The Experts below are selected from a list of 4317 Experts worldwide ranked by ideXlab platform
Xin-wei Yang - One of the best experts on this subject based on the ideXlab platform.
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Effects of Huoxue Bushen Mixture on Skin Blood Vessel neogenesis and vascular endothelial growth factor expression in hair follicle of C57BL/6 mice
Journal of Chinese Integrative Medicine, 2007Co-Authors: Shang-pu Gao, Lan Huang, Xin-wei YangAbstract:OBJECTIVE To investigate the possible stimulating mechanism of Huoxue Bushen Mixture (HXBSM), a traditional Chinese compound medicine, on hair growth of mice via measuring the variance of Skin Blood Vessel neogenesis and vascular endothelial growth factor (VEGF) expression in the hair follicle. METHODS Hot rosin and paraffin mixture depilation were used to induce C57BL/6 mice hair follicle to enter from telogen into anagen. Ninety C57BL/6 mice were divided into 3 groups randomly: HXBSM group, Yangxue Shengfa Capsule (YXSFC, another traditional Chinese compound medicine) group and untreated group. The mice were fed with corresponding drugs after modeling. The hair growth of the mice was observed every day. Every ten mice out of each group were executed respectively at day 4, 11 and day 17. Skin Blood Vessel neogenesis was counted through pathological section and VEGF expression in the hair follicle was measured via immunohistochemical method. RESULTS The number of local Blood Vessel neogenisis in the HXBSM group observed was larger than that in the untreated group at day 4 (P
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effects of huoxue bushen mixture on Skin Blood Vessel neogenesis and vascular endothelial growth factor expression in hair follicle of c57bl 6 mice
Journal of Chinese Integrative Medicine, 2007Co-Authors: Shang-pu Gao, Lan Huang, Xin-wei YangAbstract:OBJECTIVE To investigate the possible stimulating mechanism of Huoxue Bushen Mixture (HXBSM), a traditional Chinese compound medicine, on hair growth of mice via measuring the variance of Skin Blood Vessel neogenesis and vascular endothelial growth factor (VEGF) expression in the hair follicle. METHODS Hot rosin and paraffin mixture depilation were used to induce C57BL/6 mice hair follicle to enter from telogen into anagen. Ninety C57BL/6 mice were divided into 3 groups randomly: HXBSM group, Yangxue Shengfa Capsule (YXSFC, another traditional Chinese compound medicine) group and untreated group. The mice were fed with corresponding drugs after modeling. The hair growth of the mice was observed every day. Every ten mice out of each group were executed respectively at day 4, 11 and day 17. Skin Blood Vessel neogenesis was counted through pathological section and VEGF expression in the hair follicle was measured via immunohistochemical method. RESULTS The number of local Blood Vessel neogenisis in the HXBSM group observed was larger than that in the untreated group at day 4 (P<0.05); and evidently larger than that in the YXSFC group and the untreated group at day 11 (P<0.05). The expression of VEGF in the hair follicle was distinctively higher than that in the YXSFC group and the untreated group at day 11 and day 17 (P<0.05). CONCLUSION HXBSM up-regulates VEGF expression to accelerate Blood Vessel neogenesis and hair growth.
Shang-pu Gao - One of the best experts on this subject based on the ideXlab platform.
