The Experts below are selected from a list of 49752 Experts worldwide ranked by ideXlab platform
Jae Ho Byun - One of the best experts on this subject based on the ideXlab platform.
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Three-Dimensional Imaging of Hepatic Sinusoids in Mice Using Synchrotron Radiation Micro-Computed Tomography
2016Co-Authors: Yae Jin Yoon, Soeun Chang, Bo-kyeong Kang, Jae Ho Byun, Jaesung Park, Oh Youn Kim, Jae-hong Lim, Yun Huang, Yoon-keun Kim, Yong Song GhoAbstract:Hepatic Sinusoid, the smallest vessel in the liver, plays important roles in hepatic microcirculation. Although the structure of the hepatic Sinusoids affects diverse functions of the liver, little is known about morphological alterations in the Sinusoids under pathological conditions. In this study, we show that the structure of hepatic Sinusoids can be identified three-dimensionally in normal and carbon tetrachloride-injured mouse liver, using the absorption mode of synchrotron radiation micro-computed tomography. We observed that the hepatic Sinusoidal structure on tomographic slice images was similar to that on histological images of normal and acutely injured mice. Moreover, centrilobular necrosis and structural alterations of the Sinusoids in the necrotic region were detectable on tomographic slice and volume-rendered images of the acutely injured mice. Furthermore, quantitative analyses on 3D volume-rendered images of the injured Sinusoid revealed decrease in the volume of the Sinusoid and connectivity of the Sinusoidal network. Our results suggest that the use of synchrotron radiation micro-computed tomography may improve our understanding of the pathogenesis of hepatic diseases by detecting the hepatic Sinusoids and thei
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Three-dimensional imaging of hepatic Sinusoids in mice using synchrotron radiation micro-computed tomography.
PLOS ONE, 2013Co-Authors: Yae Jin Yoon, Soeun Chang, Bo-kyeong Kang, Jung Yun Huang, Jaesung Park, Jae Ho ByunAbstract:Hepatic Sinusoid, the smallest vessel in the liver, plays important roles in hepatic microcirculation. Although the structure of the hepatic Sinusoids affects diverse functions of the liver, little is known about morphological alterations in the Sinusoids under pathological conditions. In this study, we show that the structure of hepatic Sinusoids can be identified three-dimensionally in normal and carbon tetrachloride-injured mouse liver, using the absorption mode of synchrotron radiation micro-computed tomography. We observed that the hepatic Sinusoidal structure on tomographic slice images was similar to that on histological images of normal and acutely injured mice. Moreover, centrilobular necrosis and structural alterations of the Sinusoids in the necrotic region were detectable on tomographic slice and volume-rendered images of the acutely injured mice. Furthermore, quantitative analyses on 3D volume-rendered images of the injured Sinusoid revealed decrease in the volume of the Sinusoid and connectivity of the Sinusoidal network. Our results suggest that the use of synchrotron radiation micro-computed tomography may improve our understanding of the pathogenesis of hepatic diseases by detecting the hepatic Sinusoids and their alterations in three-dimensional structures of the damaged liver.
Hua Chen - One of the best experts on this subject based on the ideXlab platform.
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H (2013) High-resolution micro-CT for morphologic and quantitative assessment of the Sinusoid in human cavernous hemangioma of the liver
2016Co-Authors: Jinghao Duan, Hua ChenAbstract:Hepatic Sinusoid plays a vital role in human cavernous hemangioma of the liver (CHL), and its morphologic investigation facilitates the understanding of microcirculation mechanism and pathological change of CHL. However, precise anatomical view of the hepatic Sinusoid has been limited by the resolution and contrast available from existing imaging techniques. While liver biopsy has traditionally been the reliable method for the assessment of hepatic Sinusoids, the invasiveness and sampling error are its inherent limitations. In this study, imaging of CHL samples was performed using in-line phase-contrast imaging (ILPCI) technique with synchrotron radiation. ILPCI allowed clear visualization of soft tissues and revealed structural details that were invisible to conventional radiography. Combining the computed tomography (CT) technique, ILPCI-CT was used to acquire the high-resolution micro-CT images of CHL, and three dimensional (3D) microstructures of hepatic Sinusoids were provided for the morphologic depiction and quantitative assessment. Our study demonstrated that ILPCI-CT could substantially improve the radiographic contrast of CHL tissues in vitro with no contrast agent. ILPCI-CT yielded high-resolution micro-CT image of CHL sample at the micron scale, corresponding to information on actual structures revealed at histological section. The 3D visualization provided an excellent view of the hepatic Sinusoid. The accurate view of individual hepatic Sinusoid was achieved. The valuable morphological parameters of hepatic Sinusoids, such as thrombi, diameters, surface areas and volumes, were measured. These parameters were of great importance in the evaluation of CHL, and the
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High-Resolution Micro-CT for Morphologic and Quantitative Assessment of the Sinusoid in Human Cavernous Hemangioma of the Liver
