better ability to ‘spot read’ with the intermediate addition PALs compared to Single-Vision Spectacles suggests that elderly individuals might better comply with the use of intermediate addition PALs outside the home. A lack of difference in gait parameters for the intermediate addition PALs compared to distance Single-Vision Spectacles suggests they could be usefully used to help prevent falls in older well-adapted full addition PAL wearers. A randomised controlled trial to investigate the usefulness of intermediate multifocals in preventing falls seems warranted
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Multifocal Spectacles increase variability in toe clearance and risk of tripping in the elderly
2007Co-Authors: Buckley, John G., Elliott, David B., Johnson Louise, Scally, Andy J.Abstract:NoPURPOSE. Epidemiologic studies have indicated that elderly people who wear multifocal Spectacles have an increased risk of tripping, particularly on stairs. Yet no studies have experimentally examined how wearing multifocal Spectacles affects stair and step negotiation. The purpose of this study was to determine the effects of wearing multifocal compared with Single-distance Vision Spectacles on minimum toe clearance and risk of tripping during step negotiation in the elderly. METHODS. Nineteen healthy subjects (mean age, 71.4 years) performed a Single step up to a new level (heights, 7.5, 15, and 22 cm) while wearing multifocal (bifocals and progressive addition lenses) or Single-distance Vision Spectacles. Minimum horizontal and vertical toe clearance were assessed by analyzing data collected with a five-camera, three-dimensional motion-analysis system. RESULTS. There was no difference in mean minimum toe clearance in subjects when wearing multifocal compared with Single-distance Vision Spectacles. However, there was greater within-subject variability in vertical toe clearance when wearing multifocal Spectacles (variance ratio, 1.53; P = 0.0004). Subjects were also significantly more likely to trip when wearing multifocal compared with Single-Vision Spectacles (one-sided Fisher's exact test P = 0.025). CONCLUSIONS. Because of increased within-subject variability in vertical toe clearance when wearing multifocal Spectacles, elderly individuals may be at greater risk of falling when negotiating steps and stairs if they do not also consistently increase margins of safety (mean vertical toe clearance). This suggests that some elderly who are at high risk of falling may benefit from wearing Single-distance Vision rather than multifocal Spectacles when walking
Jacinto Santodomingorubido - One of the best experts on this subject based on the ideXlab platform.
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long term efficacy of orthokeratology contact lens wear in controlling the progression of childhood myopia
Current Eye Research, 2017Co-Authors: Jacinto Santodomingorubido, Cesar Villacollar, Bernard Gilmartin, Ramon Gutierrezortega, Keiji SugimotoAbstract:Purpose: The primary outcome of this study is to compare the axial length growth of white European myopic children wearing orthokeratology contact lenses (OK) to a control group (CT) over a 7-year period. Methods: Subjects 6–12 years of age with myopia −0.75 to −4.00DS and astigmatism ≤1.00DC were prospectively allocated OK or distance Single-Vision Spectacles (SV) correction. Measurements of axial length (Zeiss IOLMaster), corneal topography, and cycloplegic refraction were taken at 6-month intervals over a 2-year period. Subjects were invited to return to the clinic approximately 5 years later (i.e., 7 years after the beginning of the study) for assessment of their ocular refractive and biometric components. The CT consisted of 4 SV and 12 subjects who switched from SV to soft contact lens wear after the initial 2 years of SV lens wear. Changes in axial length relative to baseline over a 7-year period were compared between groups. Results: Fourteen and 16 subjects from the OK and CT groups, respectively, were examined 6.7 ± 0.5 years after the beginning of the study. Statistically significant changes in the axial length were found over time and between groups (both p <0.001), but not for the time*group interaction (p = 0.125). The change in the axial length for the OK group was 22% (p = 0.328), 42% (p = 0.007), 40% (p = 0.020), 41% (p = 0.013), and 33% (p = 0.062) lower than the CT group following 6, 12, 18, 24, and 84 months of lens wear, respectively. Conclusion: A trend toward a reduction in the rate of axial elongation of the order of 33% was found in the OK group in comparison to the CT group following 7 years of lens wear.
