The Experts below are selected from a list of 9 Experts worldwide ranked by ideXlab platform

Hiroshi Shimizu - One of the best experts on this subject based on the ideXlab platform.

  • harlequin ichthyosis model mouse reveals alveolar collapse and severe fetal Skin barrier defects
    Human Molecular Genetics, 2008
    Co-Authors: Teruki Yanagi, Masashi Akiyama, Kaori Sakai, Hiroshi Nishihara, Wataru Nishie, Shinya Tanaka, Hiroshi Shimizu
    Abstract:

    : Harlequin ichthyosis (HI), which is the most severe genodermatosis, is caused by loss-of-function mutations in ABCA12, a member of the ATP-binding cassette transporter family. To investigate the pathomechanism of HI and the function of the ABCA12 protein, we generated ABCA12-deficient mice (Abca12(-/-)) by targeting Abca12. Abca12(-/-) mice closely reproduce the human HI phenotype, showing marked hyperkeratosis with eclabium and Skin Fissure. Lamellar granule abnormalities and defective ceramide distribution were remarkable in the epidermis. Skin permeability assay of Abca12(-/-) fetuses revealed severe Skin barrier dysfunction after the initiation of keratinization. Surprisingly, the Abca12(-/-) mice also demonstrated lung alveolar collapse immediately after birth. Lamellar bodies in alveolar type II cells of the Abca12(-/-) mice lacked normal lamellar structures. The level of surfactant protein B, an essential component of alveolar surfactant, was reduced in the Abca12(-/-) mice. Fetal therapeutic trials with systemic administration of retinoid or dexamethasone, which are effective for HI and respiratory distress, respectively, to the pregnant mother mice neither improved the Skin phenotype nor extended the survival period. Our HI model mice reproduce the human HI Skin phenotype soon after the initiation of fetal Skin keratinization and provide evidence that ABCA12 plays pivotal roles in lung and Skin barrier functions.

Seyed Alireza Mortazavi - One of the best experts on this subject based on the ideXlab platform.

  • comparing the etiology and treatment of Skin Fissure in traditional and conventional medicine a brief review
    Research Journal of Pharmacognosy, 2016
    Co-Authors: A Jedkareh, Somayeh Esmaeili, A Alembagheri, Seyed Alireza Mortazavi
    Abstract:

    Dry Skin is a common problem which affects wound healing, severity of other Skin diseases and quality of life of people. One of its undesirable effects is Fissure that is a cutaneous condition in which there is a linear loss of epidermis and dermis with sharply defined, nearly vertical walls. In the present study, we have investigated the etiology of the disease and its treatments in conventional medicine and Iranian Traditional Medicine (ITM). Two traditional medicine references, current scientific data bases and medicinal texts were explored with the selected keywords such as "sheqaq-e-poosti", "Skin Fissure" and "dry Skin" to find the etiology and treatment of Skin Fissure. From the view point of both conventional medicine and ITM, dry Skin is the cause of Skin Fissure and some causes of dry Skin are similar. In conventional medicine, moisturizers are mainly used for treatment of dry Skin; while in ITM some herbs, oils and other natural remedies have been used. A topical dosage form which was called "qeirooti", a mixture of wax and oil, was used to treat Skin Fissure in ITM. It comprised of oily ingredients that acted as occlusives and also some herbal components that directly improved dry Skin (similar to moisturizers). Components efficacy of traditional dosage forms for treatment of dry Skin lead us to study about formulation of “qeirooti” for treatment of dry Skin.

Teruki Yanagi - One of the best experts on this subject based on the ideXlab platform.

  • harlequin ichthyosis model mouse reveals alveolar collapse and severe fetal Skin barrier defects
    Human Molecular Genetics, 2008
    Co-Authors: Teruki Yanagi, Masashi Akiyama, Kaori Sakai, Hiroshi Nishihara, Wataru Nishie, Shinya Tanaka, Hiroshi Shimizu
    Abstract:

    : Harlequin ichthyosis (HI), which is the most severe genodermatosis, is caused by loss-of-function mutations in ABCA12, a member of the ATP-binding cassette transporter family. To investigate the pathomechanism of HI and the function of the ABCA12 protein, we generated ABCA12-deficient mice (Abca12(-/-)) by targeting Abca12. Abca12(-/-) mice closely reproduce the human HI phenotype, showing marked hyperkeratosis with eclabium and Skin Fissure. Lamellar granule abnormalities and defective ceramide distribution were remarkable in the epidermis. Skin permeability assay of Abca12(-/-) fetuses revealed severe Skin barrier dysfunction after the initiation of keratinization. Surprisingly, the Abca12(-/-) mice also demonstrated lung alveolar collapse immediately after birth. Lamellar bodies in alveolar type II cells of the Abca12(-/-) mice lacked normal lamellar structures. The level of surfactant protein B, an essential component of alveolar surfactant, was reduced in the Abca12(-/-) mice. Fetal therapeutic trials with systemic administration of retinoid or dexamethasone, which are effective for HI and respiratory distress, respectively, to the pregnant mother mice neither improved the Skin phenotype nor extended the survival period. Our HI model mice reproduce the human HI Skin phenotype soon after the initiation of fetal Skin keratinization and provide evidence that ABCA12 plays pivotal roles in lung and Skin barrier functions.

A Jedkareh - One of the best experts on this subject based on the ideXlab platform.

  • comparing the etiology and treatment of Skin Fissure in traditional and conventional medicine a brief review
    Research Journal of Pharmacognosy, 2016
    Co-Authors: A Jedkareh, Somayeh Esmaeili, A Alembagheri, Seyed Alireza Mortazavi
    Abstract:

    Dry Skin is a common problem which affects wound healing, severity of other Skin diseases and quality of life of people. One of its undesirable effects is Fissure that is a cutaneous condition in which there is a linear loss of epidermis and dermis with sharply defined, nearly vertical walls. In the present study, we have investigated the etiology of the disease and its treatments in conventional medicine and Iranian Traditional Medicine (ITM). Two traditional medicine references, current scientific data bases and medicinal texts were explored with the selected keywords such as "sheqaq-e-poosti", "Skin Fissure" and "dry Skin" to find the etiology and treatment of Skin Fissure. From the view point of both conventional medicine and ITM, dry Skin is the cause of Skin Fissure and some causes of dry Skin are similar. In conventional medicine, moisturizers are mainly used for treatment of dry Skin; while in ITM some herbs, oils and other natural remedies have been used. A topical dosage form which was called "qeirooti", a mixture of wax and oil, was used to treat Skin Fissure in ITM. It comprised of oily ingredients that acted as occlusives and also some herbal components that directly improved dry Skin (similar to moisturizers). Components efficacy of traditional dosage forms for treatment of dry Skin lead us to study about formulation of “qeirooti” for treatment of dry Skin.

Masashi Akiyama - One of the best experts on this subject based on the ideXlab platform.

  • harlequin ichthyosis model mouse reveals alveolar collapse and severe fetal Skin barrier defects
    Human Molecular Genetics, 2008
    Co-Authors: Teruki Yanagi, Masashi Akiyama, Kaori Sakai, Hiroshi Nishihara, Wataru Nishie, Shinya Tanaka, Hiroshi Shimizu
    Abstract:

    : Harlequin ichthyosis (HI), which is the most severe genodermatosis, is caused by loss-of-function mutations in ABCA12, a member of the ATP-binding cassette transporter family. To investigate the pathomechanism of HI and the function of the ABCA12 protein, we generated ABCA12-deficient mice (Abca12(-/-)) by targeting Abca12. Abca12(-/-) mice closely reproduce the human HI phenotype, showing marked hyperkeratosis with eclabium and Skin Fissure. Lamellar granule abnormalities and defective ceramide distribution were remarkable in the epidermis. Skin permeability assay of Abca12(-/-) fetuses revealed severe Skin barrier dysfunction after the initiation of keratinization. Surprisingly, the Abca12(-/-) mice also demonstrated lung alveolar collapse immediately after birth. Lamellar bodies in alveolar type II cells of the Abca12(-/-) mice lacked normal lamellar structures. The level of surfactant protein B, an essential component of alveolar surfactant, was reduced in the Abca12(-/-) mice. Fetal therapeutic trials with systemic administration of retinoid or dexamethasone, which are effective for HI and respiratory distress, respectively, to the pregnant mother mice neither improved the Skin phenotype nor extended the survival period. Our HI model mice reproduce the human HI Skin phenotype soon after the initiation of fetal Skin keratinization and provide evidence that ABCA12 plays pivotal roles in lung and Skin barrier functions.