PloS one, 2013Co-Authors: Jinghao Duan, Hua ChenAbstract:Hepatic Sinusoid plays a vital role in human cavernous hemangioma of the liver (CHL), and its morphologic investigation facilitates the understanding of microcirculation mechanism and pathological change of CHL. However, precise anatomical view of the hepatic Sinusoid has been limited by the resolution and contrast available from existing imaging techniques. While liver biopsy has traditionally been the reliable method for the assessment of hepatic Sinusoids, the invasiveness and sampling error are its inherent limitations. In this study, imaging of CHL samples was performed using in-line phase-contrast imaging (ILPCI) technique with synchrotron radiation. ILPCI allowed clear visualization of soft tissues and revealed structural details that were invisible to conventional radiography. Combining the computed tomography (CT) technique, ILPCI-CT was used to acquire the high-resolution micro-CT images of CHL, and three dimensional (3D) microstructures of hepatic Sinusoids were provided for the morphologic depiction and quantitative assessment. Our study demonstrated that ILPCI-CT could substantially improve the radiographic contrast of CHL tissues in vitro with no contrast agent. ILPCI-CT yielded high-resolution micro-CT image of CHL sample at the micron scale, corresponding to information on actual structures revealed at histological section. The 3D visualization provided an excellent view of the hepatic Sinusoid. The accurate view of individual hepatic Sinusoid was achieved. The valuable morphological parameters of hepatic Sinusoids, such as thrombi, diameters, surface areas and volumes, were measured. These parameters were of great importance in the evaluation of CHL, and they provided quantitative descriptors that characterized anatomical properties and pathological features of hepatic Sinusoids. The results highlight the high degree of sensitivity of the ILPCI-CT technique and demonstrate the feasibility of accurate visualization of hepatic Sinusoids. Moreover, there is a correlation between the CHL and the size or morphology of hepatic Sinusoids, which offers a potential use in noninvasive study and analysis of CHL.
Yae Jin Yoon - One of the best experts on this subject based on the ideXlab platform.
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Three-Dimensional Imaging of Hepatic Sinusoids in Mice Using Synchrotron Radiation Micro-Computed Tomography
2016Co-Authors: Yae Jin Yoon, Soeun Chang, Bo-kyeong Kang, Jae Ho Byun, Jaesung Park, Oh Youn Kim, Jae-hong Lim, Yun Huang, Yoon-keun Kim, Yong Song GhoAbstract:Hepatic Sinusoid, the smallest vessel in the liver, plays important roles in hepatic microcirculation. Although the structure of the hepatic Sinusoids affects diverse functions of the liver, little is known about morphological alterations in the Sinusoids under pathological conditions. In this study, we show that the structure of hepatic Sinusoids can be identified three-dimensionally in normal and carbon tetrachloride-injured mouse liver, using the absorption mode of synchrotron radiation micro-computed tomography. We observed that the hepatic Sinusoidal structure on tomographic slice images was similar to that on histological images of normal and acutely injured mice. Moreover, centrilobular necrosis and structural alterations of the Sinusoids in the necrotic region were detectable on tomographic slice and volume-rendered images of the acutely injured mice. Furthermore, quantitative analyses on 3D volume-rendered images of the injured Sinusoid revealed decrease in the volume of the Sinusoid and connectivity of the Sinusoidal network. Our results suggest that the use of synchrotron radiation micro-computed tomography may improve our understanding of the pathogenesis of hepatic diseases by detecting the hepatic Sinusoids and thei
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Three-dimensional imaging of hepatic Sinusoids in mice using synchrotron radiation micro-computed tomography.
PLOS ONE, 2013Co-Authors: Yae Jin Yoon, Soeun Chang, Bo-kyeong Kang, Jung Yun Huang, Jaesung Park, Jae Ho ByunAbstract:Hepatic Sinusoid, the smallest vessel in the liver, plays important roles in hepatic microcirculation. Although the structure of the hepatic Sinusoids affects diverse functions of the liver, little is known about morphological alterations in the Sinusoids under pathological conditions. In this study, we show that the structure of hepatic Sinusoids can be identified three-dimensionally in normal and carbon tetrachloride-injured mouse liver, using the absorption mode of synchrotron radiation micro-computed tomography. We observed that the hepatic Sinusoidal structure on tomographic slice images was similar to that on histological images of normal and acutely injured mice. Moreover, centrilobular necrosis and structural alterations of the Sinusoids in the necrotic region were detectable on tomographic slice and volume-rendered images of the acutely injured mice. Furthermore, quantitative analyses on 3D volume-rendered images of the injured Sinusoid revealed decrease in the volume of the Sinusoid and connectivity of the Sinusoidal network. Our results suggest that the use of synchrotron radiation micro-computed tomography may improve our understanding of the pathogenesis of hepatic diseases by detecting the hepatic Sinusoids and their alterations in three-dimensional structures of the damaged liver.