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Effects of Huoxue Bushen Mixture on Skin Blood Vessel neogenesis and vascular endothelial growth factor expression in hair follicle of C57BL/6 mice
Journal of Chinese Integrative Medicine, 2007Co-Authors: Shang-pu Gao, Lan Huang, Xin-wei YangAbstract:OBJECTIVE To investigate the possible stimulating mechanism of Huoxue Bushen Mixture (HXBSM), a traditional Chinese compound medicine, on hair growth of mice via measuring the variance of Skin Blood Vessel neogenesis and vascular endothelial growth factor (VEGF) expression in the hair follicle. METHODS Hot rosin and paraffin mixture depilation were used to induce C57BL/6 mice hair follicle to enter from telogen into anagen. Ninety C57BL/6 mice were divided into 3 groups randomly: HXBSM group, Yangxue Shengfa Capsule (YXSFC, another traditional Chinese compound medicine) group and untreated group. The mice were fed with corresponding drugs after modeling. The hair growth of the mice was observed every day. Every ten mice out of each group were executed respectively at day 4, 11 and day 17. Skin Blood Vessel neogenesis was counted through pathological section and VEGF expression in the hair follicle was measured via immunohistochemical method. RESULTS The number of local Blood Vessel neogenisis in the HXBSM group observed was larger than that in the untreated group at day 4 (P
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effects of huoxue bushen mixture on Skin Blood Vessel neogenesis and vascular endothelial growth factor expression in hair follicle of c57bl 6 mice
Journal of Chinese Integrative Medicine, 2007Co-Authors: Shang-pu Gao, Lan Huang, Xin-wei YangAbstract:OBJECTIVE To investigate the possible stimulating mechanism of Huoxue Bushen Mixture (HXBSM), a traditional Chinese compound medicine, on hair growth of mice via measuring the variance of Skin Blood Vessel neogenesis and vascular endothelial growth factor (VEGF) expression in the hair follicle. METHODS Hot rosin and paraffin mixture depilation were used to induce C57BL/6 mice hair follicle to enter from telogen into anagen. Ninety C57BL/6 mice were divided into 3 groups randomly: HXBSM group, Yangxue Shengfa Capsule (YXSFC, another traditional Chinese compound medicine) group and untreated group. The mice were fed with corresponding drugs after modeling. The hair growth of the mice was observed every day. Every ten mice out of each group were executed respectively at day 4, 11 and day 17. Skin Blood Vessel neogenesis was counted through pathological section and VEGF expression in the hair follicle was measured via immunohistochemical method. RESULTS The number of local Blood Vessel neogenisis in the HXBSM group observed was larger than that in the untreated group at day 4 (P<0.05); and evidently larger than that in the YXSFC group and the untreated group at day 11 (P<0.05). The expression of VEGF in the hair follicle was distinctively higher than that in the YXSFC group and the untreated group at day 11 and day 17 (P<0.05). CONCLUSION HXBSM up-regulates VEGF expression to accelerate Blood Vessel neogenesis and hair growth.
Lan Huang - One of the best experts on this subject based on the ideXlab platform.
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Effects of Huoxue Bushen Mixture on Skin Blood Vessel neogenesis and vascular endothelial growth factor expression in hair follicle of C57BL/6 mice
Journal of Chinese Integrative Medicine, 2007Co-Authors: Shang-pu Gao, Lan Huang, Xin-wei YangAbstract:OBJECTIVE To investigate the possible stimulating mechanism of Huoxue Bushen Mixture (HXBSM), a traditional Chinese compound medicine, on hair growth of mice via measuring the variance of Skin Blood Vessel neogenesis and vascular endothelial growth factor (VEGF) expression in the hair follicle. METHODS Hot rosin and paraffin mixture depilation were used to induce C57BL/6 mice hair follicle to enter from telogen into anagen. Ninety C57BL/6 mice were divided into 3 groups randomly: HXBSM group, Yangxue Shengfa Capsule (YXSFC, another traditional Chinese compound medicine) group and untreated group. The mice were fed with corresponding drugs after modeling. The hair growth of the mice was observed every day. Every ten mice out of each group were executed respectively at day 4, 11 and day 17. Skin Blood Vessel neogenesis was counted through pathological section and VEGF expression in the hair follicle was measured via immunohistochemical method. RESULTS The number of local Blood Vessel neogenisis in the HXBSM group observed was larger than that in the untreated group at day 4 (P