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myopia control with orthokeratology contact lenses in spain refractive and biometric changes
Investigative Ophthalmology & Visual Science, 2012Co-Authors: Jacinto Santodomingorubido, Cesar Villacollar, Bernard Gilmartin, Ramon GutierrezortegaAbstract:PURPOSE. To compare axial length growth between white children with myopia wearing orthokeratology contact lenses (OK) and distance Single-Vision Spectacles (SV) over a 2-year period. METHODS. Subjects 6 to 12 years of age with myopia -0.75 to -4.00 diopters of sphere (DS) and astigmatism ≤1.00 diopters of cylinder (DC) were prospectively allocated OK or SV correction. Measurements of axial length (Zeiss IOLMaster), corneal topography, and cycloplegic refraction were taken at 6-month intervals. RESULTS. Thirty-one children were fitted with OK and 30 with SV. Following 24 months, axial length increased significantly over time for both the OK group (0.47 mm) and SV group (0.69 mm; P 0.05). Significantly greater corneal flattening was evident in the OK group for the flatter and steeper corneal powers and for corneal shape factor (all P ≤0.05). CONCLUSIONS. Orthokeratology contact lens wear reduces axial elongation in comparison to distance Single-Vision Spectacles in children.
Bernard Gilmartin - One of the best experts on this subject based on the ideXlab platform.
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Clinical and Epidemiologic Research Myopia Control with Orthokeratology Contact Lenses in Spain: Refractive and Biometric Changes
2020Co-Authors: Bernard Gilmartin, César Villa-collar, Ramón Gutiérrez-ortega, Jacinto Santodomingo-rubidoAbstract:PURPOSE. To compare axial length growth between white children with myopia wearing orthokeratology contact lenses (OK) and distance Single-Vision Spectacles (SV) over a 2-year period. METHODS. Subjects 6 to 12 years of age with myopia À0.75 to À4.00 diopters of sphere (DS) and astigmatism 1.00 diopters of cylinder (DC) were prospectively allocated OK or SV correction. Measurements of axial length (Zeiss IOLMaster), corneal topography, and cycloplegic refraction were taken at 6-month intervals. RESULTS. Thirty-one children were fitted with OK and 30 with SV. Following 24 months, axial length increased significantly over time for both the OK group (0.47 mm) and SV group (0.69 mm; P < 0.001), with a significant interaction between time and group (P ¼ 0.05) reflecting a greater increase in the SV group. Significant differences in refraction were found over time, between groups and for the interaction between time and group for spherical (all P < 0.001) but not cylindrical components of refraction (all P > 0.05). Significantly greater corneal flattening was evident in the OK group for the flatter and steeper corneal powers and for corneal shape factor (all P 0.05). T he prevalence of myopia in young adolescents has increased substantially in recent decades and has approached 10 to 25% and 60 to 80% in industrialized societies of the West and East Asia, respectively. 1,2 Furthermore, high levels of myopia (i.e., À6.00 diopters [D]) are associated with a range of ocular pathologies, such as vitreous and retinal detachment, macular degeneration, and glaucoma. CONCLUSIONS. 9-11 Spectacle intervention does not appear to significantly affect the progression of human myopia. 12 Bifocal and progressive addition spectacle lens wear have shown very modest treatment effects in controlling myopia progression, 13-17 although the effect is enhanced in children with larger accommodative lags in conjunction with near esophoria, short reading distances, and low baseline myopia. 19 Whereas progressive addition lenses produced a slowing of progression that reached statistical significance, the effect was not considered to be clinically significant. There have been reports over several decades that gaspermeable contact lenses can slow myopia progression in children. 29 A well-conducted study showed that the control of myopia progression with gas-permeable contact lenses is attributable to the temporary reduction in myopia induced by corneal flattening. 34 assessed axial length changes in 35 Hong-Kong Chinese children 7 to 12 years of age fitted with orthokeratology lenses and compared the rate of change in axial length with a well-matched historical control group of 35 children wearing Single-Vision Spectacles. At the end of 24 months, axial length increased 0.25 mm more in the spectacle lens group compared with the orthokeratology group. A later study undertaken in the United States by Walline and coworkers 35 compared the growth of the eye in myopic From th
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long term efficacy of orthokeratology contact lens wear in controlling the progression of childhood myopia