L. Almeida - One of the best experts on this subject based on the ideXlab platform.
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ICASSP - A background for Sinusoid based representation of voiced speech
ICASSP '86. IEEE International Conference on Acoustics Speech and Signal Processing, 1Co-Authors: J. Marques, L. AlmeidaAbstract:Sinusoid based models have been used in the last few years for high quality representation of voiced speech. In this paper we first review a theoretical basis for this kind of representation, and then introduce a spectral model for varying-frequency Sinusoids. This model is used for estimating the Sinusoid parameters end it is also intended for accurate representation of the spectrum of voiced speech. A time warping procedure is presented, which permits to reduce the overlap between high frequency spectral lines, with the purpose of improving their estimation.
Jinghao Duan - One of the best experts on this subject based on the ideXlab platform.
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H (2013) High-resolution micro-CT for morphologic and quantitative assessment of the Sinusoid in human cavernous hemangioma of the liver
2016Co-Authors: Jinghao Duan, Hua ChenAbstract:Hepatic Sinusoid plays a vital role in human cavernous hemangioma of the liver (CHL), and its morphologic investigation facilitates the understanding of microcirculation mechanism and pathological change of CHL. However, precise anatomical view of the hepatic Sinusoid has been limited by the resolution and contrast available from existing imaging techniques. While liver biopsy has traditionally been the reliable method for the assessment of hepatic Sinusoids, the invasiveness and sampling error are its inherent limitations. In this study, imaging of CHL samples was performed using in-line phase-contrast imaging (ILPCI) technique with synchrotron radiation. ILPCI allowed clear visualization of soft tissues and revealed structural details that were invisible to conventional radiography. Combining the computed tomography (CT) technique, ILPCI-CT was used to acquire the high-resolution micro-CT images of CHL, and three dimensional (3D) microstructures of hepatic Sinusoids were provided for the morphologic depiction and quantitative assessment. Our study demonstrated that ILPCI-CT could substantially improve the radiographic contrast of CHL tissues in vitro with no contrast agent. ILPCI-CT yielded high-resolution micro-CT image of CHL sample at the micron scale, corresponding to information on actual structures revealed at histological section. The 3D visualization provided an excellent view of the hepatic Sinusoid. The accurate view of individual hepatic Sinusoid was achieved. The valuable morphological parameters of hepatic Sinusoids, such as thrombi, diameters, surface areas and volumes, were measured. These parameters were of great importance in the evaluation of CHL, and the
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High-Resolution Micro-CT for Morphologic and Quantitative Assessment of the Sinusoid in Human Cavernous Hemangioma of the Liver
PloS one, 2013Co-Authors: Jinghao Duan, Hua ChenAbstract:Hepatic Sinusoid plays a vital role in human cavernous hemangioma of the liver (CHL), and its morphologic investigation facilitates the understanding of microcirculation mechanism and pathological change of CHL. However, precise anatomical view of the hepatic Sinusoid has been limited by the resolution and contrast available from existing imaging techniques. While liver biopsy has traditionally been the reliable method for the assessment of hepatic Sinusoids, the invasiveness and sampling error are its inherent limitations. In this study, imaging of CHL samples was performed using in-line phase-contrast imaging (ILPCI) technique with synchrotron radiation. ILPCI allowed clear visualization of soft tissues and revealed structural details that were invisible to conventional radiography. Combining the computed tomography (CT) technique, ILPCI-CT was used to acquire the high-resolution micro-CT images of CHL, and three dimensional (3D) microstructures of hepatic Sinusoids were provided for the morphologic depiction and quantitative assessment. Our study demonstrated that ILPCI-CT could substantially improve the radiographic contrast of CHL tissues in vitro with no contrast agent. ILPCI-CT yielded high-resolution micro-CT image of CHL sample at the micron scale, corresponding to information on actual structures revealed at histological section. The 3D visualization provided an excellent view of the hepatic Sinusoid. The accurate view of individual hepatic Sinusoid was achieved. The valuable morphological parameters of hepatic Sinusoids, such as thrombi, diameters, surface areas and volumes, were measured. These parameters were of great importance in the evaluation of CHL, and they provided quantitative descriptors that characterized anatomical properties and pathological features of hepatic Sinusoids. The results highlight the high degree of sensitivity of the ILPCI-CT technique and demonstrate the feasibility of accurate visualization of hepatic Sinusoids. Moreover, there is a correlation between the CHL and the size or morphology of hepatic Sinusoids, which offers a potential use in noninvasive study and analysis of CHL.