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effects of huoxue bushen mixture on Skin Blood Vessel neogenesis and vascular endothelial growth factor expression in hair follicle of c57bl 6 mice
Journal of Chinese Integrative Medicine, 2007Co-Authors: Shang-pu Gao, Lan Huang, Xin-wei YangAbstract:OBJECTIVE To investigate the possible stimulating mechanism of Huoxue Bushen Mixture (HXBSM), a traditional Chinese compound medicine, on hair growth of mice via measuring the variance of Skin Blood Vessel neogenesis and vascular endothelial growth factor (VEGF) expression in the hair follicle. METHODS Hot rosin and paraffin mixture depilation were used to induce C57BL/6 mice hair follicle to enter from telogen into anagen. Ninety C57BL/6 mice were divided into 3 groups randomly: HXBSM group, Yangxue Shengfa Capsule (YXSFC, another traditional Chinese compound medicine) group and untreated group. The mice were fed with corresponding drugs after modeling. The hair growth of the mice was observed every day. Every ten mice out of each group were executed respectively at day 4, 11 and day 17. Skin Blood Vessel neogenesis was counted through pathological section and VEGF expression in the hair follicle was measured via immunohistochemical method. RESULTS The number of local Blood Vessel neogenisis in the HXBSM group observed was larger than that in the untreated group at day 4 (P<0.05); and evidently larger than that in the YXSFC group and the untreated group at day 11 (P<0.05). The expression of VEGF in the hair follicle was distinctively higher than that in the YXSFC group and the untreated group at day 11 and day 17 (P<0.05). CONCLUSION HXBSM up-regulates VEGF expression to accelerate Blood Vessel neogenesis and hair growth.
Ueon Sang Shin - One of the best experts on this subject based on the ideXlab platform.
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fibroblast growth factors biology function and application for tissue regeneration
Journal of Tissue Engineering, 2010Co-Authors: Eunyi Jeon, Wonmo Kang, Hyejin Jo, Junhyeog Jang, Ueon Sang ShinAbstract:Fibroblast growth factors (FGFs) that signal through FGF receptors (FGFRs) regulate a broad spectrum of biological functions, including cellular proliferation, survival, migration, and differentiation. The FGF signal pathways are the RAS/MAP kinase pathway, PI3 kinase/AKT pathway, and PLCγ pathway, among which the RAS/MAP kinase pathway is known to be predominant. Several studies have recently implicated the in vitro biological functions of FGFs for tissue regeneration. However, to obtain optimal outcomes in vivo, it is important to enhance the half-life of FGFs and their biological stability. Future applications of FGFs are expected when the biological functions of FGFs are potentiated through the appropriate use of delivery systems and scaffolds. This review will introduce the biology and cellular functions of FGFs and deal with the biomaterials based delivery systems and their current applications for the regeneration of tissues, including Skin, Blood Vessel, muscle, adipose, tendon/ligament, cartilage...
Eunyi Jeon - One of the best experts on this subject based on the ideXlab platform.
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fibroblast growth factors biology function and application for tissue regeneration
Journal of Tissue Engineering, 2010Co-Authors: Eunyi Jeon, Wonmo Kang, Hyejin Jo, Junhyeog Jang, Ueon Sang ShinAbstract:Fibroblast growth factors (FGFs) that signal through FGF receptors (FGFRs) regulate a broad spectrum of biological functions, including cellular proliferation, survival, migration, and differentiation. The FGF signal pathways are the RAS/MAP kinase pathway, PI3 kinase/AKT pathway, and PLCγ pathway, among which the RAS/MAP kinase pathway is known to be predominant. Several studies have recently implicated the in vitro biological functions of FGFs for tissue regeneration. However, to obtain optimal outcomes in vivo, it is important to enhance the half-life of FGFs and their biological stability. Future applications of FGFs are expected when the biological functions of FGFs are potentiated through the appropriate use of delivery systems and scaffolds. This review will introduce the biology and cellular functions of FGFs and deal with the biomaterials based delivery systems and their current applications for the regeneration of tissues, including Skin, Blood Vessel, muscle, adipose, tendon/ligament, cartilage...