Current Eye Research, 2017Co-Authors: Jacinto Santodomingorubido, Cesar Villacollar, Bernard Gilmartin, Ramon Gutierrezortega, Keiji SugimotoAbstract:Purpose: The primary outcome of this study is to compare the axial length growth of white European myopic children wearing orthokeratology contact lenses (OK) to a control group (CT) over a 7-year period. Methods: Subjects 6–12 years of age with myopia −0.75 to −4.00DS and astigmatism ≤1.00DC were prospectively allocated OK or distance Single-Vision Spectacles (SV) correction. Measurements of axial length (Zeiss IOLMaster), corneal topography, and cycloplegic refraction were taken at 6-month intervals over a 2-year period. Subjects were invited to return to the clinic approximately 5 years later (i.e., 7 years after the beginning of the study) for assessment of their ocular refractive and biometric components. The CT consisted of 4 SV and 12 subjects who switched from SV to soft contact lens wear after the initial 2 years of SV lens wear. Changes in axial length relative to baseline over a 7-year period were compared between groups. Results: Fourteen and 16 subjects from the OK and CT groups, respectively, were examined 6.7 ± 0.5 years after the beginning of the study. Statistically significant changes in the axial length were found over time and between groups (both p <0.001), but not for the time*group interaction (p = 0.125). The change in the axial length for the OK group was 22% (p = 0.328), 42% (p = 0.007), 40% (p = 0.020), 41% (p = 0.013), and 33% (p = 0.062) lower than the CT group following 6, 12, 18, 24, and 84 months of lens wear, respectively. Conclusion: A trend toward a reduction in the rate of axial elongation of the order of 33% was found in the OK group in comparison to the CT group following 7 years of lens wear.
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Orthokeratology vs. Spectacles: adverse events and discontinuations
Optometry and Vision Science, 2012Co-Authors: Jacinto Santodomingo-rubido, Bernard Gilmartin, César Villa-collar, Ramón Gutiérrez-ortegaAbstract:Purpose. To assess the relative clinical success of orthokeratology contact lenses (OK) and distance Single-Vision Spectacles (SV) in children in terms of incidences of adverse events and discontinuations over a 2-year period. Methods. Sixty-one subjects 6 to 12 years of age with myopia of - 0.75 to - 4.00DS and astigmatism =1.00DC were prospectively allocated OK or SV correction. Subjects were followed at 6-month intervals and advised to report to the clinic immediately should adverse events occur. Adverse events were categorized into serious, significant, and non-significant. Discontinuation was defined as cessation of lens wear for the remainder of the study. Results. Thirty-one children were corrected with OK and 30 with SV. A higher incidence of adverse events was found with OK compared with SV (p < 0.001). Nine OK subjects experienced 16 adverse events (7 significant and 9 non-significant). No adverse events were found in the SV group. Most adverse events were found between 6 and 12 months of lens wear, with 11 solely attributable to OK wear. Significantly more discontinuations were found with SV in comparison with OK (p < 0.05). Conclusions. The relatively low incidence of adverse events and discontinuations with OK is conducive for the correction of myopia in children with OK contact lenses.
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myopia control with orthokeratology contact lenses in spain refractive and biometric changes
Investigative Ophthalmology & Visual Science, 2012Co-Authors: Jacinto Santodomingorubido, Cesar Villacollar, Bernard Gilmartin, Ramon GutierrezortegaAbstract:PURPOSE. To compare axial length growth between white children with myopia wearing orthokeratology contact lenses (OK) and distance Single-Vision Spectacles (SV) over a 2-year period. METHODS. Subjects 6 to 12 years of age with myopia -0.75 to -4.00 diopters of sphere (DS) and astigmatism ≤1.00 diopters of cylinder (DC) were prospectively allocated OK or SV correction. Measurements of axial length (Zeiss IOLMaster), corneal topography, and cycloplegic refraction were taken at 6-month intervals. RESULTS. Thirty-one children were fitted with OK and 30 with SV. Following 24 months, axial length increased significantly over time for both the OK group (0.47 mm) and SV group (0.69 mm; P 0.05). Significantly greater corneal flattening was evident in the OK group for the flatter and steeper corneal powers and for corneal shape factor (all P ≤0.05). CONCLUSIONS. Orthokeratology contact lens wear reduces axial elongation in comparison to distance Single-Vision Spectacles in children.