The Experts below are selected from a list of 48783 Experts worldwide ranked by ideXlab platform
Jon M Grazer - One of the best experts on this subject based on the ideXlab platform.
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dispersion of calcium hydroxylapatite accumulations in the Skin Animal studies and clinical practices
Dermatologic Surgery, 2010Co-Authors: Robert Voigts, Dale Devore, Jon M GrazerAbstract:OBJECTIVES To describe a method whereby accumulated calcium hydroxylapatite (CaHA) can be dispersed into surrounding dermal or subcutaneous tissues by local injection of an aqueous solution followed by vigorous massage. DESIGN Researchers examined three possible antidotes to correct CaHA nodularity: massage alone, injection of saline into the site followed by massage, and injection of sterile water into the site followed by massage. During the 21-day study period of CaHA alone and CaHA mixed with adjuvant, researchers observed inflammatory reactions on Day 0 and Day 21. Antidote efficacy was observed immediately after injection on Day 0 and again on Day 21. RESULTS The sterile water and CaHA+adjuvant saline solutions combined with massage demonstrated significantly less nodularity. In addition, CaHA+adjuvant blebs (nodules) were flattened out more upon massage than were CaHA-only blebs, a finding consistent with deliberate decrease in elasticity of CaHA alone. Clinical experience results also demonstrated that use of lidocaine injection followed by massage resulted in dispersion of CaHA accumulation and restoration of even contours. CONCLUSIONS The protocol described here may represent a mechanism by which improper placement of CaHA in facial tissues may be effectively corrected without the need for excision or injection of steroids. CONCLUSIONS Robert Voigts is a paid employee of Bioform Medical. Dr. DeVore is a consultant to Bioform Medical with stock options. Dr. Grazer is a paid consultant for Bioform. David J. Howell, PhD, RRT (San Francisco, CA) contributed to the writing of this manuscript.
Wolfgang Friess - One of the best experts on this subject based on the ideXlab platform.
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Reconstructed Skin models as emerging tools for drug absorption studies.
Expert Opinion on Drug Metabolism & Toxicology, 2013Co-Authors: Sarah Küchler, Kay Strüver, Wolfgang FriessAbstract:Introduction: As humans can come into contact with xenobiotics intentionally or accidentally, knowledge about the Skin absorption of these substances is crucial and requires reliable models and test procedures. Animal experiments should be avoided whenever possible, instead of making the use of in vitro systems. Furthermore, due to limited availability of normal and especially diseased human Skin, alternative test systems such as reconstructed Skin models are urgently required. Areas covered: This article discusses the advantages and limitations of excised human Skin, Animal Skin and reconstructed Skin models for absorption testing in vitro. Furthermore, the authors also describe the standard procedure for Skin absorption testing and give an excursion to the applicability of artificial membranes. Finally, the article highlights the progress in the development of reconstructed disease models and provides an extensive overview about past and ongoing research in this field. Expert opinion: The development an...
Robert Voigts - One of the best experts on this subject based on the ideXlab platform.
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dispersion of calcium hydroxylapatite accumulations in the Skin Animal studies and clinical practices
Dermatologic Surgery, 2010Co-Authors: Robert Voigts, Dale Devore, Jon M GrazerAbstract:OBJECTIVES To describe a method whereby accumulated calcium hydroxylapatite (CaHA) can be dispersed into surrounding dermal or subcutaneous tissues by local injection of an aqueous solution followed by vigorous massage. DESIGN Researchers examined three possible antidotes to correct CaHA nodularity: massage alone, injection of saline into the site followed by massage, and injection of sterile water into the site followed by massage. During the 21-day study period of CaHA alone and CaHA mixed with adjuvant, researchers observed inflammatory reactions on Day 0 and Day 21. Antidote efficacy was observed immediately after injection on Day 0 and again on Day 21. RESULTS The sterile water and CaHA+adjuvant saline solutions combined with massage demonstrated significantly less nodularity. In addition, CaHA+adjuvant blebs (nodules) were flattened out more upon massage than were CaHA-only blebs, a finding consistent with deliberate decrease in elasticity of CaHA alone. Clinical experience results also demonstrated that use of lidocaine injection followed by massage resulted in dispersion of CaHA accumulation and restoration of even contours. CONCLUSIONS The protocol described here may represent a mechanism by which improper placement of CaHA in facial tissues may be effectively corrected without the need for excision or injection of steroids. CONCLUSIONS Robert Voigts is a paid employee of Bioform Medical. Dr. DeVore is a consultant to Bioform Medical with stock options. Dr. Grazer is a paid consultant for Bioform. David J. Howell, PhD, RRT (San Francisco, CA) contributed to the writing of this manuscript.
Sarah Küchler - One of the best experts on this subject based on the ideXlab platform.
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Reconstructed Skin models as emerging tools for drug absorption studies.
Expert Opinion on Drug Metabolism & Toxicology, 2013Co-Authors: Sarah Küchler, Kay Strüver, Wolfgang FriessAbstract:Introduction: As humans can come into contact with xenobiotics intentionally or accidentally, knowledge about the Skin absorption of these substances is crucial and requires reliable models and test procedures. Animal experiments should be avoided whenever possible, instead of making the use of in vitro systems. Furthermore, due to limited availability of normal and especially diseased human Skin, alternative test systems such as reconstructed Skin models are urgently required. Areas covered: This article discusses the advantages and limitations of excised human Skin, Animal Skin and reconstructed Skin models for absorption testing in vitro. Furthermore, the authors also describe the standard procedure for Skin absorption testing and give an excursion to the applicability of artificial membranes. Finally, the article highlights the progress in the development of reconstructed disease models and provides an extensive overview about past and ongoing research in this field. Expert opinion: The development an...
Dale Devore - One of the best experts on this subject based on the ideXlab platform.
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dispersion of calcium hydroxylapatite accumulations in the Skin Animal studies and clinical practices
Dermatologic Surgery, 2010Co-Authors: Robert Voigts, Dale Devore, Jon M GrazerAbstract:OBJECTIVES To describe a method whereby accumulated calcium hydroxylapatite (CaHA) can be dispersed into surrounding dermal or subcutaneous tissues by local injection of an aqueous solution followed by vigorous massage. DESIGN Researchers examined three possible antidotes to correct CaHA nodularity: massage alone, injection of saline into the site followed by massage, and injection of sterile water into the site followed by massage. During the 21-day study period of CaHA alone and CaHA mixed with adjuvant, researchers observed inflammatory reactions on Day 0 and Day 21. Antidote efficacy was observed immediately after injection on Day 0 and again on Day 21. RESULTS The sterile water and CaHA+adjuvant saline solutions combined with massage demonstrated significantly less nodularity. In addition, CaHA+adjuvant blebs (nodules) were flattened out more upon massage than were CaHA-only blebs, a finding consistent with deliberate decrease in elasticity of CaHA alone. Clinical experience results also demonstrated that use of lidocaine injection followed by massage resulted in dispersion of CaHA accumulation and restoration of even contours. CONCLUSIONS The protocol described here may represent a mechanism by which improper placement of CaHA in facial tissues may be effectively corrected without the need for excision or injection of steroids. CONCLUSIONS Robert Voigts is a paid employee of Bioform Medical. Dr. DeVore is a consultant to Bioform Medical with stock options. Dr. Grazer is a paid consultant for Bioform. David J. Howell, PhD, RRT (San Francisco, CA) contributed to the writing of this manuscript.