The Experts below are selected from a list of 33 Experts worldwide ranked by ideXlab platform
William L Epstein - One of the best experts on this subject based on the ideXlab platform.
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immunogenetic influences on Skin Granuloma formation in mice
Experimental and Molecular Pathology, 1991Co-Authors: Toshihiro Iida, Kimie Fukuyama, Naoyoshi Sato, Daniel T Lau, William L EpsteinAbstract:Genetic influence on the development of Granulomatous tissue reaction was investigated in C57BL/6 mice. Granulomas developed in the Skin of euthymic C57BL/6 mice by transplantation of lyophilized hepatic Granulomas were excised and lyophilized. The tissue mass free of parasite egg antigen and living cells was grafted into the Skin of euthymic, athymic (nu/nu), and beige (bg/bg) C57BL/6 mice. Histological changes at the Skin sites were studied weekly by light microscopy, and cells in newly developed Granulomas at 6 weeks after grafting were examined by electron microscopy. Granulomatous inflammation occurred in all the variants but morphometric analysis showed that Granulomatous inflammation was the most extensive in beige mice and least in athymic mice. The differences in the degree of tissue reaction were also quantified by measuring angiotensin converting enzyme and prolyl endopeptidase. Statistically significant differences among the animals with varying genetic background were confirmed by the marker enzyme activity. The findings confirm that initiation of a Granulomatous response does not require T cells but T cell function is important for full expression of the reaction, while NK cell activity seems to suppress Granuloma formation.
Despina Moshous - One of the best experts on this subject based on the ideXlab platform.
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Cutaneous and Visceral Chronic Granulomatous Disease Triggered by a Rubella Virus Vaccine Strain in Children With Primary Immunodeficiencies
Clinical Infectious Diseases, 2016Co-Authors: Bénédicte Neven, Philippe Perot, Julie Bruneau, Marlène Pasquet, Marie Ramirez, Jean-sébastien Diana, Stéphanie Luzi, Nicole Corre-catelin, Christophe Chardot, Despina MoshousAbstract:Persistence of rubella live vaccine has been associated with chronic Skin Granuloma in 3 children with primary immunode-ficiency. We describe 6 additional children with these findings, including 1 with visceral extension to the spleen.
Toshihiro Iida - One of the best experts on this subject based on the ideXlab platform.
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immunogenetic influences on Skin Granuloma formation in mice
Experimental and Molecular Pathology, 1991Co-Authors: Toshihiro Iida, Kimie Fukuyama, Naoyoshi Sato, Daniel T Lau, William L EpsteinAbstract:Genetic influence on the development of Granulomatous tissue reaction was investigated in C57BL/6 mice. Granulomas developed in the Skin of euthymic C57BL/6 mice by transplantation of lyophilized hepatic Granulomas were excised and lyophilized. The tissue mass free of parasite egg antigen and living cells was grafted into the Skin of euthymic, athymic (nu/nu), and beige (bg/bg) C57BL/6 mice. Histological changes at the Skin sites were studied weekly by light microscopy, and cells in newly developed Granulomas at 6 weeks after grafting were examined by electron microscopy. Granulomatous inflammation occurred in all the variants but morphometric analysis showed that Granulomatous inflammation was the most extensive in beige mice and least in athymic mice. The differences in the degree of tissue reaction were also quantified by measuring angiotensin converting enzyme and prolyl endopeptidase. Statistically significant differences among the animals with varying genetic background were confirmed by the marker enzyme activity. The findings confirm that initiation of a Granulomatous response does not require T cells but T cell function is important for full expression of the reaction, while NK cell activity seems to suppress Granuloma formation.
Bénédicte Neven - One of the best experts on this subject based on the ideXlab platform.
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Cutaneous and Visceral Chronic Granulomatous Disease Triggered by a Rubella Virus Vaccine Strain in Children With Primary Immunodeficiencies
Clinical Infectious Diseases, 2016Co-Authors: Bénédicte Neven, Philippe Perot, Julie Bruneau, Marlène Pasquet, Marie Ramirez, Jean-sébastien Diana, Stéphanie Luzi, Nicole Corre-catelin, Christophe Chardot, Despina MoshousAbstract:Persistence of rubella live vaccine has been associated with chronic Skin Granuloma in 3 children with primary immunode-ficiency. We describe 6 additional children with these findings, including 1 with visceral extension to the spleen.
Daniel T Lau - One of the best experts on this subject based on the ideXlab platform.
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immunogenetic influences on Skin Granuloma formation in mice
Experimental and Molecular Pathology, 1991Co-Authors: Toshihiro Iida, Kimie Fukuyama, Naoyoshi Sato, Daniel T Lau, William L EpsteinAbstract:Genetic influence on the development of Granulomatous tissue reaction was investigated in C57BL/6 mice. Granulomas developed in the Skin of euthymic C57BL/6 mice by transplantation of lyophilized hepatic Granulomas were excised and lyophilized. The tissue mass free of parasite egg antigen and living cells was grafted into the Skin of euthymic, athymic (nu/nu), and beige (bg/bg) C57BL/6 mice. Histological changes at the Skin sites were studied weekly by light microscopy, and cells in newly developed Granulomas at 6 weeks after grafting were examined by electron microscopy. Granulomatous inflammation occurred in all the variants but morphometric analysis showed that Granulomatous inflammation was the most extensive in beige mice and least in athymic mice. The differences in the degree of tissue reaction were also quantified by measuring angiotensin converting enzyme and prolyl endopeptidase. Statistically significant differences among the animals with varying genetic background were confirmed by the marker enzyme activity. The findings confirm that initiation of a Granulomatous response does not require T cells but T cell function is important for full expression of the reaction, while NK cell activity seems to suppress Granuloma formation.